|
HU168776B
(enExample)
|
1973-11-09 |
1976-07-28 |
|
|
|
HU168036B
(enExample)
|
1973-11-09 |
1976-02-28 |
|
|
|
US3962448A
(en)
*
|
1974-03-11 |
1976-06-08 |
Smithkline Corporation |
8-Alkyl and alkenyl-10-hydroxy-5H[1]benzopyranopyridine derivatives having polyphagic activity
|
|
CA1098910A
(en)
|
1978-06-15 |
1981-04-07 |
Robert N. Schut |
3-amino-2-(5-fluoro and 5-methoxy-1h-indol-3-yl) propanoic acid derivatives
|
|
JPS57116067A
(en)
|
1981-01-12 |
1982-07-19 |
Sankyo Kagaku Kk |
Novel 8-quinolinesulfonyl derivative, its synthesis and use
|
|
DE3703435A1
(de)
|
1987-02-05 |
1988-08-18 |
Thomae Gmbh Dr K |
Neue thiazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
IE68593B1
(en)
|
1989-12-06 |
1996-06-26 |
Sanofi Sa |
Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
|
|
WO1996037493A1
(de)
|
1995-05-26 |
1996-11-28 |
Bayer Aktiengesellschaft |
Pyridyl-thiazole und deren verwendung zum schutz von pflanzen gegen befall durch mikroorganismen
|
|
US6187797B1
(en)
|
1996-12-23 |
2001-02-13 |
Dupont Pharmaceuticals Company |
Phenyl-isoxazoles as factor XA Inhibitors
|
|
CA2276034A1
(en)
|
1996-12-23 |
1998-07-02 |
Mimi Lifen Quan |
Oxygen or sulfur containing 5-membered heteroaromatics as factor xa inhibitors
|
|
JPH11193281A
(ja)
|
1997-10-27 |
1999-07-21 |
Takeda Chem Ind Ltd |
アデノシンａ３受容体拮抗剤およびチアゾール化合物
|
|
WO1999052906A1
(de)
|
1998-04-08 |
1999-10-21 |
Bayer Aktiengesellschaft |
Substituierte oxazolyl- und thiazolyl-uracil herbizide
|
|
KR20020069183A
(ko)
|
1999-07-26 |
2002-08-29 |
시오노기세이야쿠가부시키가이샤 |
트롬보포이에틴 작동성을 나타내는 의약 조성물
|
|
EP1268477B1
(en)
*
|
2000-03-15 |
2010-04-21 |
Sanofi-Aventis Deutschland GmbH |
Substituted beta-carbolines with ikb-kinase inhibiting activity
|
|
CA2402549A1
(en)
*
|
2000-03-15 |
2001-09-20 |
Aventis Pharma Deutschland Gmbh |
Substituted beta-carbolines
|
|
GB0010183D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
|
JP2002053566A
(ja)
|
2000-08-11 |
2002-02-19 |
Japan Tobacco Inc |
チアゾール化合物及びその医薬用途
|
|
JP4790969B2
(ja)
|
2000-08-11 |
2011-10-12 |
日本ケミファ株式会社 |
ペルオキシソーム増殖剤応答性受容体δの活性化剤
|
|
US20020173507A1
(en)
|
2000-08-15 |
2002-11-21 |
Vincent Santora |
Urea compounds and methods of uses
|
|
US20020103192A1
(en)
|
2000-10-26 |
2002-08-01 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
WO2002051442A1
(en)
|
2000-12-26 |
2002-07-04 |
Takeda Chemical Industries, Ltd. |
Concomitant drugs
|
|
JPWO2002062775A1
(ja)
|
2001-02-02 |
2004-06-10 |
山之内製薬株式会社 |
２−アシルアミノチアゾール誘導体又はその塩
|
|
MY130778A
(en)
|
2001-02-09 |
2007-07-31 |
Vertex Pharma |
Heterocyclic inhibitiors of erk2 and uses thereof
|
|
US20020177594A1
(en)
|
2001-03-14 |
2002-11-28 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
JP4157381B2
(ja)
|
2001-03-23 |
2008-10-01 |
日本ケミファ株式会社 |
