JP2013512926A5 - - Google Patents
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- JP2013512926A5 JP2013512926A5 JP2012542219A JP2012542219A JP2013512926A5 JP 2013512926 A5 JP2013512926 A5 JP 2013512926A5 JP 2012542219 A JP2012542219 A JP 2012542219A JP 2012542219 A JP2012542219 A JP 2012542219A JP 2013512926 A5 JP2013512926 A5 JP 2013512926A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- optionally substituted
- disorder
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 82
- 125000000623 heterocyclic group Chemical group 0.000 claims 21
- 125000004429 atom Chemical group 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000004103 aminoalkyl group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 208000028017 Psychotic disease Diseases 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 8
- -1 nitro, amino, hydroxyl Chemical group 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 201000000980 schizophrenia Diseases 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 208000019022 Mood disease Diseases 0.000 claims 3
- 208000017194 Affective disease Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 208000022821 personality disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000698 schizophrenic effect Effects 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 206010001497 Agitation Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 102000012437 Copper-Transporting ATPases Human genes 0.000 claims 1
- 206010012218 Delirium Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 1
- 206010013654 Drug abuse Diseases 0.000 claims 1
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 208000009625 Lesch-Nyhan syndrome Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000027099 Paranoid disease Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 201000001880 Sexual dysfunction Diseases 0.000 claims 1
- 208000019568 Shared Paranoid disease Diseases 0.000 claims 1
- 208000028810 Shared psychotic disease Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 208000032140 Sleepiness Diseases 0.000 claims 1
- 208000011963 Substance-induced psychotic disease Diseases 0.000 claims 1
- 231100000393 Substance-induced psychotic disorder Toxicity 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 208000018839 Wilson disease Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000016571 aggressive behavior Effects 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 201000002545 drug psychosis Diseases 0.000 claims 1
- 208000024732 dysthymic disease Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002964 excitative effect Effects 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 230000036651 mood Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 208000012672 seasonal affective disease Diseases 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 231100000872 sexual dysfunction Toxicity 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000037321 sleepiness Effects 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
- 0 CNC[C@](c1c(CC*)[s]c(F)c1)O Chemical compound CNC[C@](c1c(CC*)[s]c(F)c1)O 0.000 description 25
