CL2015001259A1 - Compuestos heterociclicos modulares del transporte nuclear; composicion farmaceutica; y usos de los mismos en enfermedades tales como cancer (div. sol. 224-14). - Google Patents
Compuestos heterociclicos modulares del transporte nuclear; composicion farmaceutica; y usos de los mismos en enfermedades tales como cancer (div. sol. 224-14).Info
- Publication number
- CL2015001259A1 CL2015001259A1 CL2015001259A CL2015001259A CL2015001259A1 CL 2015001259 A1 CL2015001259 A1 CL 2015001259A1 CL 2015001259 A CL2015001259 A CL 2015001259A CL 2015001259 A CL2015001259 A CL 2015001259A CL 2015001259 A1 CL2015001259 A1 CL 2015001259A1
- Authority
- CL
- Chile
- Prior art keywords
- div
- sol
- modular
- cancer
- diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E10/00—Energy generation through renewable energy sources
- Y02E10/50—Photovoltaic [PV] energy
- Y02E10/549—Organic PV cells
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161513428P | 2011-07-29 | 2011-07-29 | |
US201161513432P | 2011-07-29 | 2011-07-29 | |
US201261653588P | 2012-05-31 | 2012-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015001259A1 true CL2015001259A1 (es) | 2015-07-24 |
Family
ID=46682903
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014000224A CL2014000224A1 (es) | 2011-07-29 | 2014-01-29 | Compuestos derivados de heterociclos sustituidos, moduladores del transporte nuclear; composicion farmaceutica; y su uso para el tratamiento de un trastorno asociado con actividad crm1, tal como cancer, trastorno de crecimiento tisular anormal, fibrosis, entre otras. |
CL2015001259A CL2015001259A1 (es) | 2011-07-29 | 2015-05-11 | Compuestos heterociclicos modulares del transporte nuclear; composicion farmaceutica; y usos de los mismos en enfermedades tales como cancer (div. sol. 224-14). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014000224A CL2014000224A1 (es) | 2011-07-29 | 2014-01-29 | Compuestos derivados de heterociclos sustituidos, moduladores del transporte nuclear; composicion farmaceutica; y su uso para el tratamiento de un trastorno asociado con actividad crm1, tal como cancer, trastorno de crecimiento tisular anormal, fibrosis, entre otras. |
Country Status (16)
Country | Link |
---|---|
US (4) | US9428490B2 (es) |
EP (1) | EP2736883B1 (es) |
JP (3) | JP6006794B2 (es) |
KR (1) | KR102022715B1 (es) |
CN (1) | CN103842340B (es) |
AU (2) | AU2016213805A1 (es) |
BR (1) | BR112014001933A2 (es) |
CA (1) | CA2842364A1 (es) |
CL (2) | CL2014000224A1 (es) |
EA (1) | EA201490406A1 (es) |
HK (1) | HK1198478A1 (es) |
MX (1) | MX350442B (es) |
PE (1) | PE20141003A1 (es) |
SG (1) | SG10201609097PA (es) |
UA (1) | UA117902C2 (es) |
WO (1) | WO2013019561A1 (es) |
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RS56823B1 (sr) | 2011-07-29 | 2018-04-30 | Karyopharm Therapeutics Inc | Modulatori nukleusnog transporta koji sadrže hidrazid i njihove upotrebe |
JP6006794B2 (ja) * | 2011-07-29 | 2016-10-12 | カリオファーム セラピューティクス,インコーポレイテッド | 核内輸送調節因子およびその使用 |
DK2858991T3 (en) | 2012-05-09 | 2018-11-26 | Biogen Ma Inc | CELL NUCLEAR TRANSPORT MODULATORS AND APPLICATIONS THEREOF |
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US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
UA119238C2 (uk) * | 2013-06-21 | 2019-05-27 | Каріофарм Терапеутікс Інк. | Модулятори ядерного транспорту та їх застосування |
