JP6752821B2 - デングウイルス複製阻害剤としての一または二置換インドール誘導体 - Google Patents

デングウイルス複製阻害剤としての一または二置換インドール誘導体 Download PDF

Info

Publication number
JP6752821B2
JP6752821B2 JP2017557923A JP2017557923A JP6752821B2 JP 6752821 B2 JP6752821 B2 JP 6752821B2 JP 2017557923 A JP2017557923 A JP 2017557923A JP 2017557923 A JP2017557923 A JP 2017557923A JP 6752821 B2 JP6752821 B2 JP 6752821B2
Authority
JP
Japan
Prior art keywords
compound
mmol
indole
chloro
methoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017557923A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018515495A5 (enExample
JP2018515495A (ja
Inventor
ケステレイン，バート，ルドロフ，ロマニー
ボンファンティ，ジーン−フランソワ
ジョンカーズ，ティム，ヒューゴ，マリア
ラボイソン，ピエール，ジーン−マリー，ベルナルド
バルディオット，ドロシー，アリス，マリー−イブ
マーチャンド，アルノー，ディディエ，エム．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Original Assignee
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katholieke Universiteit Leuven filed Critical Katholieke Universiteit Leuven
Publication of JP2018515495A publication Critical patent/JP2018515495A/ja
Publication of JP2018515495A5 publication Critical patent/JP2018515495A5/ja
Priority to JP2020071412A priority Critical patent/JP6898493B2/ja
Application granted granted Critical
Publication of JP6752821B2 publication Critical patent/JP6752821B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017557923A 2015-05-08 2016-05-04 デングウイルス複製阻害剤としての一または二置換インドール誘導体 Active JP6752821B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020071412A JP6898493B2 (ja) 2015-05-08 2020-04-13 デングウイルス複製阻害剤としての一または二置換インドール誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15166900 2015-05-08
EP15166900.9 2015-05-08
EP16163342.5 2016-03-31
EP16163342 2016-03-31
PCT/EP2016/059975 WO2016180696A1 (en) 2015-05-08 2016-05-04 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020071412A Division JP6898493B2 (ja) 2015-05-08 2020-04-13 デングウイルス複製阻害剤としての一または二置換インドール誘導体

Publications (3)

Publication Number Publication Date
JP2018515495A JP2018515495A (ja) 2018-06-14
JP2018515495A5 JP2018515495A5 (enExample) 2019-04-18
JP6752821B2 true JP6752821B2 (ja) 2020-09-09

Family

ID=56026812

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017557923A Active JP6752821B2 (ja) 2015-05-08 2016-05-04 デングウイルス複製阻害剤としての一または二置換インドール誘導体
JP2020071412A Active JP6898493B2 (ja) 2015-05-08 2020-04-13 デングウイルス複製阻害剤としての一または二置換インドール誘導体
JP2021096927A Active JP7132399B2 (ja) 2015-05-08 2021-06-09 デングウイルス複製阻害剤としての一または二置換インドール誘導体
JP2022133239A Active JP7451626B2 (ja) 2015-05-08 2022-08-24 デングウイルス複製阻害剤としての一または二置換インドール誘導体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020071412A Active JP6898493B2 (ja) 2015-05-08 2020-04-13 デングウイルス複製阻害剤としての一または二置換インドール誘導体
JP2021096927A Active JP7132399B2 (ja) 2015-05-08 2021-06-09 デングウイルス複製阻害剤としての一または二置換インドール誘導体
JP2022133239A Active JP7451626B2 (ja) 2015-05-08 2022-08-24 デングウイルス複製阻害剤としての一または二置換インドール誘導体

Country Status (39)

