GB0615327D0 - Culture medium containing kinase inhibitors and uses thereof - Google Patents
Culture medium containing kinase inhibitors and uses thereofInfo
- Publication number
- GB0615327D0 GB0615327D0 GBGB0615327.4A GB0615327A GB0615327D0 GB 0615327 D0 GB0615327 D0 GB 0615327D0 GB 0615327 A GB0615327 A GB 0615327A GB 0615327 D0 GB0615327 D0 GB 0615327D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- culture medium
- medium containing
- kinase inhibitors
- containing kinase
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0273—Cloned animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/103—Ovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Abstract
Pluripotent cells are derived and maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and an antagonist of an FGF receptor.
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0615327.4A GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
GBGB0700479.9A GB0700479D0 (en) | 2006-08-01 | 2007-01-10 | Culture medium containing kinase inhibitors, and uses thereof |
CA002645170A CA2645170A1 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
GB0706239A GB2436737B (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors,and uses thereof |
EP07732217A EP1999249B8 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
US11/694,351 US9074180B2 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
AT07732217T ATE530637T1 (en) | 2006-03-30 | 2007-03-30 | CULTURE MEDIA CONTAINING KINASE INHIBITORS AND USE |
EP11182239A EP2457995A1 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
JP2009502219A JP5680850B2 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitor and use thereof |
AU2007232393A AU2007232393A1 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
PCT/GB2007/001163 WO2007113505A2 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
TW096111227A TW200815597A (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
CN201410720584.XA CN104531610A (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other specie |
US11/832,317 US8431395B2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
JP2009522328A JP5456467B2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rats and other species |
AU2007280216A AU2007280216B2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
PCT/GB2007/002913 WO2008015418A2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
CN200780036720.1A CN101657535B (en) | 2006-08-01 | 2007-08-01 | Come from the multipotential cell of rat and other animal |
GB0716426A GB2451523B (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
EP07766403A EP2049654A2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
IL193495A IL193495A0 (en) | 2006-03-30 | 2008-08-17 | Culture medium containing kinase inhibitors and uses thereof |
US12/581,981 US20100041137A1 (en) | 2006-03-30 | 2009-10-20 | Culture medium containing kinase inhibitors, and uses thereof |
JP2013011454A JP5728036B2 (en) | 2006-03-30 | 2013-01-24 | Culture medium containing kinase inhibitor and use thereof |
US13/857,449 US20130333058A1 (en) | 2006-08-01 | 2013-04-05 | Pluripotent Cells From Rat and Other Species |
JP2013127052A JP2013176400A (en) | 2006-08-01 | 2013-06-17 | Pluripotent cell derived from rat and other species |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0606392.9A GB0606392D0 (en) | 2006-03-30 | 2006-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
GBGB0615327.4A GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
GB0615327D0 true GB0615327D0 (en) | 2006-09-13 |
Family
ID=37809760
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB0615327.4A Ceased GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
GBGB0700479.9A Ceased GB0700479D0 (en) | 2006-08-01 | 2007-01-10 | Culture medium containing kinase inhibitors, and uses thereof |
GB0716426A Expired - Fee Related GB2451523B (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB0700479.9A Ceased GB0700479D0 (en) | 2006-08-01 | 2007-01-10 | Culture medium containing kinase inhibitors, and uses thereof |
GB0716426A Expired - Fee Related GB2451523B (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
Country Status (7)
Country | Link |
---|---|
US (2) | US8431395B2 (en) |
EP (1) | EP2049654A2 (en) |
JP (2) | JP5456467B2 (en) |
CN (2) | CN101657535B (en) |
AU (1) | AU2007280216B2 (en) |
GB (3) | GB0615327D0 (en) |
