PL2968290T3 - Przejściowa ochrona prawidłowych komórek podczas chemioterapii - Google Patents

Przejściowa ochrona prawidłowych komórek podczas chemioterapii

Info

Publication number
PL2968290T3
PL2968290T3 PL14762438T PL14762438T PL2968290T3 PL 2968290 T3 PL2968290 T3 PL 2968290T3 PL 14762438 T PL14762438 T PL 14762438T PL 14762438 T PL14762438 T PL 14762438T PL 2968290 T3 PL2968290 T3 PL 2968290T3
Authority
PL
Poland
Prior art keywords
normal cells
cells during
transient protection
during chemotherapy
chemotherapy
Prior art date
Application number
PL14762438T
Other languages
English (en)
Inventor
Jay Copeland Strum
John Emerson Bisi
Patrick Joseph Roberts
Francis Xavier Tavares
Original Assignee
G1 Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51527871&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2968290(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by G1 Therapeutics, Inc. filed Critical G1 Therapeutics, Inc.
Publication of PL2968290T3 publication Critical patent/PL2968290T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
PL14762438T 2013-03-15 2014-03-14 Przejściowa ochrona prawidłowych komórek podczas chemioterapii PL2968290T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361798772P 2013-03-15 2013-03-15
US201361861374P 2013-08-01 2013-08-01
US201361911354P 2013-12-03 2013-12-03
US201461949786P 2014-03-07 2014-03-07
EP14762438.1A EP2968290B1 (en) 2013-03-15 2014-03-14 Transient protection of normal cells during chemotherapy
PCT/US2014/028685 WO2014144326A1 (en) 2013-03-15 2014-03-14 Transient protection of normal cells during chemotherapy

Publications (1)

Publication Number Publication Date
PL2968290T3 true PL2968290T3 (pl) 2020-04-30

Family

ID=51527871

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14762438T PL2968290T3 (pl) 2013-03-15 2014-03-14 Przejściowa ochrona prawidłowych komórek podczas chemioterapii

Country Status (18)

