JP2019517596A5

JP2019517596A5 -

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Publication number: JP2019517596A5
Authority: JP; Japan
Prior art keywords: dicyano; thio; phenylacetamide; amino; ethyl
Prior art date: 2017-06-13
Legal status : Granted

Application number

JP2019517187A

Other languages

English (en)

Japanese (ja)

Other versions

JP2019517596A (ja

JP7051829B2 (ja

Filing date

2017-06-13

Publication date

2020-07-27

2017-06-13 Application filed filed Critical

2017-06-13 Priority claimed from PCT/IB2017/053511 external-priority patent/WO2017216727A1/en

2019-06-24 Publication of JP2019517596A publication Critical patent/JP2019517596A/ja

2020-07-27 Publication of JP2019517596A5 publication Critical patent/JP2019517596A5/ja

2022-04-11 Application granted granted Critical

2022-04-11 Publication of JP7051829B2 publication Critical patent/JP7051829B2/ja

Status Active legal-status Critical Current

2037-06-13 Anticipated expiration legal-status Critical

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125000000217 alkyl group Chemical group 0.000 claims 230
-1 -OR e Chemical group 0.000 claims 167
125000001424 substituent group Chemical group 0.000 claims 132
235000019000 fluorine Nutrition 0.000 claims 131
229910052731 fluorine Inorganic materials 0.000 claims 130
239000011737 fluorine Substances 0.000 claims 130
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 129
125000000592 heterocycloalkyl group Chemical group 0.000 claims 89
125000000753 cycloalkyl group Chemical group 0.000 claims 85
125000003118 aryl group Chemical group 0.000 claims 75
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 69
229910052801 chlorine Inorganic materials 0.000 claims 69
239000000460 chlorine Substances 0.000 claims 69
125000004093 cyano group Chemical group *C#N 0.000 claims 69
125000001072 heteroaryl group Chemical group 0.000 claims 67
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 58
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 52
125000003545 alkoxy group Chemical group 0.000 claims 48
125000004043 oxo group Chemical group O=* 0.000 claims 39
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 35
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 32
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 32
229910052794 bromium Inorganic materials 0.000 claims 32
150000001875 compounds Chemical class 0.000 claims 30
239000008194 pharmaceutical composition Substances 0.000 claims 30
150000003839 salts Chemical class 0.000 claims 27
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 24
125000003566 oxetanyl group Chemical group 0.000 claims 21
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 20
229910052739 hydrogen Inorganic materials 0.000 claims 17
239000001257 hydrogen Substances 0.000 claims 17
125000002883 imidazolyl group Chemical group 0.000 claims 17
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 17
206010028980 Neoplasm Diseases 0.000 claims 16
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 16
125000003386 piperidinyl group Chemical group 0.000 claims 16
241000124008 Mammalia Species 0.000 claims 15
NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 claims 15
229910052757 nitrogen Inorganic materials 0.000 claims 14
201000011510 cancer Diseases 0.000 claims 13
229940002612 prodrug Drugs 0.000 claims 12
239000000651 prodrug Substances 0.000 claims 12
125000000719 pyrrolidinyl group Chemical group 0.000 claims 12
125000002393 azetidinyl group Chemical group 0.000 claims 11
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 11
125000004193 piperazinyl group Chemical group 0.000 claims 11
125000003226 pyrazolyl group Chemical group 0.000 claims 11
125000002785 azepinyl group Chemical group 0.000 claims 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
150000002431 hydrogen Chemical class 0.000 claims 10
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 10
208000007056 sickle cell anemia Diseases 0.000 claims 10
229910052717 sulfur Inorganic materials 0.000 claims 10
201000010099 disease Diseases 0.000 claims 9
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
229910052760 oxygen Inorganic materials 0.000 claims 8
208000011580 syndromic disease Diseases 0.000 claims 8
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
125000005842 heteroatom Chemical group 0.000 claims 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 7
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 7
RKAYIEFADPAEOO-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)C)SC(C(=O)N)C1=CC=CC=C1 RKAYIEFADPAEOO-UHFFFAOYSA-N 0.000 claims 6
LNEBGQBVQRBDMK-UHFFFAOYSA-N 2-[6-(4-amino-4-methylpiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1(CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C LNEBGQBVQRBDMK-UHFFFAOYSA-N 0.000 claims 6
125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 6
208000006402 Ductal Carcinoma Diseases 0.000 claims 6
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 6
208000005017 glioblastoma Diseases 0.000 claims 6
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 6
125000002757 morpholinyl group Chemical group 0.000 claims 6
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
230000002159 abnormal effect Effects 0.000 claims 5
208000009956 adenocarcinoma Diseases 0.000 claims 5
125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 5
125000006311 cyclobutyl amino group Chemical group [H]N(*)C1([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 5
125000000160 oxazolidinyl group Chemical group 0.000 claims 5
150000003852 triazoles Chemical class 0.000 claims 5
AYZZJIDLBKXRKQ-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[2-(hydroxymethyl)morpholin-4-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(OCC1)CO)SC(C(=O)N)C1=CC=CC=C1 AYZZJIDLBKXRKQ-UHFFFAOYSA-N 0.000 claims 4
QVROPBZLGMQZIH-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[3-(dimethylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(CCC1)N(C)C)SC(C(=O)N)C1=CC=CC=C1 QVROPBZLGMQZIH-UHFFFAOYSA-N 0.000 claims 4
JZULSOHKMKJPIN-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(dimethylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)C)SC(C(=O)N)C1=CC=C(C=C1)F JZULSOHKMKJPIN-UHFFFAOYSA-N 0.000 claims 4
AYNULTGWVKTAEP-UHFFFAOYSA-N 2-[6-(3-aminoazetidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CN(C1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N AYNULTGWVKTAEP-UHFFFAOYSA-N 0.000 claims 4
QNAWNFWIFHMERM-UHFFFAOYSA-N 2-[6-[(2-amino-2-oxoethyl)-methylamino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(CN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C)=O QNAWNFWIFHMERM-UHFFFAOYSA-N 0.000 claims 4
CWUNMSSHZVRHPS-UHFFFAOYSA-N 2-[[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]-methylamino]ethyl dihydrogen phosphate Chemical compound P(=O)(OCCN(C)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1)(O)O CWUNMSSHZVRHPS-UHFFFAOYSA-N 0.000 claims 4
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
206010068873 Adenosquamous cell carcinoma Diseases 0.000 claims 4
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 4
206010018404 Glucagonoma Diseases 0.000 claims 4
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-Valine Natural products CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
208000018020 Sickle cell-beta-thalassemia disease syndrome Diseases 0.000 claims 4
206010043391 Thalassaemia beta Diseases 0.000 claims 4
208000006336 acinar cell carcinoma Diseases 0.000 claims 4
201000008395 adenosquamous carcinoma Diseases 0.000 claims 4
KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 4
208000034737 hemoglobinopathy Diseases 0.000 claims 4
239000003112 inhibitor Substances 0.000 claims 4
206010022498 insulinoma Diseases 0.000 claims 4
208000032839 leukemia Diseases 0.000 claims 4
201000001441 melanoma Diseases 0.000 claims 4
NJYYWQHQUOODDL-UHFFFAOYSA-N oxetane-3-carboxamide Chemical compound NC(=O)C1COC1 NJYYWQHQUOODDL-UHFFFAOYSA-N 0.000 claims 4
208000021255 pancreatic insulinoma Diseases 0.000 claims 4
239000000546 pharmaceutical excipient Substances 0.000 claims 4
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 claims 4
TWLBWWRTVQHOCK-RDTXWAMCSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[(3R)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H](CC1)O)S[C@@H](C(=O)N)C1=CC=CC=C1 TWLBWWRTVQHOCK-RDTXWAMCSA-N 0.000 claims 3
TWLBWWRTVQHOCK-KBXCAEBGSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)S[C@@H](C(=O)N)C1=CC=CC=C1 TWLBWWRTVQHOCK-KBXCAEBGSA-N 0.000 claims 3
TWLBWWRTVQHOCK-KSSFIOAISA-N (2S)-2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)S[C@H](C(=O)N)C1=CC=CC=C1 TWLBWWRTVQHOCK-KSSFIOAISA-N 0.000 claims 3
WUVHZNRMARLTQL-UHFFFAOYSA-N 2-[3,5-dicyano-4-(furan-2-yl)-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C=1OC=CC=1)C#N)N1CCN(CCC1)C)SC(C(=O)N)C1=CC=CC=C1 WUVHZNRMARLTQL-UHFFFAOYSA-N 0.000 claims 3
TWLBWWRTVQHOCK-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(3-hydroxypyrrolidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(CC1)O)SC(C(=O)N)C1=CC=CC=C1 TWLBWWRTVQHOCK-UHFFFAOYSA-N 0.000 claims 3
TWLBWWRTVQHOCK-IKJXHCRLSA-N 2-[3,5-dicyano-4-ethyl-6-[(3R)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H](CC1)O)SC(C(=O)N)C1=CC=CC=C1 TWLBWWRTVQHOCK-IKJXHCRLSA-N 0.000 claims 3
TWLBWWRTVQHOCK-PIVQAISJSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)SC(C(=O)N)C1=CC=CC=C1 TWLBWWRTVQHOCK-PIVQAISJSA-N 0.000 claims 3
206010003571 Astrocytoma Diseases 0.000 claims 3
208000012609 Cowden disease Diseases 0.000 claims 3
201000002847 Cowden syndrome Diseases 0.000 claims 3
208000032612 Glial tumor Diseases 0.000 claims 3
201000010915 Glioblastoma multiforme Diseases 0.000 claims 3
206010018338 Glioma Diseases 0.000 claims 3
208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims 3
206010039491 Sarcoma Diseases 0.000 claims 3
210000004556 brain Anatomy 0.000 claims 3
239000003795 chemical substances by application Substances 0.000 claims 3
125000006317 cyclopropyl amino group Chemical group 0.000 claims 3
239000003814 drug Substances 0.000 claims 3
210000003128 head Anatomy 0.000 claims 3
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 3
210000003734 kidney Anatomy 0.000 claims 3
210000004185 liver Anatomy 0.000 claims 3
210000003739 neck Anatomy 0.000 claims 3
210000001672 ovary Anatomy 0.000 claims 3
210000000496 pancreas Anatomy 0.000 claims 3
210000002307 prostate Anatomy 0.000 claims 3
210000001685 thyroid gland Anatomy 0.000 claims 3
125000001425 triazolyl group Chemical group 0.000 claims 3
CITLODUGFLYYPD-GOSISDBHSA-N (2R)-2-(3,5-dicyano-4-ethyl-6-morpholin-4-ylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCOCC1)S[C@@H](C(=O)N)C1=CC=CC=C1 CITLODUGFLYYPD-GOSISDBHSA-N 0.000 claims 2
XBGYNCRALWAEIG-HSZRJFAPSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1CCCC1)S[C@@H](C(=O)N)C1=CC=CC=C1 XBGYNCRALWAEIG-HSZRJFAPSA-N 0.000 claims 2
YFYRJDAXIJWXRZ-IIBYNOLFSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[(2R)-2-[[(2-hydroxyacetyl)amino]methyl]morpholin-4-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC([C@@H](C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N1C[C@H](OCC1)CNC(CO)=O)C#N)CC)C#N)=O YFYRJDAXIJWXRZ-IIBYNOLFSA-N 0.000 claims 2
NAXQRMHGLARATP-XMSQKQJNSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[(3R)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@](CC1)(CO)O)S[C@@H](C(=O)N)C1=CC=CC=C1 NAXQRMHGLARATP-XMSQKQJNSA-N 0.000 claims 2
NAXQRMHGLARATP-GCJKJVERSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@](CC1)(CO)O)S[C@@H](C(=O)N)C1=CC=CC=C1 NAXQRMHGLARATP-GCJKJVERSA-N 0.000 claims 2
