JP2016513737A5 - - Google Patents
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- JP2016513737A5 JP2016513737A5 JP2016502870A JP2016502870A JP2016513737A5 JP 2016513737 A5 JP2016513737 A5 JP 2016513737A5 JP 2016502870 A JP2016502870 A JP 2016502870A JP 2016502870 A JP2016502870 A JP 2016502870A JP 2016513737 A5 JP2016513737 A5 JP 2016513737A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- cancer
- compound
- chemotherapeutic agent
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 63
- 239000002246 antineoplastic agent Substances 0.000 claims description 35
- 229940127089 cytotoxic agent Drugs 0.000 claims description 35
- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 206010028980 Neoplasm Diseases 0.000 claims description 25
- 201000011510 cancer Diseases 0.000 claims description 25
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 24
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 claims description 21
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims description 21
- 210000004027 cell Anatomy 0.000 claims description 18
- 125000005842 heteroatom Chemical group 0.000 claims description 18
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 15
- 125000004429 atom Chemical group 0.000 claims description 13
- 241000701806 Human papillomavirus Species 0.000 claims description 12
- 230000002159 abnormal effect Effects 0.000 claims description 12
- 230000004663 cell proliferation Effects 0.000 claims description 10
- 102000013698 Cyclin-Dependent Kinase 6 Human genes 0.000 claims description 9
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 201000000582 Retinoblastoma Diseases 0.000 claims description 8
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 230000010076 replication Effects 0.000 claims description 8
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 8
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 7
- 229960004562 carboplatin Drugs 0.000 claims description 7
- 238000002512 chemotherapy Methods 0.000 claims description 7
- 229960004316 cisplatin Drugs 0.000 claims description 7
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 7
- 229960005420 etoposide Drugs 0.000 claims description 7
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 6
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 4
- 239000012625 DNA intercalator Substances 0.000 claims description 4
- 230000006820 DNA synthesis Effects 0.000 claims description 4
- 230000004568 DNA-binding Effects 0.000 claims description 4
- 229940123573 Protein synthesis inhibitor Drugs 0.000 claims description 4
- 230000006819 RNA synthesis Effects 0.000 claims description 4
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 4
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims description 4
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims description 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 4
- 229940100198 alkylating agent Drugs 0.000 claims description 4
- 239000002168 alkylating agent Substances 0.000 claims description 4
- 230000022131 cell cycle Effects 0.000 claims description 4
- 201000010881 cervical cancer Diseases 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 4
- 201000010536 head and neck cancer Diseases 0.000 claims description 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
- 239000000007 protein synthesis inhibitor Substances 0.000 claims description 4
- 150000003413 spiro compounds Chemical class 0.000 claims description 4
- 239000003277 telomerase inhibitor Substances 0.000 claims description 4
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims description 4
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 4
- 239000000225 tumor suppressor protein Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims 41
- 229940079593 drug Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 15
- 229960000303 topotecan Drugs 0.000 claims 6
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 230000008034 disappearance Effects 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 description 45
- 125000000753 cycloalkyl group Chemical group 0.000 description 20
- 125000003118 aryl group Chemical group 0.000 description 14
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 12
- 125000001072 heteroaryl group Chemical group 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 11
- 125000003710 aryl alkyl group Chemical group 0.000 description 10
- 125000001188 haloalkyl group Chemical group 0.000 description 10
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 10
- 239000001257 hydrogen Substances 0.000 description 9
- 125000003342 alkenyl group Chemical group 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- -1 heterocyclo Chemical group 0.000 description 7
- 125000000304 alkynyl group Chemical group 0.000 description 6
