JP2017531020A5 - - Google Patents
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- JP2017531020A5 JP2017531020A5 JP2017520486A JP2017520486A JP2017531020A5 JP 2017531020 A5 JP2017531020 A5 JP 2017531020A5 JP 2017520486 A JP2017520486 A JP 2017520486A JP 2017520486 A JP2017520486 A JP 2017520486A JP 2017531020 A5 JP2017531020 A5 JP 2017531020A5
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- 150000001875 compounds Chemical class 0.000 claims description 89
- 125000000217 alkyl group Chemical group 0.000 claims description 65
- 229910052739 hydrogen Inorganic materials 0.000 claims description 44
- 239000001257 hydrogen Substances 0.000 claims description 44
- 150000003839 salts Chemical class 0.000 claims description 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
- 125000000623 heterocyclic group Chemical group 0.000 claims description 34
- 208000035475 disorder Diseases 0.000 claims description 32
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 23
- 125000001072 heteroaryl group Chemical group 0.000 claims description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 210000003169 central nervous system Anatomy 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 125000006706 (C3-C6) carbocyclyl group Chemical group 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 8
- 206010002091 Anaesthesia Diseases 0.000 claims description 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 8
- 206010039897 Sedation Diseases 0.000 claims description 8
- 230000037005 anaesthesia Effects 0.000 claims description 8
- 230000036280 sedation Effects 0.000 claims description 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 7
- 206010010904 Convulsion Diseases 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 206010006550 Bulimia nervosa Diseases 0.000 claims description 4
- 208000030814 Eating disease Diseases 0.000 claims description 4
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 4
- 208000026139 Memory disease Diseases 0.000 claims description 4
- 208000019022 Mood disease Diseases 0.000 claims description 4
- 208000016285 Movement disease Diseases 0.000 claims description 4
- 208000002193 Pain Diseases 0.000 claims description 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 4
- 208000009205 Tinnitus Diseases 0.000 claims description 4
- 206010048010 Withdrawal syndrome Diseases 0.000 claims description 4
- 208000029560 autism spectrum disease Diseases 0.000 claims description 4
- 208000010877 cognitive disease Diseases 0.000 claims description 4
- 230000036461 convulsion Effects 0.000 claims description 4
- 235000014632 disordered eating Nutrition 0.000 claims description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 4
- 230000036407 pain Effects 0.000 claims description 4
- 208000022821 personality disease Diseases 0.000 claims description 4
- 201000000980 schizophrenia Diseases 0.000 claims description 4
- 208000019116 sleep disease Diseases 0.000 claims description 4
- 238000001228 spectrum Methods 0.000 claims description 4
- 201000009032 substance abuse Diseases 0.000 claims description 4
- 231100000736 substance abuse Toxicity 0.000 claims description 4
- 208000011117 substance-related disease Diseases 0.000 claims description 4
- 231100000886 tinnitus Toxicity 0.000 claims description 4
- 208000009575 Angelman syndrome Diseases 0.000 claims description 2
- 208000000103 Anorexia Nervosa Diseases 0.000 claims description 2
- 208000032841 Bulimia Diseases 0.000 claims description 2
- 206010006895 Cachexia Diseases 0.000 claims description 2
- 208000001914 Fragile X syndrome Diseases 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 201000009916 Postpartum depression Diseases 0.000 claims description 2
- 208000006289 Rett Syndrome Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 206010044565 Tremor Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 201000006517 essential tremor Diseases 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 125000002950 monocyclic group Chemical group 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000020685 sleep-wake disease Diseases 0.000 claims description 2
- 239000008247 solid mixture Substances 0.000 claims description 2
- 208000005809 status epilepticus Diseases 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 230000000472 traumatic effect Effects 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims description 2
- 208000019553 vascular disease Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 38
- 150000001721 carbon Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- -1 bicyclic compound Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 23
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 0 C[C@@](*)C([C@@](CC1)C(C)(CC2)[C@]1[C@@](CC1)[C@]2[C@@](CC2)[C@]1C[C@]2(*)O)=O Chemical compound C[C@@](*)C([C@@](CC1)C(C)(CC2)[C@]1[C@@](CC1)[C@]2[C@@](CC2)[C@]1C[C@]2(*)O)=O 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462064957P | 2014-10-16 | 2014-10-16 | |
| US62/064,957 | 2014-10-16 | ||
| PCT/US2015/056066 WO2016061537A1 (en) | 2014-10-16 | 2015-10-16 | Compositions and methods for treating cns disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020127234A Division JP7085592B2 (ja) | 2014-10-16 | 2020-07-28 | Ｃｎｓ障害を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531020A JP2017531020A (ja) | 2017-10-19 |
| JP2017531020A5 true JP2017531020A5 (enExample) | 2018-11-29 |
| JP6742308B2 JP6742308B2 (ja) | 2020-08-19 |
Family
ID=55747454