LACBFVVSYQHECW-KPZWWZAWSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-(2,4-difluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)S[C@@H](C(=O)N)C1=C(C=C(C=C1)F)F LACBFVVSYQHECW-KPZWWZAWSA-N 0.000 claims 2
XOYGSTAJAGOUHB-QGZVFWFLSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[2-hydroxyethyl(methyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCO)S[C@@H](C(=O)N)C1=CC=CC=C1 XOYGSTAJAGOUHB-QGZVFWFLSA-N 0.000 claims 2
SEPYRSOYBZMXCN-GOSISDBHSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[3-hydroxypropyl(methyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCCO)S[C@@H](C(=O)N)C1=CC=CC=C1 SEPYRSOYBZMXCN-GOSISDBHSA-N 0.000 claims 2
KYIDEMYYLVDDEB-DNVCBOLYSA-N (2R)-2-[3,5-dicyano-4-ethyl-6-[methyl-[(3R)-oxolan-3-yl]amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N([C@H]1COCC1)C)S[C@@H](C(=O)N)C1=CC=CC=C1 KYIDEMYYLVDDEB-DNVCBOLYSA-N 0.000 claims 2
KIEQQZZDWUNUQK-MRXNPFEDSA-N (2R)-2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)S[C@@H](C(=O)N)C1=CC=CC=C1 KIEQQZZDWUNUQK-MRXNPFEDSA-N 0.000 claims 2
MELQQCMEXPGRLW-OAQYLSRUSA-N (2R)-2-[3,5-dicyano-6-[4-(dimethylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)C)S[C@@H](C(=O)N)C1=CC=CC=C1 MELQQCMEXPGRLW-OAQYLSRUSA-N 0.000 claims 2
KNKHRZYILDZLRE-LJQANCHMSA-N (2R)-2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N KNKHRZYILDZLRE-LJQANCHMSA-N 0.000 claims 2
PMWNNSZNZVXNKL-DNVCBOLYSA-N (2R)-2-[6-[(2R)-2-(aminomethyl)morpholin-4-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC[C@H]1OCCN(C1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N PMWNNSZNZVXNKL-DNVCBOLYSA-N 0.000 claims 2
XUJZHDXEUODIPV-XMSQKQJNSA-N (2R)-2-[6-[(3R)-3-(aminomethyl)-3-hydroxypyrrolidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC[C@]1(CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)O XUJZHDXEUODIPV-XMSQKQJNSA-N 0.000 claims 2
PXKHEPMNNUEAGS-GUDVDZBRSA-N (2R)-2-[6-[(3R,4R)-4-amino-3-fluoropiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@H]1[C@@H](CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F PXKHEPMNNUEAGS-GUDVDZBRSA-N 0.000 claims 2
QISXCBQMUSSXPW-GUDVDZBRSA-N (2R)-2-[6-[(3R,4R)-4-amino-3-hydroxypiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@H]1[C@@H](CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)O QISXCBQMUSSXPW-GUDVDZBRSA-N 0.000 claims 2
PXKHEPMNNUEAGS-CEXWTWQISA-N (2R)-2-[6-[(3R,4S)-4-amino-3-fluoropiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@@H]1[C@@H](CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F PXKHEPMNNUEAGS-CEXWTWQISA-N 0.000 claims 2
SLFVOEJIFPFHPQ-GCJKJVERSA-N (2R)-2-[6-[(3S)-3-(aminomethyl)-3-fluoropyrrolidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC[C@@]1(CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F SLFVOEJIFPFHPQ-GCJKJVERSA-N 0.000 claims 2
XUJZHDXEUODIPV-GCJKJVERSA-N (2R)-2-[6-[(3S)-3-(aminomethyl)-3-hydroxypyrrolidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC[C@@]1(CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)O XUJZHDXEUODIPV-GCJKJVERSA-N 0.000 claims 2
PXKHEPMNNUEAGS-IPMKNSEASA-N (2R)-2-[6-[(3S,4R)-4-amino-3-fluoropiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@H]1[C@H](CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F PXKHEPMNNUEAGS-IPMKNSEASA-N 0.000 claims 2
QISXCBQMUSSXPW-CEXWTWQISA-N (2R)-2-[6-[(3S,4R)-4-amino-3-hydroxypiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@H]1[C@H](CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)O QISXCBQMUSSXPW-CEXWTWQISA-N 0.000 claims 2
PXKHEPMNNUEAGS-GBESFXJTSA-N (2R)-2-[6-[(3S,4S)-4-amino-3-fluoropiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@@H]1[C@H](CN(CC1)C1=C(C(=C(C(=N1)S[C@@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F PXKHEPMNNUEAGS-GBESFXJTSA-N 0.000 claims 2
RJMRXCDNOIGHBN-OAQYLSRUSA-N (2R)-2-[[3,5-dicyano-4-ethyl-6-(4-ethyl-1,4-diazepan-1-yl)pyridin-2-yl]amino]-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CC)N[C@@H](C(=O)N)C1=CC=CC=C1 RJMRXCDNOIGHBN-OAQYLSRUSA-N 0.000 claims 2
DXUKXJSINKNGTD-OAQYLSRUSA-N (2R)-2-[[3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl]amino]-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CCO)N[C@@H](C(=O)N)C1=CC=CC=C1 DXUKXJSINKNGTD-OAQYLSRUSA-N 0.000 claims 2
SEKLCRJQUCYDPG-AREMUKBSSA-N (2R)-2-[[3,5-dicyano-4-ethyl-6-[4-(3-pyrrolidin-1-ylpropyl)-1,4-diazepan-1-yl]pyridin-2-yl]amino]-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CCCN1CCCC1)N[C@@H](C(=O)N)C1=CC=CC=C1 SEKLCRJQUCYDPG-AREMUKBSSA-N 0.000 claims 2
HSKVBTYMHPVTJH-LJQANCHMSA-N (2R)-2-[[3,5-dicyano-6-(1,4-diazepan-1-yl)-4-ethylpyridin-2-yl]amino]-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCNCCC1)N[C@@H](C(=O)N)C1=CC=CC=C1 HSKVBTYMHPVTJH-LJQANCHMSA-N 0.000 claims 2
OKWMELWZORVWFL-QSVWIEALSA-N (2R)-2-amino-N-[1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-cyclopropylpyridin-2-yl]azetidin-3-yl]-3-hydroxypropanamide Chemical compound N[C@@H](C(=O)NC1CN(C1)C1=NC(=C(C(=C1C#N)C1CC1)C#N)SC(C(=O)N)C1=CC=CC=C1)CO OKWMELWZORVWFL-QSVWIEALSA-N 0.000 claims 2
YGJJZMSBZVUVKQ-JGHKVMFLSA-N (2R)-2-amino-N-[1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-cyclopropylpyridin-2-yl]piperidin-4-yl]propanamide Chemical compound N[C@@H](C(=O)NC1CCN(CC1)C1=NC(=C(C(=C1C#N)C1CC1)C#N)SC(C(=O)N)C1=CC=CC=C1)C YGJJZMSBZVUVKQ-JGHKVMFLSA-N 0.000 claims 2
UKIZLJJTXDLHOT-VQCQRNETSA-N (2R)-2-amino-N-[1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]piperidin-4-yl]-3-hydroxypropanamide Chemical compound N[C@@H](C(=O)NC1CCN(CC1)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1)CO UKIZLJJTXDLHOT-VQCQRNETSA-N 0.000 claims 2
ZKTQBLPUIOTRRR-RBFZIWAESA-N (2R)-2-amino-N-[1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]piperidin-4-yl]propanamide Chemical compound N[C@@H](C(=O)NC1CCN(CC1)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1)C ZKTQBLPUIOTRRR-RBFZIWAESA-N 0.000 claims 2
KIEQQZZDWUNUQK-QKHLJXARSA-N (2R)-2-deuterio-2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)S[C@](C(=O)N)([2H])C1=CC=CC=C1 KIEQQZZDWUNUQK-QKHLJXARSA-N 0.000 claims 2
KYIDEMYYLVDDEB-BEFAXECRSA-N (2S)-2-[3,5-dicyano-4-ethyl-6-[methyl-[(3R)-oxolan-3-yl]amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N([C@H]1COCC1)C)S[C@H](C(=O)N)C1=CC=CC=C1 KYIDEMYYLVDDEB-BEFAXECRSA-N 0.000 claims 2
KNKHRZYILDZLRE-IBGZPJMESA-N (2S)-2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)S[C@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N KNKHRZYILDZLRE-IBGZPJMESA-N 0.000 claims 2
PXKHEPMNNUEAGS-QYZOEREBSA-N (2S)-2-[6-[(3R,4S)-4-amino-3-fluoropiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@@H]1[C@@H](CN(CC1)C1=C(C(=C(C(=N1)S[C@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F PXKHEPMNNUEAGS-QYZOEREBSA-N 0.000 claims 2
PXKHEPMNNUEAGS-OTWHNJEPSA-N (2S)-2-[6-[(3S,4R)-4-amino-3-fluoropiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@H]1[C@H](CN(CC1)C1=C(C(=C(C(=N1)S[C@H](C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F PXKHEPMNNUEAGS-OTWHNJEPSA-N 0.000 claims 2
OKWMELWZORVWFL-LROBGIAVSA-N (2S)-2-amino-N-[1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-cyclopropylpyridin-2-yl]azetidin-3-yl]-3-hydroxypropanamide Chemical compound N[C@H](C(=O)NC1CN(C1)C1=NC(=C(C(=C1C#N)C1CC1)C#N)SC(C(=O)N)C1=CC=CC=C1)CO OKWMELWZORVWFL-LROBGIAVSA-N 0.000 claims 2
YGJJZMSBZVUVKQ-UEDXYCIISA-N (2S)-2-amino-N-[1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-cyclopropylpyridin-2-yl]piperidin-4-yl]propanamide Chemical compound N[C@H](C(=O)NC1CCN(CC1)C1=NC(=C(C(=C1C#N)C1CC1)C#N)SC(C(=O)N)C1=CC=CC=C1)C YGJJZMSBZVUVKQ-UEDXYCIISA-N 0.000 claims 2
UKIZLJJTXDLHOT-BGERDNNASA-N (2S)-2-amino-N-[1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]piperidin-4-yl]-3-hydroxypropanamide Chemical compound N[C@H](C(=O)NC1CCN(CC1)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1)CO UKIZLJJTXDLHOT-BGERDNNASA-N 0.000 claims 2
ZKTQBLPUIOTRRR-ZDGMYTEDSA-N (2S)-2-amino-N-[1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]piperidin-4-yl]propanamide Chemical compound N[C@H](C(=O)NC1CCN(CC1)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1)C ZKTQBLPUIOTRRR-ZDGMYTEDSA-N 0.000 claims 2
ITEPIAUQBCBCAW-UHFFFAOYSA-N 1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]-4-hydroxypiperidine-4-carboxamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N1CCC(CC1)(C(=O)N)O)C#N)CC)C#N)=O ITEPIAUQBCBCAW-UHFFFAOYSA-N 0.000 claims 2
JLJIZFOSRBABJL-UHFFFAOYSA-N 1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]piperidine-4-carboxamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N1CCC(CC1)C(=O)N)C#N)CC)C#N)=O JLJIZFOSRBABJL-UHFFFAOYSA-N 0.000 claims 2
DUJZKRZORJLCLM-UHFFFAOYSA-N 1-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]pyrrolidine-3-carboxamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N1CC(CC1)C(=O)N)C#N)CC)C#N)=O DUJZKRZORJLCLM-UHFFFAOYSA-N 0.000 claims 2
KYURKRFGKGRNNG-UHFFFAOYSA-N 2-(3,5-dichloro-4-ethyl-6-piperazin-1-ylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound ClC=1C(=NC(=C(C=1CC)Cl)N1CCNCC1)SC(C(=O)N)C1=CC=CC=C1 KYURKRFGKGRNNG-UHFFFAOYSA-N 0.000 claims 2
DHNDYNWUHXEKBW-UHFFFAOYSA-N 2-(3,5-dicyano-4,6-diethylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)CC)SC(C(=O)N)C1=CC=CC=C1 DHNDYNWUHXEKBW-UHFFFAOYSA-N 0.000 claims 2
AFWBPDSPAKJTII-UHFFFAOYSA-N 2-(3,5-dicyano-4-cyclopropyl-6-morpholin-4-ylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCOCC1)SC(C(=O)N)C1=CC=CC=C1 AFWBPDSPAKJTII-UHFFFAOYSA-N 0.000 claims 2
VMDVTANOJNOWGA-UHFFFAOYSA-N 2-(3,5-dicyano-4-cyclopropyl-6-morpholin-4-ylpyridin-2-yl)sulfanyl-2-pyridin-4-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCOCC1)SC(C(=O)N)C1=CC=NC=C1 VMDVTANOJNOWGA-UHFFFAOYSA-N 0.000 claims 2
JEEKMGZTZSORLV-UHFFFAOYSA-N 2-(3,5-dicyano-4-cyclopropyl-6-piperazin-1-ylpyridin-2-yl)sulfanyl-2-pyridin-4-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCNCC1)SC(C(=O)N)C1=CC=NC=C1 JEEKMGZTZSORLV-UHFFFAOYSA-N 0.000 claims 2
ZLCZVATZPMXDKH-UHFFFAOYSA-N 2-(3,5-dicyano-4-ethoxy-6-methylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1OCC)C#N)C)SC(C(=O)N)C1=CC=CC=C1 ZLCZVATZPMXDKH-UHFFFAOYSA-N 0.000 claims 2
JSCBRTMDYAZVCC-UHFFFAOYSA-N 2-(3,5-dicyano-4-ethyl-6-methylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)C)SC(C(=O)N)C1=CC=CC=C1 JSCBRTMDYAZVCC-UHFFFAOYSA-N 0.000 claims 2
CITLODUGFLYYPD-UHFFFAOYSA-N 2-(3,5-dicyano-4-ethyl-6-morpholin-4-ylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCOCC1)SC(C(=O)N)C1=CC=CC=C1 CITLODUGFLYYPD-UHFFFAOYSA-N 0.000 claims 2
VEEUARNCRSRLMI-UHFFFAOYSA-N 2-(3,5-dicyano-4-ethyl-6-piperazin-1-ylpyridin-2-yl)sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCNCC1)SC(C(=O)N)C1=CC=C(C=C1)F VEEUARNCRSRLMI-UHFFFAOYSA-N 0.000 claims 2
ZWCZXCXGYPKPTE-UHFFFAOYSA-N 2-(3,5-dicyano-4-ethyl-6-piperazin-1-ylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCNCC1)SC(C(=O)N)C1=CC=CC=C1 ZWCZXCXGYPKPTE-UHFFFAOYSA-N 0.000 claims 2
QKTOMHMXAKONNE-UHFFFAOYSA-N 2-(3,5-dicyano-4-ethyl-6-piperazin-1-ylpyridin-2-yl)sulfanyl-2-thiophen-3-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCNCC1)SC(C(=O)N)C1=CSC=C1 QKTOMHMXAKONNE-UHFFFAOYSA-N 0.000 claims 2
JWWLGAVPWYJCBJ-UHFFFAOYSA-N 2-(3-benzoylphenyl)-2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanylacetamide Chemical compound C(C1=CC=CC=C1)(=O)C=1C=C(C=CC=1)C(C(=O)N)SC1=NC(=C(C(=C1C#N)CC)C#N)N1CCN(CCC1)CCO JWWLGAVPWYJCBJ-UHFFFAOYSA-N 0.000 claims 2
XZSDQGMQWFSLJW-UHFFFAOYSA-N 2-(3-cyano-4-ethyl-5-methyl-6-piperazin-1-ylpyridin-2-yl)sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C)N1CCNCC1)SC(C(=O)N)C1=CC=CC=C1 XZSDQGMQWFSLJW-UHFFFAOYSA-N 0.000 claims 2
PTQOINFPPNUTEJ-UHFFFAOYSA-N 2-(4-benzoylphenyl)-2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanylacetamide Chemical compound C(C1=CC=CC=C1)(=O)C1=CC=C(C=C1)C(C(=O)N)SC1=NC(=C(C(=C1C#N)CC)C#N)N1CCN(CCC1)CCO PTQOINFPPNUTEJ-UHFFFAOYSA-N 0.000 claims 2
