JP6742308B2 - Ｃｎｓ障害を処置するための組成物および方法 - Google Patents
Ｃｎｓ障害を処置するための組成物および方法 Download PDFInfo
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- JP6742308B2 JP6742308B2 JP2017520486A JP2017520486A JP6742308B2 JP 6742308 B2 JP6742308 B2 JP 6742308B2 JP 2017520486 A JP2017520486 A JP 2017520486A JP 2017520486 A JP2017520486 A JP 2017520486A JP 6742308 B2 JP6742308 B2 JP 6742308B2
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- 0 C[C@](C([C@@](CC1)[C@@](C)(CC2)[C@@]1[C@](CC1)[C@]2[C@]2[C@]1C[C@](C)(*)CC2)=O)NC=CN=N Chemical compound C[C@](C([C@@](CC1)[C@@](C)(CC2)[C@@]1[C@](CC1)[C@]2[C@]2[C@]1C[C@](C)(*)CC2)=O)NC=CN=N 0.000 description 19
- QWEJWXUAXUMVFU-UHFFFAOYSA-N CCOCCNC Chemical compound CCOCCNC QWEJWXUAXUMVFU-UHFFFAOYSA-N 0.000 description 1
- QZGBELNHIUYLON-OYPVTPOMSA-N C[C@@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nccn1 Chemical compound C[C@@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nccn1 QZGBELNHIUYLON-OYPVTPOMSA-N 0.000 description 1
- BEKTVAUEXGNURQ-KHGUEKPGSA-N C[C@@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nnc2ccccc12 Chemical compound C[C@@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nnc2ccccc12 BEKTVAUEXGNURQ-KHGUEKPGSA-N 0.000 description 1
- RHSRXLADRIIXBC-OYPVTPOMSA-N C[C@@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nncc1 Chemical compound C[C@@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nncc1 RHSRXLADRIIXBC-OYPVTPOMSA-N 0.000 description 1
- JTOPQEGSOSVIHS-BMGVFIFKSA-N C[C@@H](C([C@@H](CC1)[C@@](C)(CC[C@@]([C@]2(CC[C@@]3(C[C@@](C)(CC4)O)N)N)(C34N)I)[C@@]12N)=O)N1[N-]c2c1cccc2 Chemical compound C[C@@H](C([C@@H](CC1)[C@@](C)(CC[C@@]([C@]2(CC[C@@]3(C[C@@](C)(CC4)O)N)N)(C34N)I)[C@@]12N)=O)N1[N-]c2c1cccc2 JTOPQEGSOSVIHS-BMGVFIFKSA-N 0.000 description 1
- CZIBJCCHSOBONE-YCHVKYNGSA-N C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1C(CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)N/N=C(/C=C(C[C@@](CC1)(C[C@H](CC2)[C@H]1[C@@H](CC1)[C@@H]2[C@H](CC2)[C@@]1(C)[C@H]2C([C@H](C)[n]1nc(cccc2)c2n1)=O)O)C=C1)\C1=N Chemical compound C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1C(CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)N/N=C(/C=C(C[C@@](CC1)(C[C@H](CC2)[C@H]1[C@@H](CC1)[C@@H]2[C@H](CC2)[C@@]1(C)[C@H]2C([C@H](C)[n]1nc(cccc2)c2n1)=O)O)C=C1)\C1=N CZIBJCCHSOBONE-YCHVKYNGSA-N 0.000 description 1
- BEKTVAUEXGNURQ-SMBZOAMVSA-N C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2C(CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nnc2c1cccc2 Chemical compound C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2C(CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nnc2c1cccc2 BEKTVAUEXGNURQ-SMBZOAMVSA-N 0.000 description 1
- ZJBRZUKNDWELEX-HWTXSRJOSA-N C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1ncc(C#N)c1 Chemical compound C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1ncc(C#N)c1 ZJBRZUKNDWELEX-HWTXSRJOSA-N 0.000 description 1
- QZGBELNHIUYLON-NWWKMVRUSA-N C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nccn1 Chemical compound C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nccn1 QZGBELNHIUYLON-NWWKMVRUSA-N 0.000 description 1