- 125000004093 cyano group Chemical group *C#N 0.000 description 6
- 125000006413 ring segment Chemical group 0.000 description 6
- 125000000392 cycloalkenyl group Chemical group 0.000 description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 description 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000000973 chemotherapeutic effect Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 150000002431 hydrogen Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 210000001985 kidney epithelial cell Anatomy 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000004043 oxo group Chemical group O=* 0.000 description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 description 1
- 229940126638 Akt inhibitor Drugs 0.000 description 1
- 229940122531 Anaplastic lymphoma kinase inhibitor Drugs 0.000 description 1
- 239000012664 BCL-2-inhibitor Substances 0.000 description 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 description 1
- 0 CC(C)CC(CN1*)[n]2c3nc(NC4=CC=C(*)**4)ncc3cc2C1=O Chemical compound CC(C)CC(CN1*)[n]2c3nc(NC4=CC=C(*)**4)ncc3cc2C1=O 0.000 description 1
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 description 1
- 101001105486 Homo sapiens Proteasome subunit alpha type-7 Proteins 0.000 description 1
- 229940124647 MEK inhibitor Drugs 0.000 description 1
- TWTKMJWAXOPXSX-UHFFFAOYSA-N O=C(c1c2)NCC3(CCCCC3)[n]1c1c2cnc(Nc(cc2)ncc2N2CCNCC2)n1 Chemical compound O=C(c1c2)NCC3(CCCCC3)[n]1c1c2cnc(Nc(cc2)ncc2N2CCNCC2)n1 TWTKMJWAXOPXSX-UHFFFAOYSA-N 0.000 description 1
- 239000012270 PD-1 inhibitor Substances 0.000 description 1
- 239000012668 PD-1-inhibitor Substances 0.000 description 1
- 229940116355 PI3 kinase inhibitor Drugs 0.000 description 1
- 239000012828 PI3K inhibitor Substances 0.000 description 1
- 102100021201 Proteasome subunit alpha type-7 Human genes 0.000 description 1
- 229940078123 Ras inhibitor Drugs 0.000 description 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 description 1
- 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 150000001717 carbocyclic compounds Chemical class 0.000 description 1
- 230000001767 chemoprotection Effects 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229940124302 mTOR inhibitor Drugs 0.000 description 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 description 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940121655 pd-1 inhibitor Drugs 0.000 description 1
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 description 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000003197 protein kinase B inhibitor Substances 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798772P | 2013-03-15 | 2013-03-15 | |
| US61/798,772 | 2013-03-15 | ||
| US201361861374P | 2013-08-01 | 2013-08-01 | |
| US61/861,374 | 2013-08-01 | ||
| US201361911354P | 2013-12-03 | 2013-12-03 | |
| US61/911,354 | 2013-12-03 | ||
| US201461949786P | 2014-03-07 | 2014-03-07 | |
| US61/949,786 | 2014-03-07 | ||
| PCT/US2014/028685 WO2014144326A1 (en) | 2013-03-15 | 2014-03-14 | Transient protection of normal cells during chemotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204234A Division JP6767456B2 (ja) | 2013-03-15 | 2018-10-30 | 化学療法の間の正常細胞の一時的な保護 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513737A JP2016513737A (ja) | 2016-05-16 |
| JP2016513737A5 true JP2016513737A5 (enExample) | 2017-04-20 |
| JP6430483B2 JP6430483B2 (ja) | 2018-11-28 |
Family
ID=51527871
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503092A Active JP6337083B2 (ja) | 2013-03-15 | 2014-03-14 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2016502870A Active JP6430483B2 (ja) | 2013-03-15 | 2014-03-14 | 化学療法の間の正常細胞の一時的な保護 |
| JP2018089382A Active JP6517401B2 (ja) | 2013-03-15 | 2018-05-07 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2018204234A Active JP6767456B2 (ja) | 2013-03-15 | 2018-10-30 | 化学療法の間の正常細胞の一時的な保護 |
| JP2019077828A Active JP6738933B6 (ja) | 2013-03-15 | 2019-04-16 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020123189A Active JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020155691A Active JP7213854B2 (ja) | 2013-03-15 | 2020-09-16 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023005413A Ceased JP2023052449A (ja) | 2013-03-15 | 2023-01-17 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023044746A Withdrawn JP2023078341A (ja) | 2013-03-15 | 2023-03-20 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503092A Active JP6337083B2 (ja) | 2013-03-15 | 2014-03-14 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089382A Active JP6517401B2 (ja) | 2013-03-15 | 2018-05-07 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2018204234A Active JP6767456B2 (ja) | 2013-03-15 | 2018-10-30 | 化学療法の間の正常細胞の一時的な保護 |
