JP2020536971A5 - - Google Patents

Download PDF

Info

Publication number
JP2020536971A5
JP2020536971A5 JP2020542056A JP2020542056A JP2020536971A5 JP 2020536971 A5 JP2020536971 A5 JP 2020536971A5 JP 2020542056 A JP2020542056 A JP 2020542056A JP 2020542056 A JP2020542056 A JP 2020542056A JP 2020536971 A5 JP2020536971 A5 JP 2020536971A5
Authority
JP
Japan
Prior art keywords
substituted
coor
halogen
alkyl substituted
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020542056A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020536971A (ja
JP7254821B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/056030 external-priority patent/WO2019079261A1/en
Publication of JP2020536971A publication Critical patent/JP2020536971A/ja
Publication of JP2020536971A5 publication Critical patent/JP2020536971A5/ja
Application granted granted Critical
Publication of JP7254821B2 publication Critical patent/JP7254821B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020542056A 2017-10-16 2018-10-16 抗がん剤としての環状ジヌクレオチド Active JP7254821B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762572884P 2017-10-16 2017-10-16
US62/572,884 2017-10-16
PCT/US2018/056030 WO2019079261A1 (en) 2017-10-16 2018-10-16 CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS

Publications (3)

Publication Number Publication Date
JP2020536971A JP2020536971A (ja) 2020-12-17
JP2020536971A5 true JP2020536971A5 (enExample) 2021-11-18
JP7254821B2 JP7254821B2 (ja) 2023-04-10

Family

ID=64110154

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020542056A Active JP7254821B2 (ja) 2017-10-16 2018-10-16 抗がん剤としての環状ジヌクレオチド

Country Status (7)