STOCLPJPNSTUAB-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanylacetamide Chemical compound ClC1=CC=C(C=C1)C(C(=O)N)SC1=NC(=C(C(=C1C#N)CC)C#N)N(C)C STOCLPJPNSTUAB-UHFFFAOYSA-N 0.000 claims 2
BIKGIIMWQRGVJH-UHFFFAOYSA-N 2-[3,5-dichloro-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound ClC=1C(=NC(=C(C=1CC)Cl)N1CCN(CCC1)C)SC(C(=O)N)C1=CC=CC=C1 BIKGIIMWQRGVJH-UHFFFAOYSA-N 0.000 claims 2
RXFPUVXNVRCHKD-UHFFFAOYSA-N 2-[3,5-dichloro-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound ClC=1C(=NC(=C(C=1CC)Cl)N1CCN(CCC1)CCO)SC(C(=O)N)C1=CC=CC=C1 RXFPUVXNVRCHKD-UHFFFAOYSA-N 0.000 claims 2
PAUHBDXOZUTHBS-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCNCCC1)SC(C(=O)N)C1=CC=CC=C1 PAUHBDXOZUTHBS-UHFFFAOYSA-N 0.000 claims 2
WPLNPAJJUPRGNG-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-pyridin-4-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCNCCC1)SC(C(=O)N)C1=CC=NC=C1 WPLNPAJJUPRGNG-UHFFFAOYSA-N 0.000 claims 2
UUOZMGVKHLFJBA-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(1,4-diazepan-1-yl)pyridin-2-yl]sulfanylpropanamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCNCCC1)SC(C(=O)N)C UUOZMGVKHLFJBA-UHFFFAOYSA-N 0.000 claims 2
IYEHEHCKPMJGMI-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(2,6-dimethylmorpholin-4-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(OC(C1)C)C)SC(C(=O)N)C1=CC=CC=C1 IYEHEHCKPMJGMI-UHFFFAOYSA-N 0.000 claims 2
JPVHKFLIWFESRW-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(3-hydroxyazetidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(C1)O)SC(C(=O)N)C1=CC=CC=C1 JPVHKFLIWFESRW-UHFFFAOYSA-N 0.000 claims 2
WZQFJKWYRNLKDK-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(3-hydroxypiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(CCC1)O)SC(C(=O)N)C1=CC=CC=C1 WZQFJKWYRNLKDK-UHFFFAOYSA-N 0.000 claims 2
KSEUXNSAPLLRCN-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(3-hydroxypyrrolidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(CC1)O)SC(C(=O)N)C1=CC=CC=C1 KSEUXNSAPLLRCN-UHFFFAOYSA-N 0.000 claims 2
RKGZAWAZEJZLRD-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(3-methylpiperazin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(NCC1)C)SC(C(=O)N)C1=CC=CC=C1 RKGZAWAZEJZLRD-UHFFFAOYSA-N 0.000 claims 2
GSMZCJKTZVHVCP-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(3-oxopiperazin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(NCC1)=O)SC(C(=O)N)C1=CC=CC=C1 GSMZCJKTZVHVCP-UHFFFAOYSA-N 0.000 claims 2
IPIAHZTYERRXQS-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(4-ethyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCN(CCC1)CC)SC(C(=O)N)C1=CC=CC=C1 IPIAHZTYERRXQS-UHFFFAOYSA-N 0.000 claims 2
IWCAZNGYRSJFIX-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(4-methyl-5-oxo-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCN(C(CC1)=O)C)SC(C(=O)N)C1=CC=CC=C1 IWCAZNGYRSJFIX-UHFFFAOYSA-N 0.000 claims 2
MHUDTXOVWMDNQJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(4-morpholin-4-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCC(CC1)N1CCOCC1)SC(C(=O)N)C1=CC=CC=C1 MHUDTXOVWMDNQJ-UHFFFAOYSA-N 0.000 claims 2
SMKAEMALCGLLMQ-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCC(CC1)N1CCCC1)SC(C(=O)N)C1=CC=CC=C1 SMKAEMALCGLLMQ-UHFFFAOYSA-N 0.000 claims 2
BBCJAXNYDGYRPG-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(5-oxo-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCNC(CC1)=O)SC(C(=O)N)C1=CC=CC=C1 BBCJAXNYDGYRPG-UHFFFAOYSA-N 0.000 claims 2
SQSPRRWZSIZYKO-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(dimethylamino)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N(C)C)SC(C(=O)N)C1=CC=CC=C1 SQSPRRWZSIZYKO-UHFFFAOYSA-N 0.000 claims 2
UEXXHPWRYIUMFR-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-(dimethylamino)pyridin-2-yl]sulfanyl-2-pyridin-4-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N(C)C)SC(C(=O)N)C1=CC=NC=C1 UEXXHPWRYIUMFR-UHFFFAOYSA-N 0.000 claims 2
WZQFJKWYRNLKDK-QRIPLOBPSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[(3R)-3-hydroxypiperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1C[C@@H](CCC1)O)SC(C(=O)N)C1=CC=CC=C1 WZQFJKWYRNLKDK-QRIPLOBPSA-N 0.000 claims 2
WZQFJKWYRNLKDK-DJZRFWRSSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[(3S)-3-hydroxypiperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1C[C@H](CCC1)O)SC(C(=O)N)C1=CC=CC=C1 WZQFJKWYRNLKDK-DJZRFWRSSA-N 0.000 claims 2
SQIPHLMGNXRJAF-PIVQAISJSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-pyridin-4-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1C[C@H](CC1)O)SC(C(=O)N)C1=CC=NC=C1 SQIPHLMGNXRJAF-PIVQAISJSA-N 0.000 claims 2
JJLWDWRURXASKJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[2-hydroxyethyl(methyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N(C)CCO)SC(C(=O)N)C1=CC=CC=C1 JJLWDWRURXASKJ-UHFFFAOYSA-N 0.000 claims 2
VRKPCWYOSROMON-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[3-(hydroxymethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(NCC1)CO)SC(C(=O)N)C1=CC=CC=C1 VRKPCWYOSROMON-UHFFFAOYSA-N 0.000 claims 2
MTKDQKSITHIDHV-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[3-(methylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CC(CCC1)NC)SC(C(=O)N)C1=CC=CC=C1 MTKDQKSITHIDHV-UHFFFAOYSA-N 0.000 claims 2
UIELGJHJGGLZRH-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[4-(2-hydroxyethylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCC(CC1)NCCO)SC(C(=O)N)C1=CC=CC=C1 UIELGJHJGGLZRH-UHFFFAOYSA-N 0.000 claims 2
KNBHJJWOMHZEDQ-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCC(CC1)N1CCN(CC1)C)SC(C(=O)N)C1=CC=CC=C1 KNBHJJWOMHZEDQ-UHFFFAOYSA-N 0.000 claims 2
DQOICBVYYITCQG-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCC(CC1)N(C)C)SC(C(=O)N)C1=CC=CC=C1 DQOICBVYYITCQG-UHFFFAOYSA-N 0.000 claims 2
KGRZKCREFYCZIS-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCC(CC1)CN1CCCC1)SC(C(=O)N)C1=CC=CC=C1 KGRZKCREFYCZIS-UHFFFAOYSA-N 0.000 claims 2
FTKCQZIZGOMSAJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N1CCC(CC1)CN1CCN(CC1)C)SC(C(=O)N)C1=CC=CC=C1 FTKCQZIZGOMSAJ-UHFFFAOYSA-N 0.000 claims 2
GPDJMEHJOIYQIE-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[[2-(1,3-dihydroxypropan-2-ylamino)-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NC(CO)CO)C)C#N)C1CC1)C#N)=O GPDJMEHJOIYQIE-UHFFFAOYSA-N 0.000 claims 2
WYWXZWWQTUQOHY-UHFFFAOYSA-N 2-[3,5-dicyano-4-cyclopropyl-6-[[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1C1CC1)C#N)N(C)CC(=O)N1CC(C1)O)SC(C(=O)N)C1=CC=CC=C1 WYWXZWWQTUQOHY-UHFFFAOYSA-N 0.000 claims 2
LLVIJRJBWSAQNJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethoxy-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1OCC)C#N)N1CCN(CCC1)CCO)SC(C(=O)N)C1=CC=CC=C1 LLVIJRJBWSAQNJ-UHFFFAOYSA-N 0.000 claims 2
ORMVGEMLQLEGQS-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethoxy-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanylpropanamide Chemical compound C(#N)C=1C(=NC(=C(C=1OCC)C#N)N1CCN(CCC1)CCO)SC(C(=O)N)C ORMVGEMLQLEGQS-UHFFFAOYSA-N 0.000 claims 2
MPBQEERZVDUNNN-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(1-oxa-7-azaspiro[3.4]octan-7-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC2(CCO2)CC1)SC(C(=O)N)C1=CC=CC=C1 MPBQEERZVDUNNN-UHFFFAOYSA-N 0.000 claims 2
PRTNICOWHDVOMU-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC2=C(CC1)NN=N2)SC(C(=O)N)C1=CC=CC=C1 PRTNICOWHDVOMU-UHFFFAOYSA-N 0.000 claims 2
GJXGSRAPRAPLIX-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(2-methyl-2,8-diazaspiro[4.5]decan-8-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC2(CCN(C2)C)CC1)SC(C(=O)N)C1=CC=CC=C1 GJXGSRAPRAPLIX-UHFFFAOYSA-N 0.000 claims 2
DPLBLXGKZFRVOF-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(2-methyl-2,9-diazaspiro[5.5]undecan-9-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC2(CCCN(C2)C)CC1)SC(C(=O)N)C1=CC=CC=C1 DPLBLXGKZFRVOF-UHFFFAOYSA-N 0.000 claims 2
LCVVLDODJWARPO-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(2-morpholin-4-ylethylsulfanyl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)SCCN1CCOCC1)SC(C(=O)N)C1=CC=CC=C1 LCVVLDODJWARPO-UHFFFAOYSA-N 0.000 claims 2
KXVNYMOJYHKQRG-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(2-oxa-7-azaspiro[3.4]octan-7-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC2(COC2)CC1)SC(C(=O)N)C1=CC=CC=C1 KXVNYMOJYHKQRG-UHFFFAOYSA-N 0.000 claims 2
OUSMOLFOVYHQSJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC2(CNC(O2)=O)CC1)SC(C(=O)N)C1=CC=CC=C1 OUSMOLFOVYHQSJ-UHFFFAOYSA-N 0.000 claims 2
FFMZQDFWORDQBK-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(2-oxo-3-oxa-1,8-diazaspiro[4.5]decan-8-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC2(COC(N2)=O)CC1)SC(C(=O)N)C1=CC=CC=C1 FFMZQDFWORDQBK-UHFFFAOYSA-N 0.000 claims 2
UVYKEQNHOAEAFR-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(3-hydroxyazetidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(C1)O)SC(C(=O)N)C1=CC=CC=C1 UVYKEQNHOAEAFR-UHFFFAOYSA-N 0.000 claims 2
JXAUMWOTJFLYOC-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(3-methoxyazetidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(C1)OC)SC(C(=O)N)C1=CC=CC=C1 JXAUMWOTJFLYOC-UHFFFAOYSA-N 0.000 claims 2
MLKKPDGYCFASPL-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(3-oxopiperazin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(NCC1)=O)SC(C(=O)N)C1=CC=CC=C1 MLKKPDGYCFASPL-UHFFFAOYSA-N 0.000 claims 2
AVLOZCTUBSLSSQ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-ethyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CC)SC(C(=O)N)C1=CC=CC=C1 AVLOZCTUBSLSSQ-UHFFFAOYSA-N 0.000 claims 2
AAPJDNZBMDEKFD-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-ethylpiperazin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC)SC(C(=O)N)C1=CC=CC=C1 AAPJDNZBMDEKFD-UHFFFAOYSA-N 0.000 claims 2
MZWZOPMPMLVLSG-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-hydroxypiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)O)SC(C(=O)N)C1=CC=CC=C1 MZWZOPMPMLVLSG-UHFFFAOYSA-N 0.000 claims 2
INRBWUZLUYKOMW-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-imidazol-1-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1(C=NC=C1)C1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N INRBWUZLUYKOMW-UHFFFAOYSA-N 0.000 claims 2
CJPHXICXEMPGBK-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-(2,5-difluoropyridin-4-yl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)C)SC(C(=O)N)C1=CC(=NC=C1F)F CJPHXICXEMPGBK-UHFFFAOYSA-N 0.000 claims 2
ITJZKPALGDQSHW-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-(3-pyrrolidin-1-ylphenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)C)SC(C(=O)N)C1=CC(=CC=C1)N1CCCC1 ITJZKPALGDQSHW-UHFFFAOYSA-N 0.000 claims 2
FNVUXBZITHSRAB-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-[3-(trifluoromethyl)phenyl]acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)C)SC(C(=O)N)C1=CC(=CC=C1)C(F)(F)F FNVUXBZITHSRAB-UHFFFAOYSA-N 0.000 claims 2
OGKOHDZLDNFFAB-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-[4-(trifluoromethyl)phenyl]acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)C)SC(C(=O)N)C1=CC=C(C=C1)C(F)(F)F OGKOHDZLDNFFAB-UHFFFAOYSA-N 0.000 claims 2
XRKVILGXGOHWOA-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-methyl-3-oxopiperazin-1-yl)pyridin-2-yl]sulfanyl-2-pyridin-4-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(N(CC1)C)=O)SC(C(=O)N)C1=CC=NC=C1 XRKVILGXGOHWOA-UHFFFAOYSA-N 0.000 claims 2
AWDGEAGAQJZCNC-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-methyl-5-oxo-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(C(CC1)=O)C)SC(C(=O)N)C1=CC=CC=C1 AWDGEAGAQJZCNC-UHFFFAOYSA-N 0.000 claims 2
WHHWWBOLJJWTFW-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-morpholin-4-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1CCOCC1)SC(C(=O)N)C1=CC=CC=C1 WHHWWBOLJJWTFW-UHFFFAOYSA-N 0.000 claims 2