WO (1) | WO2008015418A2 (en) |
Families Citing this family (49)
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US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
US8357666B2 (en) * | 2005-08-01 | 2013-01-22 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through RNA interference |
TW200815597A (en) * | 2006-03-30 | 2008-04-01 | Univ Edinburgh | Culture medium containing kinase inhibitors, and uses thereof |
CA2683056C (en) | 2007-04-07 | 2020-03-24 | Whitehead Institute For Biomedical Research | Reprogramming of somatic cells |
US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
JP5722628B2 (en) * | 2007-07-18 | 2015-05-27 | セレクティス アーベー | hBS cell-derived cardiomyocyte-like cell cluster |
EP2185693B1 (en) | 2007-07-31 | 2019-07-03 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
CN101855338B (en) * | 2007-08-31 | 2013-07-17 | 怀特黑德生物医学研究所 | WNT pathway stimulation in reprogramming somatic cells |
ES2690554T3 (en) | 2008-03-17 | 2018-11-21 | The Scripps Research Institute | Combined chemical and genetic approaches for the generation of induced pluripotent stem cells |
EP2276834A4 (en) * | 2008-04-07 | 2012-02-08 | Nupotential Inc | Reprogramming a cell by inducing a pluripotent gene through use of a small molecule modulator |
EP2300611B1 (en) | 2008-06-13 | 2017-08-09 | Whitehead Institute for Biomedical Research | Programming and reprogramming of cells |
ES2697798T3 (en) | 2008-06-30 | 2019-01-28 | Janssen Biotech Inc | Differentiation of pluripotent stem cells |
US8735156B2 (en) | 2008-12-01 | 2014-05-27 | The Board Of Regents Of The University Of Texas System | Production and use of rat spermatogonial stem cell lines |
EP2373784B1 (en) * | 2008-12-17 | 2017-10-25 | The Scripps Research Institute | Generation and maintenance of stem cells |
WO2010124290A2 (en) * | 2009-04-24 | 2010-10-28 | Whitehead Institute For Biomedical Research | Compositions and methods for deriving or culturing pluripotent cells |
BR112012008848A2 (en) * | 2009-10-16 | 2019-09-24 | Scripps Research Inst | in vitro or ex vivo method for inducing non-pluripotent mammalian cells into induced pluripotent stem cells |
EP2508595B1 (en) | 2009-12-01 | 2016-11-23 | National Cancer Center | Method for constructing chimeric rat using rat embryonic stem cells |
US8932853B2 (en) | 2009-12-29 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
JP5909482B2 (en) | 2010-03-31 | 2016-04-26 | ザ スクリプス リサーチ インスティテュート | Cell reprogramming |
US20130059375A1 (en) * | 2010-04-02 | 2013-03-07 | Riken | Method for preparing es cells |
US9376664B2 (en) | 2010-06-14 | 2016-06-28 | The Scripps Research Institute | Reprogramming of cells to a new fate |
CN102344490B (en) * | 2010-07-30 | 2014-03-05 | 中国科学院上海生命科学研究院 | Anti-mouse Stk40 polyclonal antibody and preparation thereof |
KR101877077B1 (en) * | 2010-08-09 | 2018-07-10 | 다케다 야쿠힌 고교 가부시키가이샤 | Method of producing pancreatic hormone-producing cells |
EP2640829A4 (en) * | 2010-11-17 | 2014-06-11 | Univ Kyoto | Cardiomyocyte- and/or cardiac progenitor cell-proliferating agent and method for proliferating cardiomyocytes and/or cardiac progenitor cells |
WO2012087965A2 (en) | 2010-12-22 | 2012-06-28 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of ipscs |
WO2012101619A1 (en) * | 2011-01-24 | 2012-08-02 | Ben Gurion University Of The Negev Research And Development Authority | A method for evaluating a mental disorder |
CN108220224A (en) | 2011-06-21 | 2018-06-29 | 诺沃—诺迪斯克有限公司 | Definitive entoderm is effectively induced from pluripotent stem cell |
RU2664232C2 (en) | 2011-08-05 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Humanised universal light chain mice |
DK2793567T3 (en) | 2011-12-20 | 2019-04-15 | Regeneron Pharma | Humanized light chain mice |
SG10201702445TA (en) | 2012-04-25 | 2017-04-27 | Regeneron Pharma | Nuclease-mediated targeting with large targeting vectors |
ES2904803T3 (en) * | 2013-02-20 | 2022-04-06 | Regeneron Pharma | Genetic modification of rats |
RS58255B1 (en) | 2013-04-16 | 2019-03-29 | Regeneron Pharma | Targeted modification of rat genome |
CA2915097C (en) | 2013-06-14 | 2021-12-07 | The University Of Queensland | Renal progenitor cells |
WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
EP3114214B1 (en) | 2014-03-04 | 2023-11-01 | Fate Therapeutics, Inc. | Improved reprogramming methods and cell culture platforms |