Country Link
US (15) US9527857B2 (pl)
EP (4) EP3653209A1 (pl)
JP (9) JP6430483B2 (pl)
CN (4) CN108283644B (pl)
CA (2) CA2906166C (pl)
CY (1) CY1122434T1 (pl)
DK (1) DK2968290T3 (pl)
ES (2) ES3032492T3 (pl)
HR (1) HRP20192168T1 (pl)
HU (1) HUE046653T2 (pl)
LT (1) LT2968290T (pl)
ME (1) ME03557B (pl)
PL (1) PL2968290T3 (pl)
PT (1) PT2968290T (pl)
RS (1) RS59790B1 (pl)
SI (1) SI2968290T1 (pl)
SM (1) SMT201900681T1 (pl)
WO (2) WO2014144326A1 (pl)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009061345A2 (en) 2007-11-07 2009-05-14 Cornell Research Foundation, Inc. Targeting cdk4 and cdk6 in cancer therapy
US8691830B2 (en) * 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
AU2013239816B2 (en) 2012-03-29 2017-08-24 G1 Therapeutics, Inc. Lactam kinase inhibitors
EP2841417A1 (en) 2012-04-26 2015-03-04 Francis Xavier Tavares Synthesis of lactams
HK1222766A1 (zh) 2013-03-15 2017-07-14 G1治疗公司 高效的抗赘生剂和抗增生剂
RS59790B1 (sr) 2013-03-15 2020-02-28 G1 Therapeutics Inc Privremena zaštita normalnih ćelija tokom hemoterapije
US20150297606A1 (en) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic Lactams for Use in the Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
WO2016040858A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
WO2016126889A1 (en) * 2015-02-03 2016-08-11 G1 Therapeutics, Inc. Cdk4/6 inhibitor dosage formulations for the protection of hematopoietic stem and progenitor cells during chemotherapy
TN2017000485A1 (en) 2015-06-17 2019-04-12 Pfizer Tricyclic compounds and their use as phosphodiesterase inhibitors
CN108348514A (zh) * 2015-08-28 2018-07-31 诺华股份有限公司 含pi3k抑制剂alpelisib和cdk4/6抑制剂ribociclib的药物组合以及其在治疗/预防癌症中的应用
JP6635374B2 (ja) * 2015-12-18 2020-01-22 京都府公立大学法人 癌におけるリン酸化rbタンパク質を指標としたイリノテカン感受性予測法
US11077110B2 (en) * 2016-03-18 2021-08-03 Tufts Medical Center Compositions and methods for treating and preventing metabolic disorders
HUE057838T2 (hu) 2016-06-07 2022-06-28 Jacobio Pharmaceuticals Co Ltd SHP2 inhibitorokként hasznos új heterociklusos származékok
WO2018005865A1 (en) * 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
WO2018005863A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based compounds for the treatment of cancer
WO2018005533A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Antiproliferative pyrimidine-based compounds
WO2018005860A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
US20190175598A1 (en) 2016-08-23 2019-06-13 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of hepatocellular carcinoma
EP3538148A1 (en) 2016-11-08 2019-09-18 Dana-Farber Cancer Institute Compositions and methods of modulating anti-tumor immunity
