KR102062262B1 - Wnt 경로 조절제로서의 퓨린 디온 - Google Patents
Wnt 경로 조절제로서의 퓨린 디온 Download PDFInfo
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- KR102062262B1 KR102062262B1 KR1020157035961A KR20157035961A KR102062262B1 KR 102062262 B1 KR102062262 B1 KR 102062262B1 KR 1020157035961 A KR1020157035961 A KR 1020157035961A KR 20157035961 A KR20157035961 A KR 20157035961A KR 102062262 B1 KR102062262 B1 KR 102062262B1
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- ZIDLLXZOOHLVHZ-UHFFFAOYSA-N Nc1cc(-c2ccccc2)c[s]1 Chemical compound Nc1cc(-c2ccccc2)c[s]1 ZIDLLXZOOHLVHZ-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
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- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1309333.1 | 2013-05-23 | ||
| GBGB1309333.1A GB201309333D0 (en) | 2013-05-23 | 2013-05-23 | Purine diones as WNT pathway modulators |
| PCT/SG2014/000217 WO2014189466A1 (en) | 2013-05-23 | 2014-05-19 | Purine diones as wnt pathway modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197038593A Division KR102153989B1 (ko) | 2013-05-23 | 2014-05-19 | Wnt 경로 조절제로서의 퓨린 디온 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160029024A KR20160029024A (ko) | 2016-03-14 |
| KR102062262B1 true KR102062262B1 (ko) | 2020-01-03 |
Family
ID=48784655
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157035961A Active KR102062262B1 (ko) | 2013-05-23 | 2014-05-19 | Wnt 경로 조절제로서의 퓨린 디온 |
| KR1020197038593A Active KR102153989B1 (ko) | 2013-05-23 | 2014-05-19 | Wnt 경로 조절제로서의 퓨린 디온 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197038593A Active KR102153989B1 (ko) | 2013-05-23 | 2014-05-19 | Wnt 경로 조절제로서의 퓨린 디온 |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9926320B2 (enExample) |
| EP (1) | EP2999699B1 (enExample) |
| JP (1) | JP6506742B2 (enExample) |
| KR (2) | KR102062262B1 (enExample) |
| CN (2) | CN105452248A (enExample) |
| AU (2) | AU2014269134B2 (enExample) |
| BR (1) | BR112015029182B1 (enExample) |
| CA (1) | CA2912757C (enExample) |
| DK (1) | DK2999699T3 (enExample) |
| ES (1) | ES2802923T3 (enExample) |
| GB (1) | GB201309333D0 (enExample) |
| SG (1) | SG11201509593TA (enExample) |
| WO (1) | WO2014189466A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201309333D0 (en) | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
| GB201322334D0 (en) | 2013-12-17 | 2014-01-29 | Agency Science Tech & Res | Maleimide derivatives as modulators of WNT pathway |
| TWI676626B (zh) * | 2014-04-23 | 2019-11-11 | 美商美國禮來大藥廠 | 抑制瞬時受體電位a1離子通道 |
| PT3193880T (pt) | 2014-09-19 | 2020-06-19 | Lilly Co Eli | Inibição do canal iónico receptor de potencial transitório a1 |
| CN105440034B (zh) * | 2015-11-16 | 2017-08-15 | 山东罗欣药业集团股份有限公司 | 一种利格列汀及其中间体的制备方法 |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| CN106632332B (zh) * | 2016-09-26 | 2018-07-06 | 杭州新博思生物医药有限公司 | 一种伊曲茶碱的制备方法 |
| WO2019054941A1 (en) | 2017-09-14 | 2019-03-21 | Agency For Science, Technology And Research | MODULATORS OF THE WNT PATH |
| BR112020014584A2 (pt) | 2018-01-31 | 2020-12-01 | Eli Lilly And Company | inibição do canal iônico do receptor de potencial transitório a1 |
| US10961534B2 (en) | 2018-07-13 | 2021-03-30 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating porphyria |
| CN114072131B (zh) * | 2019-05-22 | 2024-03-19 | 新加坡科技研究局 | 口服制剂、其制备方法及其用途 |
| WO2020236078A1 (en) * | 2019-05-22 | 2020-11-26 | Agency For Science, Technology And Research | Pharmaceutical combination |
| CN114072408B (zh) * | 2019-07-08 | 2023-05-12 | 南京明德新药研发有限公司 | 作为porcupine抑制剂的化合物及其应用 |
| JP2023511039A (ja) * | 2020-01-08 | 2023-03-16 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 組み合わせ療法 |
