JP2019510034A5 - - Google Patents
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- Publication number
- JP2019510034A5 JP2019510034A5 JP2018550545A JP2018550545A JP2019510034A5 JP 2019510034 A5 JP2019510034 A5 JP 2019510034A5 JP 2018550545 A JP2018550545 A JP 2018550545A JP 2018550545 A JP2018550545 A JP 2018550545A JP 2019510034 A5 JP2019510034 A5 JP 2019510034A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- polymorph
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 22
- 239000012453 solvate Substances 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 208000001490 Dengue Diseases 0.000 claims description 8
- 206010012310 Dengue fever Diseases 0.000 claims description 8
- 208000025729 dengue disease Diseases 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 241000725619 Dengue virus Species 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 239000003443 antiviral agent Substances 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- -1 di-substituted indole group Chemical group 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163488 | 2016-04-01 | ||
| EP16163488.6 | 2016-04-01 | ||
| PCT/EP2017/057661 WO2017167951A1 (en) | 2016-04-01 | 2017-03-31 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510034A JP2019510034A (ja) | 2019-04-11 |
| JP2019510034A5 true JP2019510034A5 (enExample) | 2020-04-23 |
| JP6970115B2 JP6970115B2 (ja) | 2021-11-24 |
Family
ID=55650311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550545A Active JP6970115B2 (ja) | 2016-04-01 | 2017-03-31 | デングウイルス複製阻害剤としての置換インドリン誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US10689340B2 (enExample) |
| EP (1) | EP3436437B1 (enExample) |
| JP (1) | JP6970115B2 (enExample) |
| KR (1) | KR102359776B1 (enExample) |
| CN (1) | CN108884037B (enExample) |
| AR (1) | AR108046A1 (enExample) |
| AU (1) | AU2017242894B2 (enExample) |
| CA (1) | CA3013406C (enExample) |
| CL (1) | CL2018002758A1 (enExample) |
| CO (1) | CO2018009563A2 (enExample) |
| CR (1) | CR20180493A (enExample) |
| DK (1) | DK3436437T3 (enExample) |
| EA (1) | EA037988B1 (enExample) |
| EC (1) | ECSP18073293A (enExample) |
| ES (1) | ES2884067T3 (enExample) |
| HR (1) | HRP20211278T1 (enExample) |
| HU (1) | HUE055577T2 (enExample) |
| IL (1) | IL261948B (enExample) |
| JO (1) | JOP20170069B1 (enExample) |
| LT (1) | LT3436437T (enExample) |
| MX (1) | MX381634B (enExample) |
| MY (1) | MY195194A (enExample) |
| PE (1) | PE20181778A1 (enExample) |
| PH (1) | PH12018502077A1 (enExample) |
| SG (1) | SG11201808409XA (enExample) |
| SI (1) | SI3436437T1 (enExample) |
| TW (1) | TWI723148B (enExample) |
| UA (1) | UA125296C2 (enExample) |
| UY (1) | UY37182A (enExample) |
| WO (1) | WO2017167951A1 (enExample) |
| ZA (1) | ZA201806482B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| WO2017167950A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| CR20180496A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN109069482B (zh) | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| MX393586B (es) | 2017-05-22 | 2025-03-24 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| CA3161338A1 (en) | 2019-11-15 | 2021-05-20 | Janssen Pharmaceuticals, Inc. | Treatment and prevention of dengue disease |
| WO2025248536A1 (en) * | 2024-05-29 | 2025-12-04 | Zydus Lifesciences Limited | Novel oxime derivatives to treat viral infections |
| WO2025253267A1 (en) | 2024-06-06 | 2025-12-11 | Janssen Pharmaceuticals, Inc. | Combination of mosnodenvir and close analogs with nitd-688 for use in the treatment and prevention of dengue disease |
| CN121378100A (zh) * | 2025-12-24 | 2026-01-23 | 浙江大学医学院附属第二医院 | 一种苯并[g]吲哚衍生物及其在制备抗登革热药物中的应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1200899A (en) | 1997-10-27 | 1999-05-17 | Eli Lilly And Company | Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| WO2003050295A2 (en) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| AU2006204917A1 (en) | 2005-01-14 | 2006-07-20 | Smithkline Beecham Corporation | Indole derivatives for treating viral infections |
| EA200701669A1 (ru) | 2005-02-09 | 2008-02-28 | Мидженикс Инк. | Композиции и способы лечения или предотвращения инфекций, вызванных вирусами семейства flaviviridae |
| AP2010005480A0 (en) | 2008-06-03 | 2010-12-31 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of denque virus infection. |