Country Link
US (1) US11427610B2 (enExample)
EP (1) EP3697801B1 (enExample)
JP (1) JP7254821B2 (enExample)
KR (1) KR102747388B1 (enExample)
CN (1) CN111406063B (enExample)
ES (1) ES2997757T3 (enExample)
WO (1) WO2019079261A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019074887A1 (en) 2017-10-10 2019-04-18 Bristol-Myers Squibb Company CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS
CN111511754B (zh) 2017-12-20 2023-09-12 捷克共和国有机化学与生物化学研究所 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸
EP3728283B1 (en) 2017-12-20 2023-11-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
WO2019173587A1 (en) * 2018-03-08 2019-09-12 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
US11161864B2 (en) 2018-10-29 2021-11-02 Venenum Biodesign, LLC Sting agonists
US12435104B2 (en) 2019-07-25 2025-10-07 Beigene, Ltd. Cyclic dinucleotides as sting agonists
WO2021177123A1 (ja) * 2020-03-03 2021-09-10 国立大学法人富山大学 人工核酸
CA3178260A1 (en) 2020-05-13 2021-11-18 Massachusetts Institute Of Technology Compositions of polymeric microdevices and their use in cancer immunotherapy
EP4687796A1 (en) 2023-04-05 2026-02-11 Massachusetts Institute of Technology Hybrid polymeric systems and methods of use thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005005450A1 (ja) 2003-07-15 2005-01-20 Mitsui Chemicals, Inc. 環状ビスジヌクレオシドの合成方法
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
WO2006105021A2 (en) 2005-03-25 2006-10-05 Tolerrx, Inc. Gitr binding molecules and uses therefor
RS52711B (sr) 2005-05-10 2013-08-30 Incyte Corporation Modulatori indolamin 2,3-dioksigenaze i postupci upotrebe istih
EP1971583B1 (en) 2005-12-20 2015-03-25 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
WO2008036642A2 (en) 2006-09-19 2008-03-27 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
CA2693677C (en) 2007-07-12 2018-02-13 Tolerx, Inc. Combination therapies employing gitr binding molecules
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
EP2227233B1 (en) 2007-11-30 2013-02-13 Newlink Genetics Ido inhibitors
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
RU2595409C2 (ru) 2009-09-03 2016-08-27 Мерк Шарп И Доум Корп., Анти-gitr-антитела
WO2011056652A1 (en) 2009-10-28 2011-05-12 Newlink Genetics Imidazole derivatives as ido inhibitors
AU2010329934B2 (en) 2009-12-10 2015-05-14 F. Hoffmann-La Roche Ag Antibodies binding preferentially human CSF1R extracellular domain 4 and their use
DK2542256T3 (da) 2010-03-04 2019-08-26 Macrogenics Inc Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
CA2789071C (en) 2010-03-05 2018-03-27 F. Hoffmann-La Roche Ag Antibodies against human csf-1r and uses thereof
MX2012010014A (es) 2010-03-05 2012-09-21 Hoffmann La Roche Anticuerpos contra csf-1r humano y sus usos.
MX355418B (es) 2010-05-04 2018-04-18 Five Prime Therapeutics Inc Anticuerpos que se unen a factor estimulante de colonias 1 (csf1r).
CN103221428B (zh) 2010-09-09 2016-02-10 辉瑞公司 4-1bb结合分子
NO2694640T3 (enExample) 2011-04-15 2018-03-17
JP6072771B2 (ja) 2011-04-20 2017-02-01 メディミューン,エルエルシー B7−h1およびpd−1に結合する抗体およびその他の分子
US10023643B2 (en) 2011-12-15 2018-07-17 Hoffmann-La Roche Inc. Antibodies against human CSF-1R and uses thereof
EP2812355A4 (en) 2012-02-06 2016-03-02 Hoffmann La Roche COMPOSITIONS AND METHODS OF USE OF CSF1R INHIBITORS
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
CN106986869A (zh) * 2012-04-17 2017-07-28 吉利德科学公司 用于抗病毒治疗的化合物和方法
JP2015517490A (ja) 2012-05-11 2015-06-22 ファイブ プライム セラピューティックス インコーポレイテッド コロニー刺激因子1受容体(csf1r)を結合させる抗体を用いて状態を治療する方法
CN104736168B (zh) 2012-05-31 2018-09-21 索伦托治疗有限公司 与pd-l1结合的抗原结合蛋白
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
SG10201906328RA (en) 2012-08-31 2019-08-27 Five Prime Therapeutics Inc Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
EP3398616A3 (en) * 2012-12-19 2019-01-30 Board of Regents, The University of Texas System Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway
KR102243062B1 (ko) 2013-05-02 2021-04-21 아납티스바이오, 아이엔씨. 예정된 사멸-1에 대한 항체
US9549944B2 (en) * 2013-05-18 2017-01-24 Aduro Biotech, Inc. Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
JP6400082B2 (ja) 2013-05-18 2018-10-03 アデュロ バイオテック,インコーポレイテッド 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法
US9676853B2 (en) 2013-05-31 2017-06-13 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-1
JP6623353B2 (ja) 2013-09-13 2019-12-25 ベイジーン スウィッツァーランド ゲーエムベーハー 抗pd−1抗体並びにその治療及び診断のための使用
ES2746805T3 (es) 2013-12-12 2020-03-06 Shanghai hengrui pharmaceutical co ltd Anticuerpo de PD-1, fragmento de unión a antígeno del mismo y aplicación médica del mismo
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
ES2716685T3 (es) 2014-01-24 2019-06-14 Dana Farber Cancer Inst Inc Moléculas de anticuerpo para PD-1 y usos de las mismas
CN107148424B (zh) * 2014-12-16 2021-01-08 凯拉治疗股份公司 用于诱导细胞因子的环状二核苷酸
AU2016233495B2 (en) 2015-03-13 2022-02-24 Cytomx Therapeutics, Inc Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of use thereof
MA42608A (fr) 2015-08-13 2018-06-20 Merck Sharp & Dohme Composés de di-nucléotide cyclique en tant qu'agonistes sting (stimulateur de gène interféron)
EP3429596B1 (en) 2016-03-18 2022-08-31 Immune Sensor, LLC Cyclic di-nucleotide compounds and methods of use
AU2017378782A1 (en) 2016-12-20 2019-07-04 Merck Sharp & Dohme Corp. Combinations of PD-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment
US20200113924A1 (en) 2016-12-20 2020-04-16 Merck Sharp & Dohme Corp. Cyclic dinucleotide sting agonists for cancer treatment

Similar Documents

Publication Publication Date Title
JP2020536971A5 (enExample)
JP2020536897A5 (enExample)
JP2019501204A5 (enExample)
JP2020532542A5 (enExample)
JP2020532529A5 (enExample)
JP2020532539A5 (enExample)
JP5881705B2 (ja) Namptの阻害のための新規化合物及び組成物
JP2009513703A5 (enExample)
JP2020529400A5 (enExample)
CN119454706A (zh) 治疗kras相关癌症的方法
JP2013056930A5 (enExample)
JP2018504418A5 (enExample)
KR101671761B1 (ko) 이미다조옥사진 화합물에 의한 항종양 효과 증강제
JP2020506951A5 (enExample)
JP2014503567A5 (enExample)
JP2014513704A5 (enExample)
JP2014518544A5 (enExample)
JP2010523681A5 (enExample)
KR20140059268A (ko) 아미노-치환된 이미다조피리다진
JP2018534289A5 (enExample)
HRP20220520T1 (hr) Ciklički dinukleotidi kao agensi protiv raka
JP2020527173A5 (enExample)
CN111511745A (zh) 吡唑并[1,5-a][1,3,5]三嗪-2-胺类衍生物、其制备方法及其在医药上的应用
IL319292A (en) Cytotoxic imidazo[2,1-A]pyridine compounds and their use in therapy
CN114364677A (zh) 作为toll-样受体激动剂的咪唑并[4,5-c]吡啶衍生物