JP2014528485A5 - - Google Patents
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- Publication number
- JP2014528485A5 JP2014528485A5 JP2014535962A JP2014535962A JP2014528485A5 JP 2014528485 A5 JP2014528485 A5 JP 2014528485A5 JP 2014535962 A JP2014535962 A JP 2014535962A JP 2014535962 A JP2014535962 A JP 2014535962A JP 2014528485 A5 JP2014528485 A5 JP 2014528485A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- WEMSTZGSMUKWJC-UHFFFAOYSA-O CC(CC1)(C(CC2)C(CC3)C1C(CC1)C3CC1(C)O)C2C(C[NH2+]N=CC=N)=O Chemical compound CC(CC1)(C(CC2)C(CC3)C1C(CC1)C3CC1(C)O)C2C(C[NH2+]N=CC=N)=O WEMSTZGSMUKWJC-UHFFFAOYSA-O 0.000 description 1
- OLMPCBGYIZOSPC-ZISZBIOLSA-N CC(CC1)([C@@H](CC2)[C@H](CC3)[C@H]1C(CCC1C(C)=C4CC4)C3(C)C[C@H]1O)[C@H]2C(C[n]1cncc1)=O Chemical compound CC(CC1)([C@@H](CC2)[C@H](CC3)[C@H]1C(CCC1C(C)=C4CC4)C3(C)C[C@H]1O)[C@H]2C(C[n]1cncc1)=O OLMPCBGYIZOSPC-ZISZBIOLSA-N 0.000 description 1
- ZOGQGFCHOXYIRA-YBLSGOOYSA-N CCN(CC([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2CC[C@H](C[C@](CCC=N)(COC)O)CC1)=O)/C=C\N Chemical compound CCN(CC([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2CC[C@H](C[C@](CCC=N)(COC)O)CC1)=O)/C=C\N ZOGQGFCHOXYIRA-YBLSGOOYSA-N 0.000 description 1
- QMEKUHVFZNKVKW-SWKGGFOOSA-N C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1C(CC1)C3C[C@]1(COC)O)[C@H]2C(C[n]1nccc1)=O Chemical compound C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1C(CC1)C3C[C@]1(COC)O)[C@H]2C(C[n]1nccc1)=O QMEKUHVFZNKVKW-SWKGGFOOSA-N 0.000 description 1
- GLMMXZCVUUYNKR-RGBBFSEBSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@H](CC1)C3C[C@]1(CF)O)[C@H]2C(C[n]1nccn1)=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@H](CC1)C3C[C@]1(CF)O)[C@H]2C(C[n]1nccn1)=O GLMMXZCVUUYNKR-RGBBFSEBSA-N 0.000 description 1
- 0 C[C@](CC1)([C@](CC2)[C@@](CC3)[C@]1C(CC1)C3(C)C[C@]1(C(F)F)O)[C@]2C(CS*)=O Chemical compound C[C@](CC1)([C@](CC2)[C@@](CC3)[C@]1C(CC1)C3(C)C[C@]1(C(F)F)O)[C@]2C(CS*)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547291P | 2011-10-14 | 2011-10-14 | |
| US61/547,291 | 2011-10-14 | ||
| US201261698204P | 2012-09-07 | 2012-09-07 | |
| US61/698,204 | 2012-09-07 | ||
| PCT/US2012/060136 WO2013056181A1 (en) | 2011-10-14 | 2012-10-12 | 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235371A Division JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014528485A JP2014528485A (ja) | 2014-10-27 |
| JP2014528485A5 true JP2014528485A5 (enExample) | 2015-11-12 |
Family
ID=47143295
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535962A Withdrawn JP2014528485A (ja) | 2011-10-14 | 2012-10-12 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2017235371A Active JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2020132282A Active JP7096864B2 (ja) | 2011-10-14 | 2020-08-04 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2022101881A Active JP7617057B2 (ja) | 2011-10-14 | 2022-06-24 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2025001804A Pending JP2025061026A (ja) | 2011-10-14 | 2025-01-06 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235371A Active JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2020132282A Active JP7096864B2 (ja) | 2011-10-14 | 2020-08-04 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2022101881A Active JP7617057B2 (ja) | 2011-10-14 | 2022-06-24 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2025001804A Pending JP2025061026A (ja) | 2011-10-14 | 2025-01-06 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20150291654A1 (enExample) |
| EP (2) | EP3572417B1 (enExample) |
| JP (5) | JP2014528485A (enExample) |
| CN (4) | CN108976272B (enExample) |
| AU (6) | AU2012323888A1 (enExample) |
| CA (2) | CA2852057C (enExample) |
| ES (1) | ES2738526T3 (enExample) |
| PT (1) | PT2766380T (enExample) |
| WO (1) | WO2013056181A1 (enExample) |
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| CN101583620B (zh) | 2005-11-28 | 2016-08-17 | 马里纳斯医药公司 | 加奈索酮组合物及其制备和使用方法 |
| US20150158903A1 (en) | 2011-09-08 | 2015-06-11 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
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| WO2013112605A2 (en) | 2012-01-23 | 2013-08-01 | Sage Therapeutics, Inc. | Neuroactive steroid formulations and methods of treating cns disorders |
| IL275725B (en) | 2012-08-21 | 2022-08-01 | Sage Therapeutics Inc | Treatment methods for epilepsy and status epilepticus |
| EP4335505A3 (en) | 2012-11-30 | 2024-06-05 | The Regents of The University of California | Anticonvulsant activity of steroids |
| LT2968369T (lt) | 2013-03-13 | 2018-12-27 | Sage Therapeutics, Inc. | Neuroaktyvūs steroidai ir jų panaudojimo būdai |
| HRP20200995T1 (hr) * | 2013-04-17 | 2020-11-27 | Sage Therapeutics, Inc. | 19-nor neuroaktivni steroidi za metode liječenja |
| US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
| HRP20190232T1 (hr) * | 2013-04-17 | 2019-03-22 | Sage Therapeutics, Inc. | 19-nor c3,3-disupstituirani c21-n-pirazolil steroidi i postupci za njihovu upotrebu |
| WO2014169831A1 (en) * | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
| SMT202100229T1 (it) | 2013-07-19 | 2021-05-07 | Sage Therapeutics Inc | Steroidi neuroattivi, composizioni e loro usi |
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| SI3250210T1 (sl) | 2015-01-26 | 2021-07-30 | Sage Therapeutics, Inc. | Sestavki in metode za zdravljenje CNS motenj |
| US10329320B2 (en) | 2015-02-20 | 2019-06-25 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
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| AR105044A1 (es) | 2015-06-18 | 2017-08-30 | Sage Therapeutics Inc | Soluciones de esteroides neuroactivos y sus métodos de uso, recipiente |
| MA42409A (fr) | 2015-07-06 | 2018-05-16 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
| RS62220B1 (sr) | 2015-07-06 | 2021-09-30 | Sage Therapeutics Inc | Oksisteroli i postupci njihovog korišćenja |
| MX376833B (es) | 2015-07-06 | 2025-03-07 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos. |
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| SG11201807785VA (en) | 2016-03-08 | 2018-10-30 | Sage Therapeutics Inc | Neuroactive steroids, compositions, and uses thereof |
| CN114272249A (zh) | 2016-04-01 | 2022-04-05 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
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| CN109689673B (zh) * | 2016-07-11 | 2023-03-14 | 萨奇治疗股份有限公司 | C17、c20和c21取代的神经活性类固醇及其使用方法 |
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