Country Link
US (5) US10696632B2 (enExample)
EP (2) EP3294738B1 (enExample)
JP (4) JP6752821B2 (enExample)
KR (2) KR102610491B1 (enExample)
CN (3) CN107873022B (enExample)
AU (2) AU2016259677B2 (enExample)
BR (1) BR112017023904A2 (enExample)
CA (1) CA2981845C (enExample)
CL (1) CL2017002817A1 (enExample)
CO (1) CO2017012381A2 (enExample)
CR (2) CR20170490A (enExample)
CY (1) CY1124548T1 (enExample)
DK (1) DK3294738T3 (enExample)
EA (1) EA034978B1 (enExample)
EC (2) ECSP17073878A (enExample)
ES (2) ES2877404T3 (enExample)
GT (1) GT201700234A (enExample)
HR (1) HRP20210675T1 (enExample)
HU (1) HUE054724T2 (enExample)
IL (2) IL255430B (enExample)
JO (2) JOP20160086B1 (enExample)
LT (1) LT3294738T (enExample)
MD (1) MD3294738T2 (enExample)
MX (2) MX383932B (enExample)
MY (1) MY198339A (enExample)
NI (1) NI201700137A (enExample)
PE (2) PE20180232A1 (enExample)
PH (1) PH12017502000A1 (enExample)
PL (1) PL3294738T3 (enExample)
RS (1) RS62029B1 (enExample)
SG (1) SG10201900315SA (enExample)
SI (1) SI3294738T1 (enExample)
SM (1) SMT202100367T1 (enExample)
SV (1) SV2017005557A (enExample)
TW (2) TWI725969B (enExample)
UA (2) UA121332C2 (enExample)
UY (2) UY36674A (enExample)
WO (1) WO2016180696A1 (enExample)
ZA (2) ZA201707524B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019511502A (ja) * 2016-04-01 2019-04-25 ヤンセン ファーマシューティカルズ，インコーポレーテッド デングウイルス複製阻害剤としての置換インドール化合物誘導体