- AITUYMATOVBOMM-UHFFFAOYSA-N C=Cc1c[s]c2c1C(CN)C(C1)C1CC2 Chemical compound C=Cc1c[s]c2c1C(CN)C(C1)C1CC2 AITUYMATOVBOMM-UHFFFAOYSA-N 0.000 description 1
- NIBDYNBWJDEMKA-UHFFFAOYSA-N CC1(CN)OCCc2c1cc[s]2 Chemical compound CC1(CN)OCCc2c1cc[s]2 NIBDYNBWJDEMKA-UHFFFAOYSA-N 0.000 description 1
- WEFZFBQIYMCFNU-VIFPVBQESA-N CCNC[C@@H]1OCCc2c1cc[s]2 Chemical compound CCNC[C@@H]1OCCc2c1cc[s]2 WEFZFBQIYMCFNU-VIFPVBQESA-N 0.000 description 1
- WEFZFBQIYMCFNU-SECBINFHSA-N CCNC[C@H]1OCCc2c1cc[s]2 Chemical compound CCNC[C@H]1OCCc2c1cc[s]2 WEFZFBQIYMCFNU-SECBINFHSA-N 0.000 description 1
- INRPJRPERXJBQV-UHFFFAOYSA-N CNC1(CCCCC1)C(CCC1)c2c1[s]cc2 Chemical compound CNC1(CCCCC1)C(CCC1)c2c1[s]cc2 INRPJRPERXJBQV-UHFFFAOYSA-N 0.000 description 1
- POTLHQVUZAJAMW-UHFFFAOYSA-N CNC1(CCCCC1)C1OCCc2c1cc[s]2 Chemical compound CNC1(CCCCC1)C1OCCc2c1cc[s]2 POTLHQVUZAJAMW-UHFFFAOYSA-N 0.000 description 1
- ZQPHNVQEKLGCPX-UHFFFAOYSA-N CNCC(C(C1)C1CC1)c2c1[s]c(cc1Cl)c2cc1Cl Chemical compound CNCC(C(C1)C1CC1)c2c1[s]c(cc1Cl)c2cc1Cl ZQPHNVQEKLGCPX-UHFFFAOYSA-N 0.000 description 1
- FVTQFFKKJVXMEI-UHFFFAOYSA-N CNCC(C1)OCCc2c1c(cccc1)c1[s]2 Chemical compound CNCC(C1)OCCc2c1c(cccc1)c1[s]2 FVTQFFKKJVXMEI-UHFFFAOYSA-N 0.000 description 1
- XYUVIJDAKOOBHM-UHFFFAOYSA-N CNCC1OCCCc2c1c(cc(cc1)Cl)c1[s]2 Chemical compound CNCC1OCCCc2c1c(cc(cc1)Cl)c1[s]2 XYUVIJDAKOOBHM-UHFFFAOYSA-N 0.000 description 1
- OZZOPYQBYKNRLX-BYDSUWOYSA-N C[C@@H](C1OCCc2c1cc[s]2)NC Chemical compound C[C@@H](C1OCCc2c1cc[s]2)NC OZZOPYQBYKNRLX-BYDSUWOYSA-N 0.000 description 1
- OZZOPYQBYKNRLX-OIBJUYFYSA-N C[C@@H]([C@H]1OCCc2c1cc[s]2)NC Chemical compound C[C@@H]([C@H]1OCCc2c1cc[s]2)NC OZZOPYQBYKNRLX-OIBJUYFYSA-N 0.000 description 1
- QRNNJKDCCSPWRW-SECBINFHSA-N C[C@H](Cc1c(CCC=C)[s]cc1)N Chemical compound C[C@H](Cc1c(CCC=C)[s]cc1)N QRNNJKDCCSPWRW-SECBINFHSA-N 0.000 description 1
- TYUOXKFOCVXJHQ-RKDXNWHRSA-N C[C@H]([C@@H](CCC1)c2c1[s]cc2)NC Chemical compound C[C@H]([C@@H](CCC1)c2c1[s]cc2)NC TYUOXKFOCVXJHQ-RKDXNWHRSA-N 0.000 description 1
- IDOCJOSQBZUOCM-VVESDKHQSA-N Cc1c(F)[s]c(CCC2)c1[C@H]2/C=N/C Chemical compound Cc1c(F)[s]c(CCC2)c1[C@H]2/C=N/C IDOCJOSQBZUOCM-VVESDKHQSA-N 0.000 description 1
- GTONKMHLSYUCMQ-QMMMGPOBSA-N Cc1c(F)[s]c2c1[C@H](CNC)CCC2 Chemical compound Cc1c(F)[s]c2c1[C@H](CNC)CCC2 GTONKMHLSYUCMQ-QMMMGPOBSA-N 0.000 description 1
- NCUVFQFEYGFGKF-UHFFFAOYSA-N Cc1c[s]c(CCCCC2)c1C2(C1)C1N Chemical compound Cc1c[s]c(CCCCC2)c1C2(C1)C1N NCUVFQFEYGFGKF-UHFFFAOYSA-N 0.000 description 1
- RQPKRDCFGLCWNM-UHFFFAOYSA-N NC1(CCCCC1)C1OCCc2c1cc[s]2 Chemical compound NC1(CCCCC1)C1OCCc2c1cc[s]2 RQPKRDCFGLCWNM-UHFFFAOYSA-N 0.000 description 1
- JWARAXKPSGYYFJ-UHFFFAOYSA-N NCC(C(C1)C1CC1)c2c1[s]c1ccc(C3[IH]C3)c(Cl)c21 Chemical compound NCC(C(C1)C1CC1)c2c1[s]c1ccc(C3[IH]C3)c(Cl)c21 JWARAXKPSGYYFJ-UHFFFAOYSA-N 0.000 description 1
- BYWRIADOSKHATA-UHFFFAOYSA-N NCC(C(CC1)C1CC1)C2=C1SC1C2CCC1 Chemical compound NCC(C(CC1)C1CC1)C2=C1SC1C2CCC1 BYWRIADOSKHATA-UHFFFAOYSA-N 0.000 description 1
- ZAUOAOTXDCDNGY-UHFFFAOYSA-N NCC(C(CC1)C1CC1)c2c1[s]c1c2cccc1Cl Chemical compound NCC(C(CC1)C1CC1)c2c1[s]c1c2cccc1Cl ZAUOAOTXDCDNGY-UHFFFAOYSA-N 0.000 description 1
- XCQJLLHUMDSONB-UHFFFAOYSA-N NCC(CCCC1)c2c1[s]cc2Cl Chemical compound NCC(CCCC1)c2c1[s]cc2Cl XCQJLLHUMDSONB-UHFFFAOYSA-N 0.000 description 1