IL317919A (en) 2016-12-05 2025-02-01 G1 Therapeutics Inc Preservation of immune response during chemotherapy regimens
CA3048057A1 (en) * 2017-01-06 2018-07-12 G1 Therapeutics, Inc. Combination therapy for the treatment of cancer
US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
EP3585389A4 (en) 2017-02-22 2020-12-23 G1 Therapeutics, Inc. EGFR-CAUSED CANCER TREATMENT WITH LESS SIDE EFFECTS
US11083722B2 (en) 2017-03-16 2021-08-10 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of breast cancer
TWI664175B (zh) 2017-03-23 2019-07-01 大陸商北京加科思新藥研發有限公司 用於作為shp2抑制劑之新穎雜環衍生物
MX392531B (es) 2017-06-29 2025-03-24 G1 Therapeutics Inc Formas morficas de g1t38 y metodos de preparacion de las mismas.
US11319323B2 (en) 2017-08-11 2022-05-03 Shengke Pharmaceuticals (Jiangsu) Ltd. Substituted pyrazolo[4,3-H]quinazolines as protein kinase inhibitors
KR20200108867A (ko) 2018-01-08 2020-09-21 쥐원 쎄라퓨틱스, 인크. G1t38 우수한 투여 요법
AU2019220746A1 (en) 2018-02-15 2020-08-27 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
CN112218634A (zh) * 2018-04-09 2021-01-12 G1治疗公司 具有驱动致癌突变的癌症的治疗
EP3830082B1 (en) * 2018-07-27 2025-02-26 California Institute of Technology Cdk inhibitors and uses thereof
WO2020041770A1 (en) 2018-08-24 2020-02-27 G1 Therapeutics, Inc. Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one
CN112839935A (zh) 2018-09-26 2021-05-25 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
JP2022506829A (ja) * 2018-11-09 2022-01-17 ジー1、セラピューティクス、インコーポレイテッド エリブリンと選択的cdk4/6阻害剤との組合せを使用する癌の処置のための治療レジメン
WO2020206035A1 (en) * 2019-04-01 2020-10-08 G1 Therapeutics, Inc. Treatment of cdk4/6 inhibitor resistant neoplastic disorders
EP3986410A4 (en) * 2019-06-18 2023-06-28 G1 Therapeutics, Inc. Patient selection for enhancement of anti-tumor immunity in cancer patients
TW202128173A (zh) * 2019-10-09 2021-08-01 美商G1治療公司 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療
MX2022014573A (es) 2020-05-19 2022-12-15 G1 Therapeutics Inc Compuestos inhibidores de cinasa dependiente de ciclina para el tratamiento de trastornos medicos.
BR112022024484A2 (pt) * 2020-06-11 2022-12-27 Lunella Biotech Inc Terapias contra o câncer com o inibidor seletivo de cdk4/6
CN120398896A (zh) * 2020-06-15 2025-08-01 海南先声再明医药股份有限公司 曲拉西利的形态及其制造方法
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
CN113788837B (zh) * 2021-08-02 2022-08-26 深圳湾实验室坪山生物医药研发转化中心 Trilaciclib的合成方法
WO2024073507A1 (en) 2022-09-28 2024-04-04 Theseus Pharmaceuticals, Inc. Macrocyclic compounds and uses thereof
WO2024116069A1 (en) * 2022-11-28 2024-06-06 Assia Chemical Industries Ltd. Novel trilaciclib intermediates, method of preparation and use thereof