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
PT3201176T (pt) * 2014-10-01 2019-03-04 Janssen Pharmaceuticals Inc Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue
DK3201177T3 (en) * 2014-10-01 2019-03-04 Janssen Pharmaceuticals Inc MONO OR DISUBSTITUTED INDOLES AS INHIBITORS OF DENGUE VIRUS REPLICATION
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
SG11201808138YA (en) 2016-03-31 2018-10-30 Janssen Pharmaceuticals Inc Substituted indole derivatives as dengue viral replication inhibitors
MA44498A (fr) 2016-03-31 2019-02-06 Janssen Pharmaceuticals Inc Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
SI3630724T1 (sl) 2017-05-22 2021-08-31 Janssen Pharmaceuticals, Inc. Substituirani derivati indolina kot zaviralci replikacije virusa denga
CA3060583C (en) 2017-05-22 2024-06-04 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
CN114980884A (zh) 2019-11-15 2022-08-30 杨森制药公司 登革热疾病的治疗和预防
WO2022094816A1 (en) 2020-11-04 2022-05-12 Janssen Pharmaceuticals, Inc. Solid formulation
WO2022094817A1 (en) * 2020-11-04 2022-05-12 Janssen Pharmaceuticals, Inc. Pharmaceutical formulation
CN113024440B (zh) * 2021-03-17 2023-05-16 凯莱英医药集团（天津）股份有限公司 连续化合成取代吲哚-2-羧酸的方法
AU2022304189A1 (en) 2021-06-29 2024-02-15 Janssen Pharmaceuticals, Inc. Processes for the preparation of (s)-2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1 -(1h-indol-3-yl)ethenone derivatives
AU2023269343A1 (en) 2022-05-12 2025-01-02 Janssen Pharmaceuticals, Inc. Treatment or prevention of dengue viral infection
CN115521307B (zh) * 2022-09-30 2023-09-22 甘肃皓天医药科技有限责任公司 一种5-卤代-7-氮杂吲哚的制备方法
WO2025253267A1 (en) 2024-06-06 2025-12-11 Janssen Pharmaceuticals, Inc. Combination of mosnodenvir and close analogs with nitd-688 for use in the treatment and prevention of dengue disease
WO2026018176A1 (en) 2024-07-17 2026-01-22 Janssen Pharmaceuticals, Inc. 2-(4-chloro-2 methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1-(5-(trifluoro¬methoxy)-1h-indol-3-yl)ethanone and pharmaceutical compositions comprising the same
WO2026057013A1 (zh) * 2024-09-14 2026-03-19 华武生物医药技术(湖北)有限责任公司 一类登革热病毒复制抑制剂、其制备方法和用途
CN119306651B (zh) * 2024-10-11 2025-12-05 山东大学 一种吲哚3-酰胺类衍生物及其制备方法与应用
CN121378100B (zh) * 2025-12-24 2026-04-21 浙江大学医学院附属第二医院 一种苯并[g]吲哚衍生物及其在制备抗登革热药物中的应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001520998A (ja) 1997-10-27 2001-11-06 イーライ・リリー・アンド・カンパニー インドールｓＰＬＡ２阻害剤のモルホリノ−Ｎ−エチルエステルプロドラッグ
GB0110832D0 (en) 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
JP2005520795A (ja) 2001-12-12 2005-07-14 コンフォーマ・セラピューティクス・コーポレイション Ｈｓｐ９０阻害活性を有するプリン類似体
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US20060211698A1 (en) 2005-01-14 2006-09-21 Genelabs, Inc. Bicyclic heteroaryl derivatives for treating viruses
AU2006221080A1 (en) 2005-02-09 2006-09-14 Migenix Inc. Compositions and methods for treating or preventing flaviviridae infections
FR2928645A1 (fr) * 2008-03-14 2009-09-18 Sanofi Aventis Sa Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
AU2009256390A1 (en) 2008-06-03 2009-12-10 Siga Technologies, Inc. Small molecule inhibitors for the treatment or prevention of dengue virus infection
PE20110368A1 (es) * 2008-08-18 2011-06-13 Univ Yale Moduladores de mif
US8143259B2 (en) 2008-08-19 2012-03-27 Janssen Pharmaceutica, Nv Cold menthol receptor antagonists
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
