JP2018070614A5 - - Google Patents
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- Publication number
- JP2018070614A5 JP2018070614A5 JP2017212845A JP2017212845A JP2018070614A5 JP 2018070614 A5 JP2018070614 A5 JP 2018070614A5 JP 2017212845 A JP2017212845 A JP 2017212845A JP 2017212845 A JP2017212845 A JP 2017212845A JP 2018070614 A5 JP2018070614 A5 JP 2018070614A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ring
- hydrogen
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 56
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 19
- 239000012453 solvate Substances 0.000 claims 18
- 229910052799 carbon Inorganic materials 0.000 claims 16
- 239000000651 prodrug Substances 0.000 claims 15
- 229940002612 prodrug Drugs 0.000 claims 15
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- 229910052717 sulfur Inorganic materials 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 claims 4
- 208000020358 Learning disease Diseases 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 201000003723 learning disability Diseases 0.000 claims 3
- 208000000044 Amnesia Diseases 0.000 claims 2
- 208000019838 Blood disease Diseases 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 2
- 208000026139 Memory disease Diseases 0.000 claims 2
- 208000031888 Mycoses Diseases 0.000 claims 2
- 230000007000 age related cognitive decline Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 230000001149 cognitive effect Effects 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 208000014951 hematologic disease Diseases 0.000 claims 2
- 208000018706 hematopoietic system disease Diseases 0.000 claims 2
- 230000006984 memory degeneration Effects 0.000 claims 2
- 208000023060 memory loss Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- -1 CF 3 Chemical class 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 1
- 208000006289 Rett Syndrome Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 230000008033 biological extinction Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000009225 cognitive behavioral therapy Methods 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 230000008434 fear extinction Effects 0.000 claims 1
- 230000014061 fear response Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000000185 intracerebroventricular administration Methods 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000001671 psychotherapy Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 201000006152 substance dependence Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 230000000946 synaptic effect Effects 0.000 claims 1
- 230000003956 synaptic plasticity Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161480133P | 2011-04-28 | 2011-04-28 | |
| US61/480,133 | 2011-04-28 | ||
| JP2014508179A JP6240063B2 (ja) | 2011-04-28 | 2012-04-30 | ヒストンデアセチラーゼ阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508179A Division JP6240063B2 (ja) | 2011-04-28 | 2012-04-30 | ヒストンデアセチラーゼ阻害剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019185842A Division JP7042244B2 (ja) | 2011-04-28 | 2019-10-09 | ヒストンデアセチラーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018070614A JP2018070614A (ja) | 2018-05-10 |
| JP2018070614A5 true JP2018070614A5 (enExample) | 2018-09-20 |
| JP6974120B2 JP6974120B2 (ja) | 2021-12-01 |
Family
ID=47072809
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508179A Active JP6240063B2 (ja) | 2011-04-28 | 2012-04-30 | ヒストンデアセチラーゼ阻害剤 |
| JP2017212845A Active JP6974120B2 (ja) | 2011-04-28 | 2017-11-02 | ヒストンデアセチラーゼ阻害剤 |
| JP2019185842A Active JP7042244B2 (ja) | 2011-04-28 | 2019-10-09 | ヒストンデアセチラーゼ阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508179A Active JP6240063B2 (ja) | 2011-04-28 | 2012-04-30 | ヒストンデアセチラーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019185842A Active JP7042244B2 (ja) | 2011-04-28 | 2019-10-09 | ヒストンデアセチラーゼ阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US9447030B2 (enExample) |
| EP (2) | EP2701699B1 (enExample) |
| JP (3) | JP6240063B2 (enExample) |
| CA (1) | CA2834548C (enExample) |
| WO (1) | WO2012149540A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2553337Y2 (ja) | 1993-06-30 | 1997-11-05 | 住友重機械工業株式会社 | 電気集塵装置 |
| JP6240063B2 (ja) | 2011-04-28 | 2017-11-29 | ザ ブロード インスティテュート， インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| WO2014018979A1 (en) | 2012-07-27 | 2014-01-30 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| WO2014047199A1 (en) * | 2012-09-19 | 2014-03-27 | The Research Foundation For The State University Of New York | Novel prodrugs for selective anticancer therapy |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| ES2718495T3 (es) | 2012-12-21 | 2019-07-02 | Celgene Quanticel Res Inc | Inhibidores de la histona desmetilasa |
| US9139583B2 (en) | 2013-02-01 | 2015-09-22 | Acetylon Pharmaceuticals, Inc. | Selective HDAC3 inhibitors |
| JP2016511237A (ja) | 2013-02-01 | 2016-04-14 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 選択的ｈｄａｃ３阻害剤 |
| WO2015031295A1 (en) | 2013-08-27 | 2015-03-05 | Bristol-Myers Squibb Company | Ido inhibitors |
| SG11201610813TA (en) | 2014-06-25 | 2017-01-27 | Quanticel Pharmaceuticals Inc | Histone demethylase inhibitors |
| WO2015200619A1 (en) * | 2014-06-26 | 2015-12-30 | Rodin Therapeutics, Inc. | Inhibitors of histone deacetylase |
| US10081624B2 (en) | 2014-08-26 | 2018-09-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2016144814A1 (en) * | 2015-03-06 | 2016-09-15 | Colorado State University Research Foundation | Synthesis and utility of new capgroup largazole analogs |
| US10676504B2 (en) | 2015-03-06 | 2020-06-09 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
| RS62639B1 (sr) | 2015-07-06 | 2021-12-31 | Alkermes Inc | Hetero-halo inhibitori histonskih deacetilaza |
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| US10357484B2 (en) | 2015-07-17 | 2019-07-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
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| KR102239776B1 (ko) * | 2016-08-26 | 2021-04-13 | 동아에스티 주식회사 | (r)-(1-메틸피롤리딘-3-일)메틸(3'-클로로-4'-플루오로-[1,1'-비페닐]-2-일)카바메이트의 신규염 및 이의 결정형 |
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| JP6756925B2 (ja) | 2017-01-11 | 2020-09-16 | ロダン・セラピューティクス，インコーポレーテッド | ヒストンデアセチラーゼの二環式阻害剤 |
| TW201910328A (zh) | 2017-07-31 | 2019-03-16 | 日商武田藥品工業股份有限公司 | 雜環化合物 |
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| EA037772B1 (ru) * | 2017-09-07 | 2021-05-20 | Родин Терапеутикс, Инк. | Бициклические ингибиторы деацетилазы гистонов |
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| CN112135610A (zh) * | 2018-01-12 | 2020-12-25 | KDAc治疗股份有限公司 | 用于治疗癌症的选择性组蛋白去乙酰酶3(hdac3)抑制剂及免疫治疗剂的组合 |
| WO2019235501A1 (ja) * | 2018-06-06 | 2019-12-12 | 塩野義製薬株式会社 | ヒストン脱アセチル化酵素阻害剤 |
| CN112805275A (zh) * | 2018-07-13 | 2021-05-14 | 奥克梅斯公司 | 组蛋白脱乙酰酶双环抑制剂 |
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| WO2022140144A1 (en) | 2020-12-21 | 2022-06-30 | Colorado State University Research Foundation | Synthesis of structural analogs of largazole and associated compounds |
| CN114957132A (zh) * | 2021-02-20 | 2022-08-30 | 中国科学院上海药物研究所 | 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用 |
| TW202434201A (zh) * | 2022-11-07 | 2024-09-01 | 美商人福醫藥美國公司 | 新型生長抑素受體亞型4（sstr4）激動劑及其應用 |
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