| JP2019077828A Active JP6738933B6 (ja) | 2013-03-15 | 2019-04-16 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020123189A Active JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020155691A Active JP7213854B2 (ja) | 2013-03-15 | 2020-09-16 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023005413A Ceased JP2023052449A (ja) | 2013-03-15 | 2023-01-17 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023044746A Withdrawn JP2023078341A (ja) | 2013-03-15 | 2023-03-20 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Country Status (18)
| Country | Link |
|---|---|
| US (15) | US9527857B2 (enExample) |
| EP (4) | EP2968291B1 (enExample) |
| JP (9) | JP6337083B2 (enExample) |
| CN (4) | CN108283644B (enExample) |
| CA (2) | CA2906166C (enExample) |
| CY (1) | CY1122434T1 (enExample) |
| DK (1) | DK2968290T3 (enExample) |
| ES (2) | ES3032492T3 (enExample) |
| HR (1) | HRP20192168T1 (enExample) |
| HU (1) | HUE046653T2 (enExample) |
| LT (1) | LT2968290T (enExample) |
| ME (1) | ME03557B (enExample) |
| PL (1) | PL2968290T3 (enExample) |
| PT (1) | PT2968290T (enExample) |
| RS (1) | RS59790B1 (enExample) |
| SI (1) | SI2968290T1 (enExample) |
| SM (1) | SMT201900681T1 (enExample) |
| WO (2) | WO2014144847A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9259399B2 (en) | 2007-11-07 | 2016-02-16 | Cornell University | Targeting CDK4 and CDK6 in cancer therapy |
| US8691830B2 (en) * | 2010-10-25 | 2014-04-08 | G1 Therapeutics, Inc. | CDK inhibitors |
| AU2013239816B2 (en) | 2012-03-29 | 2017-08-24 | G1 Therapeutics, Inc. | Lactam kinase inhibitors |
| WO2013163239A1 (en) | 2012-04-26 | 2013-10-31 | Francis Xavier Tavares | Synthesis of lactams |
| JP6435315B2 (ja) | 2013-03-15 | 2018-12-05 | ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 高活性抗新生物薬及び抗増殖剤 |
| CA2906166C (en) | 2013-03-15 | 2023-03-14 | G1 Therapeutics, Inc. | Hspc-sparing treatments for rb-positive abnormal cellular proliferation |
| US20150297608A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic Lactams for Use as Anti-Neoplastic and Anti-Proliferative Agents |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| WO2016126889A1 (en) * | 2015-02-03 | 2016-08-11 | G1 Therapeutics, Inc. | Cdk4/6 inhibitor dosage formulations for the protection of hematopoietic stem and progenitor cells during chemotherapy |
| ES2832893T3 (es) | 2015-06-17 | 2021-06-11 | Pfizer | Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa |
| US10328066B2 (en) * | 2015-08-28 | 2019-06-25 | Novartis Ag | Pharmaceutical combination comprising the PI3K inhibitor alpelisib and the CDK4/6 inhibitor ribociclib, and the use thereof in the treatment/prevention of cancer |
| JP6635374B2 (ja) * | 2015-12-18 | 2020-01-22 | 京都府公立大学法人 | 癌におけるリン酸化ｒｂタンパク質を指標としたイリノテカン感受性予測法 |
| US11077110B2 (en) * | 2016-03-18 | 2021-08-03 | Tufts Medical Center | Compositions and methods for treating and preventing metabolic disorders |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| WO2018005863A1 (en) * | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| BR112018077136A2 (pt) * | 2016-07-01 | 2019-04-30 | G1 Therapeutics, Inc. | composto, e, métodos para tratar um distúrbio associado com proliferação celular anormal e para reduzir o efeito de quimioterapia em células saudáveis. |
| KR102445288B1 (ko) * | 2016-07-01 | 2022-09-19 | 쥐원 쎄라퓨틱스, 인크. | N-(헤테로아릴)-피롤로[3,2-d]피리미딘-2-아민의 합성 |
| WO2018005533A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Antiproliferative pyrimidine-based compounds |
| US20190175598A1 (en) | 2016-08-23 | 2019-06-13 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of hepatocellular carcinoma |
| EP3538148A1 (en) | 2016-11-08 | 2019-09-18 | Dana-Farber Cancer Institute | Compositions and methods of modulating anti-tumor immunity |
| AU2017372856B9 (en) | 2016-12-05 | 2024-01-04 | Pharmacosmos Holding A/S | Preservation of immune response during chemotherapy regimens |
| AR110728A1 (es) * | 2017-01-06 | 2019-04-24 | G1 Therapeutics Inc | Terapia combinada para el tratamiento del cáncer |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| CN110325191A (zh) | 2017-02-22 | 2019-10-11 | G1治疗公司 | 以较少的副作用治疗egfr-驱动的癌症 |
| BR112019019261A2 (pt) | 2017-03-16 | 2020-06-16 | Eisai R & D Management Co., Ltd. | Terapias de combinação para o tratamento de câncer de mama |
| WO2018172984A1 (en) | 2017-03-23 | 2018-09-27 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| CA3067873A1 (en) | 2017-06-29 | 2019-01-03 | G1 Therapeutics, Inc. | Morphic forms of g1t38 and methods of manufacture thereof |
| JP7233743B2 (ja) * | 2017-08-11 | 2023-03-07 | 晟科薬業（江蘇）有限公司 | プロテインキナーゼ阻害剤としての１ｈ－ピラゾロ［４，３－ｈ］キナゾリン系化合物 |
| SG11202005937QA (en) | 2018-01-08 | 2020-07-29 | G1 Therapeutics Inc | G1t38 superior dosage regimes |
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