WO2010091413A1 (en) 2009-02-09 2010-08-12 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
KR20120123678A (ko) 2010-01-15 2012-11-09 길리애드 사이언시즈, 인코포레이티드 플라비비리다에 바이러스의 억제제
US20130023532A1 (en) 2010-03-26 2013-01-24 Casillas Linda N Indazolyl-pyrimidines as kinase inhibitors
JP5716205B2 (ja) 2011-03-29 2015-05-13 学校法人日本大学 グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
MX368158B (es) 2013-10-23 2019-09-20 Janssen Sciences Ireland Uc Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
KR20240017118A (ko) 2014-01-31 2024-02-06 브리스톨-마이어스 스큅 컴퍼니 인자 XIa 억제제로서의 헤테로시클릭 P2' 기를 갖는 마크로사이클
SG10202113019XA (en) 2014-06-04 2021-12-30 Amgen Inc Methods for harvesting mammalian cell cultures
JP6641299B2 (ja) 2014-06-04 2020-02-05 フレッド ハッチンソン キャンサー リサーチ センター Ｎｏｔｃｈ １および／またはＮｏｔｃｈ ２アゴニストを用いた幹細胞の増殖および生着
PT3201176T (pt) 2014-10-01 2019-03-04 Janssen Pharmaceuticals Inc Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue
DK3201177T3 (en) 2014-10-01 2019-03-04 Janssen Pharmaceuticals Inc MONO OR DISUBSTITUTED INDOLES AS INHIBITORS OF DENGUE VIRUS REPLICATION
NO2721243T3 (enExample) 2014-10-01 2018-10-20
EP3204517B1 (en) 2014-10-10 2021-08-11 Rutgers, the State University of New Jersey Polymerase chain reaction primers and probes for mycobacterium tuberculosis
PH12017501272B1 (en) * 2015-01-16 2023-01-11 Janssen Pharmaceuticals Inc Indole derivatives as dengue viral replication inhibitors
AR103680A1 (es) 2015-02-23 2017-05-24 Lilly Co Eli Inhibidores selectivos de bace1
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
ES2952726T3 (es) 2015-07-22 2023-11-03 Omeicos Therapeutics Gmbh Análogos metabólicamente fuertes de CYP-eicosanoides para el tratamiento de enfermedad cardíaca
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EP3370698B1 (en) 2015-11-03 2022-01-26 Zoetis Services LLC Sol-gel polymer composites and uses thereof
SG11201808138YA (en) 2016-03-31 2018-10-30 Janssen Pharmaceuticals Inc Substituted indole derivatives as dengue viral replication inhibitors
MY194647A (en) 2016-03-31 2022-12-09 Takeda Pharmaceuticals Co Heterocyclic compound
MA44498A (fr) 2016-03-31 2019-02-06 Janssen Pharmaceuticals Inc Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CA3015934A1 (en) 2016-04-01 2017-10-05 Basf Se Bicyclic compounds
EP3436004B1 (en) 2016-04-01 2024-12-11 Janssen Pharmaceuticals, Inc. Substituted indole compound derivatives as dengue viral replication inhibitors
KR102608405B1 (ko) 2016-04-01 2023-12-01 카이트 파마 인코포레이티드 키메라 수용체 및 그의 사용 방법
BR112018070163A2 (pt) 2016-04-01 2019-01-29 Signal Pharm Llc compostos de aminopurina substituída, composições e métodos de tratamento
KR102694879B1 (ko) 2016-04-01 2024-08-16 암젠 인크 Flt3에 대한 키메라 수용체 및 이의 사용 방법
US10603380B2 (en) 2016-04-01 2020-03-31 Kite Pharma, Inc. Chimeric antigen and T cell receptors and methods of use
JP6573745B2 (ja) 2017-03-17 2019-09-11 三菱電機株式会社 アダプティブアレーアンテナ装置
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
SI3630724T1 (sl) 2017-05-22 2021-08-31 Janssen Pharmaceuticals, Inc. Substituirani derivati indolina kot zaviralci replikacije virusa denga
CA3060583C (en) 2017-05-22 2024-06-04 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019511502A (ja) * 2016-04-01 2019-04-25 ヤンセン ファーマシューティカルズ，インコーポレーテッド デングウイルス複製阻害剤としての置換インドール化合物誘導体
JP7007290B2 (ja) 2016-04-01 2022-01-24 ヤンセン ファーマシューティカルズ，インコーポレーテッド デングウイルス複製阻害剤としての置換インドール化合物誘導体