ZSYCORUQBBRZST-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-oxopiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)=O)SC(C(=O)N)C1=CC=CC=C1 ZSYCORUQBBRZST-UHFFFAOYSA-N 0.000 claims 2
SHZQMUGRDNKXPI-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-piperidin-4-ylpiperazin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)C1CCNCC1)SC(C(=O)N)C1=CC=CC=C1 SHZQMUGRDNKXPI-UHFFFAOYSA-N 0.000 claims 2
SBQYYTLFKRYESN-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-piperidin-4-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1(CCC(CC1)C1CCNCC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N SBQYYTLFKRYESN-UHFFFAOYSA-N 0.000 claims 2
ADKADAJBRJLLDR-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-propyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CCC)SC(C(=O)N)C1=CC=CC=C1 ADKADAJBRJLLDR-UHFFFAOYSA-N 0.000 claims 2
BXSOWNMNUBXYQU-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-propylpiperazin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CCC)SC(C(=O)N)C1=CC=CC=C1 BXSOWNMNUBXYQU-UHFFFAOYSA-N 0.000 claims 2
XYFVYDXBONPTKL-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-propylsulfonylpiperazin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)S(=O)(=O)CCC)SC(C(=O)N)C1=CC=CC=C1 XYFVYDXBONPTKL-UHFFFAOYSA-N 0.000 claims 2
HRPNGMXDWIEOMY-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1CCCC1)SC(C(=O)N)C1=CC=C(C=C1)F HRPNGMXDWIEOMY-UHFFFAOYSA-N 0.000 claims 2
XBGYNCRALWAEIG-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1CCCC1)SC(C(=O)N)C1=CC=CC=C1 XBGYNCRALWAEIG-UHFFFAOYSA-N 0.000 claims 2
MSLAJOMOZIQQLT-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(4-pyrrolidin-3-ylpiperidin-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)C1CNCC1)SC(C(=O)N)C1=CC=CC=C1 MSLAJOMOZIQQLT-UHFFFAOYSA-N 0.000 claims 2
NKZHWEUPJPIVQG-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(5-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCNC(CC1)C)SC(C(=O)N)C1=CC=CC=C1 NKZHWEUPJPIVQG-UHFFFAOYSA-N 0.000 claims 2
OTYYPWVAZKWPHH-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C2CN(C(C1)C2)C)SC(C(=O)N)C1=CC=CC=C1 OTYYPWVAZKWPHH-UHFFFAOYSA-N 0.000 claims 2
DYRMDGWLQARAHJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(5-oxo-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCNC(CC1)=O)SC(C(=O)N)C1=CC=CC=C1 DYRMDGWLQARAHJ-UHFFFAOYSA-N 0.000 claims 2
LEXIGEPZZLZYMJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-(6-fluoro-1,4-diazepan-1-yl)pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCNCC(C1)F)SC(C(=O)N)C1=CC=CC=C1 LEXIGEPZZLZYMJ-UHFFFAOYSA-N 0.000 claims 2
KYCSIHTYWHWBLQ-QRIPLOBPSA-N 2-[3,5-dicyano-4-ethyl-6-[(3R)-3-(methylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H](CCC1)NC)SC(C(=O)N)C1=CC=CC=C1 KYCSIHTYWHWBLQ-QRIPLOBPSA-N 0.000 claims 2
KYCSIHTYWHWBLQ-DJZRFWRSSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-(methylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CCC1)NC)SC(C(=O)N)C1=CC=CC=C1 KYCSIHTYWHWBLQ-DJZRFWRSSA-N 0.000 claims 2
KUCBWFLVTKEBHS-LBOXEOMUSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-(oxetan-3-ylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CCC1)NC1COC1)SC(C(=O)N)C1=CC=CC=C1 KUCBWFLVTKEBHS-LBOXEOMUSA-N 0.000 claims 2
YPBGXKXOWKRFMU-PBVYKCSPSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-[(2-hydroxy-2-methylpropyl)amino]pyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)NCC(C)(C)O)SC(C(=O)N)C1=CC=CC=C1 YPBGXKXOWKRFMU-PBVYKCSPSA-N 0.000 claims 2
FXMCLLNYHJNMHU-FAQQKDIKSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-(2,3-difluorophenyl)acetamide Chemical compound CCC1=C(C#N)C(SC(C(N)=O)C2=C(F)C(F)=CC=C2)=NC(N2CC[C@H](O)C2)=C1C#N FXMCLLNYHJNMHU-FAQQKDIKSA-N 0.000 claims 2
LACBFVVSYQHECW-RSXQAXDFSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-(2,4-difluorophenyl)acetamide Chemical compound CCC1=C(C#N)C(SC(C(N)=O)C2=C(F)C=C(F)C=C2)=NC(N2CC[C@H](O)C2)=C1C#N LACBFVVSYQHECW-RSXQAXDFSA-N 0.000 claims 2
AJRSRLUTGVVUQN-FAQQKDIKSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-(2,6-difluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)SC(C(=O)N)C1=C(C=CC=C1F)F AJRSRLUTGVVUQN-FAQQKDIKSA-N 0.000 claims 2
SGKXYWJWSIWWEY-RSXQAXDFSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-(2-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)SC(C(=O)N)C1=C(C=CC=C1)F SGKXYWJWSIWWEY-RSXQAXDFSA-N 0.000 claims 2
OGVQOTBFEPJZRB-OOJLDXBWSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-(3-dimethylphosphorylphenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)SC(C(=O)N)C1=CC(=CC=C1)P(=O)(C)C OGVQOTBFEPJZRB-OOJLDXBWSA-N 0.000 claims 2
HLAISKDDYRGCNF-PIVQAISJSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound CCC1=C(C#N)C(SC(C(N)=O)C2=CC=C(F)C=C2)=NC(N2CC[C@H](O)C2)=C1C#N HLAISKDDYRGCNF-PIVQAISJSA-N 0.000 claims 2
ZLNMIQXSXVLFRG-WHUIICBVSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-pyridin-2-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)SC(C(=O)N)C1=NC=CC=C1 ZLNMIQXSXVLFRG-WHUIICBVSA-N 0.000 claims 2
IVLHXSIQOYWYEZ-CWQZNGJJSA-N 2-[3,5-dicyano-4-ethyl-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-pyridin-3-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)O)SC(C(=O)N)C=1C=NC=CC=1 IVLHXSIQOYWYEZ-CWQZNGJJSA-N 0.000 claims 2
BZTZVKGCRZLLBX-CWQZNGJJSA-N 2-[3,5-dicyano-4-ethyl-6-[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1OC[C@H](C1)O)SC(C(=O)N)C1=CC=CC=C1 BZTZVKGCRZLLBX-CWQZNGJJSA-N 0.000 claims 2
BINSAYRDVGYJAZ-DCFJUCRTSA-N 2-[3,5-dicyano-4-ethyl-6-[(5S,6S)-6-hydroxy-1-methylsulfonyl-1,8-diazaspiro[4.5]decan-8-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H]([C@]2(CCCN2S(=O)(=O)C)CC1)O)SC(C(=O)N)C1=CC=CC=C1 BINSAYRDVGYJAZ-DCFJUCRTSA-N 0.000 claims 2
XXLDDFUGJHQDRO-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[1H-imidazol-2-ylmethyl(methyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1C(=NC=C1)CN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C XXLDDFUGJHQDRO-UHFFFAOYSA-N 0.000 claims 2
AEGNVXPUMDPJDQ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[1H-imidazol-5-ylmethyl(methyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1C=NC=C1CN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C AEGNVXPUMDPJDQ-UHFFFAOYSA-N 0.000 claims 2
JSOIARXDGFXKJJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[2-(2-fluoroethylamino)ethyl-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCNCCF)SC(C(=O)N)C1=CC=CC=C1 JSOIARXDGFXKJJ-UHFFFAOYSA-N 0.000 claims 2
CFWYACPXXZHDAI-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[2-(2-methoxyethylamino)ethyl-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCNCCOC)SC(C(=O)N)C1=CC=CC=C1 CFWYACPXXZHDAI-UHFFFAOYSA-N 0.000 claims 2
TVKFTXSUHZNTFK-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[2-(ethylamino)ethyl-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCNCC)SC(C(=O)N)C1=CC=CC=C1 TVKFTXSUHZNTFK-UHFFFAOYSA-N 0.000 claims 2
GKIMTORUWNIQRW-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[2-(methylaminomethyl)morpholin-4-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(OCC1)CNC)SC(C(=O)N)C1=CC=CC=C1 GKIMTORUWNIQRW-UHFFFAOYSA-N 0.000 claims 2
GWIYLVSLHAAZEW-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[2-(pyrrolidin-1-ylmethyl)morpholin-4-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(OCC1)CN1CCCC1)SC(C(=O)N)C1=CC=CC=C1 GWIYLVSLHAAZEW-UHFFFAOYSA-N 0.000 claims 2
LBMSTGPCJAOOAZ-ZZWBGTBQSA-N 2-[3,5-dicyano-4-ethyl-6-[2-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN1[C@H](CCC1)CO)SC(C(=O)N)C1=CC=CC=C1 LBMSTGPCJAOOAZ-ZZWBGTBQSA-N 0.000 claims 2
LBMSTGPCJAOOAZ-HXBUSHRASA-N 2-[3,5-dicyano-4-ethyl-6-[2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN1[C@@H](CCC1)CO)SC(C(=O)N)C1=CC=CC=C1 LBMSTGPCJAOOAZ-HXBUSHRASA-N 0.000 claims 2
ZIGAZNXZOLPFOS-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[2-[ethyl(methyl)amino]ethyl-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN(C)CC)SC(C(=O)N)C1=CC=CC=C1 ZIGAZNXZOLPFOS-UHFFFAOYSA-N 0.000 claims 2
XOYGSTAJAGOUHB-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[2-hydroxyethyl(methyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCO)SC(C(=O)N)C1=CC=CC=C1 XOYGSTAJAGOUHB-UHFFFAOYSA-N 0.000 claims 2
WUIIBRJZPQPKLB-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[2-methoxyethyl(methyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCOC)SC(C(=O)N)C1=CC=CC=C1 WUIIBRJZPQPKLB-UHFFFAOYSA-N 0.000 claims 2
HIQJFAUXGXYIDL-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[3-(hydroxymethyl)azetidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(C1)CO)SC(C(=O)N)C1=CC=CC=C1 HIQJFAUXGXYIDL-UHFFFAOYSA-N 0.000 claims 2
TXXSJMRWNWLMIM-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[3-(methylamino)pyrrolidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(CC1)NC)SC(C(=O)N)C1=CC=CC=C1 TXXSJMRWNWLMIM-UHFFFAOYSA-N 0.000 claims 2
NJVYJNIZUSABLP-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[3-(methylaminomethyl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(CCC1)CNC)SC(C(=O)N)C1=CC=CC=C1 NJVYJNIZUSABLP-UHFFFAOYSA-N 0.000 claims 2
XHHMGEACDFDLES-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[3-[(2-hydroxyacetyl)amino]azetidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N1CC(C1)NC(CO)=O)C#N)CC)C#N)=O XHHMGEACDFDLES-UHFFFAOYSA-N 0.000 claims 2
QPEAFCKDCCOTNE-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[3-fluoro-4-(methylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(C(CC1)NC)F)SC(C(=O)N)C1=CC=CC=C1 QPEAFCKDCCOTNE-UHFFFAOYSA-N 0.000 claims 2
KIZVFGMDTAUJBR-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1,2-oxazol-3-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC1=NOC=C1)SC(C(=O)N)C1=CC=CC=C1 KIZVFGMDTAUJBR-UHFFFAOYSA-N 0.000 claims 2
RPQOZEOVRRPDEL-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1,2-oxazol-4-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC=1C=NOC=1)SC(C(=O)N)C1=CC=CC=C1 RPQOZEOVRRPDEL-UHFFFAOYSA-N 0.000 claims 2
RKZBTUCLUHINBO-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1,2-thiazol-4-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC=1C=NSC=1)SC(C(=O)N)C1=CC=CC=C1 RKZBTUCLUHINBO-UHFFFAOYSA-N 0.000 claims 2
IQOASBFTNDTNSC-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1,3-oxazol-2-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC=1OC=CN=1)SC(C(=O)N)C1=CC=CC=C1 IQOASBFTNDTNSC-UHFFFAOYSA-N 0.000 claims 2
DSAZSJIGPVLSCJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1,3-oxazol-5-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC1=CN=CO1)SC(C(=O)N)C1=CC=CC=C1 DSAZSJIGPVLSCJ-UHFFFAOYSA-N 0.000 claims 2
PMIYBZXAPUTCHR-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1,3-thiazol-5-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC1=CN=CS1)SC(C(=O)N)C1=CC=CC=C1 PMIYBZXAPUTCHR-UHFFFAOYSA-N 0.000 claims 2
RNDSFIUHOPIRNK-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1-hydroxy-2-methylpropan-2-yl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)C(CO)(C)C)SC(C(=O)N)C1=CC=C(C=C1)F RNDSFIUHOPIRNK-UHFFFAOYSA-N 0.000 claims 2
XTVNNJYGSVPNGZ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1-hydroxy-2-methylpropan-2-yl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)C(CO)(C)C)SC(C(=O)N)C1=CC=CC=C1 XTVNNJYGSVPNGZ-UHFFFAOYSA-N 0.000 claims 2
BTKQIZKHKDPADB-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1H-imidazol-2-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1C(=NC=C1)CN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N BTKQIZKHKDPADB-UHFFFAOYSA-N 0.000 claims 2
OMVYNAREKXDGRR-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1H-imidazol-5-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1C=NC=C1CN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N OMVYNAREKXDGRR-UHFFFAOYSA-N 0.000 claims 2
