WO2007109067A3 - Non-random aptamer libraries and methods for making - Google Patents

Non-random aptamer libraries and methods for making Download PDF

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Publication number
WO2007109067A3
WO2007109067A3 PCT/US2007/006467 US2007006467W WO2007109067A3 WO 2007109067 A3 WO2007109067 A3 WO 2007109067A3 US 2007006467 W US2007006467 W US 2007006467W WO 2007109067 A3 WO2007109067 A3 WO 2007109067A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
making
aptamer libraries
random aptamer
random
Prior art date
Application number
PCT/US2007/006467
Other languages
French (fr)
Other versions
WO2007109067A2 (en
Inventor
Neal Woodbury
Matt Greving
Original Assignee
Univ Arizona State
Neal Woodbury
Matt Greving
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona State, Neal Woodbury, Matt Greving filed Critical Univ Arizona State
Publication of WO2007109067A2 publication Critical patent/WO2007109067A2/en
Publication of WO2007109067A3 publication Critical patent/WO2007109067A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
    • C12N2330/31—Libraries, arrays

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides novel aptamers, non-random aptamer libraries, methods for generating non-random aptamer libraries, and associated computer readable storage media.
PCT/US2007/006467 2006-03-21 2007-03-15 Non-random aptamer libraries and methods for making WO2007109067A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78449606P 2006-03-21 2006-03-21
US60/784,496 2006-03-21

Publications (2)

Publication Number Publication Date
WO2007109067A2 WO2007109067A2 (en) 2007-09-27
WO2007109067A3 true WO2007109067A3 (en) 2008-04-24

Family

ID=38522940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/006467 WO2007109067A2 (en) 2006-03-21 2007-03-15 Non-random aptamer libraries and methods for making

Country Status (1)

Country Link
WO (1) WO2007109067A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4698559B2 (en) * 2006-11-24 2011-06-08 Ｎｅｃソフト株式会社 Nucleic acid molecule capable of binding to rabbit-derived IgG antibody
WO2009078939A1 (en) * 2007-12-17 2009-06-25 Brown University Methods for identifying nucleotide ligands
US11978534B1 (en) 2017-07-07 2024-05-07 Arizona Board Of Regents On Behalf Of Arizona State University Prediction of binding from binding data in peptide and other arrays
WO2020033271A1 (en) 2018-08-06 2020-02-13 Arizona Board Of Regents On Behalf Of Arizon State University Computational analysis to comprehensively predict and design molecular recognition between peptides and proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
US20030224357A1 (en) * 2000-06-07 2003-12-04 Santalucia John Method and system for predicting nucleic acid hybridization thermodynamics and computer-readable storage medium for use therein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
US20030224357A1 (en) * 2000-06-07 2003-12-04 Santalucia John Method and system for predicting nucleic acid hybridization thermodynamics and computer-readable storage medium for use therein

Also Published As

Publication number Publication date
WO2007109067A2 (en) 2007-09-27

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