BRPI0509580A - combinações de inibidores de transdução de sinal - Google Patents
combinações de inibidores de transdução de sinalInfo
- Publication number
- BRPI0509580A BRPI0509580A BRPI0509580-8A BRPI0509580A BRPI0509580A BR PI0509580 A BRPI0509580 A BR PI0509580A BR PI0509580 A BRPI0509580 A BR PI0509580A BR PI0509580 A BRPI0509580 A BR PI0509580A
- Authority
- BR
- Brazil
- Prior art keywords
- combinations
- inhibitors
- signal transduction
- combination
- specifically
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMBINAçõES DE INIBIDORES DE TRANSDUçãO DE SINAL. A presente invenção refere-se aos métodos para tratamento de câncer compreendendo emprego de uma combinação de inibidores de transdução de sinal. Mais especificamente, a presente invenção se refere às combinações dos assim chamados inibidores do ciclo celular com inibidores de transdução de sinal de cinase estimulados por mitogênio, mais especificamente combinações de inibidores de CDK com inibidores de transdução de sinal de cinase estimulados por mitogênio, mais preferivelmente inibidores de MEK. Outras concretizações da invenção se referem às combinações adicionais das combinações mencionadas anteriormente com agentes anticâncer padrão tais como, agentes citotóxicos, paliativos e antiangiogênicos. Mais especificamente essa invenção se refere às combinações de 6-acetil-8-ciclopentil-5-metil-2-(5-piperazin-1-il-piridin-2-ilamino)-8H-pir ido¢2,3-d! pirimidin-7-ona incluindo formas de sal, que é um inibidor seletivo de cina-se ciclina dependente(CDK4), em combinação com um ou mais inibidores de MEK, mais preferivelmente N-¢(R)-2,3-dihidróxi-propóxi!-3,4-diflúor-2-(2-flúor-4-iodo-fenilamino)-b enzamida. As combinações mencionadas anteriormente são úteis para tratamento de inflamação e doenças proliferativas celulares tais como, câncer e restenoses.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55762304P | 2004-03-30 | 2004-03-30 | |
PCT/IB2005/000720 WO2005094830A1 (en) | 2004-03-30 | 2005-03-18 | Combinations of signal transduction inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509580A true BRPI0509580A (pt) | 2007-11-27 |
Family
ID=34962238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509580-8A BRPI0509580A (pt) | 2004-03-30 | 2005-03-18 | combinações de inibidores de transdução de sinal |
Country Status (6)
Country | Link |
---|---|
US (1) | US20050222163A1 (pt) |
EP (1) | EP1740184A1 (pt) |
JP (1) | JP2007530654A (pt) |
BR (1) | BRPI0509580A (pt) |
CA (1) | CA2561516A1 (pt) |
WO (1) | WO2005094830A1 (pt) |
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US20040259926A1 (en) * | 2003-06-05 | 2004-12-23 | Bruendl Michelle M. | 3-Aryloxy and 3-heteroaryloxy substituted benzo[b]thiophenes as therapeutic agents |
MXPA05012894A (es) * | 2003-06-05 | 2006-02-22 | Warner Lambert Co | Benzofuranos 3-sustituidos como agentes terapeuticos. |
CA2527793A1 (en) * | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | 3-arylsulfanyl and 3-heteroarylsulfanyl substituted benzo[b]thiophenes as therapeutic agents |
CA2527779A1 (en) * | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | 3-substituted indoles and derivatives thereof as therapeutic agents |
EP1636212B1 (en) * | 2003-06-05 | 2007-06-27 | Warner-Lambert Company LLC | Cycloalkylsulfanyl substituted benzo¬b|thiophenes as therapeutic agents |
BRPI0410913A (pt) * | 2003-06-05 | 2006-06-27 | Warner Lambert Co | benzotiofenos substituìdos com cicloalquil e heterocicloalquil como agentes terapêuticos |
EP1648889B1 (en) * | 2003-07-11 | 2008-10-29 | Warner-Lambert Company LLC | Isethionate salt of a selective cdk4 inhibitor |
US7008953B2 (en) * | 2003-07-30 | 2006-03-07 | Agouron Pharmaceuticals, Inc. | 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
EP1699477A2 (en) * | 2003-12-11 | 2006-09-13 | Theravance, Inc. | Compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
-
2005
- 2005-03-18 CA CA002561516A patent/CA2561516A1/en not_active Abandoned
- 2005-03-18 WO PCT/IB2005/000720 patent/WO2005094830A1/en active Application Filing
- 2005-03-18 BR BRPI0509580-8A patent/BRPI0509580A/pt not_active IP Right Cessation
- 2005-03-18 EP EP05718229A patent/EP1740184A1/en not_active Withdrawn
- 2005-03-18 JP JP2007505648A patent/JP2007530654A/ja not_active Withdrawn
- 2005-03-30 US US11/095,442 patent/US20050222163A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2007530654A (ja) | 2007-11-01 |
CA2561516A1 (en) | 2005-10-13 |
EP1740184A1 (en) | 2007-01-10 |
US20050222163A1 (en) | 2005-10-06 |
WO2005094830A1 (en) | 2005-10-13 |
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