JP2019510034A5 - - Google Patents
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- Publication number
- JP2019510034A5 JP2019510034A5 JP2018550545A JP2018550545A JP2019510034A5 JP 2019510034 A5 JP2019510034 A5 JP 2019510034A5 JP 2018550545 A JP2018550545 A JP 2018550545A JP 2018550545 A JP2018550545 A JP 2018550545A JP 2019510034 A5 JP2019510034 A5 JP 2019510034A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- polymorph
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 22
- 239000012453 solvate Substances 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 208000001490 Dengue Diseases 0.000 claims description 8
- 206010012310 Dengue fever Diseases 0.000 claims description 8
- 208000025729 dengue disease Diseases 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 241000725619 Dengue virus Species 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 239000003443 antiviral agent Substances 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- -1 di-substituted indole group Chemical group 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163488 | 2016-04-01 | ||
| EP16163488.6 | 2016-04-01 | ||
| PCT/EP2017/057661 WO2017167951A1 (en) | 2016-04-01 | 2017-03-31 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510034A JP2019510034A (ja) | 2019-04-11 |
| JP2019510034A5 true JP2019510034A5 (enExample) | 2020-04-23 |
| JP6970115B2 JP6970115B2 (ja) | 2021-11-24 |
Family
ID=55650311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550545A Active JP6970115B2 (ja) | 2016-04-01 | 2017-03-31 | デングウイルス複製阻害剤としての置換インドリン誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US10689340B2 (enExample) |
| EP (1) | EP3436437B1 (enExample) |
| JP (1) | JP6970115B2 (enExample) |
| KR (1) | KR102359776B1 (enExample) |
| CN (1) | CN108884037B (enExample) |
| AR (1) | AR108046A1 (enExample) |
| AU (1) | AU2017242894B2 (enExample) |
| CA (1) | CA3013406C (enExample) |
| CL (1) | CL2018002758A1 (enExample) |
| CO (1) | CO2018009563A2 (enExample) |
| CR (1) | CR20180493A (enExample) |
| DK (1) | DK3436437T3 (enExample) |
| EA (1) | EA037988B1 (enExample) |
| EC (1) | ECSP18073293A (enExample) |
| ES (1) | ES2884067T3 (enExample) |
| HR (1) | HRP20211278T1 (enExample) |
| HU (1) | HUE055577T2 (enExample) |
| IL (1) | IL261948B (enExample) |
| JO (1) | JOP20170069B1 (enExample) |
| LT (1) | LT3436437T (enExample) |
| MX (1) | MX381634B (enExample) |
| MY (1) | MY195194A (enExample) |
| PE (1) | PE20181778A1 (enExample) |
| PH (1) | PH12018502077A1 (enExample) |
| SG (1) | SG11201808409XA (enExample) |
| SI (1) | SI3436437T1 (enExample) |
| TW (1) | TWI723148B (enExample) |
| UA (1) | UA125296C2 (enExample) |
| UY (1) | UY37182A (enExample) |
| WO (1) | WO2017167951A1 (enExample) |
| ZA (1) | ZA201806482B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SG11201808138YA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole derivatives as dengue viral replication inhibitors |
| US10913716B2 (en) | 2016-03-31 | 2021-02-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| CR20180494A (es) | 2016-04-01 | 2019-01-29 | Janssen Pharmaceuticals Inc | Derivados de compuestos de indol sustituidos como inhibidores de la replicación vírica del dengue |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) * | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR102625988B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| EA039702B1 (ru) | 2017-05-22 | 2022-03-01 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| BR112022009199A2 (pt) | 2019-11-15 | 2022-07-26 | Janssen Pharmaceuticals Inc | Tratamento e prevenção da dengue |
| WO2025248536A1 (en) * | 2024-05-29 | 2025-12-04 | Zydus Lifesciences Limited | Novel oxime derivatives to treat viral infections |
| WO2025253267A1 (en) | 2024-06-06 | 2025-12-11 | Janssen Pharmaceuticals, Inc. | Combination of mosnodenvir and close analogs with nitd-688 for use in the treatment and prevention of dengue disease |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2308443A1 (en) | 1997-10-27 | 1999-05-06 | Michael Lyle Denney | Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| US20050074457A1 (en) | 2001-12-12 | 2005-04-07 | Adeela Kamal | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| RU2007130896A (ru) | 2005-01-14 | 2009-02-20 | Дженелэбс Текнолоджиз, Инк. (Us) | Индольные производные для лечения вирусных инфекций |
| EA200701669A1 (ru) | 2005-02-09 | 2008-02-28 | Мидженикс Инк. | Композиции и способы лечения или предотвращения инфекций, вызванных вирусами семейства flaviviridae |
| AU2009256390A1 (en) | 2008-06-03 | 2009-12-10 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