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JP6527149B2 (ja) * | 2013-11-28 | 2019-06-05 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | ベータ−サラセミアの処置のための方法及び医薬組成物 |
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CN113061089A (zh) | 2015-09-23 | 2021-07-02 | 凯瑞康宁生物工程(武汉)有限公司 | γ-羟基丁酸的前药及其组合物和用途 |
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-
2012
- 2012-07-26 JP JP2014523015A patent/JP6006794B2/ja active Active
- 2012-07-26 CA CA2842364A patent/CA2842364A1/en not_active Abandoned
- 2012-07-26 EP EP12748083.8A patent/EP2736883B1/en active Active
- 2012-07-26 US US14/235,342 patent/US9428490B2/en active Active
- 2012-07-26 SG SG10201609097PA patent/SG10201609097PA/en unknown
- 2012-07-26 KR KR1020147005649A patent/KR102022715B1/ko active IP Right Grant
- 2012-07-26 EA EA201490406A patent/EA201490406A1/ru unknown
- 2012-07-26 PE PE2014000137A patent/PE20141003A1/es active IP Right Grant
- 2012-07-26 CN CN201280047930.1A patent/CN103842340B/zh active Active
- 2012-07-26 WO PCT/US2012/048368 patent/WO2013019561A1/en active Application Filing
- 2012-07-26 UA UAA201401884A patent/UA117902C2/uk unknown
- 2012-07-26 BR BR112014001933A patent/BR112014001933A2/pt not_active Application Discontinuation
- 2012-07-26 MX MX2014001180A patent/MX350442B/es active IP Right Grant
-
2014
- 2014-01-29 CL CL2014000224A patent/CL2014000224A1/es unknown
- 2014-11-27 HK HK14111985.8A patent/HK1198478A1/xx unknown
-
2015
- 2015-05-11 CL CL2015001259A patent/CL2015001259A1/es unknown
-
2016
- 2016-07-22 US US15/217,514 patent/US20170137430A1/en not_active Abandoned
- 2016-08-11 AU AU2016213805A patent/AU2016213805A1/en not_active Abandoned
- 2016-09-09 JP JP2016176098A patent/JP2016199604A/ja not_active Withdrawn
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2018
- 2018-01-18 JP JP2018006773A patent/JP6752235B2/ja active Active
- 2018-06-14 AU AU2018204256A patent/AU2018204256A1/en not_active Abandoned
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2019
- 2019-04-25 US US16/394,986 patent/US20200087313A1/en not_active Abandoned
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2021
- 2021-05-04 US US17/307,656 patent/US20220056038A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2018083832A (ja) | 2018-05-31 |
AU2016213805A1 (en) | 2016-09-01 |
WO2013019561A1 (en) | 2013-02-07 |
MX350442B (es) | 2017-09-06 |
AU2012290467A1 (en) | 2014-03-13 |
US20220056038A1 (en) | 2022-02-24 |
MX2014001180A (es) | 2015-01-27 |
CL2014000224A1 (es) | 2014-12-05 |
PE20141003A1 (es) | 2014-09-02 |
CA2842364A1 (en) | 2013-02-07 |
JP6752235B2 (ja) | 2020-09-09 |
HK1198478A1 (en) | 2015-05-08 |
NZ621520A (en) | 2016-05-27 |
EA201490406A1 (ru) | 2014-07-30 |
US9428490B2 (en) | 2016-08-30 |
EP2736883B1 (en) | 2019-09-04 |
US20170137430A1 (en) | 2017-05-18 |
JP2016199604A (ja) | 2016-12-01 |
CN103842340B (zh) | 2017-09-22 |
CN103842340A (zh) | 2014-06-04 |
BR112014001933A2 (pt) | 2017-02-21 |
KR20140062480A (ko) | 2014-05-23 |
WO2013019561A8 (en) | 2013-07-04 |
US20150018332A1 (en) | 2015-01-15 |
EP2736883A1 (en) | 2014-06-04 |
US20200087313A1 (en) | 2020-03-19 |
UA117902C2 (uk) | 2018-10-25 |
JP2014521653A (ja) | 2014-08-28 |
SG10201609097PA (en) | 2016-12-29 |
JP6006794B2 (ja) | 2016-10-12 |
KR102022715B1 (ko) | 2019-09-18 |
AU2018204256A1 (en) | 2018-07-05 |
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