JP2014528485A5 - - Google Patents
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- Publication number
- JP2014528485A5 JP2014528485A5 JP2014535962A JP2014535962A JP2014528485A5 JP 2014528485 A5 JP2014528485 A5 JP 2014528485A5 JP 2014535962 A JP2014535962 A JP 2014535962A JP 2014535962 A JP2014535962 A JP 2014535962A JP 2014528485 A5 JP2014528485 A5 JP 2014528485A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- WEMSTZGSMUKWJC-UHFFFAOYSA-O CC(CC1)(C(CC2)C(CC3)C1C(CC1)C3CC1(C)O)C2C(C[NH2+]N=CC=N)=O Chemical compound CC(CC1)(C(CC2)C(CC3)C1C(CC1)C3CC1(C)O)C2C(C[NH2+]N=CC=N)=O WEMSTZGSMUKWJC-UHFFFAOYSA-O 0.000 description 1
- OLMPCBGYIZOSPC-ZISZBIOLSA-N CC(CC1)([C@@H](CC2)[C@H](CC3)[C@H]1C(CCC1C(C)=C4CC4)C3(C)C[C@H]1O)[C@H]2C(C[n]1cncc1)=O Chemical compound CC(CC1)([C@@H](CC2)[C@H](CC3)[C@H]1C(CCC1C(C)=C4CC4)C3(C)C[C@H]1O)[C@H]2C(C[n]1cncc1)=O OLMPCBGYIZOSPC-ZISZBIOLSA-N 0.000 description 1
- ZOGQGFCHOXYIRA-YBLSGOOYSA-N CCN(CC([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2CC[C@H](C[C@](CCC=N)(COC)O)CC1)=O)/C=C\N Chemical compound CCN(CC([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H]1[C@H]2CC[C@H](C[C@](CCC=N)(COC)O)CC1)=O)/C=C\N ZOGQGFCHOXYIRA-YBLSGOOYSA-N 0.000 description 1
- QMEKUHVFZNKVKW-SWKGGFOOSA-N C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1C(CC1)C3C[C@]1(COC)O)[C@H]2C(C[n]1nccc1)=O Chemical compound C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1C(CC1)C3C[C@]1(COC)O)[C@H]2C(C[n]1nccc1)=O QMEKUHVFZNKVKW-SWKGGFOOSA-N 0.000 description 1
- GLMMXZCVUUYNKR-RGBBFSEBSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@H](CC1)C3C[C@]1(CF)O)[C@H]2C(C[n]1nccn1)=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@H](CC1)C3C[C@]1(CF)O)[C@H]2C(C[n]1nccn1)=O GLMMXZCVUUYNKR-RGBBFSEBSA-N 0.000 description 1
- 0 C[C@](CC1)([C@](CC2)[C@@](CC3)[C@]1C(CC1)C3(C)C[C@]1(C(F)F)O)[C@]2C(CS*)=O Chemical compound C[C@](CC1)([C@](CC2)[C@@](CC3)[C@]1C(CC1)C3(C)C[C@]1(C(F)F)O)[C@]2C(CS*)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547291P | 2011-10-14 | 2011-10-14 | |
| US61/547,291 | 2011-10-14 | ||
| US201261698204P | 2012-09-07 | 2012-09-07 | |
| US61/698,204 | 2012-09-07 | ||
| PCT/US2012/060136 WO2013056181A1 (en) | 2011-10-14 | 2012-10-12 | 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235371A Division JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014528485A JP2014528485A (ja) | 2014-10-27 |
| JP2014528485A5 true JP2014528485A5 (enExample) | 2015-11-12 |
Family
ID=47143295
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535962A Withdrawn JP2014528485A (ja) | 2011-10-14 | 2012-10-12 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2017235371A Active JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2020132282A Active JP7096864B2 (ja) | 2011-10-14 | 2020-08-04 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2022101881A Active JP7617057B2 (ja) | 2011-10-14 | 2022-06-24 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2025001804A Pending JP2025061026A (ja) | 2011-10-14 | 2025-01-06 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235371A Active JP6745783B2 (ja) | 2011-10-14 | 2017-12-07 | ３，３−二置換１９−ノルプレグナン化合物およびその使用 |
| JP2020132282A Active JP7096864B2 (ja) | 2011-10-14 | 2020-08-04 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2022101881A Active JP7617057B2 (ja) | 2011-10-14 | 2022-06-24 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
| JP2025001804A Pending JP2025061026A (ja) | 2011-10-14 | 2025-01-06 | ３，３－二置換１９－ノルプレグナン化合物およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20150291654A1 (enExample) |
| EP (3) | EP3572417B1 (enExample) |
| JP (5) | JP2014528485A (enExample) |
| CN (4) | CN104136452A (enExample) |
| AU (6) | AU2012323888A1 (enExample) |
| CA (2) | CA2852057C (enExample) |
| ES (1) | ES2738526T3 (enExample) |
| PT (1) | PT2766380T (enExample) |
| WO (1) | WO2013056181A1 (enExample) |
Families Citing this family (62)
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| US7858609B2 (en) | 2005-11-28 | 2010-12-28 | Marinus Pharmaceuticals | Solid ganaxolone formulations and methods for the making and use thereof |