| WO2010021878A1 (en) * | 2008-08-19 | 2010-02-25 | Janssen Pharmaceutica Nv | Cold menthol receptor antagonists |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| EP2393359A4 (en) | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| UA108221C2 (uk) | 2010-01-15 | 2015-04-10 | Похідні тіофен-2-карбонової кислоти як інгібітори вірусів flaviviridae | |
| EP2552211A4 (en) | 2010-03-26 | 2013-10-23 | Glaxo Group Ltd | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) * | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| ES2784841T3 (es) | 2014-01-31 | 2020-10-01 | Bristol Myers Squibb Co | Macrociclos con grupos aromáticos P2' como inhibidores del factor XIa |
| CA2958022A1 (en) | 2014-10-01 | 2016-04-07 | Janssen Pharmaceuticals, Inc | Mono- or di-substituted indoles as dengue viral replication inhibitors |
| LT3201176T (lt) | 2014-10-01 | 2019-03-25 | Janssen Pharmaceuticals, Inc. | Mono- arba dipakeistieji indolo dariniai kaip dengės viruso replikacijos slopikliai |
| NO2721243T3 (enExample) | 2014-10-01 | 2018-10-20 | ||
| PH12017501272B1 (en) * | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| ES2907686T3 (es) | 2015-11-03 | 2022-04-26 | Zoetis Services Llc | Compuestos poliméricos sol-gel y sus usos |
| JP6788683B2 (ja) | 2016-03-31 | 2020-11-25 | 武田薬品工業株式会社 | 複素環化合物 |
| US10913716B2 (en) | 2016-03-31 | 2021-02-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| SG11201808138YA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| WO2017173410A1 (en) | 2016-04-01 | 2017-10-05 | Amgen Inc. | Chimeric receptors to flt3 and methods of use thereof |
| CR20180494A (es) | 2016-04-01 | 2019-01-29 | Janssen Pharmaceuticals Inc | Derivados de compuestos de indol sustituidos como inhibidores de la replicación vírica del dengue |
| BR112018070163A2 (pt) | 2016-04-01 | 2019-01-29 | Signal Pharm Llc | compostos de aminopurina substituída, composições e métodos de tratamento |
| BR112018068851B1 (pt) | 2016-04-01 | 2022-11-22 | Basf Se | Composto de fórmula i, composição, métodos de combate ou controle de pragas invertebradas e de proteção de plantas, semente revestida e uso de pelo menos um composto |
| UA128781C2 (uk) | 2016-04-01 | 2024-10-23 | Кайт Фарма, Інк. | Т-клітина, спосіб її отримання та застосування |
| SG11201808411RA (en) | 2016-04-01 | 2018-10-30 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR102625988B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| EA039702B1 (ru) | 2017-05-22 | 2022-03-01 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
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2017
- 2017-03-22 JO JOP/2017/0069A patent/JOP20170069B1/ar active
- 2017-03-30 TW TW106110686A patent/TWI723148B/zh not_active IP Right Cessation
- 2017-03-30 AR ARP170100795A patent/AR108046A1/es unknown
- 2017-03-31 DK DK17714751.9T patent/DK3436437T3/da active
- 2017-03-31 CN CN201780021323.0A patent/CN108884037B/zh active Active
- 2017-03-31 HR HRP20211278TT patent/HRP20211278T1/hr unknown
- 2017-03-31 EA EA201892219A patent/EA037988B1/ru unknown
- 2017-03-31 CA CA3013406A patent/CA3013406C/en active Active
- 2017-03-31 MY MYPI2018001596A patent/MY195194A/en unknown
- 2017-03-31 CR CR20180493A patent/CR20180493A/es unknown
- 2017-03-31 CO CONC2018/0009563A patent/CO2018009563A2/es unknown
- 2017-03-31 PE PE2018001870A patent/PE20181778A1/es unknown
- 2017-03-31 LT LTEP17714751.9T patent/LT3436437T/lt unknown
- 2017-03-31 HU HUE17714751A patent/HUE055577T2/hu unknown
- 2017-03-31 AU AU2017242894A patent/AU2017242894B2/en active Active
- 2017-03-31 EP EP17714751.9A patent/EP3436437B1/en active Active
- 2017-03-31 JP JP2018550545A patent/JP6970115B2/ja active Active
- 2017-03-31 UY UY0001037182A patent/UY37182A/es unknown
- 2017-03-31 US US16/088,090 patent/US10689340B2/en active Active
- 2017-03-31 KR KR1020187028180A patent/KR102359776B1/ko active Active
- 2017-03-31 WO PCT/EP2017/057661 patent/WO2017167951A1/en not_active Ceased
- 2017-03-31 SG SG11201808409XA patent/SG11201808409XA/en unknown
- 2017-03-31 SI SI201730871T patent/SI3436437T1/sl unknown
- 2017-03-31 ES ES17714751T patent/ES2884067T3/es active Active
- 2017-03-31 MX MX2018011785A patent/MX381634B/es unknown
- 2017-03-31 UA UAA201810728A patent/UA125296C2/uk unknown
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2018
- 2018-09-26 IL IL261948A patent/IL261948B/en unknown
- 2018-09-27 PH PH12018502077A patent/PH12018502077A1/en unknown
- 2018-09-27 CL CL2018002758A patent/CL2018002758A1/es unknown
- 2018-09-28 ZA ZA2018/06482A patent/ZA201806482B/en unknown
- 2018-09-28 EC ECSENADI201873293A patent/ECSP18073293A/es unknown
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2020
- 2020-06-05 US US16/893,685 patent/US11180450B2/en active Active