| US8143259B2 (en) | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| WO2010091413A1 (en) | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| PT2523951E (pt) | 2010-01-15 | 2015-09-14 | Gilead Sciences Inc | Inibidores de vírus flaviviridae |
| JP2013523657A (ja) | 2010-03-26 | 2013-06-17 | グラクソ グループ リミテッド | キナーゼ阻害剤としてのインダゾリル‐ピリミジン |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR102290189B1 (ko) | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| TWI688564B (zh) | 2014-01-31 | 2020-03-21 | 美商必治妥美雅史谷比公司 | 作為凝血因子ｘｉａ抑制劑之具有雜環p2'基團之巨環化合物 |
| NO2721243T3 (enExample) | 2014-10-01 | 2018-10-20 | ||
| PL3201177T3 (pl) * | 2014-10-01 | 2019-05-31 | Janssen Pharmaceuticals Inc | Mono- lub di-podstawione indole jako inhibitory replikacji wirusa dengi |
| EP3201176B1 (en) | 2014-10-01 | 2018-12-12 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| PH12017501272B1 (en) * | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EP3370698B1 (en) | 2015-11-03 | 2022-01-26 | Zoetis Services LLC | Sol-gel polymer composites and uses thereof |
| WO2017167950A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| EA036637B1 (ru) | 2016-03-31 | 2020-12-02 | Такеда Фармасьютикал Компани Лимитед | Гетероциклические спиросоединения, ингибирующие моноацилглицерин-липазу |
| CR20180496A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| CN109069482B (zh) | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| PT3436079T (pt) | 2016-04-01 | 2021-10-06 | Kite Pharma Inc | Recetores de antigénios quiméricos e de células t e métodos de uso |
| BR112018070163A2 (pt) | 2016-04-01 | 2019-01-29 | Signal Pharm Llc | compostos de aminopurina substituída, composições e métodos de tratamento |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3015934A1 (en) | 2016-04-01 | 2017-10-05 | Basf Se | Bicyclic compounds |
| UA123276C2 (uk) | 2016-04-01 | 2021-03-10 | Кайт Фарма, Інк. | Химерний рецептор та спосіб лікування пухлини або злоякісного новоутворення |
| KR102694879B1 (ko) | 2016-04-01 | 2024-08-16 | 암젠 인크 | Flt3에 대한 키메라 수용체 및 이의 사용 방법 |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX393586B (es) | 2017-05-22 | 2025-03-24 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
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2017
- 2017-03-22 JO JOP/2017/0069A patent/JOP20170069B1/ar active
- 2017-03-30 TW TW106110686A patent/TWI723148B/zh not_active IP Right Cessation
- 2017-03-30 AR ARP170100795A patent/AR108046A1/es unknown
- 2017-03-31 CO CONC2018/0009563A patent/CO2018009563A2/es unknown
- 2017-03-31 PE PE2018001870A patent/PE20181778A1/es unknown
- 2017-03-31 CR CR20180493A patent/CR20180493A/es unknown
- 2017-03-31 EA EA201892219A patent/EA037988B1/ru unknown
- 2017-03-31 LT LTEP17714751.9T patent/LT3436437T/lt unknown
- 2017-03-31 KR KR1020187028180A patent/KR102359776B1/ko active Active
- 2017-03-31 CN CN201780021323.0A patent/CN108884037B/zh active Active
- 2017-03-31 AU AU2017242894A patent/AU2017242894B2/en active Active
- 2017-03-31 CA CA3013406A patent/CA3013406C/en active Active
- 2017-03-31 HR HRP20211278TT patent/HRP20211278T1/hr unknown
- 2017-03-31 MY MYPI2018001596A patent/MY195194A/en unknown
- 2017-03-31 SG SG11201808409XA patent/SG11201808409XA/en unknown
- 2017-03-31 UY UY0001037182A patent/UY37182A/es unknown
- 2017-03-31 WO PCT/EP2017/057661 patent/WO2017167951A1/en not_active Ceased
- 2017-03-31 MX MX2018011785A patent/MX381634B/es unknown
- 2017-03-31 SI SI201730871T patent/SI3436437T1/sl unknown
- 2017-03-31 JP JP2018550545A patent/JP6970115B2/ja active Active
- 2017-03-31 DK DK17714751.9T patent/DK3436437T3/da active
- 2017-03-31 ES ES17714751T patent/ES2884067T3/es active Active
- 2017-03-31 UA UAA201810728A patent/UA125296C2/uk unknown
- 2017-03-31 US US16/088,090 patent/US10689340B2/en active Active
- 2017-03-31 HU HUE17714751A patent/HUE055577T2/hu unknown
- 2017-03-31 EP EP17714751.9A patent/EP3436437B1/en active Active
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2018
- 2018-09-26 IL IL261948A patent/IL261948B/en unknown
- 2018-09-27 CL CL2018002758A patent/CL2018002758A1/es unknown
- 2018-09-27 PH PH12018502077A patent/PH12018502077A1/en unknown
- 2018-09-28 EC ECSENADI201873293A patent/ECSP18073293A/es unknown
- 2018-09-28 ZA ZA2018/06482A patent/ZA201806482B/en unknown
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2020
- 2020-06-05 US US16/893,685 patent/US11180450B2/en active Active