MX362412B - Inhibidores de biaril meta-pirimidina de cinasas. - Google Patents
Inhibidores de biaril meta-pirimidina de cinasas.Info
- Publication number
- MX362412B MX362412B MX2010010772A MX2010010772A MX362412B MX 362412 B MX362412 B MX 362412B MX 2010010772 A MX2010010772 A MX 2010010772A MX 2010010772 A MX2010010772 A MX 2010010772A MX 362412 B MX362412 B MX 362412B
- Authority
- MX
- Mexico
- Prior art keywords
- kinases
- meta
- pyrimidine inhibitors
- aryl meta
- pyrimidine
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 2
- 102000020233 phosphotransferase Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 108091005682 Receptor kinases Proteins 0.000 abstract 1
- 125000005841 biaryl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
Classifications
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
La invención provee compuestos de biaril-meta-pirimidina que tiene la estructura general (A); (Ver fórmula A) los compuestos de pirimidina de la invención son capaces de inhibir cinasas, tales como miembros de la familia Jak de la cinasa, y algunas otras cinasas específicas de receptor y que no son de receptor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73262905P | 2005-11-01 | 2005-11-01 | |
| US83800306P | 2006-08-15 | 2006-08-15 | |
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