JP2014528485A5 - - Google Patents
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- Publication number
- JP2014528485A5 JP2014528485A5 JP2014535962A JP2014535962A JP2014528485A5 JP 2014528485 A5 JP2014528485 A5 JP 2014528485A5 JP 2014535962 A JP2014535962 A JP 2014535962A JP 2014535962 A JP2014535962 A JP 2014535962A JP 2014528485 A5 JP2014528485 A5 JP 2014528485A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- WEMSTZGSMUKWJC-UHFFFAOYSA-O CC(CC1)(C(CC2)C(CC3)C1C(CC1)C3CC1(C)O)C2C(C[NH2+]N=CC=N)=O Chemical compound CC(CC1)(C(CC2)C(CC3)C1C(CC1)C3CC1(C)O)C2C(C[NH2+]N=CC=N)=O WEMSTZGSMUKWJC-UHFFFAOYSA-O 0.000 description 1
- OLMPCBGYIZOSPC-ZISZBIOLSA-N CC(CC1)([C@@H](CC2)[C@H](CC3)[C@H]1C(CCC1C(C)=C4CC4)C3(C)C[C@H]1O)[C@H]2C(C[n]1cncc1)=O Chemical compound CC(CC1)([C@@H](CC2)[C@H](CC3)[C@H]1C(CCC1C(C)=C4CC4)C3(C)C[C@H]1O)[C@H]2C(C[n]1cncc1)=O OLMPCBGYIZOSPC-ZISZBIOLSA-N 0.000 description 1
- ZOGQGFCHOXYIRA-YBLSGOOYSA-N CCN(CC([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2CC[C@H](C[C@](CCC=N)(COC)O)CC1)=O)/C=C\N Chemical compound CCN(CC([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2CC[C@H](C[C@](CCC=N)(COC)O)CC1)=O)/C=C\N ZOGQGFCHOXYIRA-YBLSGOOYSA-N 0.000 description 1
- QMEKUHVFZNKVKW-SWKGGFOOSA-N C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1C(CC1)C3C[C@]1(COC)O)[C@H]2C(C[n]1nccc1)=O Chemical compound C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1C(CC1)C3C[C@]1(COC)O)[C@H]2C(C[n]1nccc1)=O QMEKUHVFZNKVKW-SWKGGFOOSA-N 0.000 description 1
- GLMMXZCVUUYNKR-RGBBFSEBSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@H](CC1)C3C[C@]1(CF)O)[C@H]2C(C[n]1nccn1)=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@H](CC1)C3C[C@]1(CF)O)[C@H]2C(C[n]1nccn1)=O GLMMXZCVUUYNKR-RGBBFSEBSA-N 0.000 description 1
- 0 C[C@](CC1)([C@](CC2)[C@@](CC3)[C@]1C(CC1)C3(C)C[C@]1(C(F)F)O)[C@]2C(CS*)=O Chemical compound C[C@](CC1)([C@](CC2)[C@@](CC3)[C@]1C(CC1)C3(C)C[C@]1(C(F)F)O)[C@]2C(CS*)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547291P | 2011-10-14 | 2011-10-14 | |
| US61/547,291 | 2011-10-14 | ||
| US201261698204P | 2012-09-07 | 2012-09-07 | |
| US61/698,204 | 2012-09-07 | ||
| PCT/US2012/060136 WO2013056181A1 (en) | 2011-10-14 | 2012-10-12 | 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235371A Division JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014528485A JP2014528485A (ja) | 2014-10-27 |
| JP2014528485A5 true JP2014528485A5 (enExample) | 2015-11-12 |
Family
ID=47143295
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535962A Withdrawn JP2014528485A (ja) | 2011-10-14 | 2012-10-12 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2017235371A Active JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2020132282A Active JP7096864B2 (ja) | 2011-10-14 | 2020-08-04 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2022101881A Active JP7617057B2 (ja) | 2011-10-14 | 2022-06-24 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2025001804A Pending JP2025061026A (ja) | 2011-10-14 | 2025-01-06 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235371A Active JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2020132282A Active JP7096864B2 (ja) | 2011-10-14 | 2020-08-04 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2022101881A Active JP7617057B2 (ja) | 2011-10-14 | 2022-06-24 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2025001804A Pending JP2025061026A (ja) | 2011-10-14 | 2025-01-06 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20150291654A1 (enExample) |
