JP2014526469A5 - - Google Patents
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- JP2014526469A5 JP2014526469A5 JP2014529913A JP2014529913A JP2014526469A5 JP 2014526469 A5 JP2014526469 A5 JP 2014526469A5 JP 2014529913 A JP2014529913 A JP 2014529913A JP 2014529913 A JP2014529913 A JP 2014529913A JP 2014526469 A5 JP2014526469 A5 JP 2014526469A5
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- 150000001875 compounds Chemical class 0.000 claims description 86
- 229910052739 hydrogen Inorganic materials 0.000 claims description 38
- 239000001257 hydrogen Substances 0.000 claims description 38
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 10
- 150000002431 hydrogen Chemical class 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 125000005842 heteroatom Chemical group 0.000 claims description 9
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 8
- 230000009529 traumatic brain injury Effects 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 6
- 125000002947 alkylene group Chemical group 0.000 claims description 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 4
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 208000029560 autism spectrum disease Diseases 0.000 claims description 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 4
- 206010015037 epilepsy Diseases 0.000 claims description 4
- 125000004474 heteroalkylene group Chemical group 0.000 claims description 4
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- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- 229940127240 opiate Drugs 0.000 claims description 3
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- 206010012289 Dementia Diseases 0.000 claims description 2
- 208000027534 Emotional disease Diseases 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
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- 206010041250 Social phobia Diseases 0.000 claims description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 206010048010 Withdrawal syndrome Diseases 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 2
- 229960003920 cocaine Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000024732 dysthymic disease Diseases 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 206010022437 insomnia Diseases 0.000 claims description 2
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- 230000000698 schizophrenic effect Effects 0.000 claims description 2
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- 125000000547 substituted alkyl group Chemical group 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 238000000034 method Methods 0.000 description 5
- 125000004450 alkenylene group Chemical group 0.000 description 4
- 125000004419 alkynylene group Chemical group 0.000 description 4
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- QLQYZOMZOGPIOC-QTFZZFSVSA-N CC(C)C(CO[C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1)=O Chemical compound CC(C)C(CO[C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1)=O QLQYZOMZOGPIOC-QTFZZFSVSA-N 0.000 description 1
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- CHGDJFGOJYCPHZ-QQHYONEASA-N CC(CCC(C)O)[C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@H](CC[C@@H](C2)O)C2=CC1 Chemical compound CC(CCC(C)O)[C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@H](CC[C@@H](C2)O)C2=CC1 CHGDJFGOJYCPHZ-QQHYONEASA-N 0.000 description 1