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591855A (en) 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5628984A (en) 1995-07-31 1997-05-13 University Of North Carolina At Chapel Hill Method of detecting lung disease
ES2301194T3 (es) 1997-02-05 2008-06-16 Warner-Lambert Company Llc Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular.
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US20040006074A1 (en) 1998-04-28 2004-01-08 The Government Of The United States Of America Cyclin dependent kinase (CDK)4 inhibitors and their use for treating cancer
EP1086105B1 (en) 1998-06-16 2006-03-01 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Fused azepinone cyclin dependent kinase inhibitors
NZ513487A (en) 1999-01-29 2003-02-28 Univ Illinois The use of a P53 inhibitor for the treatment of cancer, hyperthermia, hypoxia, a burn, trauma to the central nervous system, a seizure, acute inflammation, tissue ageing, preservation of organs for transplant and preparation of a host for bone marrow transplant
DE60024631T2 (de) 1999-07-26 2006-06-14 Banyu Pharma Co Ltd Biaryl-harnstoff-derivate
US6387900B1 (en) 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
EP1242420A2 (en) 1999-12-16 2002-09-25 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US7053070B2 (en) 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
EA006153B1 (ru) 2000-06-26 2005-10-27 Пфайзер Продактс Инк. СОЕДИНЕНИЯ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ ИММУНОДЕПРЕССАНТОВ
ES2220811T3 (es) 2000-09-29 2004-12-16 Eli Lilly And Company Procedimiento y compuestos para el tratamiento de enfermedades proliferativas.
AU2002228692A1 (en) 2000-12-01 2002-06-11 Bristol-Myers Squibb Pharma Company 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors
DE60228692D1 (de) 2001-02-28 2008-10-16 Univ Temple Verwendung von alpha, beta ungesättigten arylsulfonen zum schutz von zellen und geweben vor toxizität ionischer strahlung
CN101172158A (zh) 2001-05-11 2008-05-07 得克萨斯州立大学董事会 抗cd26单克隆抗体作为对与表达cd26的细胞相关疾病的治疗
PL218692B1 (pl) 2002-01-22 2015-01-30 Warner Lambert Co Podstawiony 2-(pirydyn-2-yloamino)pirydo[2,3-d]pirymidyn-7-on oraz jego zastosowanie do leczenia zaburzenia lub stanu spowodowanego nieprawidłową proliferacją komórek
AU2003221584A1 (en) 2002-05-01 2003-11-17 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
JP2006516561A (ja) 2003-01-17 2006-07-06 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 細胞増殖の阻害剤としての2−アミノピリジン置換ヘテロ環類
KR101084871B1 (ko) 2003-05-22 2011-11-21 네르비아노 메디칼 사이언시스 에스.알.엘. 피라졸로-퀴나졸린 유도체, 그의 제조 방법 및 상기유도체의 키나제 저해제로서의 용도
AU2004255934B2 (en) 2003-07-11 2010-02-25 Warner-Lambert Company Llc Isethionate salt of a selective CDK4 inhibitor
DE602004010419T2 (de) 2003-10-23 2008-10-09 F. Hoffmann-La Roche Ag Triazaspiropiperidinderivate zur verwendung als glyt-1-inhibitoren bei der behandlung von neurologischen und neuropsychiatrischen erkrankungen
GB0327380D0 (en) 2003-11-25 2003-12-31 Cyclacel Ltd Method
CA2561516A1 (en) 2004-03-30 2005-10-13 Pfizer Products Inc. Combinations of signal transduction inhibitors
WO2005100999A2 (en) 2004-04-08 2005-10-27 Cornell Research Foundation, Inc. Functional immunohistochemical cell cycle analysis as a prognostic indicator for cancer
ITMI20040874A1 (it) 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici ed azaindolici con azione antitumorale
WO2005117908A2 (en) 2004-05-28 2005-12-15 Gemin X Biotechnologies, Inc. Triheterocyclic compounds compositions, and methods for treating cancer or viral diseases
ES2411975T3 (es) 2005-01-14 2013-07-09 Janssen Pharmaceutica Nv Pirimidinas heterocíclicas anilladas de 5 miembros como inhibidores de cinasas