| CA2848212C (en) | 2011-09-08 | 2022-03-29 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| EP3572417B1 (en) | 2011-10-14 | 2025-12-17 | Sage Therapeutics, LLC | 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof |
| EP2806877B2 (en) | 2012-01-23 | 2025-01-29 | Sage Therapeutics, Inc. | Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin |
| CA2882708A1 (en) | 2012-08-21 | 2014-02-27 | Sage Therapeutics, Inc. | Methods of treating epilepsy or status epilepticus |
| AU2013352141B2 (en) | 2012-11-30 | 2018-04-05 | The Regents Of The University Of California | Anticonvulsant activity of steroids |
| PT2968369T (pt) | 2013-03-13 | 2018-12-05 | Sage Therapeutics Inc | Esteroides neuroativos e métodos para o seu uso |
| EP2986624B1 (en) * | 2013-04-17 | 2020-03-25 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids for methods of treatment |
| KR102396328B1 (ko) * | 2013-04-17 | 2022-05-10 | 세이지 테라퓨틱스, 인크. | 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법 |
| US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| SI3021852T1 (sl) | 2013-07-19 | 2021-07-30 | Sage Therapeutics, Inc. | Nevroaktivni steroidi, sestavki in uporabe le-teh |
| AU2014308621C1 (en) | 2013-08-23 | 2022-01-06 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| ES2805598T3 (es) * | 2014-05-29 | 2021-02-12 | Sage Therapeutics Inc | Esteroides neuroactivos, composiciones y usos de los mismos |
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| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| TW201625660A (zh) * | 2014-09-17 | 2016-07-16 | 普瑞弗克斯公司 | Ｃ－２０類固醇化合物、其組成物及用於治療包含震盪之創傷性腦損傷（ｔｂｉ）的用途 |
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| CN117024501A (zh) * | 2014-10-16 | 2023-11-10 | 萨奇治疗股份有限公司 | 靶向cns障碍的组合物和方法 |
| WO2016082789A1 (en) | 2014-11-27 | 2016-06-02 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| RS61530B1 (sr) | 2015-01-26 | 2021-04-29 | Sage Therapeutics Inc | Kompozicije i postupci za lečenje poremećaja cns |
| EP4155314A1 (en) | 2015-02-20 | 2023-03-29 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| EP3280420B1 (en) * | 2015-04-10 | 2024-03-27 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| AR105044A1 (es) | 2015-06-18 | 2017-08-30 | Sage Therapeutics Inc | Soluciones de esteroides neuroactivos y sus métodos de uso, recipiente |
| HUE071964T2 (hu) | 2015-07-06 | 2025-10-28 | Sage Therapeutics Inc | Oxiszterolok és alkalmazási eljárásaik |
| EP3828194B1 (en) | 2015-07-06 | 2025-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| CA2991311C (en) * | 2015-07-06 | 2025-05-06 | Sage Therapeutics, Inc. | OXYSTEROLS AND THEIR METHODS OF USE |
| AU2016338672A1 (en) | 2015-10-16 | 2018-04-12 | Marinus Pharmaceuticals, Inc. | Injectable neurosteroid formulations containing nanoparticles |
| KR20240157128A (ko) | 2016-03-08 | 2024-10-31 | 세이지 테라퓨틱스, 인크. | 신경활성 스테로이드, 조성물, 및 그의 용도 |
| SMT202200300T1 (it) | 2016-04-01 | 2022-09-14 | Sage Therapeutics Inc | Ossisteroli e relativi metodi d'uso |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| ES2884071T3 (es) | 2016-07-07 | 2021-12-10 | Sage Therapeutics Inc | 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA |
| WO2018013615A1 (en) | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | C7, c12, and c16 substituted neuroactive steroids and their methods of use |
| MA45599A (fr) | 2016-07-11 | 2019-05-15 | Sage Therapeutics Inc | Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation |
| EP3481387A4 (en) | 2016-08-11 | 2020-04-08 | Ovid Therapeutics Inc | METHOD AND COMPOSITIONS FOR TREATING EPILEPTIC DISEASES |
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| EP3750909B1 (en) * | 2018-02-11 | 2025-03-05 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Steroid derivative regulators, method for preparing the same, and uses thereof |
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| JP7754799B2 (ja) | 2019-08-05 | 2025-10-15 | マリナス ファーマシューティカルズ， インコーポレイテッド | てんかん重積状態の治療に使用するためのガナキソロン |
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