- MKZGIOMVPDPCBC-UHFFFAOYSA-N NCC1OCCc([s]c2c3)c1c2cc(Cl)c3Cl Chemical compound NCC1OCCc([s]c2c3)c1c2cc(Cl)c3Cl MKZGIOMVPDPCBC-UHFFFAOYSA-N 0.000 description 1
- MGNDZEHNXZDELF-UHFFFAOYSA-N NCC1OCCc2c1c(CCC=C1)c1[s]2 Chemical compound NCC1OCCc2c1c(CCC=C1)c1[s]2 MGNDZEHNXZDELF-UHFFFAOYSA-N 0.000 description 1
- AZSVLAYHORYULP-UHFFFAOYSA-N NCC1OCCc2c1c(cc(C1[I]=CC1)cc1)c1[s]2 Chemical compound NCC1OCCc2c1c(cc(C1[I]=CC1)cc1)c1[s]2 AZSVLAYHORYULP-UHFFFAOYSA-N 0.000 description 1
- RDSQWIWOHKRUMG-VIFPVBQESA-N NC[C@@H]1OCCc2c1c(cccc1)c1[s]2 Chemical compound NC[C@@H]1OCCc2c1c(cccc1)c1[s]2 RDSQWIWOHKRUMG-VIFPVBQESA-N 0.000 description 1
- RDSQWIWOHKRUMG-SECBINFHSA-N NC[C@H]1OCCc2c1c1ccccc1[s]2 Chemical compound NC[C@H]1OCCc2c1c1ccccc1[s]2 RDSQWIWOHKRUMG-SECBINFHSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26688009P | 2009-12-04 | 2009-12-04 | |
| US61/266,880 | 2009-12-04 | ||
| PCT/US2010/058884 WO2011069063A2 (en) | 2009-12-04 | 2010-12-03 | Multicyclic compounds and methods of use thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014253082A Division JP5710064B1 (ja) | 2009-12-04 | 2014-12-15 | 多環式化合物及びその使用方法 |
| JP2015136603A Division JP6005807B2 (ja) | 2009-12-04 | 2015-07-08 | 多環式化合物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512926A JP2013512926A (ja) | 2013-04-18 |
| JP2013512926A5 true JP2013512926A5 (enExample) | 2014-01-23 |
| JP5778168B2 JP5778168B2 (ja) | 2015-09-16 |
Family
ID=44115515
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542219A Active JP5778168B2 (ja) | 2009-12-04 | 2010-12-03 | 多環式化合物及びその使用方法 |
| JP2014253082A Active JP5710064B1 (ja) | 2009-12-04 | 2014-12-15 | 多環式化合物及びその使用方法 |
| JP2015136603A Active JP6005807B2 (ja) | 2009-12-04 | 2015-07-08 | 多環式化合物及びその使用方法 |
| JP2016131247A Active JP6028310B1 (ja) | 2009-12-04 | 2016-07-01 | 多環式化合物及びその使用方法 |
| JP2016191898A Active JP6297655B2 (ja) | 2009-12-04 | 2016-09-29 | 多環式化合物及びその使用方法 |
| JP2018028819A Pending JP2018104454A (ja) | 2009-12-04 | 2018-02-21 | 多環式化合物及びその使用方法 |
| JP2020108727A Active JP7104746B2 (ja) | 2009-12-04 | 2020-06-24 | 多環式化合物及びその使用方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014253082A Active JP5710064B1 (ja) | 2009-12-04 | 2014-12-15 | 多環式化合物及びその使用方法 |
| JP2015136603A Active JP6005807B2 (ja) | 2009-12-04 | 2015-07-08 | 多環式化合物及びその使用方法 |
| JP2016131247A Active JP6028310B1 (ja) | 2009-12-04 | 2016-07-01 | 多環式化合物及びその使用方法 |
| JP2016191898A Active JP6297655B2 (ja) | 2009-12-04 | 2016-09-29 | 多環式化合物及びその使用方法 |
| JP2018028819A Pending JP2018104454A (ja) | 2009-12-04 | 2018-02-21 | 多環式化合物及びその使用方法 |
| JP2020108727A Active JP7104746B2 (ja) | 2009-12-04 | 2020-06-24 | 多環式化合物及びその使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (9) | US8710245B2 (enExample) |
| EP (2) | EP2507245B1 (enExample) |
| JP (7) | JP5778168B2 (enExample) |
| KR (7) | KR101772834B1 (enExample) |
| CN (5) | CN111560025A (enExample) |
| AU (3) | AU2010325925B2 (enExample) |
| BR (2) | BR112012013431B1 (enExample) |
| CA (2) | CA2781716A1 (enExample) |
| DK (2) | DK3252057T3 (enExample) |
| ES (2) | ES2625330T3 (enExample) |
| FI (1) | FI3252057T3 (enExample) |
| HK (1) | HK1212969A1 (enExample) |