GFFDCWJMRYYKPH-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1H-pyrazol-4-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1N=CC(=C1)CN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N GFFDCWJMRYYKPH-UHFFFAOYSA-N 0.000 claims 2
CLTWRYNIRGEYRE-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1H-pyrrol-2-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1C(=CC=C1)CN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N CLTWRYNIRGEYRE-UHFFFAOYSA-N 0.000 claims 2
PEBIUNFFJUYUEC-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(1H-pyrrol-3-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1C=C(C=C1)CN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N PEBIUNFFJUYUEC-UHFFFAOYSA-N 0.000 claims 2
XHCSPVVTYDYEFH-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxy-2-methylpropyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CC(C)(C)O)SC(C(=O)N)C1=CC=CC=C1 XHCSPVVTYDYEFH-UHFFFAOYSA-N 0.000 claims 2
QXYIXZOLKPEBJL-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethoxy)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)OCCO)SC(C(=O)N)C1=CC=CC=C1 QXYIXZOLKPEBJL-UHFFFAOYSA-N 0.000 claims 2
IHXXDZHXEBKTKE-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CCO)SC(C(=O)N)C1=CC=CC=C1 IHXXDZHXEBKTKE-UHFFFAOYSA-N 0.000 claims 2
HBKDLBCIDCHZSV-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-3-oxopiperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(N(CC1)CCO)=O)SC(C(=O)N)C1=CC=CC=C1 HBKDLBCIDCHZSV-UHFFFAOYSA-N 0.000 claims 2
DHHQTWDRYOCVNT-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CCO)SC(C(=O)N)C1=CC=CC=C1 DHHQTWDRYOCVNT-UHFFFAOYSA-N 0.000 claims 2
BFMFJWREJHGPKE-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethylamino)-4-(hydroxymethyl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)(CO)NCCO)SC(C(=O)N)C1=CC=CC=C1 BFMFJWREJHGPKE-UHFFFAOYSA-N 0.000 claims 2
NTPKLKPQZNOIJT-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-hydroxypropyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CC(C)O)SC(C(=O)N)C1=CC=CC=C1 NTPKLKPQZNOIJT-UHFFFAOYSA-N 0.000 claims 2
OQLDOBSEBOWDCU-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-methoxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CCC1)CCOC)SC(C(=O)N)C1=CC=CC=C1 OQLDOBSEBOWDCU-UHFFFAOYSA-N 0.000 claims 2
XICDBICWYVZRIF-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-methoxyethylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCCOC)SC(C(=O)N)C1=CC=CC=C1 XICDBICWYVZRIF-UHFFFAOYSA-N 0.000 claims 2
SEKRLNNIWWYPDC-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-oxoimidazolidin-1-yl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1C(NCC1)=O)SC(C(=O)N)C1=CC=CC=C1 SEKRLNNIWWYPDC-UHFFFAOYSA-N 0.000 claims 2
XVIJFPOMYTUTOS-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CCN1CCCC1)SC(C(=O)N)C1=CC=CC=C1 XVIJFPOMYTUTOS-UHFFFAOYSA-N 0.000 claims 2
HMMVROADJJIGTL-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(3-methoxyazetidin-1-yl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1CC(C1)OC)SC(C(=O)N)C1=CC=C(C=C1)F HMMVROADJJIGTL-UHFFFAOYSA-N 0.000 claims 2
FHNBIFLOYRQNAW-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(3-methoxyazetidin-1-yl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1CC(C1)OC)SC(C(=O)N)C1=CC=CC=C1 FHNBIFLOYRQNAW-UHFFFAOYSA-N 0.000 claims 2
ZZGFAGXPUQJHON-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1CCN(CC1)C)SC(C(=O)N)C1=CC=CC=C1 ZZGFAGXPUQJHON-UHFFFAOYSA-N 0.000 claims 2
ZYLLCQFEFGXLIG-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(furan-3-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC1=COC=C1)SC(C(=O)N)C1=CC=CC=C1 ZYLLCQFEFGXLIG-UHFFFAOYSA-N 0.000 claims 2
KBKLXIFMIVJIII-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(methylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NC)SC(C(=O)N)C1=CC=C(C=C1)F KBKLXIFMIVJIII-UHFFFAOYSA-N 0.000 claims 2
UFTKGXPMSNOOTN-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(methylamino)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NC)SC(C(=O)N)C1=CC=CC=C1 UFTKGXPMSNOOTN-UHFFFAOYSA-N 0.000 claims 2
GBWTUGZWJNAVLE-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(oxetan-3-yloxy)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)OC1COC1)SC(C(=O)N)C1=CC=CC=C1 GBWTUGZWJNAVLE-UHFFFAOYSA-N 0.000 claims 2
HOIWOTUORCYCGG-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(pyridin-4-ylmethyl)piperazin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CC1=CC=NC=C1)SC(C(=O)N)C1=CC=CC=C1 HOIWOTUORCYCGG-UHFFFAOYSA-N 0.000 claims 2
XXDQNQJEPNVGBO-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)CN1CCCC1)SC(C(=O)N)C1=CC=CC=C1 XXDQNQJEPNVGBO-UHFFFAOYSA-N 0.000 claims 2
IVDBFJXQDPWQRW-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(2-hydroxy-2-methylpropyl)-methylamino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)CC(C)(C)O)SC(C(=O)N)C1=CC=CC=C1 IVDBFJXQDPWQRW-UHFFFAOYSA-N 0.000 claims 2
SCMIHGKFSROBLR-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(2-hydroxy-2-methylpropyl)amino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCC(C)(C)O)SC(C(=O)N)C1=CC=C(C=C1)F SCMIHGKFSROBLR-UHFFFAOYSA-N 0.000 claims 2
YMKSTCPMALFTRO-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(2-hydroxyacetyl)amino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N1CCC(CC1)NC(CO)=O)C#N)CC)C#N)=O YMKSTCPMALFTRO-UHFFFAOYSA-N 0.000 claims 2
AQAGUJBKESAHAB-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(2-methoxy-2-methylpropyl)-methylamino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)CC(C)(C)OC)SC(C(=O)N)C1=CC=CC=C1 AQAGUJBKESAHAB-UHFFFAOYSA-N 0.000 claims 2
MTIHTGQEJCRVHD-CGHJUBPDSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1[C@H](CCC1)CO)SC(C(=O)N)C1=CC=CC=C1 MTIHTGQEJCRVHD-CGHJUBPDSA-N 0.000 claims 2
UEARZJBSXHFNRJ-QFADGXAASA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(2R)-2-methylpyrrolidin-1-yl]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1[C@@H](CCC1)C)SC(C(=O)N)C1=CC=CC=C1 UEARZJBSXHFNRJ-QFADGXAASA-N 0.000 claims 2
MTIHTGQEJCRVHD-QHELBMECSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1[C@@H](CCC1)CO)SC(C(=O)N)C1=CC=CC=C1 MTIHTGQEJCRVHD-QHELBMECSA-N 0.000 claims 2
UEARZJBSXHFNRJ-VEXWJQHLSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(2S)-2-methylpyrrolidin-1-yl]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1[C@H](CCC1)C)SC(C(=O)N)C1=CC=CC=C1 UEARZJBSXHFNRJ-VEXWJQHLSA-N 0.000 claims 2
IEGUDBMUKZBOIA-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(3-methyloxetan-3-yl)methylamino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCC1(COC1)C)SC(C(=O)N)C1=CC=CC=C1 IEGUDBMUKZBOIA-UHFFFAOYSA-N 0.000 claims 2
UPIDRZFDVJKDAR-FKSKYRLFSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(3R)-3-fluoropyrrolidin-1-yl]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1C[C@@H](CC1)F)SC(C(=O)N)C1=CC=CC=C1 UPIDRZFDVJKDAR-FKSKYRLFSA-N 0.000 claims 2
UPIDRZFDVJKDAR-XNUZUHMRSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(3S)-3-fluoropyrrolidin-1-yl]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1C[C@H](CC1)F)SC(C(=O)N)C1=CC=CC=C1 UPIDRZFDVJKDAR-XNUZUHMRSA-N 0.000 claims 2
IQPDOUJLTIQQNF-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(4-fluorophenyl)methylamino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCC1=CC=C(C=C1)F)SC(C(=O)N)C1=CC=CC=C1 IQPDOUJLTIQQNF-UHFFFAOYSA-N 0.000 claims 2
NIWGXXSRIJYYQK-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(6-methoxypyridin-2-yl)methylamino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCC1=NC(=CC=C1)OC)SC(C(=O)N)C1=CC=CC=C1 NIWGXXSRIJYYQK-UHFFFAOYSA-N 0.000 claims 2
JZLXWXHKODYZML-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[(6-methoxypyridin-3-yl)methylamino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCC=1C=NC(=CC=1)OC)SC(C(=O)N)C1=CC=CC=C1 JZLXWXHKODYZML-UHFFFAOYSA-N 0.000 claims 2
RKMJIGDAMDXJMQ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[1-(2-hydroxyethyl)piperidin-4-yl]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)C1CCN(CC1)CCO)SC(C(=O)N)C1=CC=CC=C1 RKMJIGDAMDXJMQ-UHFFFAOYSA-N 0.000 claims 2
SZJGIJPYCAHINT-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[2-hydroxyethyl(methyl)amino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)CCO)SC(C(=O)N)C1=CC=CC=C1 SZJGIJPYCAHINT-UHFFFAOYSA-N 0.000 claims 2
MZUYDNIDARRTKI-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-[ethyl(methyl)amino]piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)CC)SC(C(=O)N)C1=CC=CC=C1 MZUYDNIDARRTKI-UHFFFAOYSA-N 0.000 claims 2
XZKAHJSGNPZLNY-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[4-hydroxy-4-(hydroxymethyl)piperidin-1-yl]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)(CO)O)SC(C(=O)N)C1=CC=CC=C1 XZKAHJSGNPZLNY-UHFFFAOYSA-N 0.000 claims 2
YVMIQLHNHFIPJM-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-(2-hydroxyethylamino)-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NCCO)C)C#N)CC)C#N)=O YVMIQLHNHFIPJM-UHFFFAOYSA-N 0.000 claims 2
CSFVKQAXFPKGMN-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1CC(C1)O)SC(C(=O)N)C1=CC=CC=C1 CSFVKQAXFPKGMN-UHFFFAOYSA-N 0.000 claims 2
FHUNQIPUXZVGHZ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-(3-hydroxypropylamino)-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NCCCO)C)C#N)CC)C#N)=O FHUNQIPUXZVGHZ-UHFFFAOYSA-N 0.000 claims 2
PHJQREKPOYTERI-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-(4-hydroxypiperidin-1-yl)-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1CCC(CC1)O)SC(C(=O)N)C1=CC=CC=C1 PHJQREKPOYTERI-UHFFFAOYSA-N 0.000 claims 2
MMXJOQNWUOEIHO-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-(hydroxyamino)-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NO)C)C#N)CC)C#N)=O MMXJOQNWUOEIHO-UHFFFAOYSA-N 0.000 claims 2
DOEGYPGFKNQPFF-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-(methoxyamino)-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NOC)C)C#N)CC)C#N)=O DOEGYPGFKNQPFF-UHFFFAOYSA-N 0.000 claims 2
ZIAOVEGAKJALAA-PLEWWHCXSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(2R)-2-(hydroxymethyl)morpholin-4-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@@H](OCC1)CO)SC(C(=O)N)C1=CC=CC=C1 ZIAOVEGAKJALAA-PLEWWHCXSA-N 0.000 claims 2
ZIAOVEGAKJALAA-LBOXEOMUSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@H](OCC1)CO)SC(C(=O)N)C1=CC=CC=C1 ZIAOVEGAKJALAA-LBOXEOMUSA-N 0.000 claims 2
ZAPHVOWJURLYDS-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3-hydroxy-2,2-dimethylpropyl)-methylamino]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)N(C)CC(CO)(C)C)C)C#N)CC)C#N)=O ZAPHVOWJURLYDS-UHFFFAOYSA-N 0.000 claims 2
SXIDJQRZNJGGHF-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3-hydroxy-2,2-dimethylpropyl)amino]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NCC(CO)(C)C)C)C#N)CC)C#N)=O SXIDJQRZNJGGHF-UHFFFAOYSA-N 0.000 claims 2
DXRYEUXKCNACDD-XESZBRCGSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3R)-3-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@@H](CC1)CO)SC(C(=O)N)C1=CC=CC=C1 DXRYEUXKCNACDD-XESZBRCGSA-N 0.000 claims 2
FWMQSCDFVUDXPV-UJONTBEJSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3R)-3-hydroxypyrrolidin-1-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@@H](CC1)O)SC(C(=O)N)C1=CC=CC=C1 FWMQSCDFVUDXPV-UJONTBEJSA-N 0.000 claims 2
SYVCBYSQKVUBDF-FLWMDHGKSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@@H]([C@H](C1)CO)O)SC(C(=O)N)C1=CC=CC=C1 SYVCBYSQKVUBDF-FLWMDHGKSA-N 0.000 claims 2
SYVCBYSQKVUBDF-MZRGNRRKSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3R,4S)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@@H]([C@@H](C1)CO)O)SC(C(=O)N)C1=CC=CC=C1 SYVCBYSQKVUBDF-MZRGNRRKSA-N 0.000 claims 2
DXRYEUXKCNACDD-CISYCMJJSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@H](CC1)CO)SC(C(=O)N)C1=CC=CC=C1 DXRYEUXKCNACDD-CISYCMJJSA-N 0.000 claims 2