ペルオキシソーム増殖剤応答性受容体の活性化剤
|
|
JPWO2002087589A1
(ja)
|
2001-04-26 |
2004-08-12 |
第一製薬株式会社 |
薬剤排出ポンプ阻害薬
|
|
EP1402900A1
(en)
|
2001-06-11 |
2004-03-31 |
Takeda Chemical Industries, Ltd. |
Medicinal compositions
|
|
GB0123589D0
(en)
|
2001-10-01 |
2001-11-21 |
Syngenta Participations Ag |
Organic compounds
|
|
WO2003048140A1
(en)
|
2001-12-03 |
2003-06-12 |
Japan Tobacco Inc. |
Azole compound and medicinal use thereof
|
|
PT1466912E
(pt)
|
2002-01-18 |
2013-06-28 |
Astellas Pharma Inc |
Derivado de 2-aciloaminotiazol ou seu sal
|
|
EP1467981A1
(en)
|
2002-01-25 |
2004-10-20 |
Kylix Pharmaceuticals B.V. |
4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2
|
|
US7229987B2
(en)
|
2002-05-13 |
2007-06-12 |
Eli Lilly And Company |
Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes
|
|
JP2006508042A
(ja)
|
2002-07-18 |
2006-03-09 |
ブリストル−マイヤーズ スクイブ カンパニー |
グルココルチコイド受容体の修飾物質および方法
|
|
CN1691944A
(zh)
|
2002-08-09 |
2005-11-02 |
阿斯利康(瑞典)有限公司 |
作为代谢型谷氨酸受体－5调节剂的噁二唑
|
|
WO2004016592A1
(en)
|
2002-08-14 |
2004-02-26 |
Ppd Discovery, Inc. |
Prenylation inhibitors and methods of their synthesis and use
|
|
AU2003288956A1
(en)
|
2002-10-30 |
2004-06-07 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of rock and other protein kinases
|
|
GB0230087D0
(en)
|
2002-12-24 |
2003-01-29 |
Astrazeneca Ab |
Therapeutic agents
|
|
GB0302672D0
(en)
|
2003-02-06 |
2003-03-12 |
Astrazeneca Ab |
Pharmaceutical formulations
|
|
WO2004071509A1
(ja)
|
2003-02-12 |
2004-08-26 |
Nippon Chemiphar Co., Ltd. |
オリゴデンドロサイト分化促進剤
|
|
PT1611088E
(pt)
|
2003-04-07 |
2009-09-24 |
Pharmacyclics Inc |
Hidroxamatos como agentes terapêuticos
|
|
US7696198B2
(en)
|
2003-04-16 |
2010-04-13 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors
|
|
CN100545161C
(zh)
|
2003-08-15 |
2009-09-30 |
中国科学院上海药物研究所 |
一类杂环衍生物、制备方法及其用途
|
|
US7351727B2
(en)
|
2003-09-02 |
2008-04-01 |
Bristol-Myers Squibb Company |
Inhibitors of 15-lipoxygenase
|
|
US7973169B2
(en)
|
2003-09-06 |
2011-07-05 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
AR045651A1
(es)
|
2003-09-19 |
2005-11-02 |
Solvay Pharm Bv |
Derivados de tiazol como moduladores del receptor de cannabinoide
|
|
WO2005044194A2
(en)
|
2003-10-28 |
2005-05-19 |
Pharmacia Corporation |
TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR
|
|
EP1682143A2
(en)
|
2003-10-28 |
2006-07-26 |
Pharmacia Corporation |
Combinations comprising an hsp90 inhibitor and a phophodiesterase inhibitor for treating or preventing neoplasia
|
|
BRPI0507278A
(pt)
|
2004-01-30 |
2007-06-26 |
Vertex Pharma |
moduladores dos transportadores do cassete de ligação ao atp
|
|
JP2007519754A
(ja)
|
2004-01-30 |
2007-07-19 |
スミスクライン ビーチャム コーポレーション |
化合物
|
|
WO2005077373A2
(en)
|
2004-02-03 |
2005-08-25 |
Astrazeneca Ab |