- RHSRXLADRIIXBC-NWWKMVRUSA-N C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nncc1 Chemical compound C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(C)O)=O)[n]1nncc1 RHSRXLADRIIXBC-NWWKMVRUSA-N 0.000 description 1
- FMFBOXIUYIJMFO-YKUAYROGSA-N C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(Cc1cc2n[n]([C@@H](C)C([C@@H](CC3)[C@@](C)(CC4)[C@@H]3C(CC3)[C@H]4[C@@H](CC4)[C@@H]3C[C@]4(C)O)=O)nc2cc1)O)=O)[n]1nnc2ccccc12 Chemical compound C[C@H](C([C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@H](CC2)[C@@H]1C[C@]2(Cc1cc2n[n]([C@@H](C)C([C@@H](CC3)[C@@](C)(CC4)[C@@H]3C(CC3)[C@H]4[C@@H](CC4)[C@@H]3C[C@]4(C)O)=O)nc2cc1)O)=O)[n]1nnc2ccccc12 FMFBOXIUYIJMFO-YKUAYROGSA-N 0.000 description 1
- NGCXHCGUQHIOLZ-UHFFFAOYSA-N C[n]1nccn1 Chemical compound C[n]1nccn1 NGCXHCGUQHIOLZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462064957P | 2014-10-16 | 2014-10-16 | |
| US62/064,957 | 2014-10-16 | ||
| PCT/US2015/056066 WO2016061537A1 (en) | 2014-10-16 | 2015-10-16 | Compositions and methods for treating cns disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020127234A Division JP7085592B2 (ja) | 2014-10-16 | 2020-07-28 | Ｃｎｓ障害を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531020A JP2017531020A (ja) | 2017-10-19 |
| JP2017531020A5 JP2017531020A5 (enExample) | 2018-11-29 |
| JP6742308B2 true JP6742308B2 (ja) | 2020-08-19 |
Family
ID=55747454
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017520486A Active JP6742308B2 (ja) | 2014-10-16 | 2015-10-16 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2020127234A Active JP7085592B2 (ja) | 2014-10-16 | 2020-07-28 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2022091738A Active JP7510461B2 (ja) | 2014-10-16 | 2022-06-06 | Ｃｎｓ障害を処置するための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020127234A Active JP7085592B2 (ja) | 2014-10-16 | 2020-07-28 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2022091738A Active JP7510461B2 (ja) | 2014-10-16 | 2022-06-06 | Ｃｎｓ障害を処置するための組成物および方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US20170233433A1 (enExample) |
| EP (3) | EP4275748A3 (enExample) |
| JP (3) | JP6742308B2 (enExample) |
| AU (3) | AU2015331597B2 (enExample) |
| CY (1) | CY1123246T1 (enExample) |
| DK (1) | DK3206493T3 (enExample) |
| ES (1) | ES2808855T3 (enExample) |
| HR (1) | HRP20201216T1 (enExample) |
| HU (1) | HUE051488T2 (enExample) |
| LT (1) | LT3206493T (enExample) |
| ME (1) | ME03809B (enExample) |
| NZ (1) | NZ769042A (enExample) |
| PL (1) | PL3206493T3 (enExample) |
| PT (1) | PT3206493T (enExample) |
| RS (1) | RS60642B1 (enExample) |
| SI (1) | SI3206493T1 (enExample) |
| SM (1) | SMT202000414T1 (enExample) |
| WO (1) | WO2016061537A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3152410A1 (en) | 2011-10-14 | 2013-04-18 | Sage Therapeutics, Inc. | 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders |
| PL2887944T3 (pl) | 2012-08-21 | 2022-02-21 | Sage Therapeutics, Inc. | Allopregnanolon do leczenia lekoopornego stanu padaczkowego |
| WO2014169831A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
| CN113527400B (zh) | 2013-04-17 | 2024-06-28 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 |
| RU2019126333A (ru) | 2013-04-17 | 2019-10-08 | Сейдж Терапьютикс, Инк. | 19-нор нейроактивные стероиды и способы их применения |
