BR112017027582A2 - método para inibição do crescimento de uma célula tumoral ou promoção da eliminação de uma célula tumoral, e, composição farmacêutica. - Google Patents
método para inibição do crescimento de uma célula tumoral ou promoção da eliminação de uma célula tumoral, e, composição farmacêutica.Info
- Publication number
- BR112017027582A2 BR112017027582A2 BR112017027582A BR112017027582A BR112017027582A2 BR 112017027582 A2 BR112017027582 A2 BR 112017027582A2 BR 112017027582 A BR112017027582 A BR 112017027582A BR 112017027582 A BR112017027582 A BR 112017027582A BR 112017027582 A2 BR112017027582 A2 BR 112017027582A2
- Authority
- BR
- Brazil
- Prior art keywords
- target molecule
- tumor cell
- binding
- antigen binding
- present
- Prior art date
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Abstract
a presente invenção fornece moléculas de ligação a antígeno multiespecíficas e usos das mesmas. as moléculas de ligação a antígeno multiespecíficas compreendem um primeiro domínio de ligação a antígeno que se liga especificamente a uma molécula alvo, e um segundo domínio de ligação a antígeno que se liga especificamente a uma proteína efetora de internalização. as moléculas de ligação a antígeno multiespecíficas da presente invenção, em algumas modalidades, podem ser anticorpos biespecíficos que são capazes de se ligar a uma molécula alvo e a uma proteína efetora de internalização. em certas modalidades da invenção, a ligação simultânea da molécula alvo e da proteína efetora de internalização pela molécula de ligação a antígeno multiespecífica da presente invenção resulta na atenuação da atividade da molécula alvo em um grau maior do que a ligação da molécula alvo sozinha. em outras modalidades da invenção, a molécula alvo é um antígeno associado ao tumor, e a ligação simultânea do antígeno associado ao tumor e da proteína efetora de internalização pela molécula de ligação a antígeno multiespecífica da presente invenção provoca ou facilita a eliminação direcionada de células tumorais.
Applications Claiming Priority (4)
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US201562188860P | 2015-07-06 | 2015-07-06 | |
US201662328900P | 2016-04-28 | 2016-04-28 | |
US201662347179P | 2016-06-08 | 2016-06-08 | |
PCT/US2016/041055 WO2017007796A1 (en) | 2015-07-06 | 2016-07-06 | Multispecific antigen-binding molecules and uses thereof |
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BR112017027582A BR112017027582A2 (pt) | 2015-07-06 | 2016-07-06 | método para inibição do crescimento de uma célula tumoral ou promoção da eliminação de uma célula tumoral, e, composição farmacêutica. |
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US (3) | US11129903B2 (pt) |
EP (2) | EP3319994B1 (pt) |
JP (3) | JP6993958B2 (pt) |
KR (1) | KR20180025865A (pt) |
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SG (1) | SG10202112460VA (pt) |
WO (1) | WO2017007796A1 (pt) |
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