JP2016517857A5 - - Google Patents
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- JP2016517857A5 JP2016517857A5 JP2016509276A JP2016509276A JP2016517857A5 JP 2016517857 A5 JP2016517857 A5 JP 2016517857A5 JP 2016509276 A JP2016509276 A JP 2016509276A JP 2016509276 A JP2016509276 A JP 2016509276A JP 2016517857 A5 JP2016517857 A5 JP 2016517857A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally
- alkyl
- alkynyl
- alkenyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2013/074780 | 2013-04-26 | ||
| CN2013074780 | 2013-04-26 | ||
| PCT/CN2014/075257 WO2014173241A1 (en) | 2013-04-26 | 2014-04-14 | Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517857A JP2016517857A (ja) | 2016-06-20 |
| JP2016517857A5 true JP2016517857A5 (enExample) | 2017-06-01 |
| JP6388915B2 JP6388915B2 (ja) | 2018-09-12 |
Family
ID=51791046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016509276A Expired - Fee Related JP6388915B2 (ja) | 2013-04-26 | 2014-04-14 | 置換５−（３，５−ジメチルイソオキサゾール−４−イル）インドリン−２−オン |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9393232B2 (enExample) |
| EP (1) | EP2989096B1 (enExample) |
| JP (1) | JP6388915B2 (enExample) |
| AU (1) | AU2014256750B2 (enExample) |
| BR (1) | BR112015027130A2 (enExample) |
| CA (1) | CA2901083A1 (enExample) |
| EA (1) | EA027139B1 (enExample) |
| HK (1) | HK1217484A1 (enExample) |
| IL (1) | IL240126A0 (enExample) |
| MX (1) | MX366623B (enExample) |
| SG (1) | SG11201506829XA (enExample) |
| WO (1) | WO2014173241A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| US9271978B2 (en) | 2012-12-21 | 2016-03-01 | Zenith Epigenetics Corp. | Heterocyclic compounds as bromodomain inhibitors |
| US9227985B2 (en) | 2013-03-15 | 2016-01-05 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| WO2014173241A1 (en) | 2013-04-26 | 2014-10-30 | Beigene, Ltd. | Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones |
| SG11201510409QA (en) | 2013-06-21 | 2016-01-28 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
| WO2015004533A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| EP3019502B1 (en) | 2013-07-08 | 2017-05-17 | Incyte Holdings Corporation | Tricyclic heterocycles as bet protein inhibitors |
| AU2014298051B2 (en) | 2013-07-31 | 2018-11-15 | Zenith Epigenetics Ltd. | Novel quinazolinones as bromodomain inhibitors |
| US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| MY180775A (en) | 2014-04-23 | 2020-12-09 | Incyte Corp | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
| US9527864B2 (en) | 2014-09-15 | 2016-12-27 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
| WO2016087942A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridines as bromodomain inhibitors |
| CN107207474B (zh) | 2014-12-11 | 2021-05-07 | 恒翼生物医药科技(上海)有限公司 | 被取代的杂环作为溴结构域抑制剂 |
| CA2966450A1 (en) | 2014-12-17 | 2016-06-23 | Olesya KHARENKO | Inhibitors of bromodomains |
| CN105985282B (zh) * | 2015-01-28 | 2020-12-08 | 中国科学院广州生物医药与健康研究院 | 一种2-氧代-1,2-二氢苯并[cd]吲哚类化合物及其应用 |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| WO2016203335A1 (en) | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
| WO2017075377A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
| KR102643344B1 (ko) | 2016-06-20 | 2024-03-07 | 인사이트 코포레이션 | Bet 저해제의 결정질 고체 형태 |
| US10159660B2 (en) * | 2016-07-29 | 2018-12-25 | Oncternal Therapeutics, Inc. | Uses of indolinone compounds |
| GB201716392D0 (en) * | 2017-10-06 | 2017-11-22 | Glaxosmithkline Intellectual Property (No 2) Ltd | Compounds |