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- PQNBSROBFNWPRX-XLUYLUSISA-N CC(CCCO)[C@@H](CC1)C(C)(CC2)C1C1C2C(CC[C@@H](C2)O)C2=CC1 Chemical compound CC(CCCO)[C@@H](CC1)C(C)(CC2)C1C1C2C(CC[C@@H](C2)O)C2=CC1 PQNBSROBFNWPRX-XLUYLUSISA-N 0.000 description 1
- HBKQWULJDAALRY-NLIMMPQESA-N CC([C@@H](CC1)C(C)(CC2)C1C1C2[C@@H](CC[C@@H](C2)O)C2=CC1)C(CO)(F)F Chemical compound CC([C@@H](CC1)C(C)(CC2)C1C1C2[C@@H](CC[C@@H](C2)O)C2=CC1)C(CO)(F)F HBKQWULJDAALRY-NLIMMPQESA-N 0.000 description 1
- RVXHMRSBDNBDEY-UHFFFAOYSA-N CCOC(C(C)C)(F)F Chemical compound CCOC(C(C)C)(F)F RVXHMRSBDNBDEY-UHFFFAOYSA-N 0.000 description 1
- VOXRDLZRMKBAFE-UHFFFAOYSA-N CCO[IH][IH]CC(C)OCC(C)(F)F Chemical compound CCO[IH][IH]CC(C)OCC(C)(F)F VOXRDLZRMKBAFE-UHFFFAOYSA-N 0.000 description 1
- UIIQWGBQZPMASR-UHFFFAOYSA-N COCC(F)(F)I Chemical compound COCC(F)(F)I UIIQWGBQZPMASR-UHFFFAOYSA-N 0.000 description 1
- ZOOUPKHXFIPMMF-DYNRJKDWSA-N C[C@@H]([C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1)OC(c1ccccc1)=O Chemical compound C[C@@H]([C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1)OC(c1ccccc1)=O ZOOUPKHXFIPMMF-DYNRJKDWSA-N 0.000 description 1
- XDYKAHLZXSUEFM-FQJGFYLYSA-N C[C@@H]([C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1)OCC(C(F)(F)F)=O Chemical compound C[C@@H]([C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1)OCC(C(F)(F)F)=O XDYKAHLZXSUEFM-FQJGFYLYSA-N 0.000 description 1
- RJXMOBXFLJYGMG-GRMHXZAGSA-N C[C@@](CC1)([C@@H](CCCC(O)=O)CC2)C2C2C1[C@@](C)(CC[C@@](C)(C1)O)C1=CC2 Chemical compound C[C@@](CC1)([C@@H](CCCC(O)=O)CC2)C2C2C1[C@@](C)(CC[C@@](C)(C1)O)C1=CC2 RJXMOBXFLJYGMG-GRMHXZAGSA-N 0.000 description 1
- HSPFXQHDOBRBLE-QRIWCCNGSA-N C[C@@](CC1)([C@@H](COCC(C(F)(F)F)=O)CC2)C2C2C1[C@@](C)(CC[C@@](C)(C1)O)C1=CC2 Chemical compound C[C@@](CC1)([C@@H](COCC(C(F)(F)F)=O)CC2)C2C2C1[C@@](C)(CC[C@@](C)(C1)O)C1=CC2 HSPFXQHDOBRBLE-QRIWCCNGSA-N 0.000 description 1
- LSWHPMWXDZERPR-IVFIPZGWSA-N C[C@H](CC(C(F)(F)F)=O)[C@@H](CC1)[C@@](C)(CC2)C1C1C2C(C)(CC[C@@](C)(C2)O)C2=CC1 Chemical compound C[C@H](CC(C(F)(F)F)=O)[C@@H](CC1)[C@@](C)(CC2)C1C1C2C(C)(CC[C@@](C)(C2)O)C2=CC1 LSWHPMWXDZERPR-IVFIPZGWSA-N 0.000 description 1
- BJHUPERNCXCFTH-JFBOSTTDSA-N C[C@H](CCC(C)(C)O)[C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@H](CCC(C2)=O)C2=CC1 Chemical compound C[C@H](CCC(C)(C)O)[C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@H](CCC(C2)=O)C2=CC1 BJHUPERNCXCFTH-JFBOSTTDSA-N 0.000 description 1
- LLAUXVXYDZUXBL-VKHMYHEASA-N C[C@H](OC(C)(F)F)I Chemical compound C[C@H](OC(C)(F)F)I LLAUXVXYDZUXBL-VKHMYHEASA-N 0.000 description 1
- ZOOUPKHXFIPMMF-HZKWPTRHSA-N C[C@H]([C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1)OC(c1ccccc1)=O Chemical compound C[C@H]([C@@H](CC1)[C@@](C)(CC2)C1C1C2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1)OC(c1ccccc1)=O ZOOUPKHXFIPMMF-HZKWPTRHSA-N 0.000 description 1
- ZZLABZROPODDLV-DNCNGORPSA-N C[C@](CC1)(C(CC2)C3C1[C@@](C)(CC[C@@](C)(C1)O)C1=CC3)[C@H]2OCC(C(F)(F)F)=O Chemical compound C[C@](CC1)(C(CC2)C3C1[C@@](C)(CC[C@@](C)(C1)O)C1=CC3)[C@H]2OCC(C(F)(F)F)=O ZZLABZROPODDLV-DNCNGORPSA-N 0.000 description 1
- JLWWULDDVJQPID-HHZWQIATSA-N C[C@](CC1)(C(CC2)C3C1[C@@](C)(CC[C@@](C)(C1)O)C1=CC3)[C@H]2OCCC(C(F)(F)F)=O Chemical compound C[C@](CC1)(C(CC2)C3C1[C@@](C)(CC[C@@](C)(C1)O)C1=CC3)[C@H]2OCCC(C(F)(F)F)=O JLWWULDDVJQPID-HHZWQIATSA-N 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532427P | 2011-09-08 | 2011-09-08 | |