FWMQSCDFVUDXPV-BJQOMGFOSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3S)-3-hydroxypyrrolidin-1-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@H](CC1)O)SC(C(=O)N)C1=CC=CC=C1 FWMQSCDFVUDXPV-BJQOMGFOSA-N 0.000 claims 2
SYVCBYSQKVUBDF-LMYOSFIVSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[(3S,4S)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@H]([C@@H](C1)CO)O)SC(C(=O)N)C1=CC=CC=C1 SYVCBYSQKVUBDF-LMYOSFIVSA-N 0.000 claims 2
REKRNEBMFQNOPB-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[2-hydroxyethyl(methyl)amino]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)N(C)CCO)C)C#N)CC)C#N)=O REKRNEBMFQNOPB-UHFFFAOYSA-N 0.000 claims 2
RPHPDPXBKSZFBC-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[3-hydroxypropyl(methyl)amino]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)N(C)CCCO)C)C#N)CC)C#N)=O RPHPDPXBKSZFBC-UHFFFAOYSA-N 0.000 claims 2
KXCSCVBNPHMMHE-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[[1-(hydroxymethyl)cyclopropyl]methyl-methylamino]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)N(C)CC1(CC1)CO)C)C#N)CC)C#N)=O KXCSCVBNPHMMHE-UHFFFAOYSA-N 0.000 claims 2
WAVPTLOLGBOKPG-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[[1-(hydroxymethyl)cyclopropyl]methylamino]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NCC1(CC1)CO)C)C#N)CC)C#N)=O WAVPTLOLGBOKPG-UHFFFAOYSA-N 0.000 claims 2
VLTAETQBPNTGJB-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[[2-[[3-(hydroxymethyl)oxetan-3-yl]amino]-2-oxoethyl]-methylamino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NC1(COC1)CO)C)C#N)CC)C#N)=O VLTAETQBPNTGJB-UHFFFAOYSA-N 0.000 claims 2
PXDGHDPYXXCUOJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl(1H-1,2,4-triazol-5-ylmethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N=1N=C(NC=1)CN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C PXDGHDPYXXCUOJ-UHFFFAOYSA-N 0.000 claims 2
XAGXVCSOGVMAKK-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl(1H-pyrazol-5-ylmethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1N=C(C=C1)CN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C XAGXVCSOGVMAKK-UHFFFAOYSA-N 0.000 claims 2
QWCYDTNDPXJDQJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl(2-morpholin-4-ylethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCN1CCOCC1)C)SC(C(=O)N)C1=CC=CC=C1 QWCYDTNDPXJDQJ-UHFFFAOYSA-N 0.000 claims 2
YOLKANZDCJBWCN-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl(2-piperazin-1-ylethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCN1CCNCC1)C)SC(C(=O)N)C1=CC=CC=C1 YOLKANZDCJBWCN-UHFFFAOYSA-N 0.000 claims 2
WSRKQFVILNOYDU-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl(2-piperidin-1-ylethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCN1CCCCC1)C)SC(C(=O)N)C1=CC=CC=C1 WSRKQFVILNOYDU-UHFFFAOYSA-N 0.000 claims 2
JRVWPOXQXJNLHI-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl(2-pyrrolidin-1-ylethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCN1CCCC1)C)SC(C(=O)N)C1=CC=CC=C1 JRVWPOXQXJNLHI-UHFFFAOYSA-N 0.000 claims 2
BXKMICZSTUMFTI-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-(1-methylpyrrolidin-3-yl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C1CN(CC1)C)C)SC(C(=O)N)C1=CC=CC=C1 BXKMICZSTUMFTI-UHFFFAOYSA-N 0.000 claims 2
AZCDJBJGTWPUEH-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-(2-morpholin-4-yl-2-oxoethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CC(=O)N1CCOCC1)C)SC(C(=O)N)C1=CC=CC=C1 AZCDJBJGTWPUEH-UHFFFAOYSA-N 0.000 claims 2
QHGZKWOEXDKSNP-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-(2-oxo-2-piperazin-1-ylethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CC(N1CCNCC1)=O)C)SC(C(=O)N)C1=CC=CC=C1 QHGZKWOEXDKSNP-UHFFFAOYSA-N 0.000 claims 2
GOTMZVBKIJOKNM-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-(2-oxo-2-pyrrolidin-1-ylethyl)amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CC(N1CCCC1)=O)C)SC(C(=O)N)C1=CC=CC=C1 GOTMZVBKIJOKNM-UHFFFAOYSA-N 0.000 claims 2
YAGFDFMTNLEVAD-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-[2-(1,2,4-triazol-4-yl)ethyl]amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N=1N=CN(C=1)CCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C YAGFDFMTNLEVAD-UHFFFAOYSA-N 0.000 claims 2
FLMFAKLJVLHPCJ-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-[2-(methylamino)ethyl]amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCNC)C)SC(C(=O)N)C1=CC=CC=C1 FLMFAKLJVLHPCJ-UHFFFAOYSA-N 0.000 claims 2
GYTNFNQZAZKEBM-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-[2-[(1-methylcyclopropyl)amino]ethyl]amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCNC1(CC1)C)C)SC(C(=O)N)C1=CC=CC=C1 GYTNFNQZAZKEBM-UHFFFAOYSA-N 0.000 claims 2
AFYYBIJBKDLIFQ-PLEWWHCXSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCN1[C@@H](CCC1)C)C)SC(C(=O)N)C1=CC=CC=C1 AFYYBIJBKDLIFQ-PLEWWHCXSA-N 0.000 claims 2
AFYYBIJBKDLIFQ-LBOXEOMUSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-[2-[(2S)-2-methylpyrrolidin-1-yl]ethyl]amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCN1[C@H](CCC1)C)C)SC(C(=O)N)C1=CC=CC=C1 AFYYBIJBKDLIFQ-LBOXEOMUSA-N 0.000 claims 2
XMAWVXNSOLWLDD-UHFFFAOYSA-N 2-[3,5-dicyano-4-ethyl-6-[methyl-[2-oxo-2-[2-(1,2,4-triazol-4-yl)ethylamino]ethyl]amino]pyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N=1N=CN(C=1)CCNC(CN(C)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1)=O XMAWVXNSOLWLDD-UHFFFAOYSA-N 0.000 claims 2
TYESDUSDOSXIOA-UHFFFAOYSA-N 2-[3,5-dicyano-6-(1,4-diazepan-1-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCNCCC1)SC(C(=O)N)C1=CC=CC=C1 TYESDUSDOSXIOA-UHFFFAOYSA-N 0.000 claims 2
XWKHPFHSUYTASB-UHFFFAOYSA-N 2-[3,5-dicyano-6-(1,7-diazaspiro[3.5]nonan-1-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC11CCNCC1)SC(C(=O)N)C1=CC=CC=C1 XWKHPFHSUYTASB-UHFFFAOYSA-N 0.000 claims 2
LEWPINXKUHMGEL-UHFFFAOYSA-N 2-[3,5-dicyano-6-(2,6-diazaspiro[3.4]octan-6-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC2(CNC2)CC1)SC(C(=O)N)C1=CC=CC=C1 LEWPINXKUHMGEL-UHFFFAOYSA-N 0.000 claims 2
JMLPWQOLWATUHA-UHFFFAOYSA-N 2-[3,5-dicyano-6-(2,7-diazaspiro[3.5]nonan-7-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC2(CNC2)CC1)SC(C(=O)N)C1=CC=CC=C1 JMLPWQOLWATUHA-UHFFFAOYSA-N 0.000 claims 2
BEBNLHNDQXVVCT-UHFFFAOYSA-N 2-[3,5-dicyano-6-(2,8-diazaspiro[4.5]decan-8-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC2(CCNC2)CC1)SC(C(=O)N)C1=CC=CC=C1 BEBNLHNDQXVVCT-UHFFFAOYSA-N 0.000 claims 2
PXUHGLRILYSXLC-UHFFFAOYSA-N 2-[3,5-dicyano-6-(2,9-diazaspiro[5.5]undecan-9-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC2(CCCNC2)CC1)SC(C(=O)N)C1=CC=CC=C1 PXUHGLRILYSXLC-UHFFFAOYSA-N 0.000 claims 2
XUKVOWURBPFJOR-UHFFFAOYSA-N 2-[3,5-dicyano-6-(3,4-dihydro-1H-2,7-naphthyridin-2-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC2=CN=CC=C2CC1)SC(C(=O)N)C1=CC=CC=C1 XUKVOWURBPFJOR-UHFFFAOYSA-N 0.000 claims 2
NDADFHCJBWQSAN-UHFFFAOYSA-N 2-[3,5-dicyano-6-(4,4-difluoropiperidin-1-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)(F)F)SC(C(=O)N)C1=CC=CC=C1 NDADFHCJBWQSAN-UHFFFAOYSA-N 0.000 claims 2
MOMXNTDAKQMDGL-UHFFFAOYSA-N 2-[3,5-dicyano-6-(4-cyanopiperidin-1-yl)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)C#N)SC(C(=O)N)C1=CC=CC=C1 MOMXNTDAKQMDGL-UHFFFAOYSA-N 0.000 claims 2
ZOKFQKIHTSQWMB-UHFFFAOYSA-N 2-[3,5-dicyano-6-(4-methyl-1,4-diazepan-1-yl)-4-methylsulfanylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1SC)C#N)N1CCN(CCC1)C)SC(C(=O)N)C1=CC=CC=C1 ZOKFQKIHTSQWMB-UHFFFAOYSA-N 0.000 claims 2
VJZCIQKFGZRKOZ-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethoxypyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1OCC)C#N)N(C)C)SC(C(=O)N)C1=CC=CC=C1 VJZCIQKFGZRKOZ-UHFFFAOYSA-N 0.000 claims 2
DGPYYDAKNCUFTM-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-(3-dimethylphosphorylphenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=CC(=CC=C1)P(=O)(C)C DGPYYDAKNCUFTM-UHFFFAOYSA-N 0.000 claims 2
XJPACZHPKYWNAI-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=CC=C(C=C1)F XJPACZHPKYWNAI-UHFFFAOYSA-N 0.000 claims 2
JAOCSOYTIDHNNZ-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-(5-fluoropyridin-2-yl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=NC=C(C=C1)F JAOCSOYTIDHNNZ-UHFFFAOYSA-N 0.000 claims 2
RLKIRELOSIQUOZ-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-(5-methoxypyridin-2-yl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=NC=C(C=C1)OC RLKIRELOSIQUOZ-UHFFFAOYSA-N 0.000 claims 2
BKTPFLWAQPACLF-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-(5-methylpyridin-2-yl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=NC=C(C=C1)C BKTPFLWAQPACLF-UHFFFAOYSA-N 0.000 claims 2
PBCCXXFCZHRVEH-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-[3-[2-(dimethylamino)ethoxy]phenyl]acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=CC(=CC=C1)OCCN(C)C PBCCXXFCZHRVEH-UHFFFAOYSA-N 0.000 claims 2
XNLJPIURINSBAY-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-[4-(methylsulfamoyl)phenyl]acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=CC=C(C=C1)S(NC)(=O)=O XNLJPIURINSBAY-UHFFFAOYSA-N 0.000 claims 2
KIEQQZZDWUNUQK-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=CC=CC=C1 KIEQQZZDWUNUQK-UHFFFAOYSA-N 0.000 claims 2
PMUMTMWTHCXFJB-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-piperidin-4-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1CCNCC1 PMUMTMWTHCXFJB-UHFFFAOYSA-N 0.000 claims 2
CEFQBSLEFRRXOP-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanyl-2-pyridin-4-ylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)C)SC(C(=O)N)C1=CC=NC=C1 CEFQBSLEFRRXOP-UHFFFAOYSA-N 0.000 claims 2
PGEYCFMOSDKGRP-UHFFFAOYSA-N 2-[3,5-dicyano-6-(dimethylamino)-4-methoxypyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1OC)C#N)N(C)C)SC(C(=O)N)C1=CC=CC=C1 PGEYCFMOSDKGRP-UHFFFAOYSA-N 0.000 claims 2
AXKAVBGAZHPOHC-HWYAHNCWSA-N 2-[3,5-dicyano-6-[(2R)-2-(diethylaminomethyl)morpholin-4-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](OCC1)CN(CC)CC)SC(C(=O)N)C1=CC=CC=C1 AXKAVBGAZHPOHC-HWYAHNCWSA-N 0.000 claims 2
PDBFXYQPIAOBSW-HWYAHNCWSA-N 2-[3,5-dicyano-6-[(2R)-2-[(2,2-dimethylpropylamino)methyl]morpholin-4-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](OCC1)CNCC(C)(C)C)SC(C(=O)N)C1=CC=CC=C1 PDBFXYQPIAOBSW-HWYAHNCWSA-N 0.000 claims 2
PDBFXYQPIAOBSW-HSTJUUNISA-N 2-[3,5-dicyano-6-[(2S)-2-[(2,2-dimethylpropylamino)methyl]morpholin-4-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H](OCC1)CNCC(C)(C)C)SC(C(=O)N)C1=CC=CC=C1 PDBFXYQPIAOBSW-HSTJUUNISA-N 0.000 claims 2
UXBDLRYUGBZZNB-QRIPLOBPSA-N 2-[3,5-dicyano-6-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H](CC1)N(C)C)SC(C(=O)N)C1=CC=CC=C1 UXBDLRYUGBZZNB-QRIPLOBPSA-N 0.000 claims 2
AODJRWVDEBWQQH-BJQOMGFOSA-N 2-[3,5-dicyano-6-[(3S)-3-(2,2-difluoroethylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CCC1)NCC(F)F)SC(C(=O)N)C1=CC=CC=C1 AODJRWVDEBWQQH-BJQOMGFOSA-N 0.000 claims 2
GUZMORBPNRJGHC-HSTJUUNISA-N 2-[3,5-dicyano-6-[(3S)-3-(2,2-dimethylpropylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CCC1)NCC(C)(C)C)SC(C(=O)N)C1=CC=CC=C1 GUZMORBPNRJGHC-HSTJUUNISA-N 0.000 claims 2
XRDSGFIUOVUAFR-HXBUSHRASA-N 2-[3,5-dicyano-6-[(3S)-3-(cyclopropylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CCC1)NC1CC1)SC(C(=O)N)C1=CC=CC=C1 XRDSGFIUOVUAFR-HXBUSHRASA-N 0.000 claims 2
TYRGVNLUHJKMQZ-PIVQAISJSA-N 2-[3,5-dicyano-6-[(3S)-3-(diaminomethylideneamino)oxypyrrolidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)ONC(=N)N)SC(C(=O)N)C1=CC=CC=C1 TYRGVNLUHJKMQZ-PIVQAISJSA-N 0.000 claims 2
UXBDLRYUGBZZNB-DJZRFWRSSA-N 2-[3,5-dicyano-6-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@H](CC1)N(C)C)SC(C(=O)N)C1=CC=CC=C1 UXBDLRYUGBZZNB-DJZRFWRSSA-N 0.000 claims 2