MX2007008809A (es) 2005-01-21 2007-09-07 Astex Therapeutics Ltd Combinaciones de inhibidores de pirazol cinasa y otros agentes antitumor.
US8921376B2 (en) 2005-05-20 2014-12-30 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
WO2007025090A2 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
DE602006010433D1 (de) 2005-12-09 2009-12-24 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
BRPI0620151A2 (pt) 2005-12-22 2010-06-29 Wyeth Corp composto; composição farmacêutica; método de tratar ou inibir o crescimento de células tumorais cancerosas em um mamìfero que deste necessita; método; e processo
RU2447891C2 (ru) 2006-04-05 2012-04-20 Новартис Аг Комбинации терапевтических средств, предназначенные для лечения рака
US20070270362A1 (en) 2006-05-18 2007-11-22 The University Of Washington Methods and compositions for prevention or treatment of inflammatory-related diseases and disorders
US8222256B2 (en) 2006-07-05 2012-07-17 Exelixis, Inc. Methods of using IGFIR and ABL kinase modulators
WO2008033748A2 (en) 2006-09-11 2008-03-20 Curis, Inc. Quinazoline based egfr inhibitors containing a zinc binding moiety
AU2007333791A1 (en) 2006-12-14 2008-06-26 Panacea Pharmaceuticals, Inc. Methods of neuroprotection by cyclin-dependent kinase inhibition
JP2010514689A (ja) 2006-12-22 2010-05-06 ノバルティス アーゲー 癌、炎症およびウイルス感染症の処置のためのcdk阻害剤としてのヘテロアリール−ヘテロアリール化合物
KR20100040872A (ko) 2007-06-25 2010-04-21 뉴로젠 코포레이션 피페라지닐 옥소알킬 테트라하이드로-베타-카르볼린 및 이의 관련 유사체
WO2009061345A2 (en) 2007-11-07 2009-05-14 Cornell Research Foundation, Inc. Targeting cdk4 and cdk6 in cancer therapy
MX2010006457A (es) 2007-12-19 2010-07-05 Amgen Inc Compuestos fusionados de piridina, pirimidina y triazina como inhibidores de ciclo celular.
ES2964764T3 (es) 2008-07-29 2024-04-09 Nerviano Medical Sciences Srl Combinación terapéutica que comprende un inhibidor de cdk y oxaliplatino
BRPI0917791B1 (pt) 2008-08-22 2022-03-22 Novartis Ag Compostos de pirrolopirimidina como inibidores de cdk, bem como composição farmacêutica e combinação
EP2341911A4 (en) 2008-10-01 2012-10-24 Univ North Carolina HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE INHIBITORS OF KINASES DEPENDENT ON CYCLINES 4/6
WO2010051127A2 (en) 2008-10-01 2010-05-06 The University Of North Carolina At Chapel Hill Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors
JO2885B1 (en) 2008-12-22 2015-03-15 ايلي ليلي اند كومباني Protein kinase inhibitors
AU2010248886A1 (en) 2009-05-13 2011-12-01 The University Of North Carolina At Chapel Hill Cyclin dependent kinase inhibitors and methods of use
US9040519B2 (en) 2010-02-18 2015-05-26 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
UY33226A (es) 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina deuterada como inhibidores de la cdk4/6
UY33227A (es) 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
FR2957748B1 (fr) * 2010-03-16 2012-09-07 St Microelectronics Grenoble 2 Composant electronique a montage en surface
CN102299073A (zh) 2010-06-25 2011-12-28 无锡华润上华半导体有限公司 Vdmos器件及其制作方法
US8691830B2 (en) * 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
ES2592515T3 (es) 2010-10-25 2016-11-30 G1 Therapeutics, Inc. Inhibidores de CDK
ES2543913T3 (es) 2010-11-02 2015-08-25 Promega Corporation Derivados de coelenterazina y métodos de uso de los mismos
WO2012068381A2 (en) 2010-11-17 2012-05-24 The University Of North Carolina At Chapel Hill Protection of renal tissues from schema through inhibition of the proliferative kisses cdk4 and cdk6
PL2655375T3 (pl) 2010-12-23 2015-05-29 Sanofi Sa Pochodne pirymidynonu, ich wytwarzanie i ich farmaceutyczne zastosowanie
CN103703000B (zh) 2011-03-23 2015-11-25 安姆根有限公司 Cdk4/6和flt3的稠合三环双重抑制剂
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