| US61/532,427 | 2011-09-08 | ||
| PCT/US2012/054261 WO2013036835A1 (en) | 2011-09-08 | 2012-09-07 | Neuroactive steroids, compositions, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017169737A Division JP2018021059A (ja) | 2011-09-08 | 2017-09-04 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526469A JP2014526469A (ja) | 2014-10-06 |
| JP2014526469A5 true JP2014526469A5 (enExample) | 2015-10-29 |
| JP6205362B2 JP6205362B2 (ja) | 2017-09-27 |
Family
ID=46964032
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529913A Active JP6205362B2 (ja) | 2011-09-08 | 2012-09-07 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
| JP2017169737A Withdrawn JP2018021059A (ja) | 2011-09-08 | 2017-09-04 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
| JP2019011169A Active JP6777773B2 (ja) | 2011-09-08 | 2019-01-25 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
| JP2020170611A Withdrawn JP2021008504A (ja) | 2011-09-08 | 2020-10-08 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
| JP2025064398A Pending JP2025108535A (ja) | 2011-09-08 | 2025-04-09 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017169737A Withdrawn JP2018021059A (ja) | 2011-09-08 | 2017-09-04 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
| JP2019011169A Active JP6777773B2 (ja) | 2011-09-08 | 2019-01-25 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
| JP2020170611A Withdrawn JP2021008504A (ja) | 2011-09-08 | 2020-10-08 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
| JP2025064398A Pending JP2025108535A (ja) | 2011-09-08 | 2025-04-09 | 神経刺激性のステロイド、組成物、およびそれらの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US20150158903A1 (enExample) |
| EP (2) | EP4245369A3 (enExample) |
| JP (5) | JP6205362B2 (enExample) |
| CN (4) | CN107936076B (enExample) |
| AU (6) | AU2012304412A1 (enExample) |
| BR (1) | BR112014005373B1 (enExample) |
| CA (1) | CA2848212C (enExample) |
| DK (1) | DK2753632T3 (enExample) |
| ES (1) | ES2951664T3 (enExample) |
| FI (1) | FI2753632T3 (enExample) |
| HR (1) | HRP20230747T1 (enExample) |
| HU (1) | HUE062616T2 (enExample) |
| LT (1) | LT2753632T (enExample) |
| PL (1) | PL2753632T3 (enExample) |
| PT (1) | PT2753632T (enExample) |
| RS (1) | RS64332B1 (enExample) |
| RU (1) | RU2665571C2 (enExample) |
| SI (1) | SI2753632T1 (enExample) |
| SM (1) | SMT202300232T1 (enExample) |
| WO (1) | WO2013036835A1 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006047022A1 (en) | 2004-10-25 | 2006-05-04 | Virginia Commonwealth University | Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis |
| MX2008006888A (es) | 2005-11-28 | 2008-09-30 | Marinus Pharmaceuticals | Formulas y metodos para la manufactura y uso de la ganaxolona. |
| US9034859B2 (en) | 2011-04-06 | 2015-05-19 | Virginia Commonwealth University | Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation |
| CN107936076B (zh) | 2011-09-08 | 2021-10-15 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物、及其用途 |
| WO2013043985A1 (en) | 2011-09-23 | 2013-03-28 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| ES2738526T3 (es) | 2011-10-14 | 2020-01-23 | Sage Therapeutics Inc | Compuestos 19-norpregnano 3,3-disustituidos, composiciones y usos de los mismos |
| NZ773177A (en) | 2012-01-23 | 2022-09-30 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