| US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
| WO2015010054A2 (en) | 2013-07-19 | 2015-01-22 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| AU2014308621C1 (en) | 2013-08-23 | 2022-01-06 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| CN106661078A (zh) * | 2014-05-29 | 2017-05-10 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物、及其用途 |
| WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| SMT202000414T1 (it) | 2014-10-16 | 2020-09-10 | Sage Therapeutics Inc | Composizioni e metodi per trattare disturbi del snc |
| MX2021004492A (es) | 2014-10-16 | 2022-12-05 | Sage Therapeutics Inc | Composiciones para el tratamiento de trastornos del snc. |
| ME03749B (me) | 2014-11-27 | 2021-04-20 | Sage Therapeutics Inc | KOMPOZICIJE I POSTUPCIZA LEČENJE POREMEĆAJA CNS-a |
| DK3250210T3 (da) | 2015-01-26 | 2021-03-08 | Sage Therapeutics Inc | Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser |
| JP6875996B2 (ja) | 2015-02-20 | 2021-05-26 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド、組成物、およびその使用 |
| CA3030420C (en) | 2016-07-11 | 2025-11-18 | Sage Therapeutics, Inc. | C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE |
| WO2018013613A1 (en) * | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | C17, c20, and c21 substituted neuroactive steroids and their methods of use |
| CN115974956A (zh) | 2016-08-23 | 2023-04-18 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇的晶体 |
| EP3681510A1 (en) * | 2017-09-14 | 2020-07-22 | Sage Therapeutics, Inc. | A 19-nor c3,3-disubstituted c21-n-pyrazolyl steroid and methods of use thereof |
| WO2019075362A1 (en) * | 2017-10-12 | 2019-04-18 | Sage Therapeutics, Inc. | METHOD OF TREATING CENTRAL NERVOUS SYSTEM DISORDERS WITH NEUROSTEROIDS AND GABAERGIC COMPOUNDS |
| KR20200096596A (ko) | 2017-12-08 | 2020-08-12 | 세이지 테라퓨틱스, 인크. | Cns 장애의 치료를 위한 중수소화 21 -[4-시아노-피라졸-1 -일]-19-노르-프레간-3. 알파-올-20-온 유도체 |
| IL275562B2 (en) * | 2017-12-22 | 2024-07-01 | Sage Therapeutics Inc | Compositions and methods for treating cns disorders |
| MA51568A (fr) | 2018-01-12 | 2021-04-21 | Sage Therapeutics Inc | Composés aza-, oxa et thia-pregnan-20-one-3.alpha.-ol s'utilisant dans le traitement de troubles du système nerveux central |
| EP3750909B1 (en) * | 2018-02-11 | 2025-03-05 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Steroid derivative regulators, method for preparing the same, and uses thereof |
| KR102917075B1 (ko) | 2018-02-11 | 2026-01-26 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 스테로이드 유도체 조절제, 그의 제조 방법 및 그의 용도 |
| CN117959309A (zh) * | 2018-06-12 | 2024-05-03 | 萨奇治疗股份有限公司 | 19-去甲基c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 |
| CN109503694A (zh) * | 2018-11-21 | 2019-03-22 | 苏州闻天医药科技有限公司 | 一种新型gabaa受体调节剂及其用途 |
| CA3121636A1 (en) | 2018-12-17 | 2020-06-25 | Intra-Cellular Therapies, Inc. | Analogs of (3alpha,5alpha)-3-hydroxy-21-(1h-imidazol-1-yl)-3-methoxymethyl)-pregnan-20-one |
| CN114206900A (zh) | 2019-05-31 | 2022-03-18 | 萨奇治疗股份有限公司 | 神经活性类固醇及其组合物 |
| EP4011897A4 (en) | 2019-08-07 | 2024-02-21 | Shanghai Hansoh Biomedical Co., Ltd. | SALT AND CRYSTAL FORM OF A STEROID DERIVATIVE REGULATOR |
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