JP2017518323A5 - - Google Patents
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- JP2017518323A5 JP2017518323A5 JP2016572739A JP2016572739A JP2017518323A5 JP 2017518323 A5 JP2017518323 A5 JP 2017518323A5 JP 2016572739 A JP2016572739 A JP 2016572739A JP 2016572739 A JP2016572739 A JP 2016572739A JP 2017518323 A5 JP2017518323 A5 JP 2017518323A5
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- Prior art keywords
- compound
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- disorders
- hydrogen
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 85
- 229910052739 hydrogen Inorganic materials 0.000 claims description 38
- 239000001257 hydrogen Substances 0.000 claims description 38
- 125000000217 alkyl group Chemical group 0.000 claims description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 150000002431 hydrogen Chemical class 0.000 claims description 22
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 20
- 208000035475 disorder Diseases 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000000623 heterocyclic group Chemical group 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 10
- 125000005842 heteroatom Chemical group 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 6
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 6
- 208000002193 Pain Diseases 0.000 claims description 6
- 229930182558 Sterol Natural products 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000304 alkynyl group Chemical group 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 230000002496 gastric effect Effects 0.000 claims description 6
- 235000003702 sterols Nutrition 0.000 claims description 6
- 238000003786 synthesis reaction Methods 0.000 claims description 6
- 125000004429 atom Chemical group 0.000 claims description 5
- 208000019022 Mood disease Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 210000003169 central nervous system Anatomy 0.000 claims description 4
- 206010015037 epilepsy Diseases 0.000 claims description 4
- 208000014617 hemorrhoid Diseases 0.000 claims description 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 201000000980 schizophrenia Diseases 0.000 claims description 4
- 150000003432 sterols Chemical class 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 125000004434 sulfur atom Chemical group 0.000 claims description 3
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 206010002091 Anaesthesia Diseases 0.000 claims description 2
- 206010048946 Anal abscess Diseases 0.000 claims description 2
- 208000008958 Anti-N-Methyl-D-Aspartate Receptor Encephalitis Diseases 0.000 claims description 2
- 208000016583 Anus disease Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 208000020925 Bipolar disease Diseases 0.000 claims description 2
- 208000000094 Chronic Pain Diseases 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 206010010774 Constipation Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 206010012289 Dementia Diseases 0.000 claims description 2
- 241000004297 Draba Species 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims description 2
- 206010072378 Encephalitis autoimmune Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 208000034693 Laceration Diseases 0.000 claims description 2
- 208000016285 Movement disease Diseases 0.000 claims description 2
- 208000032580 NMDA receptor encephalitis Diseases 0.000 claims description 2
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 201000009916 Postpartum depression Diseases 0.000 claims description 2
- 208000028017 Psychotic disease Diseases 0.000 claims description 2
- 208000004680 Rectal Fistula Diseases 0.000 claims description 2
- 208000006289 Rett Syndrome Diseases 0.000 claims description 2
- 102100030681 SH3 and multiple ankyrin repeat domains protein 3 Human genes 0.000 claims description 2
- 101710101741 SH3 and multiple ankyrin repeat domains protein 3 Proteins 0.000 claims description 2
- 206010039897 Sedation Diseases 0.000 claims description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 2
- 206010041250 Social phobia Diseases 0.000 claims description 2
- 208000006011 Stroke Diseases 0.000 claims description 2
- 206010042458 Suicidal ideation Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 208000026911 Tuberous sclerosis complex Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 206010047571 Visual impairment Diseases 0.000 claims description 2
- 208000005298 acute pain Diseases 0.000 claims description 2
- 208000012826 adjustment disease Diseases 0.000 claims description 2
- 230000037005 anaesthesia Effects 0.000 claims description 2
- 206010002156 anal fistula Diseases 0.000 claims description 2
- 208000029188 anti-NMDA receptor encephalitis Diseases 0.000 claims description 2
- 208000029560 autism spectrum disease Diseases 0.000 claims description 2
- 230000006931 brain damage Effects 0.000 claims description 2
- 231100000874 brain damage Toxicity 0.000 claims description 2
- 208000029028 brain injury Diseases 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 206010009887 colitis Diseases 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 208000018459 dissociative disease Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000001037 epileptic effect Effects 0.000 claims description 2
