JPS57116067A - Novel 8-quinolinesulfonyl derivative, its synthesis and use - Google Patents

Novel 8-quinolinesulfonyl derivative, its synthesis and use

Info

Publication number
JPS57116067A
JPS57116067A JP56003000A JP300081A JPS57116067A JP S57116067 A JPS57116067 A JP S57116067A JP 56003000 A JP56003000 A JP 56003000A JP 300081 A JP300081 A JP 300081A JP S57116067 A JPS57116067 A JP S57116067A
Authority
JP
Japan
Prior art keywords
quinolinesulfonyl
derivative
group
synthesis
formulai
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56003000A
Other languages
Japanese (ja)
Inventor
Hiroshi Takaku
Takeshi Noda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANKIYOU KAGAKU KK
SANKYO KAGAKU KK
Original Assignee
SANKIYOU KAGAKU KK
SANKYO KAGAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SANKIYOU KAGAKU KK, SANKYO KAGAKU KK filed Critical SANKIYOU KAGAKU KK
Priority to JP56003000A priority Critical patent/JPS57116067A/en
Priority claimed from JP213481A external-priority patent/JPS57118573A/en
Priority to GB8200577A priority patent/GB2096596A/en
Priority to PCT/JP1982/000009 priority patent/WO1982002385A1/en
Publication of JPS57116067A publication Critical patent/JPS57116067A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A 8-quinolinesulfonyl derivative shown by the formulaI(A is tetrazolyl group or triazolyl group or imidazolyl group which may be replaced by an attractive group).
EXAMPLE: 8-Quinolinesulfonyl tetrazolide.
USE: Useful as a condensation agent for oligonucleotide synthesis. Nucleotide-3'- diphosphate and 3'-triphosphate are dissolved in pyridine and reacted with a 8- quinolinesulfonyl derivative to give oligonucleotide in a short time in high yield without causing side reactions.
PROCESS: A halo 8-quinolinesulfonyl shown by the formula II (X is halogen) is reacted with tetrazole or triazole or imidazole which may be replaced by an attractive group, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56003000A 1981-01-12 1981-01-12 Novel 8-quinolinesulfonyl derivative, its synthesis and use Pending JPS57116067A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP56003000A JPS57116067A (en) 1981-01-12 1981-01-12 Novel 8-quinolinesulfonyl derivative, its synthesis and use
GB8200577A GB2096596A (en) 1981-01-12 1982-01-08 8-quinolinesulfonyl derivatives and their synthesis and use as coupling agents in nucleotide chemistry
PCT/JP1982/000009 WO1982002385A1 (en) 1981-01-12 1982-01-12 N-(2-thiazolyl)carbamate derivatives,process for their preparation,and medicinal composition containing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56003000A JPS57116067A (en) 1981-01-12 1981-01-12 Novel 8-quinolinesulfonyl derivative, its synthesis and use
JP213481A JPS57118573A (en) 1981-01-12 1981-01-12 N-(2-thiazolyl)carbamate derivative, its preparation, and drug composition comprising it

Publications (1)

Publication Number Publication Date
JPS57116067A true JPS57116067A (en) 1982-07-19

Family

ID=26335456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56003000A Pending JPS57116067A (en) 1981-01-12 1981-01-12 Novel 8-quinolinesulfonyl derivative, its synthesis and use

Country Status (3)

Country Link
JP (1) JPS57116067A (en)
GB (1) GB2096596A (en)
WO (1) WO1982002385A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015002926A1 (en) 2013-07-02 2015-01-08 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
TW201506024A (en) 2013-07-02 2015-02-16 必治妥美雅史谷比公司 Tricyclic carboxamide derivatives as potent ROCK inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1068607A (en) * 1976-04-14 1979-12-25 Don R. Baker 2-cyclopropanecarboxamido-5-halothiazole as anti-inflammatory agents
FR2406634A1 (en) * 1977-10-19 1979-05-18 Fabre Sa Pierre IMMUNOSTIMULANTS DERIVED FROM AMINO THIAZOLES
US4217355A (en) * 1978-04-24 1980-08-12 Pfizer Inc. Amide therapeutic agents
DK150068C (en) * 1978-06-02 1987-06-29 Pfizer METHOD OF ANALOGUE FOR THE PREPARATION OF AMINOTHIAZOLES

Also Published As

Publication number Publication date
WO1982002385A1 (en) 1982-07-22
GB2096596A (en) 1982-10-20

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