| BR112023025403A2 (pt) | 2021-06-25 | 2024-02-20 | Korea Res Inst Chemical Tech | Composto heterocíclico bifuncional tendo função de degradação de btk por meio da via ubiquitina proteassoma e uso do mesmo |
| WO2023072263A1 (zh) | 2021-10-29 | 2023-05-04 | 南京明德新药研发有限公司 | 5-取代的吡啶-2(1h)-酮类化合物及其应用 |
| CN114671875A (zh) * | 2022-04-27 | 2022-06-28 | 成都施贝康生物医药科技有限公司 | 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途 |
| CN120737092B (zh) * | 2025-09-05 | 2025-11-14 | 利诚检测认证集团股份有限公司 | 别嘌醇半抗原及其制备方法、人工抗原、抗体及其应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009140519A1 (en) * | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| WO2010075353A1 (en) * | 2008-12-22 | 2010-07-01 | Hydra Biosciences, Inc. | Compositions useful for treating disorders related to trpa1 |
| WO2011042798A1 (en) * | 2009-10-08 | 2011-04-14 | Incozen Therapeutics Pvt. Ltd. | Pyrazoles derivatives modulators of calcium release -activated calcium channel and methods for treatment of non- small cell lung cancer |
| US20120316136A1 (en) * | 2011-06-13 | 2012-12-13 | Glenmark Pharmaceuticals S.A. | Treatment of respiratory disorders using trpa1 antagonists |
| WO2013023102A1 (en) * | 2011-08-09 | 2013-02-14 | Hydra Biosciences, Inc. | Inhibiting transient receptor potential ion channel trpa1 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA71971C2 (en) | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
| ES2436225T3 (es) | 2005-12-22 | 2013-12-27 | Hydra Biosciences, Inc. | Inhibidores TRPA1 para tratamiento del dolor |
| EP3663295A1 (en) * | 2007-06-22 | 2020-06-10 | Eli Lilly And Co. | 2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel |
| CN101909630A (zh) * | 2007-11-02 | 2010-12-08 | 新加坡科技研究局 | 预防和治疗肿瘤的方法和化合物 |
| JP2011507910A (ja) * | 2007-12-21 | 2011-03-10 | ユニバーシティー オブ ロチェスター | 真核生物の寿命を変更するための方法 |
| US20120046305A1 (en) | 2008-09-24 | 2012-02-23 | Moran Magdalene M | Methods and compositions for treating respiratory disorders |
| UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| UY33469A (es) | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
| EP2655377B1 (en) * | 2010-12-20 | 2016-03-30 | Glenmark Pharmaceuticals S.A. | 2-amino-4-arylthiazole compounds as trpa1 antagonists |
| JP5659098B2 (ja) * | 2011-07-19 | 2015-01-28 | 株式会社東芝 | 半導体装置の製造方法 |
| WO2013014597A1 (en) * | 2011-07-25 | 2013-01-31 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising a trpa1 antagonist and a steroid |
| AU2012308570B2 (en) * | 2011-09-14 | 2016-11-10 | Samumed, Llc | Indazole-3-carboxamides and their use as Wnt/b-catenin signaling pathway inhibitors |
| AU2013259294B2 (en) | 2012-05-11 | 2017-04-06 | Synchronicity Pharma, Inc. | Carbazole-containing sulfonamides as cryptochrome modulators |
| GB201309333D0 (en) | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
-
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009140519A1 (en) * | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| WO2010075353A1 (en) * | 2008-12-22 | 2010-07-01 | Hydra Biosciences, Inc. | Compositions useful for treating disorders related to trpa1 |
| WO2011042798A1 (en) * | 2009-10-08 | 2011-04-14 | Incozen Therapeutics Pvt. Ltd. | Pyrazoles derivatives modulators of calcium release -activated calcium channel and methods for treatment of non- small cell lung cancer |
| US20120316136A1 (en) * | 2011-06-13 | 2012-12-13 | Glenmark Pharmaceuticals S.A. | Treatment of respiratory disorders using trpa1 antagonists |
| WO2013023102A1 (en) * | 2011-08-09 | 2013-02-14 | Hydra Biosciences, Inc. | Inhibiting transient receptor potential ion channel trpa1 |
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