UMDFJCAWFVOWTN-XGLRFROISA-N 2-[3,5-dicyano-6-[(3S)-3-[(2,2-dimethylpropylamino)methyl]piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H](CCC1)CNCC(C)(C)C)SC(C(=O)N)C1=CC=CC=C1 UMDFJCAWFVOWTN-XGLRFROISA-N 0.000 claims 2
JVFVJIMPWTUARY-CWQZNGJJSA-N 2-[3,5-dicyano-6-[(3S)-3-hydroxypyrrolidin-1-yl]-4-methoxypyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1OC)C#N)N1C[C@H](CC1)O)SC(C(=O)N)C1=CC=CC=C1 JVFVJIMPWTUARY-CWQZNGJJSA-N 0.000 claims 2
YNRHPBVVQIDNPF-JWTNVVGKSA-N 2-[3,5-dicyano-6-[(3S,4R)-3,4-dihydroxypyrrolidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H]([C@@H](C1)O)O)SC(C(=O)N)C1=CC=CC=C1 YNRHPBVVQIDNPF-JWTNVVGKSA-N 0.000 claims 2
PJLCPZDEFOJRNH-DBIVSCPCSA-N 2-[3,5-dicyano-6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1C[C@@H](N[C@@H](C1)C)C)SC(C(=O)N)C1=CC=CC=C1 PJLCPZDEFOJRNH-DBIVSCPCSA-N 0.000 claims 2
XMZRJKUIERXLEA-UHFFFAOYSA-N 2-[3,5-dicyano-6-[2-(2,2-dimethylpropylamino)ethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(CCNCC(C)(C)C)C)SC(C(=O)N)C1=CC=CC=C1 XMZRJKUIERXLEA-UHFFFAOYSA-N 0.000 claims 2
FLQWEYKWBPGAQZ-UHFFFAOYSA-N 2-[3,5-dicyano-6-[2-(cyclopropylmethyl)-2,9-diazaspiro[5.5]undecan-9-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC2(CCCN(C2)CC2CC2)CC1)SC(C(=O)N)C1=CC=CC=C1 FLQWEYKWBPGAQZ-UHFFFAOYSA-N 0.000 claims 2
XXJFYRYKHCNOQK-UHFFFAOYSA-N 2-[3,5-dicyano-6-[2-(diaminomethylideneamino)oxyethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCONC(=N)N)SC(C(=O)N)C1=CC=CC=C1 XXJFYRYKHCNOQK-UHFFFAOYSA-N 0.000 claims 2
BIZYAOCWRROOTD-UHFFFAOYSA-N 2-[3,5-dicyano-6-[2-(diethylamino)ethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN(CC)CC)SC(C(=O)N)C1=CC=CC=C1 BIZYAOCWRROOTD-UHFFFAOYSA-N 0.000 claims 2
AXKAVBGAZHPOHC-UHFFFAOYSA-N 2-[3,5-dicyano-6-[2-(diethylaminomethyl)morpholin-4-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(OCC1)CN(CC)CC)SC(C(=O)N)C1=CC=CC=C1 AXKAVBGAZHPOHC-UHFFFAOYSA-N 0.000 claims 2
QBTLPLHSROYOIB-UHFFFAOYSA-N 2-[3,5-dicyano-6-[2-(dimethylamino)ethoxy]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)OCCN(C)C)SC(C(=O)N)C1=CC=CC=C1 QBTLPLHSROYOIB-UHFFFAOYSA-N 0.000 claims 2
CMFOAXMRKJAQAS-UHFFFAOYSA-N 2-[3,5-dicyano-6-[2-(dimethylamino)ethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN(C)C)SC(C(=O)N)C1=CC=CC=C1 CMFOAXMRKJAQAS-UHFFFAOYSA-N 0.000 claims 2
XDSCOQKNRNKTDB-UHFFFAOYSA-N 2-[3,5-dicyano-6-[2-(dimethylamino)ethylsulfanyl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)SCCN(C)C)SC(C(=O)N)C1=CC=CC=C1 XDSCOQKNRNKTDB-UHFFFAOYSA-N 0.000 claims 2
GJEASOAIHWLCJZ-JGUPTHKFSA-N 2-[3,5-dicyano-6-[2-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]ethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN1[C@@H](CC[C@H]1C)C)SC(C(=O)N)C1=CC=CC=C1 GJEASOAIHWLCJZ-JGUPTHKFSA-N 0.000 claims 2
GJEASOAIHWLCJZ-NHJWOMDBSA-N 2-[3,5-dicyano-6-[2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]ethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN1[C@H](CC[C@H]1C)C)SC(C(=O)N)C1=CC=CC=C1 GJEASOAIHWLCJZ-NHJWOMDBSA-N 0.000 claims 2
GJEASOAIHWLCJZ-JOHXPNBHSA-N 2-[3,5-dicyano-6-[2-[(2S,5S)-2,5-dimethylpyrrolidin-1-yl]ethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN1[C@H](CC[C@@H]1C)C)SC(C(=O)N)C1=CC=CC=C1 GJEASOAIHWLCJZ-JOHXPNBHSA-N 0.000 claims 2
NITLTHGIWLRPFL-HWYAHNCWSA-N 2-[3,5-dicyano-6-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]ethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN1C[C@@H](CC1)N(C)C)SC(C(=O)N)C1=CC=CC=C1 NITLTHGIWLRPFL-HWYAHNCWSA-N 0.000 claims 2
NITLTHGIWLRPFL-HSTJUUNISA-N 2-[3,5-dicyano-6-[2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]ethyl-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CCN1C[C@H](CC1)N(C)C)SC(C(=O)N)C1=CC=CC=C1 NITLTHGIWLRPFL-HSTJUUNISA-N 0.000 claims 2
ZGBWULPYTNVDDE-UHFFFAOYSA-N 2-[3,5-dicyano-6-[3-(diaminomethylideneamino)oxyazetidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(C1)ONC(=N)N)SC(C(=O)N)C1=CC=CC=C1 ZGBWULPYTNVDDE-UHFFFAOYSA-N 0.000 claims 2
OGHLVJPRXFDONV-UHFFFAOYSA-N 2-[3,5-dicyano-6-[3-[(dimethylamino)methyl]piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(CCC1)CN(C)C)SC(C(=O)N)C1=CC=CC=C1 OGHLVJPRXFDONV-UHFFFAOYSA-N 0.000 claims 2
CPKKLVQNKMXDBL-UHFFFAOYSA-N 2-[3,5-dicyano-6-[3-[(dimethylamino)methyl]pyrrolidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(CC1)CN(C)C)SC(C(=O)N)C1=CC=CC=C1 CPKKLVQNKMXDBL-UHFFFAOYSA-N 0.000 claims 2
MQDOWKIITDXHFY-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(2,2-difluoroethylamino)-4-methylpiperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)(C)NCC(F)F)SC(C(=O)N)C1=CC=CC=C1 MQDOWKIITDXHFY-UHFFFAOYSA-N 0.000 claims 2
NRXLLIYFPGEQKW-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(2,2-difluoroethylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCC(F)F)SC(C(=O)N)C1=CC=CC=C1 NRXLLIYFPGEQKW-UHFFFAOYSA-N 0.000 claims 2
KYWHKTGBQIOFPC-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(2,2-dimethylpropylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCC(C)(C)C)SC(C(=O)N)C1=CC=C(C=C1)F KYWHKTGBQIOFPC-UHFFFAOYSA-N 0.000 claims 2
NUOFNLUIHZRQHJ-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(2,2-dimethylpropylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NCC(C)(C)C)SC(C(=O)N)C1=CC=CC=C1 NUOFNLUIHZRQHJ-UHFFFAOYSA-N 0.000 claims 2
JCXGKQLJABWGKP-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(2,5-dioxoimidazolidin-1-yl)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1C(NCC1=O)=O)SC(C(=O)N)C1=CC=CC=C1 JCXGKQLJABWGKP-UHFFFAOYSA-N 0.000 claims 2
FZYBTOYDEPQYRI-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]-4-methoxypyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1OC)C#N)N1CCN(CCC1)CCO)SC(C(=O)N)C1=CC=CC=C1 FZYBTOYDEPQYRI-UHFFFAOYSA-N 0.000 claims 2
WBNRGSXBRABHNI-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]-4-propoxypyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1OCCC)C#N)N1CCN(CCC1)CCO)SC(C(=O)N)C1=CC=CC=C1 WBNRGSXBRABHNI-UHFFFAOYSA-N 0.000 claims 2
KKHSDHHCWMBFOK-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(3,3-difluoropyrrolidin-1-yl)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1CC(CC1)(F)F)SC(C(=O)N)C1=CC=CC=C1 KKHSDHHCWMBFOK-UHFFFAOYSA-N 0.000 claims 2
OHYCOVOLCLJBIQ-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(cyclobutylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NC1CCC1)SC(C(=O)N)C1=CC=CC=C1 OHYCOVOLCLJBIQ-UHFFFAOYSA-N 0.000 claims 2
BZCKIEYSRQOOEW-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(cyclopropylamino)-3-fluoropiperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC(C(CC1)NC1CC1)F)SC(C(=O)N)C1=CC=CC=C1 BZCKIEYSRQOOEW-UHFFFAOYSA-N 0.000 claims 2
WLGBTBSZMJKZFA-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(cyclopropylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)NC1CC1)SC(C(=O)N)C1=CC=CC=C1 WLGBTBSZMJKZFA-UHFFFAOYSA-N 0.000 claims 2
BUFHWVIJQMGNTB-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(diaminomethylideneamino)oxypiperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)ONC(=N)N)SC(C(=O)N)C1=CC=CC=C1 BUFHWVIJQMGNTB-UHFFFAOYSA-N 0.000 claims 2
DICLIVFTTAAJBE-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(dimethylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-(2,4-difluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)C)SC(C(=O)N)C1=C(C=C(C=C1)F)F DICLIVFTTAAJBE-UHFFFAOYSA-N 0.000 claims 2
COCVXPUQYSCVKV-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(dimethylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-(3,4-difluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)C)SC(C(=O)N)C1=CC(=C(C=C1)F)F COCVXPUQYSCVKV-UHFFFAOYSA-N 0.000 claims 2
MELQQCMEXPGRLW-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-(dimethylamino)piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)C)SC(C(=O)N)C1=CC=CC=C1 MELQQCMEXPGRLW-UHFFFAOYSA-N 0.000 claims 2
JMHYFCLKDJIHGI-CKPMZPGQSA-N 2-[3,5-dicyano-6-[4-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1[C@@H](CC[C@H]1C)C)SC(C(=O)N)C1=CC=CC=C1 JMHYFCLKDJIHGI-CKPMZPGQSA-N 0.000 claims 2
JMHYFCLKDJIHGI-OOEJVQDLSA-N 2-[3,5-dicyano-6-[4-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1[C@@H](CC[C@@H]1C)C)SC(C(=O)N)C1=CC=CC=C1 JMHYFCLKDJIHGI-OOEJVQDLSA-N 0.000 claims 2
JMHYFCLKDJIHGI-NHDFCTKWSA-N 2-[3,5-dicyano-6-[4-[(2S,5S)-2,5-dimethylpyrrolidin-1-yl]piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N1[C@H](CC[C@@H]1C)C)SC(C(=O)N)C1=CC=CC=C1 JMHYFCLKDJIHGI-NHDFCTKWSA-N 0.000 claims 2
SGDORTBLSHVRCN-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-[3-(dimethylamino)propyl]piperazin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCN(CC1)CCCN(C)C)SC(C(=O)N)C1=CC=CC=C1 SGDORTBLSHVRCN-UHFFFAOYSA-N 0.000 claims 2
WAUGZLFVUIBDBC-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-[cyclobutyl(methyl)amino]piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)C1CCC1)SC(C(=O)N)C1=CC=C(C=C1)F WAUGZLFVUIBDBC-UHFFFAOYSA-N 0.000 claims 2
WYIMAUGPLBALGL-UHFFFAOYSA-N 2-[3,5-dicyano-6-[4-[cyclobutyl(methyl)amino]piperidin-1-yl]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CCC(CC1)N(C)C1CCC1)SC(C(=O)N)C1=CC=CC=C1 WYIMAUGPLBALGL-UHFFFAOYSA-N 0.000 claims 2
IRHOOYHPPHGTRC-UHFFFAOYSA-N 2-[3,5-dicyano-6-[[2-(1,3-dihydroxypropan-2-ylamino)-2-oxoethyl]-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NC(CO)CO)C)C#N)CC)C#N)=O IRHOOYHPPHGTRC-UHFFFAOYSA-N 0.000 claims 2
JOXMAWTUMNYVAU-AQFHOAJTSA-N 2-[3,5-dicyano-6-[[2-[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]-2-oxoethyl]-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@H]([C@@H](C1)O)O)SC(C(=O)N)C1=CC=CC=C1 JOXMAWTUMNYVAU-AQFHOAJTSA-N 0.000 claims 2
JOXMAWTUMNYVAU-PMSBKCLSSA-N 2-[3,5-dicyano-6-[[2-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-oxoethyl]-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@H]([C@H](C1)O)O)SC(C(=O)N)C1=CC=CC=C1 JOXMAWTUMNYVAU-PMSBKCLSSA-N 0.000 claims 2
JOXMAWTUMNYVAU-CHEUHSMRSA-N 2-[3,5-dicyano-6-[[2-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-oxoethyl]-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@@H]([C@H](C1)O)O)SC(C(=O)N)C1=CC=CC=C1 JOXMAWTUMNYVAU-CHEUHSMRSA-N 0.000 claims 2
TUGBHEYYCADQIE-AQKKSAQBSA-N 2-[3,5-dicyano-6-[[2-[(3S,5R)-3,5-dihydroxypiperidin-1-yl]-2-oxoethyl]-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N(C)CC(=O)N1C[C@@H](C[C@@H](C1)O)O)SC(C(=O)N)C1=CC=CC=C1 TUGBHEYYCADQIE-AQKKSAQBSA-N 0.000 claims 2
RHNQQNKFFAMZHT-IWPPFLRJSA-N 2-[3,5-dicyano-6-[[2-[[(2R)-2,3-dihydroxypropyl]amino]-2-oxoethyl]-methylamino]-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(C(C1=CC=CC=C1)SC1=C(C(=C(C(=N1)N(CC(=O)NC[C@H](CO)O)C)C#N)CC)C#N)=O RHNQQNKFFAMZHT-IWPPFLRJSA-N 0.000 claims 2
IMKNMPXUIJTVKF-UHFFFAOYSA-N 2-[4-(2-amino-2-oxoethyl)phenyl]-2-[3,5-dicyano-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl]sulfanylacetamide Chemical compound NC(CC1=CC=C(C=C1)C(C(=O)N)SC1=NC(=C(C(=C1C#N)CC)C#N)N1CCN(CCC1)C)=O IMKNMPXUIJTVKF-UHFFFAOYSA-N 0.000 claims 2
MBQJFQOCMNTMNQ-UHFFFAOYSA-N 2-[4-(2-amino-2-oxoethyl)phenyl]-2-[3,5-dicyano-6-(dimethylamino)-4-ethylpyridin-2-yl]sulfanylacetamide Chemical compound NC(CC1=CC=C(C=C1)C(C(=O)N)SC1=NC(=C(C(=C1C#N)CC)C#N)N(C)C)=O MBQJFQOCMNTMNQ-UHFFFAOYSA-N 0.000 claims 2
LZZBRZDORPAYHM-UHFFFAOYSA-N 2-[6-(1,3,4,5,7,8,9,9a-octahydropyrrolo[1,2-a][1,4]diazepin-2-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC2N(CCC1)CCC2)SC(C(=O)N)C1=CC=CC=C1 LZZBRZDORPAYHM-UHFFFAOYSA-N 0.000 claims 2
PPXIQBJVGVIWDI-UHFFFAOYSA-N 2-[6-(2-amino-2-oxo-1-phenylethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)SC(C(=O)N)C1=CC=CC=C1)SC(C(=O)N)C1=CC=CC=C1 PPXIQBJVGVIWDI-UHFFFAOYSA-N 0.000 claims 2
IKEVWYBPAUJEDN-UHFFFAOYSA-N 2-[6-(2-amino-2-oxoethyl)sulfanyl-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(CSC1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)=O IKEVWYBPAUJEDN-UHFFFAOYSA-N 0.000 claims 2