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017520486A Active JP6742308B2 (ja) | 2014-10-16 | 2015-10-16 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2020127234A Active JP7085592B2 (ja) | 2014-10-16 | 2020-07-28 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2022091738A Active JP7510461B2 (ja) | 2014-10-16 | 2022-06-06 | Ｃｎｓ障害を処置するための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020127234A Active JP7085592B2 (ja) | 2014-10-16 | 2020-07-28 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2022091738A Active JP7510461B2 (ja) | 2014-10-16 | 2022-06-06 | Ｃｎｓ障害を処置するための組成物および方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US20170233433A1 (enExample) |
| EP (3) | EP4275748A3 (enExample) |
| JP (3) | JP6742308B2 (enExample) |
| AU (3) | AU2015331597B2 (enExample) |
| CY (1) | CY1123246T1 (enExample) |
| DK (1) | DK3206493T3 (enExample) |
| ES (1) | ES2808855T3 (enExample) |
| HR (1) | HRP20201216T1 (enExample) |
| HU (1) | HUE051488T2 (enExample) |
| LT (1) | LT3206493T (enExample) |
| ME (1) | ME03809B (enExample) |
| NZ (1) | NZ769042A (enExample) |
| PL (1) | PL3206493T3 (enExample) |
| PT (1) | PT3206493T (enExample) |
| RS (1) | RS60642B1 (enExample) |
| SI (1) | SI3206493T1 (enExample) |
| SM (1) | SMT202000414T1 (enExample) |
| WO (1) | WO2016061537A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3152410A1 (en) | 2011-10-14 | 2013-04-18 | Sage Therapeutics, Inc. | 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders |
| PL2887944T3 (pl) | 2012-08-21 | 2022-02-21 | Sage Therapeutics, Inc. | Allopregnanolon do leczenia lekoopornego stanu padaczkowego |
| WO2014169831A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
| CN113527400B (zh) | 2013-04-17 | 2024-06-28 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 |
| RU2019126333A (ru) | 2013-04-17 | 2019-10-08 | Сейдж Терапьютикс, Инк. | 19-нор нейроактивные стероиды и способы их применения |
| US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
| WO2015010054A2 (en) | 2013-07-19 | 2015-01-22 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| AU2014308621C1 (en) | 2013-08-23 | 2022-01-06 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| CN106661078A (zh) * | 2014-05-29 | 2017-05-10 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物、及其用途 |
| WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| SMT202000414T1 (it) | 2014-10-16 | 2020-09-10 | Sage Therapeutics Inc | Composizioni e metodi per trattare disturbi del snc |
| MX2021004492A (es) | 2014-10-16 | 2022-12-05 | Sage Therapeutics Inc | Composiciones para el tratamiento de trastornos del snc. |
| ME03749B (me) | 2014-11-27 | 2021-04-20 | Sage Therapeutics Inc | KOMPOZICIJE I POSTUPCIZA LEČENJE POREMEĆAJA CNS-a |
| DK3250210T3 (da) | 2015-01-26 | 2021-03-08 | Sage Therapeutics Inc | Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser |
| JP6875996B2 (ja) | 2015-02-20 | 2021-05-26 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド、組成物、およびその使用 |
| CA3030420C (en) | 2016-07-11 | 2025-11-18 | Sage Therapeutics, Inc. | C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE |
| WO2018013613A1 (en) * | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | C17, c20, and c21 substituted neuroactive steroids and their methods of use |
| CN115974956A (zh) | 2016-08-23 | 2023-04-18 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇的晶体 |
| EP3681510A1 (en) * | 2017-09-14 | 2020-07-22 | Sage Therapeutics, Inc. | A 19-nor c3,3-disubstituted c21-n-pyrazolyl steroid and methods of use thereof |
| WO2019075362A1 (en) * | 2017-10-12 | 2019-04-18 | Sage Therapeutics, Inc. | METHOD OF TREATING CENTRAL NERVOUS SYSTEM DISORDERS WITH NEUROSTEROIDS AND GABAERGIC COMPOUNDS |
| KR20200096596A (ko) | 2017-12-08 | 2020-08-12 | 세이지 테라퓨틱스, 인크. | Cns 장애의 치료를 위한 중수소화 21 -[4-시아노-피라졸-1 -일]-19-노르-프레간-3. 알파-올-20-온 유도체 |
| IL275562B2 (en) * | 2017-12-22 | 2024-07-01 | Sage Therapeutics Inc | Compositions and methods for treating cns disorders |
| MA51568A (fr) | 2018-01-12 | 2021-04-21 | Sage Therapeutics Inc | Composés aza-, oxa et thia-pregnan-20-one-3.alpha.-ol s'utilisant dans le traitement de troubles du système nerveux central |
| EP3750909B1 (en) * | 2018-02-11 | 2025-03-05 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Steroid derivative regulators, method for preparing the same, and uses thereof |
| KR102917075B1 (ko) | 2018-02-11 | 2026-01-26 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 스테로이드 유도체 조절제, 그의 제조 방법 및 그의 용도 |
| CN117959309A (zh) * | 2018-06-12 | 2024-05-03 | 萨奇治疗股份有限公司 | 19-去甲基c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 |
| CN109503694A (zh) * | 2018-11-21 | 2019-03-22 | 苏州闻天医药科技有限公司 | 一种新型gabaa受体调节剂及其用途 |
| CA3121636A1 (en) | 2018-12-17 | 2020-06-25 | Intra-Cellular Therapies, Inc. | Analogs of (3alpha,5alpha)-3-hydroxy-21-(1h-imidazol-1-yl)-3-methoxymethyl)-pregnan-20-one |
| CN114206900A (zh) | 2019-05-31 | 2022-03-18 | 萨奇治疗股份有限公司 | 神经活性类固醇及其组合物 |
| EP4011897A4 (en) | 2019-08-07 | 2024-02-21 | Shanghai Hansoh Biomedical Co., Ltd. | SALT AND CRYSTAL FORM OF A STEROID DERIVATIVE REGULATOR |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| IL296371A (en) * | 2020-03-18 | 2022-11-01 | Sage Therapeutics Inc | Neuroactive steroids and methods of using them |
| PE20221911A1 (es) | 2020-03-25 | 2022-12-23 | Sage Therapeutics Inc | Uso de agentes para el tratamiento de condiciones respiratorias |
| US20230381192A1 (en) * | 2020-10-17 | 2023-11-30 | Cornell University | Methods for controlling and predicting recovery after nmba administration |
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