JP2018504437A5 - - Google Patents
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- Publication number
- JP2018504437A5 JP2018504437A5 JP2017541333A JP2017541333A JP2018504437A5 JP 2018504437 A5 JP2018504437 A5 JP 2018504437A5 JP 2017541333 A JP2017541333 A JP 2017541333A JP 2017541333 A JP2017541333 A JP 2017541333A JP 2018504437 A5 JP2018504437 A5 JP 2018504437A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- solvate
- compound
- optionally substituted
- stereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 62
- 125000000217 alkyl group Chemical group 0.000 claims description 51
- 239000012453 solvate Substances 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 24
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 22
- 125000000623 heterocyclic group Chemical group 0.000 claims description 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 12
- 125000003342 alkenyl group Chemical group 0.000 claims description 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 7
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 125000004429 atom Chemical group 0.000 claims description 4
- -1 cyano, nitro, trimethylsilanyl Chemical group 0.000 claims description 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 3
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims description 3
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims description 2
- 208000000323 Tourette Syndrome Diseases 0.000 claims description 2
- 208000016620 Tourette disease Diseases 0.000 claims description 2
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- BSBULIBDCGMEJA-UHFFFAOYSA-N 1H-isoquinolin-2-ylmethanol Chemical compound C1N(C=CC2=CC=CC=C12)CO BSBULIBDCGMEJA-UHFFFAOYSA-N 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562113316P | 2015-02-06 | 2015-02-06 | |
| US62/113,316 | 2015-02-06 | ||
| PCT/US2016/016892 WO2016127133A1 (en) | 2015-02-06 | 2016-02-05 | [9,10-dimethoxy-3-(2-methylpropyl)-1h,2h,3h,4h,6h,7h,11bh-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504437A JP2018504437A (ja) | 2018-02-15 |
| JP2018504437A5 true JP2018504437A5 (enExample) | 2019-03-14 |
| JP6755254B2 JP6755254B2 (ja) | 2020-09-16 |
Family
ID=55404854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541333A Active JP6755254B2 (ja) | 2015-02-06 | 2016-02-05 | ［９，１０−ジメトキシ−３−（２−メチルプロピル）−１Ｈ，２Ｈ，３Ｈ，４Ｈ，６Ｈ，７Ｈ，１１ｂＨ−ピリド［２，１−ａ］イソキノリン−２−イル］メタノール、ならびにそれに関する化合物、組成物、および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9714246B2 (enExample) |
| EP (1) | EP3253752B1 (enExample) |
| JP (1) | JP6755254B2 (enExample) |
| KR (1) | KR102586138B1 (enExample) |
| CN (1) | CN107438606B (enExample) |
| AU (1) | AU2016215033B2 (enExample) |
| CA (1) | CA2974540C (enExample) |
| ES (1) | ES2960717T3 (enExample) |
| IL (1) | IL253704B (enExample) |
| MX (1) | MX375718B (enExample) |
| RU (1) | RU2736509C2 (enExample) |
| WO (1) | WO2016127133A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3096756T (lt) | 2014-01-21 | 2024-08-26 | Neurocrine Biosciences, Inc. | Crf1 receptoriaus antagonistai, skirti įgimtos antinksčių hiperplazijos gydymui |
| WO2016127133A1 (en) | 2015-02-06 | 2016-08-11 | Neurocrine Biosciences, Inc. | [9,10-dimethoxy-3-(2-methylpropyl)-1h,2h,3h,4h,6h,7h,11bh-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto |
| MA56137B1 (fr) | 2015-10-30 | 2024-03-29 | Neurocrine Biosciences Inc | Sels de dihydrochlorure de valbénazine et leurs polymorphes |
| CA3009169A1 (en) | 2015-12-23 | 2017-06-29 | Neurocrine Biosciences, Inc. | Synthetic methods for preparation of (s)-(2r,3r,11br)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) |