US20170165230A1 (en) | 2014-04-09 | 2017-06-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
JP6652334B2 (en) | 2014-05-31 | 2020-02-19 | Jcrファーマ株式会社 | Medium containing uridine and N-acetyl-D-mannosamine |
RU2704283C9 (en) | 2014-06-06 | 2020-02-07 | Регенерон Фармасьютикалз, Инк. | Methods and compositions for modifying target locus |
ES2694629T3 (en) | 2014-06-26 | 2018-12-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for objective genetic modifications and methods of use |
PT3221457T (en) | 2014-11-21 | 2019-06-27 | Regeneron Pharma | Methods and compositions for targeted genetic modification using paired guide rnas |
KR102530821B1 (en) | 2014-12-19 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | Methods and compositions for targeted genetic modification through single-step multiple targeting |
KR20170132281A (en) * | 2015-03-30 | 2017-12-01 | 아지노모토 가부시키가이샤 | Neural stem cell proliferation medium containing human serum albumin |
CN117737124A (en) | 2015-10-16 | 2024-03-22 | 菲特治疗公司 | Platform for inducing and maintaining ground state pluripotency |
MA45479A (en) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN ENDODERMAL CELLS OF MIDDLE INTESTINE |
US11268950B2 (en) | 2016-09-28 | 2022-03-08 | Organovo, Inc. | Use of engineered renal tissues in assays |
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GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
WO1995006716A1 (en) | 1993-08-30 | 1995-03-09 | Northwestern University | Rat pluripotent embryonic stem cells and method of obtaining and using same |
EP0941310A1 (en) * | 1996-10-11 | 1999-09-15 | THE TEXAS A&M UNIVERSITY SYSTEM | Methods for the generation of primordial germ cells and transgenic animal species |
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JP2002176973A (en) | 2000-12-14 | 2002-06-25 | Shigeo Saito | Mammalian embryonic stem cell and method for establishing the same and subculture method for the same |
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US20080268533A1 (en) | 2004-08-25 | 2008-10-30 | University Of Georgia Research Foundation, Inc. | Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells |
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TW200815597A (en) * | 2006-03-30 | 2008-04-01 | Univ Edinburgh | Culture medium containing kinase inhibitors, and uses thereof |
WO2007113705A1 (en) * | 2006-04-03 | 2007-10-11 | Koninklijke Philips Electronics N. V. | Determining tissue surrounding an object being inserted into a patient |
BRPI0711628A2 (en) | 2006-05-15 | 2011-12-06 | Irm Llc | compound, pharmaceutical composition, use and process for preparing the compound |
-
2006
- 2006-08-01 GB GBGB0615327.4A patent/GB0615327D0/en not_active Ceased
-
2007
- 2007-01-10 GB GBGB0700479.9A patent/GB0700479D0/en not_active Ceased
- 2007-08-01 WO PCT/GB2007/002913 patent/WO2008015418A2/en active Application Filing
- 2007-08-01 GB GB0716426A patent/GB2451523B/en not_active Expired - Fee Related
- 2007-08-01 US US11/832,317 patent/US8431395B2/en not_active Expired - Fee Related
- 2007-08-01 EP EP07766403A patent/EP2049654A2/en not_active Withdrawn
- 2007-08-01 CN CN200780036720.1A patent/CN101657535B/en not_active Expired - Fee Related
- 2007-08-01 AU AU2007280216A patent/AU2007280216B2/en not_active Ceased
- 2007-08-01 CN CN201410720584.XA patent/CN104531610A/en active Pending
- 2007-08-01 JP JP2009522328A patent/JP5456467B2/en not_active Expired - Fee Related
-
2013
- 2013-04-05 US US13/857,449 patent/US20130333058A1/en not_active Abandoned
- 2013-06-17 JP JP2013127052A patent/JP2013176400A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2013176400A (en) | 2013-09-09 |
GB2451523A (en) | 2009-02-04 |
CN104531610A (en) | 2015-04-22 |
GB2451523B (en) | 2010-03-17 |
AU2007280216B2 (en) | 2012-12-20 |
GB2451523A8 (en) | 2009-02-18 |
GB0716426D0 (en) | 2007-10-10 |
CN101657535B (en) | 2016-03-02 |
WO2008015418A3 (en) | 2008-04-10 |
US20080066197A1 (en) | 2008-03-13 |
GB0700479D0 (en) | 2007-02-21 |
CN101657535A (en) | 2010-02-24 |
WO2008015418A2 (en) | 2008-02-07 |
EP2049654A2 (en) | 2009-04-22 |
JP5456467B2 (en) | 2014-03-26 |
JP2009545302A (en) | 2009-12-24 |
US20130333058A1 (en) | 2013-12-12 |
AU2007280216A1 (en) | 2008-02-07 |
US8431395B2 (en) | 2013-04-30 |
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