CN103635189B (zh) 2011-07-01 2016-05-04 诺华股份有限公司 用于治疗癌症的含有cdk4/6抑制剂和pi3k抑制剂的联合治疗
ME02887B (me) 2011-07-27 2018-04-20 Astrazeneca Ab 2-(2,4,5-supstituisani-anilino) pirimidinski derivati kao egfr modulatori korisni za tretman raka
AU2013239816B2 (en) 2012-03-29 2017-08-24 G1 Therapeutics, Inc. Lactam kinase inhibitors
EP2841417A1 (en) 2012-04-26 2015-03-04 Francis Xavier Tavares Synthesis of lactams
CA3163776A1 (en) 2012-08-03 2014-02-06 Foundation Medicine, Inc. Human papilloma virus as predictor of cancer prognosis
US9241941B2 (en) 2012-09-20 2016-01-26 Memorial Sloan-Kettering Cancer Center Methods for treatment of lymphomas with mutations in cell cycle genes
HK1211475A1 (en) 2012-11-28 2016-05-27 Novartis Ag Combination therapy
HK1222766A1 (zh) 2013-03-15 2017-07-14 G1治疗公司 高效的抗赘生剂和抗增生剂
US20140274896A1 (en) * 2013-03-15 2014-09-18 G1 Therapeutics, Inc. Transient Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
RS59790B1 (sr) * 2013-03-15 2020-02-28 G1 Therapeutics Inc Privremena zaštita normalnih ćelija tokom hemoterapije
US20160287592A1 (en) 2013-04-08 2016-10-06 Pharmacyclics Llc Ibrutinib combination therapy
RU2019134551A (ru) 2013-05-30 2019-11-22 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
WO2015061407A1 (en) 2013-10-24 2015-04-30 Francis Xavier Tavares Process for synthesis of lactams
US10314842B2 (en) 2013-12-02 2019-06-11 Cornell University Methods for treating B cell proliferative disorders
PL3091008T3 (pl) 2013-12-31 2018-12-31 Xuanzhu Pharma Co., Ltd. Inhibitor kinazy i jego zastosowanie
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
US20150297606A1 (en) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic Lactams for Use in the Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
WO2016040858A1 (en) * 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
US9374037B2 (en) 2014-10-30 2016-06-21 M/A-Com Technology Solutions Holdings, Inc. Voltage-controlled oscillator with mask-selectable performance
WO2016126889A1 (en) 2015-02-03 2016-08-11 G1 Therapeutics, Inc. Cdk4/6 inhibitor dosage formulations for the protection of hematopoietic stem and progenitor cells during chemotherapy
WO2018005863A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based compounds for the treatment of cancer
WO2018005865A1 (en) * 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
IL317919A (en) * 2016-12-05 2025-02-01 G1 Therapeutics Inc Preservation of immune response during chemotherapy regimens
AU2017370694A1 (en) * 2016-12-08 2019-07-25 Icahn School Of Medicine At Mount Sinai Compositions and methods for treating CDK4/6-mediated cancer
CA3048057A1 (en) * 2017-01-06 2018-07-12 G1 Therapeutics, Inc. Combination therapy for the treatment of cancer
US11395821B2 (en) * 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
CA3052810A1 (en) * 2017-02-10 2018-08-16 G1 Therapeutics, Inc. Benzothiophene estrogen receptor modulators
EP3585389A4 (en) * 2017-02-22 2020-12-23 G1 Therapeutics, Inc. EGFR-CAUSED CANCER TREATMENT WITH LESS SIDE EFFECTS
MX392531B (es) * 2017-06-29 2025-03-24 G1 Therapeutics Inc Formas morficas de g1t38 y metodos de preparacion de las mismas.
EP3735247A1 (en) 2018-01-04 2020-11-11 G1 Therapeutics, Inc. Heterocyclic compounds for the treatment of abnormal cellular proliferation
KR20200108867A (ko) * 2018-01-08 2020-09-21 쥐원 쎄라퓨틱스, 인크. G1t38 우수한 투여 요법
CN112218634A (zh) * 2018-04-09 2021-01-12 G1治疗公司 具有驱动致癌突变的癌症的治疗
WO2020023502A1 (en) * 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP3986410A4 (en) * 2019-06-18 2023-06-28 G1 Therapeutics, Inc. Patient selection for enhancement of anti-tumor immunity in cancer patients
TW202128173A (zh) * 2019-10-09 2021-08-01 美商G1治療公司 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療

