HRP20192168T1 - Privremena zaštita normalnih stanica tijekom kemoterapije - Google Patents
Privremena zaštita normalnih stanica tijekom kemoterapije Download PDFInfo
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- HRP20192168T1 HRP20192168T1 HRP20192168TT HRP20192168T HRP20192168T1 HR P20192168 T1 HRP20192168 T1 HR P20192168T1 HR P20192168T T HRP20192168T T HR P20192168TT HR P20192168 T HRP20192168 T HR P20192168T HR P20192168 T1 HRP20192168 T1 HR P20192168T1
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- 238000002512 chemotherapy Methods 0.000 title claims 3
- 230000001052 transient effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 36
- 150000003839 salts Chemical class 0.000 claims 27
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 14
- 229960004316 cisplatin Drugs 0.000 claims 14
- 229960004768 irinotecan Drugs 0.000 claims 14
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 14
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 11
- 229960004562 carboplatin Drugs 0.000 claims 11
- 239000002246 antineoplastic agent Substances 0.000 claims 10
- 229940127089 cytotoxic agent Drugs 0.000 claims 10
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 8
- 229960005420 etoposide Drugs 0.000 claims 8
- 206010041067 Small cell lung cancer Diseases 0.000 claims 6
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 6
- 229960000303 topotecan Drugs 0.000 claims 6
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
- 241000701806 Human papillomavirus Species 0.000 claims 3
- 201000000582 Retinoblastoma Diseases 0.000 claims 3
- 230000002159 abnormal effect Effects 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 3
- 230000001767 chemoprotection Effects 0.000 claims 3
- 238000011275 oncology therapy Methods 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 101000715943 Caenorhabditis elegans Cyclin-dependent kinase 4 homolog Proteins 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 229940083697 etoposide 50 mg Drugs 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- 230000003442 weekly effect Effects 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 claims 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 1
- 102000013698 Cyclin-Dependent Kinase 6 Human genes 0.000 claims 1
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 239000012625 DNA intercalator Substances 0.000 claims 1
- 229940122029 DNA synthesis inhibitor Drugs 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 229940123573 Protein synthesis inhibitor Drugs 0.000 claims 1
- 229940123752 RNA synthesis inhibitor Drugs 0.000 claims 1
- 229940123582 Telomerase inhibitor Drugs 0.000 claims 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000022131 cell cycle Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 229940065639 etoposide 100 mg Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000007 protein synthesis inhibitor Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 239000003277 telomerase inhibitor Substances 0.000 claims 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1
- 239000000225 tumor suppressor protein Substances 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Claims (23)
1. Spoj formule:
ili njegova farmaceutski prihvatljiva sol, za upotrebu u postupku smanjenja efekta kemoterapije na zdravim stanicama kod subjekta koji se liječi od ciklin ovisne kinaze 4/6 (CDK4/6) replike samostalnoga karcinoma ili abnormalne proliferacije stanica, gdje su spomenute zdrave stanice matične hematopoetske stanice, hematopoetske progenitorne stanice, ili epitelne stanice bubrega, postupak obuhvaća davanje subjektu efektivne količine spoja.
2. Spoj za upotrebu prema zahtjevu 1, gdje se spoj daje subjektu prije tretmana s kemoterapeutskim agensom, u tijeku tretmana s kemoterapeutskim agensom, nakon izlaganja kemoterapeutskom agensu, ili njihovoj kombinaciji.
3. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 2, gdje je subjekt čovjek.
4. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 3, gdje je spoj ili sol dana subjektu 24 sata ili manje prije izlaganja bar jednom kemoterapeutskom agensu.
5. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 4, gdje subjekt ima karcinom.
6. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 4, gdje subjekt ima abnormalnu proliferaciju stanica.
7. Spoj ili sol, za upotrebu prema bilo kojem od zahtjeva 1 do 6, gdje se spoj ili sol daju subjektu oko 4 sata ili manje prije izlaganja bar jednom kemoterapeutskom agensu.
8. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 7, gdje je karcinom ili abnormalna proliferacija stanica naznačena s gubitkom ili odsutnosti supresorskog proteina tumora retinoblastoma (RB).
9. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 7, gdje je karcinom karcinom pluća malih stanica, retinoblastom, trostruko negativni karcinom dojke, humani papiloma virus (HPV) pozitivni karcinom glave ili vrata, HPV pozitivni karcinom vrata maternice, ili Rb-negativni karcinom mokraćnog mjehura.
10. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 9, gdje je kemoterapija izabrana između alkilirajućeg agensa, DNK interkalatora, inhibitora proteinske sinteze, inhibitora sinteze DNK ili RNK, baznog analoga DNK, inhibitora topoizomeraze, inhibitora telomeraze, ili spoja koji se veže za telomernu DNK.
11. Spoj ili sol za upotrebu prema zahtjevu 5, gdje je karcinom karcinom pluća malih stanica i bar jednan kemoterapeutski agens izabran iz grupe koja obuhvaća etopozid, cisplatin ili karboplatin, ili njihovu kombinaciju.
12. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 11, gdje se bar 80% ili više matičnih hematopoetskih stanica, hematopoetskih progenitorskih stanica, ili epitelnih stanica bubrega u subjektu vrati ili pristupi osnovnoj aktivnosti staničnog ciklusa prije tretmana za manje od oko 36 sati od posljednjeg davanja spoja ljudima.
13. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 11, gdje se razgradnja spoja ili soli CDK4/6 inhibitornog efekta događa u manje od 36 sati od davanja spoja.
14. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 13, gdje je bar jedan kemoterapeutski agens etopozid.
15. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 13, gdje je bar jedan kemoterapeutski agens cisplatin.
16. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 13, gdje je bar jedan kemoterapeutski agens karboplatin.
17. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 3, 5 ili 9 gdje se spoj unosi da se osigura kemozaštita u protokolu terapije karcinoma malih stanica pluća kao što je, bez ograničenja na: cisplatin 60 mg/m2 IV na dan 1 plus etopozid 120 mg/m2 IV na dane 1-3 svakih 21d tijekom 4 ciklusa; cisplatin 80 mg/m2 IV na dan 1 plus etopozid 100 mg/m2 IV na dane 1-3 svakih 28d tijekom 4 ciklusa; cisplatin 60-80 mg/m2 IV na dan 1 plus etopozid 80-120 mg/m2 IV na dane 1-3 svakih 21-28d (maksimum 4 ciklusa); karboplatin AUC 5-6 IV na dan 1 plus etopozid 80-100 mg/m2 IV na dane 1-3 svakih 28d (maksimum 6 ciklusa); cisplatin 60-80 mg/m2 IV na dan 1 plus etopozid 80-120 mg/m2 IV na dane 1-3 svakih 21-28d; karboplatin AUC 5-6 IV na dan 1 plus etopozid 80-100 mg/m2 IV na dane 1-3 svakih 28d (maksimum 6 ciklusa); cisplatin 60 mg/m2 IV na dan 1 plus irinotekan 60 mg/m2 IV na dan 1, 8, i 15 svakih 28d (maksimum 6 ciklusa); cisplatin 30 mg/m2 IV na dane 1 i 8 ili 80 mg/m2 IV na dan 1 plus irinotekan 65 mg/m2 IV na dane 1 i 8 svakih 21d (maksimum 6 ciklusa); karboplatin AUC 5 IV na dan 1 plus irinotekan 50 mg/m2 IV na dane 1, 8, i 15 svakih 28d (maksimum 6 ciklusa); karboplatin AUC 4-5 IV na dan 1 plus irinotekan 150-200 mg/m2 IV na dan 1 svakih 21d (maksimum 6 ciklusa); ciklofosfamid 800-1000 mg/m2 IV na dan 1 plus doxorubicin 40-50 mg/m2 IV na dan 1 plus vinkristin 1-1.4 mg/m2 IV na dan 1 svakih 21-28d (maksimum 6 ciklusa); Etopozid 50 mg/m2 PO dnevno 3tj svaka 4tj; topotekan 2.3 mg/m2 PO na dane 1-5 svakih 21d; topotekan 1.5 mg/m2 IV na dane 1-5 svakih 