Treatment of gastro-esophageal reflux disease (gerd)
|
|
WO2005077345A1
(en)
|
2004-02-03 |
2005-08-25 |
Astrazeneca Ab |
Compounds for the treatment of gastro-esophageal reflux disease
|
|
AU2005212073B2
(en)
|
2004-02-18 |
2010-07-08 |
Kyorin Pharmaceutical Co., Ltd. |
Bicyclic amide derivatives
|
|
MY148488A
(en)
|
2004-02-18 |
2013-04-30 |
Astrazeneca Ab |
Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
US7259155B2
(en)
|
2004-05-05 |
2007-08-21 |
Otsuka Pharmaceutical Factory, Inc. |
Phosphonic diester derivatives
|
|
TW200637559A
(en)
|
2005-03-29 |
2006-11-01 |
Shionogi & Co |
3-propenylcefem derivative
|
|
FR2885129B1
(fr)
|
2005-04-29 |
2007-06-15 |
Proskelia Sas |
Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
|
|
AU2006244203B2
(en)
|
2005-05-09 |
2012-05-03 |
Achillion Pharmaceuticals, Inc. |
Thiazole compounds and methods of use
|
|
US7655446B2
(en)
|
2005-06-28 |
2010-02-02 |
Vertex Pharmaceuticals Incorporated |
Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof
|
|
JP2009505948A
(ja)
*
|
2005-07-11 |
2009-02-12 |
デブジェン エヌブイ |
キナーゼ阻害剤としてのアミド誘導体
|
|
EP1962892A4
(en)
|
2005-11-22 |
2011-10-12 |
Univ South Florida |
INHIBITION OF CELL PROLIFERATION
|
|
WO2007075896A2
(en)
|
2005-12-22 |
2007-07-05 |
Kemia, Inc. |
Heterocyclic cytokine inhibitors
|
|
JP2009524677A
(ja)
|
2006-01-25 |
2009-07-02 |
シンタ ファーマシューティカルズ コーポレーション |
炎症および免疫関連使用用のチアゾールおよびチアジアゾール化合物
|
|
WO2007116106A1
(es)
|
2006-04-12 |
2007-10-18 |
Palobiofarma, S.L. |
Nuevos compuestos como antagonistas de los receptores a1 de adenosina
|
|
EP2032562B1
(en)
|
2006-05-12 |
2010-08-25 |
Vertex Pharmaceuticals Incorporated |
Selective inhibitors of rock protein kinase and uses thereof
|
|
WO2008014199A2
(en)
|
2006-07-28 |
2008-01-31 |
Boehringer Ingelheim International Gmbh |
Sulfonyl compounds which modulate the cb2 receptor
|
|
KR20090069318A
(ko)
|
2006-09-25 |
2009-06-30 |
베링거 인겔하임 인터내셔날 게엠베하 |
Ｃｂ2 수용체를 조절하는 화합물
|
|
TW200831081A
(en)
|
2006-12-25 |
2008-08-01 |
Kyorin Seiyaku Kk |
Glucokinase activator
|
|
WO2008124000A2
(en)
|
2007-04-02 |
2008-10-16 |
Ligand Pharmaceuticals Incorporated |
Thiazole derivatives as androgen receptor modulator compounds
|
|
GB0706793D0
(en)
|
2007-04-05 |
2007-05-16 |
Evotec Ag |
Compounds
|
|
WO2009002933A1
(en)
|
2007-06-22 |
2008-12-31 |
Hydra Biosciences, Inc. |
Methods and compositions for treating disorders
|
|
US8445686B2
(en)
|
2007-08-27 |
2013-05-21 |
Abbvie Inc. |
4-(4-pyridinyl)-benzamides and their use as rock activity modulators
|
|
WO2009026701A1
(en)
|
2007-08-29 |
2009-03-05 |
Methylgene Inc. |
Sirtuin inhibitors
|
|
ES2331220B1
(es)
|
2007-10-02 |
2010-09-23 |
Palobiofarma, S.L. |
Nuevos compuestos como antagonistas de los receptores a1 de adenosina.
