|
HU168036B
(enExample)
|
1973-11-09 |
1976-02-28 |
|
|
|
HU168776B
(enExample)
|
1973-11-09 |
1976-07-28 |
|
|
|
US3962448A
(en)
*
|
1974-03-11 |
1976-06-08 |
Smithkline Corporation |
8-Alkyl and alkenyl-10-hydroxy-5H[1]benzopyranopyridine derivatives having polyphagic activity
|
|
CA1098910A
(en)
|
1978-06-15 |
1981-04-07 |
Robert N. Schut |
3-amino-2-(5-fluoro and 5-methoxy-1h-indol-3-yl) propanoic acid derivatives
|
|
JPS57116067A
(en)
|
1981-01-12 |
1982-07-19 |
Sankyo Kagaku Kk |
Novel 8-quinolinesulfonyl derivative, its synthesis and use
|
|
DE3703435A1
(de)
|
1987-02-05 |
1988-08-18 |
Thomae Gmbh Dr K |
Neue thiazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
IE68593B1
(en)
|
1989-12-06 |
1996-06-26 |
Sanofi Sa |
Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
|
|
EP0828738B1
(de)
|
1995-05-26 |
2003-12-17 |
Bayer CropScience AG |
Pyridyl-thiazole und deren verwendung zum schutz von pflanzen gegen befall durch mikroorganismen
|
|
US6187797B1
(en)
|
1996-12-23 |
2001-02-13 |
Dupont Pharmaceuticals Company |
Phenyl-isoxazoles as factor XA Inhibitors
|
|
DE69720773T2
(de)
|
1996-12-23 |
2004-01-29 |
Bristol Myers Squibb Pharma Co |
SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER
|
|
US6436966B1
(en)
|
1997-10-27 |
2002-08-20 |
Takeda Chemical Ind., Ltd. |
Adenosine A3 receptor antagonists
|
|
AU3702699A
(en)
|
1998-04-08 |
1999-11-01 |
Bayer Aktiengesellschaft |
Substituted oxazolyle and thiazolyl uracil herbicides
|
|
CN1376150A
(zh)
|
1999-07-26 |
2002-10-23 |
盐野义制药株式会社 |
具有血栓形成素受体拮抗作用的药物组合物
|
|
HK1054039B
(zh)
*
|
2000-03-15 |
2010-04-16 |
萨诺费－阿文蒂斯德国有限公司 |
取代的β-咔啉
|
|
EP1268477B1
(en)
*
|
2000-03-15 |
2010-04-21 |
Sanofi-Aventis Deutschland GmbH |
Substituted beta-carbolines with ikb-kinase inhibiting activity
|
|
GB0010183D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
|
EP1310494B1
(en)
|
2000-08-11 |
2012-01-25 |
Nippon Chemiphar Co., Ltd. |
PPAR (delta) ACTIVATORS
|
|
JP2002053566A
(ja)
|
2000-08-11 |
2002-02-19 |
Japan Tobacco Inc |
チアゾール化合物及びその医薬用途
|
|
US20020173507A1
(en)
|
2000-08-15 |
2002-11-21 |
Vincent Santora |
Urea compounds and methods of uses
|
|
US20020103192A1
(en)
|
2000-10-26 |
2002-08-01 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
WO2002051442A1
(en)
|
2000-12-26 |
2002-07-04 |
Takeda Chemical Industries, Ltd. |
Concomitant drugs
|
|
JPWO2002062775A1
(ja)
|
2001-02-02 |
2004-06-10 |
山之内製薬株式会社 |
２−アシルアミノチアゾール誘導体又はその塩
|
|
MY130778A
(en)
|
2001-02-09 |
2007-07-31 |
Vertex Pharma |
Heterocyclic inhibitiors of erk2 and uses thereof
|
|
US20020177594A1
(en)
|
2001-03-14 |
2002-11-28 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
US7078422B2
(en)
|
2001-03-23 |
2006-07-18 |
Nippon Chemiphar Co., Ltd. |