Also Published As

Publication number Publication date
ES2761406T3 (es) 2020-05-19
US9931345B2 (en) 2018-04-03
CN108434149A (zh) 2018-08-24
HK1222792A1 (zh) 2017-07-14
WO2014144326A1 (en) 2014-09-18
EP2968291B1 (en) 2025-04-16
CN108283644A (zh) 2018-07-17
JP2023078341A (ja) 2023-06-06
US20140271466A1 (en) 2014-09-18
PT2968290T (pt) 2019-11-27
US9487530B2 (en) 2016-11-08
HRP20192168T1 (hr) 2020-02-21
US11717523B2 (en) 2023-08-08
EP2968291A2 (en) 2016-01-20
JP2016513737A (ja) 2016-05-16
US20180360841A1 (en) 2018-12-20
CN105473140A (zh) 2016-04-06
JP2020183422A (ja) 2020-11-12
US20170037051A1 (en) 2017-02-09
US10434104B2 (en) 2019-10-08
JP7213854B2 (ja) 2023-01-27
EP2968290A4 (en) 2016-09-28
JP2019055954A (ja) 2019-04-11
US20210299130A1 (en) 2021-09-30
JP2019131609A (ja) 2019-08-08
US10966984B2 (en) 2021-04-06
US20140275067A1 (en) 2014-09-18
JP7250737B2 (ja) 2023-04-03
US20210213022A1 (en) 2021-07-15
SI2968290T1 (sl) 2020-02-28
CN108434149B (zh) 2021-05-28
JP2021001197A (ja) 2021-01-07
US20140275066A1 (en) 2014-09-18
US9527857B2 (en) 2016-12-27
US20230364098A1 (en) 2023-11-16
JP2016514689A (ja) 2016-05-23
JP6767456B2 (ja) 2020-10-14
JP6738933B2 (ja) 2020-08-12
ME03557B (me) 2020-07-20
CA2906156C (en) 2023-03-14
SMT201900681T1 (it) 2020-01-14
CN105407889B (zh) 2018-06-01
EP4596051A2 (en) 2025-08-06
US10076523B2 (en) 2018-09-18
JP6738933B6 (ja) 2020-09-09
US20180221378A1 (en) 2018-08-09
HK1258477A1 (zh) 2019-11-15
CA2906156A1 (en) 2014-09-18
JP2018150333A (ja) 2018-09-27
CN105407889A (zh) 2016-03-16
US20180360840A1 (en) 2018-12-20
CY1122434T1 (el) 2021-01-27
WO2014144847A3 (en) 2015-07-02
US20230381189A1 (en) 2023-11-30
US20200345742A1 (en) 2020-11-05
US20170100405A1 (en) 2017-04-13
US9464092B2 (en) 2016-10-11
US10085992B2 (en) 2018-10-02
WO2014144847A2 (en) 2014-09-18
JP6517401B2 (ja) 2019-05-22
EP2968290A1 (en) 2016-01-20
CN105473140B (zh) 2018-04-10
JP6430483B2 (ja) 2018-11-28
JP2023052449A (ja) 2023-04-11
US11654148B2 (en) 2023-05-23
US11040042B2 (en) 2021-06-22
HK1223293A1 (zh) 2017-07-28
ES3032492T3 (en) 2025-07-21
EP2968290B1 (en) 2019-09-25
US10925878B2 (en) 2021-02-23
CA2906166C (en) 2023-03-14
EP2968291C0 (en) 2025-04-16
RS59790B1 (sr) 2020-02-28
US10660896B2 (en) 2020-05-26
CN108283644B (zh) 2022-03-18
US20170065597A1 (en) 2017-03-09
LT2968290T (lt) 2019-12-10
EP2968291A4 (en) 2016-09-28
HUE046653T2 (hu) 2020-03-30
JP6337083B2 (ja) 2018-06-06
US20190070185A1 (en) 2019-03-07
CA2906166A1 (en) 2014-09-18
EP3653209A1 (en) 2020-05-20
EP4596051A3 (en) 2025-10-29
DK2968290T3 (da) 2019-11-25

Similar Documents

Publication Publication Date Title
PL2968290T3 (pl) Przejściowa ochrona prawidłowych komórek podczas chemioterapii
IL267864B (en) Overvoltage protection for electrical systems
GB2513727B (en) Memory protection
IL245572A0 (en) cell
GB2515541B (en) Floating turbine
GB201415457D0 (en) Short-circuit protection
EP3004493A4 (en) ENVIRONMENTAL PROTECTION FOR SUSPENDED POSTS
GB2514450B (en) Lightning protection system
PL2759993T3 (pl) Ochrona płytki dotykowej
PL3057669T3 (pl) Ochrona tryskacza
GB201318498D0 (en) Hydro Turbine
GB2518228B (en) Structure Protector
PL3266944T3 (pl) Układ ochrony przed wyciekiem
GB201307416D0 (en) Operation of fuel cell system
GB2518227B (en) Structure protector
GB2518229B (en) Structure Protector
TWM476425U (en) Protection structure with microphone
GB201318231D0 (en) Improvements relating to protection devices
GB201320928D0 (en) Lightning protection for vehicles
GB201302056D0 (en) Flood Protection System
TH1601002376B (th) โครงสร้างการคุ้มกันแบตเตอรี่
GB201317589D0 (en) Cell
GB201303132D0 (en) Cell Line