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 208000016354 hearing loss disease Diseases 0.000 claims description 2
- 208000007386 hepatic encephalopathy Diseases 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 206010022437 insomnia Diseases 0.000 claims description 2
- 201000007772 internal hemorrhoid Diseases 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 208000030459 obsessive-compulsive personality disease Diseases 0.000 claims description 2
- 230000036407 pain Effects 0.000 claims description 2
- 208000022821 personality disease Diseases 0.000 claims description 2
- 208000014081 polyp of colon Diseases 0.000 claims description 2
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 230000036280 sedation Effects 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 125000002328 sterol group Chemical group 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 208000029257 vision disease Diseases 0.000 claims description 2
- 230000004393 visual impairment Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 13
- -1 C 1 -C 6 alkyl Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462014014P | 2014-06-18 | 2014-06-18 | |
| US62/014,014 | 2014-06-18 | ||
| US201562107236P | 2015-01-23 | 2015-01-23 | |
| US62/107,236 | 2015-01-23 | ||
| PCT/US2015/036510 WO2015195967A1 (en) | 2014-06-18 | 2015-06-18 | Oxysterols and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018113423A Division JP2018138619A (ja) | 2014-06-18 | 2018-06-14 | オキシステロールおよびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518323A JP2017518323A (ja) | 2017-07-06 |
| JP2017518323A5 true JP2017518323A5 (enExample) | 2018-07-26 |
| JP6628745B2 JP6628745B2 (ja) | 2020-01-15 |
Family
ID=54936111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572739A Active JP6628745B2 (ja) | 2014-06-18 | 2015-06-18 | オキシステロールおよびその使用方法 |
| JP2018113423A Withdrawn JP2018138619A (ja) | 2014-06-18 | 2018-06-14 | オキシステロールおよびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018113423A Withdrawn JP2018138619A (ja) | 2014-06-18 | 2018-06-14 | オキシステロールおよびその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US10259840B2 (enExample) |
| EP (2) | EP4306114A1 (enExample) |
| JP (2) | JP6628745B2 (enExample) |
| ES (1) | ES2970222T3 (enExample) |
| WO (1) | WO2015195967A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4245369A3 (en) | 2011-09-08 | 2023-11-22 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| MX362544B (es) | 2013-03-13 | 2019-01-24 | Sage Therapeutics Inc | Esteroides neuroactivos y metodos para su uso. |
| JP6628745B2 (ja) | 2014-06-18 | 2020-01-15 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびその使用方法 |
| BR112017007053A2 (pt) * | 2014-10-07 | 2018-06-19 | Sage Therapeutics Inc | compostos neuroativos e métodos de utilização deste composto. |
| MA42410B1 (fr) | 2015-07-06 | 2021-04-30 | Sage Therapeutics Inc | Oxystérols et leurs méthodes d'utilisation |
| WO2017007832A1 (en) | 2015-07-06 | 2017-01-12 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| SI3812392T1 (sl) | 2015-07-06 | 2025-09-30 | Sage Therapeutics, Inc. | Oksisteroli in postopki za uporabo le-teh |
| HUE059491T2 (hu) * | 2016-04-01 | 2022-11-28 | Sage Therapeutics Inc | Oxiszterolok és azok alkalmazási eljárásai |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| PT3481846T (pt) | 2016-07-07 | 2021-08-13 | Sage Therapeutics Inc | 24-hidroxiesteroides 11-substituídos para utilização no tratamento de afeções relacionadas com nmda |
| DK3481845T3 (da) * | 2016-07-11 | 2023-11-27 | Sage Therapeutics Inc | C17, c20 og c21 substituerede neuroaktive steroider og deres anvendelsesmetoder |
| EP3519422B1 (en) | 2016-09-30 | 2022-08-31 | Sage Therapeutics, Inc. | C7 substituted oxysterols and these compounds for use as nmda modulators |
| EP4105223B1 (en) | 2016-10-18 | 2025-04-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| MA46566A (fr) * | 2016-10-18 | 2019-08-28 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| CA3223179A1 (en) | 2021-06-11 | 2022-12-15 | Sage Therapeutics, Inc. | Neuroactive steroid for the treatment of alzheimer's disease |
| US20250002526A1 (en) * | 2021-10-22 | 2025-01-02 | Kyushu University, National University Corporation | Pharmaceutical composition having anti-cancer immunostimulating effect and/or immune checkpoint inhibition potentiating effect |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| JP2025504580A (ja) * | 2022-01-28 | 2025-02-12 | コレスゲン （シャンハイ） カンパニー リミテッド | ステロイド系化合物、その製造方法及び使用 |
| WO2025221731A1 (en) | 2024-04-15 | 2025-10-23 | Sage Therapeutics, Inc. | Nmda receptor-modulating compounds and methods of use thereof |
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2015
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2018
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2020
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2023
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2024
- 2024-09-23 US US18/893,565 patent/US20250257091A1/en active Pending