Also Published As

Publication number Publication date
EA034978B1 (ru) 2020-04-14
EP3896072A1 (en) 2021-10-20
US12172959B2 (en) 2024-12-24
KR102610493B1 (ko) 2023-12-05
JOP20210109A1 (ar) 2023-01-30
EP3294738A1 (en) 2018-03-21
AU2016259677B2 (en) 2020-10-01
CN113045476B (zh) 2024-07-16
RS62029B1 (sr) 2021-07-30
US10919854B2 (en) 2021-02-16
KR102610491B1 (ko) 2023-12-06
TW202041499A (zh) 2020-11-16
UA121332C2 (uk) 2020-05-12
ZA202002435B (en) 2023-03-29
PH12017502000B1 (en) 2018-03-26
KR20180002644A (ko) 2018-01-08
ECSP17073878A (es) 2018-02-28
CA2981845A1 (en) 2016-11-17
US20210171462A1 (en) 2021-06-10
ES2877404T3 (es) 2021-11-16
IL255430B (en) 2020-03-31
US11827602B2 (en) 2023-11-28
LT3294738T (lt) 2021-08-25
CA2981845C (en) 2022-03-08
GT201700234A (es) 2018-11-26
AU2020273314B2 (en) 2021-10-21
CN113045476A (zh) 2021-06-29
JP2020125316A (ja) 2020-08-20
US20250230127A1 (en) 2025-07-17
UA128183C2 (uk) 2024-05-01
UY39706A (es) 2022-05-31
TWI725969B (zh) 2021-05-01
JP7451626B2 (ja) 2024-03-18
EA201792429A1 (ru) 2018-02-28
MD3294738T2 (ro) 2021-08-31
IL272814A (en) 2020-04-30
MX383932B (es) 2025-03-14
CY1124548T1 (el) 2022-07-22
JOP20160086B1 (ar) 2021-08-17
ZA201707524B (en) 2024-06-26
SI3294738T1 (sl) 2021-08-31
SMT202100367T1 (it) 2021-07-12
DK3294738T3 (da) 2021-06-28
CN107873022B (zh) 2021-03-12
US20200270209A1 (en) 2020-08-27
PE20221579A1 (es) 2022-10-06
NZ765879A (en) 2024-09-27
CR20170490A (es) 2018-03-08
JP6898493B2 (ja) 2021-07-07
HK1252446A1 (zh) 2019-05-24
MY198339A (en) 2023-08-27
TWI744963B (zh) 2021-11-01
TW201704208A (zh) 2017-02-01
CR20200152A (es) 2020-09-08
AU2016259677A1 (en) 2017-10-26
HRP20210675T1 (hr) 2021-06-25
SV2017005557A (es) 2018-06-26
CN107873022A (zh) 2018-04-03
ECSP22023220A (es) 2022-05-31
EP3294738B1 (en) 2021-04-07
MX2020011156A (es) 2022-04-21
AU2020273314A1 (en) 2020-12-17
CL2017002817A1 (es) 2018-05-11
NZ736934A (en) 2023-11-24
CN111303000B (zh) 2023-11-28
HK1252496A1 (zh) 2019-05-31
PH12017502000A1 (en) 2018-03-26
MX391754B (es) 2025-03-21
CO2017012381A2 (es) 2018-03-28
MX2017014293A (es) 2018-08-09
US10696632B2 (en) 2020-06-30
EP3896072B1 (en) 2022-11-16
IL255430A0 (en) 2017-12-31
JP7132399B2 (ja) 2022-09-06
HUE054724T2 (hu) 2021-09-28
SG10201900315SA (en) 2019-02-27
CN111303000A (zh) 2020-06-19
NI201700137A (es) 2019-05-07
JP2021138752A (ja) 2021-09-16
KR20210048578A (ko) 2021-05-03
PL3294738T3 (pl) 2021-12-13
UY36674A (es) 2016-11-30
US20240182414A1 (en) 2024-06-06
WO2016180696A1 (en) 2016-11-17
IL272814B (en) 2021-02-28
JP2018515495A (ja) 2018-06-14
US20180346419A1 (en) 2018-12-06
BR112017023904A2 (pt) 2018-07-17
ES2941674T3 (es) 2023-05-24
JP2022166289A (ja) 2022-11-01
PE20180232A1 (es) 2018-01-31
JOP20210109B1 (ar) 2024-12-22

Similar Documents

Publication Publication Date Title
JP6898493B2 (ja) デングウイルス複製阻害剤としての一または二置換インドール誘導体
JP7050666B2 (ja) デングウイルス複製阻害剤としての一または二置換インドール誘導体
KR102478311B1 (ko) 뎅기 바이러스 복제 억제제로서의 １치환 또는 ２치환 인돌 유도체
JP7045984B2 (ja) デングウイルス複製阻害剤としての一または二置換インドール誘導体
JP6830438B2 (ja) デングウィルス複製阻害剤としてのインドール誘導体
JP2017531638A (ja) デングウィルス複製阻害剤としての一または二置換インドール
EA040657B1 (ru) Производные моно- или дизамещенных индолов в качестве ингибиторов репликации вирусов денге
HK1252446B (zh) 作为登革热病毒复制抑制剂的单取代的或二取代的吲哚衍生物
BR122021010102B1 (pt) Derivados indol mono- ou dissubstituídos, seu uso como inibidores da replicação viral da dengue e composição farmacêutica que os compreende

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190308

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190308

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20191219

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200413

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200811

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200819

R150 Certificate of patent or registration of utility model

Ref document number: 6752821

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250