| EP (2) | EP2766380B1 (enExample) |
| JP (5) | JP2014528485A (enExample) |
| CN (4) | CN113234114A (enExample) |
| AU (6) | AU2012323888A1 (enExample) |
| CA (2) | CA3152410A1 (enExample) |
| ES (1) | ES2738526T3 (enExample) |
| PT (1) | PT2766380T (enExample) |
| WO (1) | WO2013056181A1 (enExample) |
Families Citing this family (62)
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| KR20120107533A (ko) | 2005-11-28 | 2012-10-02 | 마리누스 파마슈티컬스 | ｇａｎａｘｏｌｏｎｅ 제형, 이의 제조방법 및 용도 |
| HRP20230747T1 (hr) | 2011-09-08 | 2024-01-05 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, pripravci i njihova uporaba |
| CN113234114A (zh) | 2011-10-14 | 2021-08-10 | 萨奇治疗股份有限公司 | 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途 |
| SG10201606063RA (en) | 2012-01-23 | 2016-09-29 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
| NZ705410A (en) | 2012-08-21 | 2018-03-23 | Sage Therapeutics Inc | Methods of treating epilepsy or status epilepticus |
| EP2925327B1 (en) | 2012-11-30 | 2024-01-10 | The Regents of The University of California | Allopregnanolone for treating, reducing or mitigating symptoms of post-partum depression |
| RS67266B1 (sr) | 2013-03-13 | 2025-10-31 | Sage Therapeutics Inc | Neuroaktivni steroidi i postupci za njihovu upotrebu |
| SG10201802389SA (en) | 2013-04-17 | 2018-04-27 | Sage Therapeutics Inc | 19-nor c3,3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| PL2986624T3 (pl) * | 2013-04-17 | 2020-11-16 | Sage Therapeutics, Inc. | Neuroaktywne steroidy 19-NOR do stosowania w sposobach leczenia |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| AU2014290400B2 (en) | 2013-07-19 | 2019-12-05 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| ES2706180T3 (es) * | 2013-08-23 | 2019-03-27 | Sage Therapeutics Inc | Esteroides neuroactivos, composiciones y usos de los mismos |
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| ME03809B (me) | 2014-10-16 | 2021-04-20 | Sage Therapeutics Inc | KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a |
| SI3224269T1 (sl) | 2014-11-27 | 2020-10-30 | Sage Therapeutics, Inc. | Sestavki in metode za zdravljenje CNS motenj |
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| EP3258939B1 (en) | 2015-02-20 | 2022-09-07 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| EP3280420B1 (en) * | 2015-04-10 | 2024-03-27 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| MA45276A (fr) | 2015-06-18 | 2018-04-25 | Sage Therapeutics Inc | Solutions de stéroïdes neuroactifs et leurs méthodes d'utilisation |
| JP6882996B2 (ja) * | 2015-07-06 | 2021-06-02 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびそれらの使用の方法 |
| MD3319611T2 (ro) | 2015-07-06 | 2021-06-30 | Sage Therapeutics Inc | Oxisteroli și metode de utilizare a acestora |
| HUE055199T2 (hu) | 2015-07-06 | 2021-11-29 | Sage Therapeutics Inc | Oxiszterolok és alkalmazási eljárásaik |
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| PT3436022T (pt) * | 2016-04-01 | 2022-07-04 | Sage Therapeutics Inc | Oxisteróis e métodos de utilização dos mesmos |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| MD3481846T2 (ro) | 2016-07-07 | 2021-11-30 | Sage Therapeutics Inc | 24-Hidroxisteroli 11-substituiți pentru utilizare în tratamentul stărilor legate de NMDA |
| CN116162121A (zh) * | 2016-07-11 | 2023-05-26 | 萨奇治疗股份有限公司 | C17、c20和c21取代的神经活性类固醇及其使用方法 |
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