MX2020007271A - Sales y cristales novedosos. - Google Patents

Sales y cristales novedosos.

Info

Publication number
MX2020007271A
MX2020007271A MX2020007271A MX2020007271A MX2020007271A MX 2020007271 A MX2020007271 A MX 2020007271A MX 2020007271 A MX2020007271 A MX 2020007271A MX 2020007271 A MX2020007271 A MX 2020007271A MX 2020007271 A MX2020007271 A MX 2020007271A
Authority
MX
Mexico
Prior art keywords
crystals
novel salts
utan
quinoxalin
pyrido
Prior art date
Application number
MX2020007271A
Other languages
English (en)
Inventor
Lawrence P Wennogle
Peng Li
Edwin Aret
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of MX2020007271A publication Critical patent/MX2020007271A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La divulgación provee formas de sal clorhidrato nuevas, farmacéuticamente aceptables, de 1-(4-fluoro-fenil)-4-((6bR,10aS)- 3-metil-2,3,6b,9,10,10a-hexahidro-1H,7H-pirido[3',4':4,5]pirrolo[ 1,2,3-de]quinoxalin-8-il)-butan-1-ona, junto con métodos de preparación y uso de las mismas, y composiciones farmacéuticas que las comprenden.
MX2020007271A 2017-09-26 2018-09-26 Sales y cristales novedosos. MX2020007271A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762563341P 2017-09-26 2017-09-26
PCT/US2018/052922 WO2019067591A1 (en) 2017-09-26 2018-09-26 NEW SALTS AND CRYSTALS

Publications (1)

Publication Number Publication Date
MX2020007271A true MX2020007271A (es) 2020-08-17

Family

ID=65903143

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020007271A MX2020007271A (es) 2017-09-26 2018-09-26 Sales y cristales novedosos.

Country Status (6)

Country Link
US (2) US11440911B2 (es)
EP (1) EP3687535A4 (es)
JP (1) JP2020535231A (es)
CN (1) CN111107847A (es)
MX (1) MX2020007271A (es)
WO (1) WO2019067591A1 (es)

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
CA2374239A1 (en) 1999-06-15 2000-12-21 Albert J. Robichaud Substituted heterocycle fused gamma-carbolines
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
US6849619B2 (en) 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
EP1343791A2 (en) 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists
CA2445159C (en) 2001-04-24 2012-09-11 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
JP2006528187A (ja) 2003-07-21 2006-12-14 スミスクライン ビーチャム コーポレーション （２Ｓ，４Ｓ）−４−フルオロ−１−［４−フルオロ−β−（４−フルオロフェニル）−Ｌ−フェニルアラニル］−２−ピロリジンカルボニトリルｐ−トルエンスルホン酸塩及びその無水結晶形態
US20100204470A1 (en) * 2006-06-27 2010-08-12 Sandoz Ag method for salt preparation
CN101796051B (zh) * 2007-03-12 2013-11-06 细胞内治疗公司 与取代的杂环稠合的γ-咔啉的合成
CN101842010A (zh) 2007-08-01 2010-09-22 梅迪维新神经学公司 使用抗精神病的组合治疗产品来治疗精神分裂症的方法和组合物
PL2262505T3 (pl) 2008-03-12 2015-04-30 Intra Cellular Therapies Inc Podstawione heterocykliczne skondensowane gamma-karboliny w postaci stałej
CN102105059B (zh) * 2008-05-27 2015-09-30 细胞内治疗公司 用于睡眠障碍和其他疾病的方法和组合物
RU2591194C2 (ru) 2010-04-22 2016-07-10 Интра-Селлулар Терапиз, Инк. Органические соединения
WO2013155504A1 (en) * 2012-04-14 2013-10-17 Intra-Cellular Therapies, Inc. Novel methods
WO2014145192A1 (en) 2013-03-15 2014-09-18 Intra-Cellular Therapies, Inc. Organic compounds
ES2893621T3 (es) 2013-12-03 2022-02-09 Intra Cellular Therapies Inc Métodos para el tratamiento de los síntomas residuales de la esquizofrenia
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
JP6686168B2 (ja) 2016-03-25 2020-04-22 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2017172811A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel co-crystals
WO2017172784A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel salts and crystals
WO2018031535A1 (en) 2016-08-09 2018-02-15 Assia Chemical Industries Ltd. Solid state forms of lumateperone ditosylate salt
CN116327770A (zh) 2017-03-24 2023-06-27 细胞内治疗公司 新组合物和方法
CN110636845A (zh) 2017-04-10 2019-12-31 雷迪博士实验室有限公司 卢美哌隆对甲苯磺酸盐的无定形形式和固体分散体
EP3717484A4 (en) 2017-11-27 2021-08-04 Egis Gyógyszergyár Zrt. PROCESS FOR THE PRODUCTION OF LUMATEPERON AND ITS SALT
JP7483671B2 (ja) 2018-06-11 2024-05-15 イントラ－セルラー・セラピーズ・インコーポレイテッド 置換ヘテロ環縮合ガンマ－カルボリン類合成

Also Published As

Publication number Publication date
EP3687535A4 (en) 2021-06-09
US20200247805A1 (en) 2020-08-06
EP3687535A1 (en) 2020-08-05
US11440911B2 (en) 2022-09-13
WO2019067591A1 (en) 2019-04-04
JP2020535231A (ja) 2020-12-03
US20220363682A1 (en) 2022-11-17
CN111107847A (zh) 2020-05-05

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