Activator for peroxisome proliferator-activated receptor
|
|
US20050009843A1
(en)
|
2001-04-26 |
2005-01-13 |
Kiyoshi Nakayama |
Medicine for inhibiting drug elimination pump
|
|
EP1402900A1
(en)
|
2001-06-11 |
2004-03-31 |
Takeda Chemical Industries, Ltd. |
Medicinal compositions
|
|
GB0123589D0
(en)
|
2001-10-01 |
2001-11-21 |
Syngenta Participations Ag |
Organic compounds
|
|
AU2002349705A1
(en)
|
2001-12-03 |
2003-06-17 |
Japan Tobacco Inc. |
Azole compound and medicinal use thereof
|
|
JP4120586B2
(ja)
|
2002-01-18 |
2008-07-16 |
アステラス製薬株式会社 |
２−アシルアミノチアゾール誘導体又はその塩
|
|
EP1467981A1
(en)
|
2002-01-25 |
2004-10-20 |
Kylix Pharmaceuticals B.V. |
4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2
|
|
US7229987B2
(en)
|
2002-05-13 |
2007-06-12 |
Eli Lilly And Company |
Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes
|
|
EP1534273A4
(en)
|
2002-07-18 |
2007-08-22 |
Bristol Myers Squibb Co |
MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND METHOD
|
|
TW200424183A
(en)
|
2002-08-09 |
2004-11-16 |
Nps Pharma Inc |
New compounds
|
|
AU2003265395A1
(en)
|
2002-08-14 |
2004-03-03 |
Ppd Discovery, Inc. |
Prenylation inhibitors and methods of their synthesis and use
|
|
AR043057A1
(es)
|
2002-10-30 |
2005-07-13 |
Vertex Pharma |
Compuestos derivados de piridintiazoles como inhibidores de la quinasa rock y otras proteinas quinasa
|
|
GB0230087D0
(en)
|
2002-12-24 |
2003-01-29 |
Astrazeneca Ab |
Therapeutic agents
|
|
GB0302672D0
(en)
|
2003-02-06 |
2003-03-12 |
Astrazeneca Ab |
Pharmaceutical formulations
|
|
WO2004071509A1
(ja)
|
2003-02-12 |
2004-08-26 |
Nippon Chemiphar Co., Ltd. |
オリゴデンドロサイト分化促進剤
|
|
BRPI0409227C1
(pt)
|
2003-04-07 |
2021-05-25 |
Axys Pharm Inc |
composto, composição farmacêutica, uso de um composto e processo para a preparação de um composto de fórmula (i)
|
|
SG169900A1
(en)
|
2003-04-16 |
2011-04-29 |
Memory Pharm Corp |
4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
|
|
CN100545161C
(zh)
|
2003-08-15 |
2009-09-30 |
中国科学院上海药物研究所 |
一类杂环衍生物、制备方法及其用途
|
|
US7351727B2
(en)
|
2003-09-02 |
2008-04-01 |
Bristol-Myers Squibb Company |
Inhibitors of 15-lipoxygenase
|
|
ZA200602755B
(en)
|
2003-09-06 |
2007-06-27 |
Vertex Pharma |
Modulators of ATP-binding cassette transporters
|
|
TWI336697B
(en)
|
2003-09-19 |
2011-02-01 |
Solvay Pharm Bv |
Thiazole derivatives as cannabinoid receptor modulators
|
|
JP2007509968A
(ja)
|
2003-10-28 |
2007-04-19 |
ファルマシア・コーポレーション |
新形成を治療または予防するためのｈｓｐ９０阻害剤およびホスホジエステラーゼ阻害剤を含む組み合わせ
|
|
WO2005044194A2
(en)
|
2003-10-28 |
2005-05-19 |
Pharmacia Corporation |
TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR
|
|
MXPA06008606A
(es)
|
2004-01-30 |
2007-04-13 |
Vertex Pharma |
Moduladores de transportadores con casete de union a atp.