| WO2020046813A1 (en) * | 2018-08-27 | 2020-03-05 | Arcus Biosciences, Inc. | Cd73 inhibitors |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| EP4457224A4 (en) * | 2021-12-29 | 2025-12-24 | Beone Medicines I Gmbh | HETEROCYCLICAL COMPOUNDS |
| WO2025064918A1 (en) * | 2023-09-20 | 2025-03-27 | The Board Of Regents Of The University Of Texas System | First-in-class phospho-brd4 inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0420970D0 (en) | 2004-09-21 | 2004-10-20 | Smithkline Beecham Corp | Novel triazoloquinoline compounds |
| US8476260B2 (en) | 2007-12-28 | 2013-07-02 | Mitsubishi Tanabe Pharma Corporation | Antitumor agent |
| CA2728228A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| GB0919431D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919426D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919432D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
| SI2496582T1 (sl) | 2009-11-05 | 2016-04-29 | Glaxosmithkline Llc Corporation Service Company | Benzodiazepinski inhibitor bromodomene |
| EP2496580B1 (en) | 2009-11-05 | 2013-12-11 | GlaxoSmithKline LLC | Benzodiazepine bromodomain inhibitor |
| GB0919434D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| WO2011069298A1 (en) | 2009-12-11 | 2011-06-16 | F. Hoffmann-La Roche Ag | Novel cyclopropane indolinone derivatives |
| CN102656147A (zh) | 2009-12-11 | 2012-09-05 | 霍夫曼-拉罗奇有限公司 | 可用作ampk调节剂的螺吲哚-环丙烷二氢吲哚酮 |
| MX384074B (es) | 2010-05-14 | 2025-03-12 | Dana Farber Cancer Inst Inc | Composiciones y métodos para tratar neoplasias, enfermedades inflamatorias y otros trastornos. |
| US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
| ES2526671T3 (es) | 2010-06-22 | 2015-01-14 | Glaxosmithkline Llc | Compuestos de benzotriazoldiazepina inhibidores de bromodominios |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| CA2828437A1 (en) | 2011-04-21 | 2012-10-26 | Sanofi-Aventis Deutschland Gmbh | Medicated module with lock ring |
| EP2705039B1 (en) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2014159837A1 (en) | 2013-03-14 | 2014-10-02 | Convergene Llc | Methods and compositions for inhibition of bromodomain-containing proteins |
| EP2978757B1 (en) | 2013-03-27 | 2017-02-08 | Boehringer Ingelheim International GmbH | Indolinone analogues as brd4 inhibitors |
| WO2014173241A1 (en) | 2013-04-26 | 2014-10-30 | Beigene, Ltd. | Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones |
-
2014
- 2014-04-14 WO PCT/CN2014/075257 patent/WO2014173241A1/en not_active Ceased
- 2014-04-14 MX MX2015014947A patent/MX366623B/es active IP Right Grant
- 2014-04-14 SG SG11201506829XA patent/SG11201506829XA/en unknown
- 2014-04-14 HK HK16105442.5A patent/HK1217484A1/zh unknown
- 2014-04-14 AU AU2014256750A patent/AU2014256750B2/en not_active Ceased
- 2014-04-14 JP JP2016509276A patent/JP6388915B2/ja not_active Expired - Fee Related
- 2014-04-14 EP EP14788064.5A patent/EP2989096B1/en active Active
- 2014-04-14 BR BR112015027130A patent/BR112015027130A2/pt not_active Application Discontinuation
- 2014-04-14 CA CA2901083A patent/CA2901083A1/en not_active Abandoned
- 2014-04-14 EA EA201592024A patent/EA027139B1/ru not_active IP Right Cessation
- 2014-04-14 US US14/404,798 patent/US9393232B2/en active Active
-
2015
- 2015-07-23 IL IL240126A patent/IL240126A0/en unknown
-
2016
- 2016-06-06 US US15/174,229 patent/US9827226B2/en active Active
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