| WO2014028398A2 (en) | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids |
| IL275725B (en) | 2012-08-21 | 2022-08-01 | Sage Therapeutics Inc | Treatment methods for epilepsy and status epilepticus |
| DK2925327T3 (da) | 2012-11-30 | 2024-03-25 | Univ California | Allopregnanolon til behandling, reduktion eller lindring af symptomer på fødselsdepression |
| MX2015012437A (es) * | 2013-03-13 | 2016-04-15 | Sage Therapeutics Inc | Esteroides neuroactivos, composiciones, y usos de los mismos. |
| AU2014243773B2 (en) * | 2013-03-13 | 2018-12-13 | Sage Therapeutics, Inc. | Neuroactive steroids and methods of use thereof |
| RS60420B1 (sr) | 2013-04-17 | 2020-07-31 | Sage Therapeutics Inc | 19-nor neuroaktivni steroidi za metode lečenja |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| AU2014256229B2 (en) | 2013-04-17 | 2018-10-04 | Sage Therapeutics, Inc. | 19-nor C3,3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| CN103333216A (zh) * | 2013-06-04 | 2013-10-02 | 苏州大学 | 5α-6-酮-胆甾烷类似物及其应用 |
| PL3021852T3 (pl) | 2013-07-19 | 2021-07-05 | Sage Therapeutics, Inc. | Neuroaktywne steroidy, kompozycje i ich zastosowania |
| JP6466942B2 (ja) | 2013-08-23 | 2019-02-06 | セージ セラピューティクス， インコーポレイテッド | 向神経活性ステロイド、組成物、及びその使用 |
| TWI734665B (zh) | 2013-12-24 | 2021-08-01 | 維吉尼亞聯邦大學 | 氧化膽固醇硫酸鹽（ｏｃｓ）之用途 |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| US10259840B2 (en) | 2014-06-18 | 2019-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| EP3204011A4 (en) | 2014-10-07 | 2018-06-20 | Sage Therapeutics, Inc. | Neuroactive compounds and methods of use thereof |
| HUE051488T2 (hu) | 2014-10-16 | 2021-03-01 | Sage Therapeutics Inc | Készítmények és eljárások központi idegrendszeri rendellenességek kezelésére |
| WO2016061527A1 (en) | 2014-10-16 | 2016-04-21 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| US10774108B2 (en) | 2014-11-27 | 2020-09-15 | Sage Therapeutics, Inc. | Compositions and methods for treating CNS disorders |
| PL3250210T3 (pl) | 2015-01-26 | 2021-07-26 | Sage Therapeutics, Inc. | Kompozycje i sposoby leczenia zaburzeń OUN |
| JP6875996B2 (ja) | 2015-02-20 | 2021-05-26 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド、組成物、およびその使用 |
| CA2991214C (en) * | 2015-07-06 | 2024-04-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| JP6882996B2 (ja) | 2015-07-06 | 2021-06-02 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびそれらの使用の方法 |
| US11117924B2 (en) | 2015-07-06 | 2021-09-14 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| NZ739219A (en) * | 2015-07-30 | 2019-03-29 | Intercept Pharmaceuticals Inc | Methods for preparation of bile acids and derivatives thereof |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| US10780099B2 (en) | 2015-10-16 | 2020-09-22 | Marinus Pharmaceuticals, Inc. | Injectable neurosteroid formulations containing nanoparticles |
| US9637514B1 (en) | 2015-10-26 | 2017-05-02 | MAX BioPharma, Inc. | Oxysterols and hedgehog signaling |
| EP3394030B2 (en) | 2015-12-22 | 2025-02-12 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of agents |
| WO2017149052A1 (en) * | 2016-03-02 | 2017-09-08 | Patheon Austria Gmbh Co. & Kg | Process and intermediates for the production of 17(20)-ene b-seco steroids |
| WO2017156103A1 (en) | 2016-03-08 | 2017-09-14 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
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