|
|
US20080275062A1
(en)
|
2004-01-30 |
2008-11-06 |
David Harold Drewry |
Chemical Compounds
|
|
WO2005077373A2
(en)
|
2004-02-03 |
2005-08-25 |
Astrazeneca Ab |
Treatment of gastro-esophageal reflux disease (gerd)
|
|
WO2005077345A1
(en)
|
2004-02-03 |
2005-08-25 |
Astrazeneca Ab |
Compounds for the treatment of gastro-esophageal reflux disease
|
|
MY148488A
(en)
|
2004-02-18 |
2013-04-30 |
Astrazeneca Ab |
Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
EP1717225A4
(en)
|
2004-02-18 |
2009-10-21 |
Kyorin Seiyaku Kk |
BICYCLIC AMID DERIVATIVES
|
|
US7259155B2
(en)
|
2004-05-05 |
2007-08-21 |
Otsuka Pharmaceutical Factory, Inc. |
Phosphonic diester derivatives
|
|
TW200637559A
(en)
|
2005-03-29 |
2006-11-01 |
Shionogi & Co |
3-propenylcefem derivative
|
|
FR2885129B1
(fr)
|
2005-04-29 |
2007-06-15 |
Proskelia Sas |
Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
|
|
UA92746C2
(en)
|
2005-05-09 |
2010-12-10 |
Акилайон Фармасьютикалз, Инк. |
Thiazole compounds and methods of use
|
|
US7655446B2
(en)
|
2005-06-28 |
2010-02-02 |
Vertex Pharmaceuticals Incorporated |
Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof
|
|
US20100168102A9
(en)
*
|
2005-07-11 |
2010-07-01 |
Devgen Nv |
Amide Derivatives as Kinase Inhibitors
|
|
CA2630920A1
(en)
|
2005-11-22 |
2007-05-31 |
University Of South Florida |
Inhibition of cell proliferation
|
|
WO2007075896A2
(en)
|
2005-12-22 |
2007-07-05 |
Kemia, Inc. |
Heterocyclic cytokine inhibitors
|
|
US8455658B2
(en)
|
2006-01-25 |
2013-06-04 |
Synta Pharmaceuticals Corp. |
Thiazole and thiadiazole compounds for inflammation and immune-related uses
|
|
WO2007116106A1
(es)
|
2006-04-12 |
2007-10-18 |
Palobiofarma, S.L. |
Nuevos compuestos como antagonistas de los receptores a1 de adenosina
|
|
RU2008148962A
(ru)
|
2006-05-12 |
2010-06-20 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Избирательно действующие ингибиторы rоск протеинкиназы и их применение
|
|
CA2657247A1
(en)
|
2006-07-28 |
2008-01-31 |
Boehringer Ingelheim International Gmbh |
Compounds which modulate the cb2 receptor
|
|
US7928123B2
(en)
|
2006-09-25 |
2011-04-19 |
Boehringer Ingelheim International Gmbh |
Compounds which modulate the CB2 receptor
|
|
TW200831081A
(en)
|
2006-12-25 |
2008-08-01 |
Kyorin Seiyaku Kk |
Glucokinase activator
|
|
WO2008124000A2
(en)
|
2007-04-02 |
2008-10-16 |
Ligand Pharmaceuticals Incorporated |
Thiazole derivatives as androgen receptor modulator compounds
|
|
GB0706793D0
(en)
|
2007-04-05 |
2007-05-16 |
Evotec Ag |
Compounds
|
|
ES2609912T3
(es)
|
2007-06-22 |
2017-04-25 |
Hydra Biosciences, Inc. |
Compuestos de 2,6-dioxo, -2,3-dihidro-1h-purina útiles para el tratamiento de trastornos relacionados con la actividad del canal trpa1
|
|
CN101903349B
(zh)
|
2007-08-27 |
2014-01-08 |
Abbvie德国有限责任两合公司 |
4-(4-吡啶基)-苯甲酰胺及其作为rock活性调节剂的应用
|
|
TW200916447A
(en)
|
2007-08-29 |
2009-04-16 |
Methylgene Inc |
Sirtuin inhibitors
|
|
ES2331220B1
(es)
|
2007-10-02 |
2010-09-23 |
Palobiofarma, S.L. |
Nuevos compuestos como antagonistas de los receptores a1 de adenosina.
