JP2015512951A5 - - Google Patents
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- JP2015512951A5 JP2015512951A5 JP2015505972A JP2015505972A JP2015512951A5 JP 2015512951 A5 JP2015512951 A5 JP 2015512951A5 JP 2015505972 A JP2015505972 A JP 2015505972A JP 2015505972 A JP2015505972 A JP 2015505972A JP 2015512951 A5 JP2015512951 A5 JP 2015512951A5
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- Prior art keywords
- compound
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- dementia
- pharmaceutical composition
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical group 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000020706 Autistic disease Diseases 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 238000013019 agitation Methods 0.000 claims 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 claims 1
- 206010001497 Agitation Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000026331 Disruptive, Impulse Control, and Conduct disease Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000006264 Korsakoff syndrome Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010061296 Motor dysfunction Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 208000024777 Prion disease Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 210000004227 basal ganglia Anatomy 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000001054 cortical effect Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 229960003638 dopamine Drugs 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000015046 intermittent explosive disease Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000000697 serotonin reuptake Effects 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000015891 sexual disease Diseases 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624292P | 2012-04-14 | 2012-04-14 | |
| US201261624291P | 2012-04-14 | 2012-04-14 | |
| US201261624293P | 2012-04-14 | 2012-04-14 | |
| US61/624,291 | 2012-04-14 | ||
| US61/624,292 | 2012-04-14 | ||
| US61/624,293 | 2012-04-14 | ||
| US201261671713P | 2012-07-14 | 2012-07-14 | |
| US201261671723P | 2012-07-14 | 2012-07-14 | |
| US61/671,713 | 2012-07-14 | ||
| US61/671,723 | 2012-07-14 | ||
| PCT/US2013/036514 WO2013155505A1 (en) | 2012-04-14 | 2013-04-14 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512951A JP2015512951A (ja) | 2015-04-30 |
| JP2015512951A5 true JP2015512951A5 (enExample) | 2016-06-09 |
| JP6242855B2 JP6242855B2 (ja) | 2017-12-06 |
Family
ID=49328233
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505971A Active JP6334511B2 (ja) | 2012-04-14 | 2013-04-14 | 新規方法 |
| JP2015505972A Active JP6242855B2 (ja) | 2012-04-14 | 2013-04-14 | 有機化合物 |
| JP2015505973A Withdrawn JP2015514135A (ja) | 2012-04-14 | 2013-04-14 | 新規組成物および方法 |
| JP2018107717A Withdrawn JP2018168161A (ja) | 2012-04-14 | 2018-06-05 | 新規組成物および方法 |
| JP2021035948A Pending JP2021098724A (ja) | 2012-04-14 | 2021-03-08 | 新規組成物および方法 |
| JP2023136052A Pending JP2023159345A (ja) | 2012-04-14 | 2023-08-24 | 新規組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505971A Active JP6334511B2 (ja) | 2012-04-14 | 2013-04-14 | 新規方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505973A Withdrawn JP2015514135A (ja) | 2012-04-14 | 2013-04-14 | 新規組成物および方法 |
| JP2018107717A Withdrawn JP2018168161A (ja) | 2012-04-14 | 2018-06-05 | 新規組成物および方法 |
| JP2021035948A Pending JP2021098724A (ja) | 2012-04-14 | 2021-03-08 | 新規組成物および方法 |
| JP2023136052A Pending JP2023159345A (ja) | 2012-04-14 | 2023-08-24 | 新規組成物および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US20150080404A1 (enExample) |
| EP (4) | EP2836211B1 (enExample) |
| JP (6) | JP6334511B2 (enExample) |
| KR (1) | KR20140146192A (enExample) |
| CN (1) | CN104519886B (enExample) |
| AU (1) | AU2013245702A1 (enExample) |
| CA (1) | CA2870303A1 (enExample) |
| ES (1) | ES2727815T3 (enExample) |
| IN (1) | IN2014DN08562A (enExample) |
| MX (1) | MX2014012374A (enExample) |
| RU (1) | RU2014145682A (enExample) |
| WO (3) | WO2013155504A1 (enExample) |
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| KR102107954B1 (ko) | 2007-03-12 | 2020-05-07 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
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| KR20140146192A (ko) | 2012-04-14 | 2014-12-24 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| US9724396B2 (en) | 2013-03-15 | 2017-08-08 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
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| US10317418B2 (en) | 2015-02-24 | 2019-06-11 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
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| US20210008065A1 (en) | 2018-03-23 | 2021-01-14 | Intra-Cellular Therapies, Inc. | Organic compounds |
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