21d; karboplatin AUC 5 IV na dan 1 plus irinotekan 50 mg/m2 IV na dane 1, 8, i 15 svakih 28d; karboplatin AUC 4 - 5 IV na dan 1 plus irinotekan 150-200 mg/m2 IV na dan 1 svakih 21d; cisplatin 30 mg/m2 IV na dane 1, 8, i 15 plus irinotekan 60 mg/m2 IV na dane 1, 8, i 15 svakih 28d; cisplatin 60 mg/m2 IV na dan 1 plus irinotekan 60 mg/m2 IV na dane 1, 8, i 15 svakih 28d; cisplatin 30 mg/m2 IV na dane 1 i 8 ili 80 mg/m2 IV na dan 1 plus irinotekan 65 mg/m2 IV na dane 1 i 8 svakih 21d; paklitaksel 80 mg/m2 IV tjedno tijekom 6tj svakih 8tj; paklitaksel 175 mg/m2 IV na dan 1 svakih 3tj; etopozid 50 mg/m2 PO dnevno 3tj svaka 4tj; topotekan 2.3 mg/m2 PO na dane 1-5 svakih 21d; topotekan 1.5 mg/m2 IV na dane 1-5 svakih 21d; karboplatin AUC 5 IV na dan 1 plus irinotekan 50 mg/m2 IV na dane 1, 8, i 15 svakih 28d; karboplatin AUC 4-5 IV na dan 1 plus irinotekan 150-200 mg/m2 IV na dan 1 svakih 21d; cisplatin 30 mg/m2 IV na dane 1, 8, i 15 plus irinotekan 60 mg/m2 IV na dane 1, 8, i 15 svakih 28d; cisplatin 60 mg/m2 IV na dan 1 plus irinotekan 60 mg/m2 IV na dane 1, 8, i 15 svakih 28d; cisplatin 30 mg/m2 IV u dane 1 i 8 ili 80 mg/m2 IV na dan 1 plus irinotekan 65 mg/m2 IV na dane 1 i 8 svakih 21d; paklitaksel 80 mg/m2 IV tjedno 6tj svakih 8tj; i paklitaksel 175 mg/m2 IV na dan 1 svakih 3tj..
18. Spoj ili sol za upotrebu prema zahtjevu 17, gdje se spoj unosi da se osigura kemozaštita u protokolu terapije karcinoma malih stanica pluća s topotekanom od 1.5 mg/m2 IV na dane 1-5 svakih 21d.
19. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 17 gdje se spoj unosi da se osigura kemozaštita u protokolu terapije karcinoma malih stanica pluća topotekanom od 2.3 mg/m2 PO na dane 1-5 svakog 21d.
20. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 16, gdje se spoj ili sol unosi intravenozno.
21. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 16, gdje se spoj ili sol unosi oralno u farmaceutskom sastavu.
22. Spoj ili sol za upotrebu prema bilo kojem od zahtjeva 1 do 13, gdje se subjekt liječi od karcinoma malih stanica pluća, i bar je jedan kemoterapeutski agens izabran iz grupe koja obuhvaća etopozid i karboplatin, ili njihovu kombinaciju.
23. Spoj ili sol za upotrebu prema zahtjevu 9, gdje se subjekt liječi od trostruko negativnog karcinoma dojke.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361798772P | 2013-03-15 | 2013-03-15 | |
US201361861374P | 2013-08-01 | 2013-08-01 | |
US201361911354P | 2013-12-03 | 2013-12-03 | |
US201461949786P | 2014-03-07 | 2014-03-07 | |
PCT/US2014/028685 WO2014144326A1 (en) | 2013-03-15 | 2014-03-14 | Transient protection of normal cells during chemotherapy |
EP14762438.1A EP2968290B1 (en) | 2013-03-15 | 2014-03-14 | Transient protection of normal cells during chemotherapy |
Publications (1)
Publication Number | Publication Date |
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HRP20192168T1 true HRP20192168T1 (hr) | 2020-02-21 |
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Application Number | Title | Priority Date | Filing Date |
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HRP20192168TT HRP20192168T1 (hr) | 2013-03-15 | 2019-11-29 | Privremena zaštita normalnih stanica tijekom kemoterapije |
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