BR122016002916B8 - diacorpo, molécula de ácido nucleico, composição farmacêutica e usos do diacorpo - Google Patents

diacorpo, molécula de ácido nucleico, composição farmacêutica e usos do diacorpo

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Publication number
BR122016002916B8
BR122016002916B8 BR122016002916A BR122016002916A BR122016002916B8 BR 122016002916 B8 BR122016002916 B8 BR 122016002916B8 BR 122016002916 A BR122016002916 A BR 122016002916A BR 122016002916 A BR122016002916 A BR 122016002916A BR 122016002916 B8 BR122016002916 B8 BR 122016002916B8
Authority
BR
Brazil
Prior art keywords
diabody
nucleic acid
pharmaceutical composition
acid molecule
reagent
Prior art date
Application number
BR122016002916A
Other languages
English (en)
Other versions
BR122016002916A2 (pt
BR122016002916B1 (pt
Inventor
Deryk T Loo
Francine Zhifen Chen
Leslie S Johnson
Ling Huang
Paul A Moore
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of BR122016002916A2 publication Critical patent/BR122016002916A2/pt
Publication of BR122016002916B1 publication Critical patent/BR122016002916B1/pt
Publication of BR122016002916B8 publication Critical patent/BR122016002916B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/77—Internalization into the cell
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

reagente de redirecionamento de dupla afinidade, molécula de ácido nucleico, composição farmacêutica e usos do reagente de redirecionamento de dupla afinidade. a presente invenção se refere a anticorpos e seus fragmentos que são imunorreativos para os mamíferos, e mais particularmente, o receptor b7-h3 humano e o uso dos mesmos, particularmente no tratamento de câncer e inflamação. a invenção assim particularmente diz respeito a anticorpos humanizados b7-h3 reativos e seus fragmentos imunorreativos que são capazer de mediar, e mais preferivelmente aumentar a ativação do sistema imune contra células cancerígenas que estão associadas com uma variedade de câncers humanos.
BR122016002916A 2010-03-04 2011-03-01 diacorpo, molécula de ácido nucleico, composição farmacêutica e usos do diacorpo BR122016002916B8 (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US31069210P 2010-03-04 2010-03-04
US31069510P 2010-03-04 2010-03-04
US61/310,695 2010-03-04
US61/310,692 2010-03-04
US31105710P 2010-03-05 2010-03-05
US61/311,057 2010-03-05
PCT/US2011/026689 WO2011109400A2 (en) 2010-03-04 2011-03-01 Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
BR112012022210-4A BR112012022210B1 (pt) 2010-03-04 2011-03-01 Anticorpo isolado ou seu fragmento imunorreativo, molécula de ácido nucleico, composição farmacêutica, e, uso do anticorpo isolado

Publications (3)

Publication Number Publication Date
BR122016002916A2 BR122016002916A2 (pt) 2019-05-28
BR122016002916B1 BR122016002916B1 (pt) 2021-05-11
BR122016002916B8 true BR122016002916B8 (pt) 2021-05-25

Family

ID=44542802

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122016002916A BR122016002916B8 (pt) 2010-03-04 2011-03-01 diacorpo, molécula de ácido nucleico, composição farmacêutica e usos do diacorpo
BR112012022210-4A BR112012022210B1 (pt) 2010-03-04 2011-03-01 Anticorpo isolado ou seu fragmento imunorreativo, molécula de ácido nucleico, composição farmacêutica, e, uso do anticorpo isolado

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Application Number Title Priority Date Filing Date
BR112012022210-4A BR112012022210B1 (pt) 2010-03-04 2011-03-01 Anticorpo isolado ou seu fragmento imunorreativo, molécula de ácido nucleico, composição farmacêutica, e, uso do anticorpo isolado

Country Status (41)

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US (5) US9150656B2 (pt)
EP (2) EP2982380B1 (pt)
JP (2) JP5998060B2 (pt)
KR (1) KR101828570B1 (pt)
CN (2) CN106279416B (pt)
AU (1) AU2011223782B2 (pt)
BR (2) BR122016002916B8 (pt)
CA (1) CA2791658C (pt)
CL (4) CL2012002433A1 (pt)
CO (1) CO6630123A2 (pt)
CR (1) CR20120450A (pt)
CY (1) CY1121913T1 (pt)
DK (1) DK2542256T3 (pt)
EA (1) EA030226B1 (pt)
EC (1) ECSP12012139A (pt)
ES (2) ES2742351T3 (pt)
GE (2) GEP201706660B (pt)
HK (1) HK1221154A1 (pt)
HN (1) HN2012001846A (pt)
HR (1) HRP20191483T1 (pt)
HU (1) HUE045487T2 (pt)
IL (1) IL221767B (pt)
JO (1) JO3538B1 (pt)
LT (1) LT2542256T (pt)
MA (1) MA34062B1 (pt)
ME (1) ME03447B (pt)
MX (1) MX345232B (pt)
MY (1) MY156358A (pt)
NZ (3) NZ602161A (pt)
PE (2) PE20170779A1 (pt)
PH (1) PH12018501083A1 (pt)
PL (1) PL2542256T3 (pt)
PT (1) PT2542256T (pt)
RS (1) RS59269B1 (pt)
SA (1) SA114350709B1 (pt)
SG (2) SG10201604336VA (pt)
SI (1) SI2542256T1 (pt)
TN (1) TN2012000437A1 (pt)
TW (6) TWI645858B (pt)
WO (1) WO2011109400A2 (pt)
ZA (1) ZA201206556B (pt)

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