|
|
WO2009057827A1
(en)
|
2007-10-31 |
2009-05-07 |
Nissan Chemical Industries, Ltd. |
Pyridazinone derivatives and use thereof as p2x7 receptor inhibitors
|
|
CA2704684A1
(en)
|
2007-11-07 |
2009-05-14 |
Boehringer Ingelheim International Gmbh |
Compounds which modulate the cb2 receptor
|
|
WO2009067607A2
(en)
|
2007-11-20 |
2009-05-28 |
Memory Pharmaceuticals Corporation |
Combinations of pde4 inhibitors and antipsychotics for the treatment of psychotic disorders
|
|
WO2009086303A2
(en)
|
2007-12-21 |
2009-07-09 |
University Of Rochester |
Method for altering the lifespan of eukaryotic organisms
|
|
WO2009081222A1
(en)
|
2007-12-21 |
2009-07-02 |
Glenmark Pharmaceuticals, S.A. |
Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
|
|
WO2009099195A1
(ja)
|
2008-02-08 |
2009-08-13 |
Shiseido Company Ltd. |
美白剤及び皮膚外用剤
|
|
WO2009114552A1
(en)
|
2008-03-10 |
2009-09-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Heteroaryl compounds, compositions, and methods of use in cancer treatment
|
|
US20120108614A1
(en)
|
2008-05-14 |
2012-05-03 |
Chong Jayhong A |
Compounds and compositions for treating chemical warfare agent-induced injuries
|
|
WO2010028193A1
(en)
|
2008-09-03 |
2010-03-11 |
Repligen Corporation |
Compounds including pimelic acid derivatives as hdac inhibitors
|
|
US20100063085A1
(en)
*
|
2008-09-11 |
2010-03-11 |
University Court Of The University Of Dundee |
Method of treating learning impairment in down's syndrome subjects
|
|
WO2010029300A1
(en)
|
2008-09-12 |
2010-03-18 |
Biolipox Ab |
Bis aromatic compounds for use in the treatment of inflammation
|
|
US20120046305A1
(en)
|
2008-09-24 |
2012-02-23 |
Moran Magdalene M |
Methods and compositions for treating respiratory disorders
|
|
CA2747354C
(en)
|
2008-12-19 |
2016-12-06 |
Novartis Ag |
Isoxazoline derivatives and their use as pesticide
|
|
EP2370407B1
(en)
*
|
2008-12-19 |
2014-06-18 |
Bristol-Myers Squibb Company |
Carbazole and carboline kinase inhibitors
|
|
SG172352A1
(en)
|
2008-12-23 |
2011-07-28 |
Abbott Lab |
Anti-viral compounds
|
|
JP2012051804A
(ja)
*
|
2008-12-26 |
2012-03-15 |
Kyoto Univ |
Ｅｇ５阻害剤
|
|
UA103918C2
(en)
|
2009-03-02 |
2013-12-10 |
Айерем Элелси |
N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
|
|
US8362249B2
(en)
|
2009-04-27 |
2013-01-29 |
Boehringer Ingelheim International Gmbh |
CXCR3 receptor antagonists
|
|
JP2012529518A
(ja)
|
2009-06-09 |
2012-11-22 |
アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー |
ヘッジホッグシグナル伝達のピリジル−トリアジン阻害剤
|
|
EP3103452A1
(en)
|
2009-08-25 |
2016-12-14 |
Abraxis BioScience, LLC |
Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
|
|
JP5856064B2
(ja)
*
|
2009-11-17 |
2016-02-09 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
治療特性を有する１，４−ベンゾジアゼピン−２，５−ジオンおよび関連化合物
|
|
AU2010330743A1
(en)
|
2009-12-18 |
2012-07-05 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
US9216995B2
(en)
|
2010-04-12 |
2015-12-22 |
Shionogi & Co., Ltd. |
Pyridone derivative having integrase inhibitory activity
|
|
WO2011130740A2
(en)
|
2010-04-16 |
2011-10-20 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Pyridylthiazole-based ureas as inhibitors of rho associated protein kinase (rock) and methods of use
|
|
WO2011159857A1
(en)
|
2010-06-16 |
2011-12-22 |
Bristol-Myers Squibb Company |
Carboline carboxamide compounds useful as kinase inhibitors
|
|
WO2012054367A1
(en)
*
|
2010-10-19 |
2012-04-26 |
Boehringer Ingelheim International Gmbh |
Rho kinase inhibitors
|
|
US8703953B2
(en)
|
2012-03-09 |
2014-04-22 |
Bristol-Myers Squibb Company |
Aryl ether-base kinase inhibitors
|
|
AR096788A1
(es)
|
2013-07-02 |
2016-02-03 |
Bristol Myers Squibb Co |
Compuestos tricíclicos de carboxamida como inhibidores potentes de rock
|
|
WO2015002926A1
(en)
|
2013-07-02 |
2015-01-08 |
Bristol-Myers Squibb Company |
Tricyclic pyrido-carboxamide derivatives as rock inhibitors
|