MX2017017117A - Moleculas multiespecificas de union a antigenos y usos de estas. - Google Patents
Moleculas multiespecificas de union a antigenos y usos de estas.Info
- Publication number
- MX2017017117A MX2017017117A MX2017017117A MX2017017117A MX2017017117A MX 2017017117 A MX2017017117 A MX 2017017117A MX 2017017117 A MX2017017117 A MX 2017017117A MX 2017017117 A MX2017017117 A MX 2017017117A MX 2017017117 A MX2017017117 A MX 2017017117A
- Authority
- MX
- Mexico
- Prior art keywords
- binding
- antigen
- target molecule
- multispecific antigen
- present disclosure
- Prior art date
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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Abstract
La presente invención proporciona moléculas multiespecíficas de unión a antígenos y usos de estas. Las moléculas multiespecíficas de unión a antígenos comprenden un primer dominio de unión a un antígeno que se une específicamente a una molécula objetivo, y un segundo dominio de unión a un antígeno que se une específicamente a una proteína efectora con internalización. Las moléculas multiespecíficas de unión a antígenos de la presente invención puede, en algunas modalidades, ser anticuerpos biespecíficos que son capaces de unirse tanto a una molécula objetivo como a una proteína efectora con internalización. En ciertas modalidades de la invención, la unión simultánea de la molécula objetivo y la proteína efectora con internalización por la molécula multiespecífica de unión a antígenos de la presente invención da como resultado la atenuación de la actividad de la molécula objetivo en mayor medida que la unión de la molécula objetivo sola. En otras modalidades de la invención, la molécula objetivo es un antígeno asociado a un tumor, y la unión simultánea del antígeno asociado al tumor y la proteína efectora con internalización por la molécula multiespecífica de unión a antígenos de la presente invención provoca o facilita la destrucción dirigida de las células tumorales.
Applications Claiming Priority (4)
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US201562188860P | 2015-07-06 | 2015-07-06 | |
US201662328900P | 2016-04-28 | 2016-04-28 | |
US201662347179P | 2016-06-08 | 2016-06-08 | |
PCT/US2016/041055 WO2017007796A1 (en) | 2015-07-06 | 2016-07-06 | Multispecific antigen-binding molecules and uses thereof |
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MX2017017117A true MX2017017117A (es) | 2018-03-06 |
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MX2017017117A MX2017017117A (es) | 2015-07-06 | 2016-07-06 | Moleculas multiespecificas de union a antigenos y usos de estas. |
MX2023003418A MX2023003418A (es) | 2015-07-06 | 2017-12-20 | Moleculas multiespecificas de union a antigenos y usos de estas. |
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MX2023003418A MX2023003418A (es) | 2015-07-06 | 2017-12-20 | Moleculas multiespecificas de union a antigenos y usos de estas. |
Country Status (15)
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US (3) | US11129903B2 (es) |
EP (2) | EP3319994B1 (es) |
JP (3) | JP6993958B2 (es) |
KR (1) | KR20180025865A (es) |
CN (1) | CN107849131A (es) |
AU (2) | AU2016289480C1 (es) |
BR (1) | BR112017027582A2 (es) |
CA (1) | CA2987641A1 (es) |
EA (1) | EA038973B1 (es) |
IL (3) | IL296285A (es) |
MX (2) | MX2017017117A (es) |
MY (2) | MY189159A (es) |
NZ (1) | NZ737726A (es) |
SG (1) | SG10202112460VA (es) |
WO (1) | WO2017007796A1 (es) |
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