| MY203491A (en) | 2017-01-27 | 2024-06-30 | Neurocrine Biosciences Inc | Methods for the administration of certain vmat2 inhibitors |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| JOP20190239A1 (ar) * | 2017-04-19 | 2019-10-09 | Neurocrine Biosciences Inc | مركبات مثبطة لـ vmat2 وتركيبات منها |
| PL3684333T3 (pl) | 2017-09-21 | 2025-06-23 | Neurocrine Biosciences, Inc. | Formulacja walbenazyny o wysokiej dawce oraz kompozycje, sposoby i zestawy z nią związane |
| KR20250110361A (ko) | 2017-10-10 | 2025-07-18 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| MX2020013004A (es) | 2018-06-14 | 2021-02-17 | Neurocrine Biosciences Inc | Compuestos inhibidores del transportador de monoamina 2 (vmat2), composiciones, y metodos relacionados con los mismos. |
| MX2021001017A (es) | 2018-08-15 | 2021-04-19 | Neurocrine Biosciences Inc | Metodos para la administracion de ciertos inhibidores de transportador vesicular de monoamina de proteinas transportadoras-2 (vmat2). |
| EP3860599B1 (en) | 2018-10-04 | 2024-05-15 | Adeptio Pharmaceuticals Limited | (+)-alpha-dihydrotetrabenazine dosage regimen for treating movement disorders |
| FI3984523T3 (fi) | 2018-12-07 | 2025-10-21 | Neurocrine Biosciences Inc | Crf1-reseptorin antagonisti, lääkeformulaatioita ja niiden kiinteitä muotoja synnynnäisen lisämunuaisten liikakasvun hoitoon |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| CA3152590A1 (en) * | 2019-09-27 | 2021-04-01 | Evan Smith | Crf receptor antagonists and methods of use |
| RS67052B1 (sr) | 2021-03-22 | 2025-08-29 | Neurocrine Biosciences Inc | Vmat2 inhibitori i postupci primene |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54125699A (en) * | 1978-03-17 | 1979-09-29 | Nippon Chemiphar Co Ltd | Preparation of ( ) dihydroprotoemetine |
| ES2327740T3 (es) * | 2003-06-20 | 2009-11-03 | F. Hoffmann-La Roche Ag | Hexahidropiridoisoquinolinas como inhibidoras de la dpp-iv. |
| BRPI0718247B1 (pt) * | 2006-11-08 | 2021-09-21 | Neurocrine Biosciences, Inc. | Composto usado como inibidor do transportador de monoamina vesicular 2, composição farmacêutica compreendendo o dito composto e uso da dita composição farmacêutica no tratamento de transtornos hipercinéticos |
| RU2339363C2 (ru) | 2006-12-28 | 2008-11-27 | Лидия Ибрагимовна Гайсанова | Мазь "бунхо", обладающая противовоспалительным и регенерирующим действием |
| US9782398B2 (en) | 2014-02-07 | 2017-10-10 | Neurocrine Biosciences, Inc. | Pharmaceutical compositions comprising an antipsychotic drug and a VMAT2 inhibitor and uses thereof |
| WO2016127133A1 (en) | 2015-02-06 | 2016-08-11 | Neurocrine Biosciences, Inc. | [9,10-dimethoxy-3-(2-methylpropyl)-1h,2h,3h,4h,6h,7h,11bh-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto |
-
2016
- 2016-02-05 WO PCT/US2016/016892 patent/WO2016127133A1/en not_active Ceased
- 2016-02-05 CA CA2974540A patent/CA2974540C/en active Active
- 2016-02-05 CN CN201680008945.5A patent/CN107438606B/zh active Active
- 2016-02-05 EP EP16705684.5A patent/EP3253752B1/en active Active
- 2016-02-05 US US15/017,480 patent/US9714246B2/en active Active
- 2016-02-05 AU AU2016215033A patent/AU2016215033B2/en active Active
- 2016-02-05 KR KR1020177024606A patent/KR102586138B1/ko active Active
- 2016-02-05 MX MX2017010062A patent/MX375718B/es active IP Right Grant
- 2016-02-05 RU RU2017130514A patent/RU2736509C2/ru active
- 2016-02-05 JP JP2017541333A patent/JP6755254B2/ja active Active
- 2016-02-05 ES ES16705684T patent/ES2960717T3/es active Active
-
2017
- 2017-06-19 US US15/627,145 patent/US9988382B2/en active Active
- 2017-07-27 IL IL253704A patent/IL253704B/en active IP Right Grant
-
2018
- 2018-04-30 US US15/967,187 patent/US20180273533A1/en not_active Abandoned
-
2020
- 2020-01-22 US US16/748,999 patent/US11053242B2/en active Active
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