|
|
JP5423679B2
(ja)
|
2007-10-31 |
2014-02-19 |
日産化学工業株式会社 |
ピリダジノン化合物及びｐ２ｘ７受容体阻害剤
|
|
EP2217565B1
(en)
|
2007-11-07 |
2013-05-22 |
Boehringer Ingelheim International GmbH |
Compounds which modulate the cb2 receptor
|
|
WO2009067607A2
(en)
|
2007-11-20 |
2009-05-28 |
Memory Pharmaceuticals Corporation |
Combinations of pde4 inhibitors and antipsychotics for the treatment of psychotic disorders
|
|
WO2009081222A1
(en)
|
2007-12-21 |
2009-07-02 |
Glenmark Pharmaceuticals, S.A. |
Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
|
|
AU2008345225A1
(en)
|
2007-12-21 |
2009-07-09 |
University Of Rochester |
Method for altering the lifespan of eukaryotic organisms
|
|
EP2250999B1
(en)
|
2008-02-08 |
2016-04-13 |
Shiseido Company, Ltd. |
Skin whitening agent and external preparation for the skin
|
|
US20110105436A1
(en)
|
2008-03-10 |
2011-05-05 |
Auckland Uniservices Limited |
Heteroaryl compounds, compositions, and methods of use in cancer treatment
|
|
WO2009140519A1
(en)
|
2008-05-14 |
2009-11-19 |
Hydra Biosciences, Inc. |
Compounds and compositions for treating chemical warfare agent-induced injuries
|
|
WO2010028193A1
(en)
|
2008-09-03 |
2010-03-11 |
Repligen Corporation |
Compounds including pimelic acid derivatives as hdac inhibitors
|
|
US20100063085A1
(en)
*
|
2008-09-11 |
2010-03-11 |
University Court Of The University Of Dundee |
Method of treating learning impairment in down's syndrome subjects
|
|
US20110294853A1
(en)
|
2008-09-12 |
2011-12-01 |
Benjamin Pelcman |
Bis Aromatic Compounds for Use in the Treatment of Inflammation
|
|
WO2010036821A1
(en)
|
2008-09-24 |
2010-04-01 |
Hydra Biosciences, Inc. |
Methods and compositions for treating respiratory disorders
|
|
AR074790A1
(es)
|
2008-12-19 |
2011-02-09 |
Novartis Ag |
Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente.
|
|
EP2370407B1
(en)
*
|
2008-12-19 |
2014-06-18 |
Bristol-Myers Squibb Company |
Carbazole and carboline kinase inhibitors
|
|
CN102264737A
(zh)
|
2008-12-23 |
2011-11-30 |
雅培制药有限公司 |
抗病毒化合物
|
|
JP2012051804A
(ja)
*
|
2008-12-26 |
2012-03-15 |
Kyoto Univ |
Ｅｇ５阻害剤
|
|
UA103918C2
(en)
|
2009-03-02 |
2013-12-10 |
Айерем Элелси |
N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
|
|
US8362249B2
(en)
|
2009-04-27 |
2013-01-29 |
Boehringer Ingelheim International Gmbh |
CXCR3 receptor antagonists
|
|
CN102573487A
(zh)
|
2009-06-09 |
2012-07-11 |
加利福尼亚资本权益有限责任公司 |
Hedgehog信号传导的吡啶基-三嗪抑制剂
|
|
BR112012004149A2
(pt)
|
2009-08-25 |
2016-03-22 |
Abraxis Bioscience Llc |
terapia de combinação com composições de nanopartículas de taxano e inibidores de hedgehog
|
|
JP5856064B2
(ja)
|
2009-11-17 |
2016-02-09 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
治療特性を有する１，４−ベンゾジアゼピン−２，５−ジオンおよび関連化合物
|
|
US8609866B2
(en)
|
2009-12-18 |
2013-12-17 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
WO2011129095A1
(ja)
|
2010-04-12 |
2011-10-20 |
塩野義製薬株式会社 |
インテグラーゼ阻害活性を有するピリドン誘導体
|
|
US9221808B2
(en)
|
2010-04-16 |
2015-12-29 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use
|
|
US8685969B2
(en)
*
|
2010-06-16 |
2014-04-01 |
Bristol-Myers Squibb Company |
Carboline carboxamide compounds useful as kinase inhibitors
|
|
US9000154B2
(en)
|
2010-10-19 |
2015-04-07 |
Boehringer Ingelheim International Gmbh |
Rho kinase inhibitors
|
|
US8703953B2
(en)
|
2012-03-09 |
2014-04-22 |
Bristol-Myers Squibb Company |
Aryl ether-base kinase inhibitors
|
|
WO2015002926A1
(en)
|
2013-07-02 |
2015-01-08 |
Bristol-Myers Squibb Company |
Tricyclic pyrido-carboxamide derivatives as rock inhibitors
|
|
JP6434968B2
(ja)
|
2013-07-02 |
2018-12-05 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
Ｒｏｃｋ阻害剤としての三環式ピリド−カルボキサミド誘導体
|