AUSILSIUFIKOSS-UHFFFAOYSA-N 2-[6-(3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazin-6-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(#N)C=1C(=NC(=C(C=1CC)C#N)N1CC2OCCNC2C1)SC(C(=O)N)C1=CC=CC=C1 AUSILSIUFIKOSS-UHFFFAOYSA-N 0.000 claims 2
ZGFSVDFCYOMEJY-UHFFFAOYSA-N 2-[6-(3-aminopiperidin-1-yl)-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CN(CCC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N ZGFSVDFCYOMEJY-UHFFFAOYSA-N 0.000 claims 2
WOFWYIKKGDFRKO-UHFFFAOYSA-N 2-[6-(4-acetylpiperazin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(C)(=O)N1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N WOFWYIKKGDFRKO-UHFFFAOYSA-N 0.000 claims 2
LWCTZINLTSJCET-UHFFFAOYSA-N 2-[6-(4-amino-3,3-difluoropiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1C(CN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)(F)F LWCTZINLTSJCET-UHFFFAOYSA-N 0.000 claims 2
BEWQRCQQIKNSEB-UHFFFAOYSA-N 2-[6-(4-amino-4-methylpiperidin-1-yl)-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1(CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N)C BEWQRCQQIKNSEB-UHFFFAOYSA-N 0.000 claims 2
ALNFMEKLSGMBDG-UHFFFAOYSA-N 2-[6-(4-aminopiperazin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N ALNFMEKLSGMBDG-UHFFFAOYSA-N 0.000 claims 2
UTKLFRLMLLGCFI-UHFFFAOYSA-N 2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N UTKLFRLMLLGCFI-UHFFFAOYSA-N 0.000 claims 2
MUZQFFCMSJIQRT-UHFFFAOYSA-N 2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-(3-fluoropyridin-2-yl)acetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=NC=CC=C1F)C#N)CC)C#N MUZQFFCMSJIQRT-UHFFFAOYSA-N 0.000 claims 2
CZNRJQMBRCCVPE-UHFFFAOYSA-N 2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-(4-fluorophenyl)acetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=C(C=C1)F)C#N)CC)C#N CZNRJQMBRCCVPE-UHFFFAOYSA-N 0.000 claims 2
HCPBFQRBYJPHKZ-UHFFFAOYSA-N 2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-[4-(trifluoromethyl)phenyl]acetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=C(C=C1)C(F)(F)F)C#N)CC)C#N HCPBFQRBYJPHKZ-UHFFFAOYSA-N 0.000 claims 2
KNKHRZYILDZLRE-UHFFFAOYSA-N 2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N KNKHRZYILDZLRE-UHFFFAOYSA-N 0.000 claims 2
OYAWXAXYBNYPBS-UHFFFAOYSA-N 2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-methoxypyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)OC)C#N OYAWXAXYBNYPBS-UHFFFAOYSA-N 0.000 claims 2
UOBFRXJLZIFHJN-UHFFFAOYSA-N 2-[6-(4-aminopiperidin-1-yl)-3-cyano-4-ethyl-5-methylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C UOBFRXJLZIFHJN-UHFFFAOYSA-N 0.000 claims 2
QPYOXRCZBIGMHI-UHFFFAOYSA-N 2-[6-(4-benzoylpiperazin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound C(C1=CC=CC=C1)(=O)N1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N QPYOXRCZBIGMHI-UHFFFAOYSA-N 0.000 claims 2
SRZPYPCNFUTKLJ-UHFFFAOYSA-N 2-[6-(azetidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1(CCC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N SRZPYPCNFUTKLJ-UHFFFAOYSA-N 0.000 claims 2
WEGOHWICAIDWSC-UHFFFAOYSA-N 2-[6-[(2-amino-2-oxoethyl)-methylamino]-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(CN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N)C)=O WEGOHWICAIDWSC-UHFFFAOYSA-N 0.000 claims 2
PMWNNSZNZVXNKL-NYRJJRHWSA-N 2-[6-[(2R)-2-(aminomethyl)morpholin-4-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC[C@H]1OCCN(C1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N PMWNNSZNZVXNKL-NYRJJRHWSA-N 0.000 claims 2
LNKYKKANMBILNL-UJONTBEJSA-N 2-[6-[(2R)-2-[[(2-aminoacetyl)amino]methyl]morpholin-4-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCC(=O)NC[C@@H]1CN(CCO1)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1 LNKYKKANMBILNL-UJONTBEJSA-N 0.000 claims 2
PMWNNSZNZVXNKL-FUKCDUGKSA-N 2-[6-[(2S)-2-(aminomethyl)morpholin-4-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC[C@@H]1OCCN(C1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N PMWNNSZNZVXNKL-FUKCDUGKSA-N 0.000 claims 2
LNKYKKANMBILNL-BJQOMGFOSA-N 2-[6-[(2S)-2-[[(2-aminoacetyl)amino]methyl]morpholin-4-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCC(=O)NC[C@H]1CN(CCO1)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1 LNKYKKANMBILNL-BJQOMGFOSA-N 0.000 claims 2
RNQDUYUPMICSPU-UHFFFAOYSA-N 2-[6-[(3-aminocyclobutyl)-methylamino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1CC(C1)N(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C RNQDUYUPMICSPU-UHFFFAOYSA-N 0.000 claims 2
SLFVOEJIFPFHPQ-LMNIDFBRSA-N 2-[6-[(3R)-3-(aminomethyl)-3-fluoropyrrolidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC[C@]1(CN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F SLFVOEJIFPFHPQ-LMNIDFBRSA-N 0.000 claims 2
FFCIAYQYQHQCAI-NYRJJRHWSA-N 2-[6-[(3R)-3-aminopiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@H]1CN(CCC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N FFCIAYQYQHQCAI-NYRJJRHWSA-N 0.000 claims 2
KBEGRXPEEBEXGI-IKJXHCRLSA-N 2-[6-[(3R)-3-aminopyrrolidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@H]1CN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N KBEGRXPEEBEXGI-IKJXHCRLSA-N 0.000 claims 2
XQNVHJPYTYGCQE-OOJLDXBWSA-N 2-[6-[(3S)-3-(aminomethyl)piperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC[C@H]1CN(CCC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N XQNVHJPYTYGCQE-OOJLDXBWSA-N 0.000 claims 2
GYGKBXDKKKPZHQ-CISYCMJJSA-N 2-[6-[(3S)-3-[[(2-aminoacetyl)amino]methyl]piperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCC(=O)NC[C@H]1CN(CCC1)C1=NC(=C(C(=C1C#N)CC)C#N)SC(C(=O)N)C1=CC=CC=C1 GYGKBXDKKKPZHQ-CISYCMJJSA-N 0.000 claims 2
FFCIAYQYQHQCAI-FUKCDUGKSA-N 2-[6-[(3S)-3-aminopiperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@@H]1CN(CCC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N FFCIAYQYQHQCAI-FUKCDUGKSA-N 0.000 claims 2
XSBOMFPXGIVJLB-FUKCDUGKSA-N 2-[6-[(3S)-3-aminopyrrolidin-1-yl]-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@@H]1CN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N XSBOMFPXGIVJLB-FUKCDUGKSA-N 0.000 claims 2
KBEGRXPEEBEXGI-PIVQAISJSA-N 2-[6-[(3S)-3-aminopyrrolidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@@H]1CN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N KBEGRXPEEBEXGI-PIVQAISJSA-N 0.000 claims 2
YWBVSTLJPZTNFH-UHFFFAOYSA-N 2-[6-[2-(2-aminoethoxy)ethyl-methylamino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCOCCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C YWBVSTLJPZTNFH-UHFFFAOYSA-N 0.000 claims 2
PMWNNSZNZVXNKL-UHFFFAOYSA-N 2-[6-[2-(aminomethyl)morpholin-4-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCC1OCCN(C1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N PMWNNSZNZVXNKL-UHFFFAOYSA-N 0.000 claims 2
JVYSQUPZSLVXHG-UHFFFAOYSA-N 2-[6-[2-(azepan-1-yl)ethyl-methylamino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N1(CCCCCC1)CCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C JVYSQUPZSLVXHG-UHFFFAOYSA-N 0.000 claims 2
XCJYJCQYRHMCIO-OQHSHRKDSA-N 2-[6-[2-[(3R)-3-aminopyrrolidin-1-yl]ethyl-methylamino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@H]1CN(CC1)CCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C XCJYJCQYRHMCIO-OQHSHRKDSA-N 0.000 claims 2
XCJYJCQYRHMCIO-PBVYKCSPSA-N 2-[6-[2-[(3S)-3-aminopyrrolidin-1-yl]ethyl-methylamino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound N[C@@H]1CN(CC1)CCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C XCJYJCQYRHMCIO-PBVYKCSPSA-N 0.000 claims 2
QDSUGZANEFECHV-UHFFFAOYSA-N 2-[6-[2-[4-(aminomethyl)-4-hydroxypiperidin-1-yl]ethyl-methylamino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCC1(CCN(CC1)CCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C)O QDSUGZANEFECHV-UHFFFAOYSA-N 0.000 claims 2
KQXPWVJENBGGLC-UHFFFAOYSA-N 2-[6-[2-aminoethyl(methyl)amino]-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N)C KQXPWVJENBGGLC-UHFFFAOYSA-N 0.000 claims 2
FGEUXSPNUVMYFN-UHFFFAOYSA-N 2-[6-[2-aminoethyl(methyl)amino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C FGEUXSPNUVMYFN-UHFFFAOYSA-N 0.000 claims 2
GEDMGGLPWSSKKL-UHFFFAOYSA-N 2-[6-[3-(2-amino-2-oxoethyl)azetidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC(CC1CN(C1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)=O GEDMGGLPWSSKKL-UHFFFAOYSA-N 0.000 claims 2
BNSFJHRMFNFDAG-UHFFFAOYSA-N 2-[6-[3-(aminomethyl)-3-fluoroazetidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCC1(CN(C1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)F BNSFJHRMFNFDAG-UHFFFAOYSA-N 0.000 claims 2
OQGJRMRSVCAYGC-UHFFFAOYSA-N 2-[6-[3-(aminomethyl)azetidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCC1CN(C1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N OQGJRMRSVCAYGC-UHFFFAOYSA-N 0.000 claims 2
NZDNIYAPZBEWSL-UHFFFAOYSA-N 2-[6-[3-(aminomethyl)pyrrolidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCC1CN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N NZDNIYAPZBEWSL-UHFFFAOYSA-N 0.000 claims 2
ZZEYJFMVGDINRK-UHFFFAOYSA-N 2-[6-[3-aminopropyl(methyl)amino]-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N)C ZZEYJFMVGDINRK-UHFFFAOYSA-N 0.000 claims 2
VWIPKZUTTPRYHJ-UHFFFAOYSA-N 2-[6-[3-aminopropyl(methyl)amino]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCCN(C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)C VWIPKZUTTPRYHJ-UHFFFAOYSA-N 0.000 claims 2
RJOBZQUOAKRYGL-UHFFFAOYSA-N 2-[6-[4-(2-aminoethoxy)piperidin-1-yl]-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCOC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N RJOBZQUOAKRYGL-UHFFFAOYSA-N 0.000 claims 2
BLZTZJSUGNBLSO-UHFFFAOYSA-N 2-[6-[4-(2-aminoethoxy)piperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCOC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N BLZTZJSUGNBLSO-UHFFFAOYSA-N 0.000 claims 2
MAFFWBYHTVLIIC-UHFFFAOYSA-N 2-[6-[4-(2-aminoethyl)piperazin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N MAFFWBYHTVLIIC-UHFFFAOYSA-N 0.000 claims 2
ITNCPVQXCAIRIB-UHFFFAOYSA-N 2-[6-[4-(2-aminoethylamino)piperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCNC1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N ITNCPVQXCAIRIB-UHFFFAOYSA-N 0.000 claims 2
WXFQMTXWVFGFAT-UHFFFAOYSA-N 2-[6-[4-(3-amino-2-oxopyrrolidin-1-yl)piperidin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1C(N(CC1)C1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N)=O WXFQMTXWVFGFAT-UHFFFAOYSA-N 0.000 claims 2
UFWLOSHEGGYLCG-UHFFFAOYSA-N 2-[6-[4-(3-aminooxetane-3-carbonyl)piperazin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1(COC1)C(=O)N1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N UFWLOSHEGGYLCG-UHFFFAOYSA-N 0.000 claims 2
VSKHLYUJBSIEJD-UHFFFAOYSA-N 2-[6-[4-(3-aminopropyl)piperazin-1-yl]-3,5-dicyano-4-cyclopropylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCCN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)C1CC1)C#N VSKHLYUJBSIEJD-UHFFFAOYSA-N 0.000 claims 2
VPSZPHFSSKMVRD-UHFFFAOYSA-N 2-[6-[4-(3-aminopropyl)piperazin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NCCCN1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N VPSZPHFSSKMVRD-UHFFFAOYSA-N 0.000 claims 2
QNPCTZHGKDIXRX-UHFFFAOYSA-N 2-[6-[4-(4-aminooxane-4-carbonyl)piperazin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound NC1(CCOCC1)C(=O)N1CCN(CC1)C1=C(C(=C(C(=N1)SC(C(=O)N)C1=CC=CC=C1)C#N)CC)C#N QNPCTZHGKDIXRX-UHFFFAOYSA-N 0.000 claims 2
VZGOPXHEQIDXJK-UHFFFAOYSA-N 2-[6-[4-(4-bromobenzoyl)piperazin-1-yl]-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide Chemical compound BrC1=CC=C(C(=O)N2CCN(CC2)C2=C(C(=C(C(=N2)SC(C(=O)N)C2=CC=CC=C2)C#N)CC)C#N)C=C1 VZGOPXHEQIDXJK-UHFFFAOYSA-N 0.000 claims 2
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JP2019517187A 2016-06-13 2017-06-13 Ｄｎｍｔ１の阻害剤としての置換ピリジン Active JP7051829B2 (ja)