AR110728A1 - Terapia combinada para el tratamiento del cáncer - Google Patents

Terapia combinada para el tratamiento del cáncer

Info

Publication number
AR110728A1
AR110728A1 ARP180100028A ARP180100028A AR110728A1 AR 110728 A1 AR110728 A1 AR 110728A1 AR P180100028 A ARP180100028 A AR P180100028A AR P180100028 A ARP180100028 A AR P180100028A AR 110728 A1 AR110728 A1 AR 110728A1
Authority
AR
Argentina
Prior art keywords
cancer
formula
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
ARP180100028A
Other languages
English (en)
Inventor
Debra A Tonetti
Jiong Zhao
Rui Xiong
Gregory R Thatcher
Jay C Strum
Original Assignee
G1 Therapeutics Inc
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G1 Therapeutics Inc, Univ Illinois filed Critical G1 Therapeutics Inc
Publication of AR110728A1 publication Critical patent/AR110728A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composiciones, combinaciones y métodos que comprenden la administración de un inhibidor de CDK4/6 de la fórmula D con un regulador negativo de la expresión selectivo del receptor de estrógeno de la fórmula A, B o C, que ofrecen ventajas en el tratamiento de una proliferación celular anormal, incluido un cáncer o un tumor. Reivindicación 1: Una combinación farmacéutica para tratar un cáncer o un tumor en un sujeto caracterizada porque incluye una cantidad terapéuticamente eficaz en una o más formas de dosificación separadas de un compuesto de fórmula A con una cantidad terapéuticamente eficaz de un compuesto de fórmula D, en donde la fórmula A se selecciona entre los compuestos de fórmulas (1), (2) y (3), o una sal farmacéuticamente aceptable del mismo, y en donde fórmula D es un compuesto seleccionado entre los compuestos de fórmulas (4), (5), (6) y (7), o una sal farmacéuticamente aceptable del mismo. Reivindicación 3: La combinación de la reivindicación 2, caracterizada porque el cáncer es cáncer de mama, cáncer de ovario, cáncer de endometrio, cáncer de riñón, cáncer de útero, cáncer de próstata, o cáncer de pulmón. Reivindicación 20: La combinación de cualquiera de las reivindicaciones 1 - 19, caracterizada porque la fórmula A es un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo.
ARP180100028A 2017-01-06 2018-01-05 Terapia combinada para el tratamiento del cáncer AR110728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762443588P 2017-01-06 2017-01-06

Publications (1)

Publication Number Publication Date
AR110728A1 true AR110728A1 (es) 2019-04-24

Family

ID=62791140

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180100028A AR110728A1 (es) 2017-01-06 2018-01-05 Terapia combinada para el tratamiento del cáncer

Country Status (16)

Country Link
US (1) US11364222B2 (es)
EP (1) EP3565558B1 (es)
JP (1) JP7229162B2 (es)
KR (1) KR102576011B1 (es)
CN (1) CN110177554B (es)
AR (1) AR110728A1 (es)
AU (2) AU2018205262A1 (es)
BR (1) BR112019013814A2 (es)
CA (1) CA3048057A1 (es)
EA (1) EA201991622A1 (es)
IL (1) IL267795B2 (es)
MX (1) MX2019008158A (es)
NZ (1) NZ754865A (es)
TW (1) TWI823845B (es)
WO (1) WO2018129387A1 (es)
ZA (1) ZA201904188B (es)

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EP3710096A1 (en) 2017-11-17 2020-09-23 Convergascent LLC Devices and systems for intraluminal local drug delivery
US12017022B2 (en) 2017-11-17 2024-06-25 Isola Therapeutics, Inc. Devices and systems for intraluminal local drug delivery
JP2021504384A (ja) 2017-12-01 2021-02-15 ノバルティス アーゲー Ｌｓｚ１０２及びアルペリシブを含む医薬品の組合せ
JP7085056B2 (ja) * 2018-07-12 2022-06-15 イーライ リリー アンド カンパニー 選択的エストロゲン受容体分解剤
AU2019321588A1 (en) 2018-08-17 2021-03-04 Genentech, Inc. Diagnostic and therapeutic methods for the treatment of breast cancer
EP3877422A4 (en) * 2018-11-09 2022-08-24 G1 Therapeutics, Inc. THERAPEUTIC DOSING SCHEDULES FOR THE TREATMENT OF CANCER WITH ERIBULIN AND SELECTIVE CDK4/6 INHIBITOR COMBINATIONS
WO2021042237A1 (zh) * 2019-09-02 2021-03-11 北京哲源科技有限责任公司 获得细胞内确定性事件的方法及电子设备
US20230073301A1 (en) * 2020-01-27 2023-03-09 Isola Therapeutics, Inc. Tissue dosing for intraluminal local drug delivery
IL298294A (en) 2020-05-19 2023-01-01 G1 Therapeutics Inc Cyclin-dependent kinase inhibitory compounds for the treatment of medical disorders
WO2022199656A1 (zh) * 2021-03-24 2022-09-29 贝达药业股份有限公司 药物组合、包含其的试剂盒及其用途

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