| IL (6) | IL272376B2 (enExample) |
| MX (3) | MX2012006326A (enExample) |
| NZ (5) | NZ600008A (enExample) |
| PT (2) | PT3252057T (enExample) |
| RU (3) | RU2557059C2 (enExample) |
| SG (3) | SG10201510665WA (enExample) |
| WO (1) | WO2011069063A2 (enExample) |
| ZA (1) | ZA201203533B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2781716A1 (en) | 2009-12-04 | 2011-06-09 | Sunovion Pharmaceuticals Inc. | Multicyclic thieno compounds and use thereof for the treatment of a neurological disorder |
| WO2013066152A1 (en) * | 2011-10-31 | 2013-05-10 | N.V. Nutricia | Method for improving executive function |
| US10189825B2 (en) * | 2012-02-08 | 2019-01-29 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| CN103755727B (zh) * | 2013-12-20 | 2015-12-30 | 南京华威医药科技开发有限公司 | 布林佐胺中间体制备方法 |
| EP3096755A4 (en) * | 2014-01-23 | 2017-12-27 | Sova Pharmaceuticals, Inc. | CYSTATHIONINE-(gamma)-LYASE (CSE) INHIBITORS FOR TREATING PAIN |
| LT3186257T (lt) * | 2014-08-27 | 2019-04-25 | Prexton Therapeutics Sa | Nauji chromono oksimo dariniai ir jų panaudojimas kaip metabotropinių gliutamato receptorių alosterinių moduliatorių |
| CN104193722A (zh) * | 2014-08-27 | 2014-12-10 | 湖南华腾制药有限公司 | 一种n-叔丁氧羰基-3-甲胺噻吩的制备方法 |
| EA201791804A1 (ru) * | 2015-02-11 | 2018-02-28 | Суновион Фармасьютикалз Инк. | Соединения 1-гетероциклил изохроманила и аналоги для лечения расстройств цнс |
| CA2976092A1 (en) * | 2015-02-11 | 2016-08-18 | Sunovion Pharmaceuticals Inc. | Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders |
| CN108349993A (zh) | 2015-08-27 | 2018-07-31 | 普雷克斯顿医疗股份公司 | 用于左旋多巴诱导的运动障碍疗法的脑-穿透剂色酮肟衍生物 |
| JO3638B1 (ar) * | 2015-09-09 | 2020-08-27 | Lilly Co Eli | مركبات مفيدة في تثبيط ror - جاما- t |
| CA3011983A1 (en) * | 2016-01-26 | 2017-08-03 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines |
| WO2017144341A1 (de) | 2016-02-23 | 2017-08-31 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| SG10202100751YA (en) | 2016-07-29 | 2021-03-30 | Sunovion Pharmaceuticals Inc | Compounds and compositions and uses thereof |
| AU2017301769B2 (en) * | 2016-07-29 | 2022-07-28 | Pgi Drug Discovery Llc | Compounds and compositions and uses thereof |
| AU2018220509B2 (en) * | 2017-02-16 | 2022-04-28 | Sumitomo Pharma America, Inc. | Methods of treating schizophrenia |
| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| SG11202000669VA (en) | 2017-08-02 | 2020-02-27 | Sunovion Pharmaceuticals Inc | Isochroman compounds and uses thereof |
| CA3091292A1 (en) | 2018-02-16 | 2019-08-22 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
| US20210008030A1 (en) | 2018-02-16 | 2021-01-14 | Sunovion Pharmaceuticals Inc. | Methods of treating social function disorders |
| JP2022511509A (ja) | 2018-12-06 | 2022-01-31 | サノビオン ファーマシューティカルズ インク | 神経障害および神経障害の処置方法 |
| JP7703449B2 (ja) | 2019-03-14 | 2025-07-07 | スミトモ・ファーマ・アメリカ・インコーポレイテッド | イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物 |
| CN110894195A (zh) * | 2019-12-09 | 2020-03-20 | 门希国 | 一种新的2-噻吩乙酸的制备新方法 |
| JP2023519882A (ja) | 2020-03-27 | 2023-05-15 | ソム、イノベーション、バイオテック、ソシエダッド、アノニマ | シヌクレイノパチーの治療に有用な化合物 |
| CN115734785A (zh) | 2020-04-14 | 2023-03-03 | 桑诺维恩药品公司 | (S)-(4,5-二氢-7H-噻吩并[2,3-c]吡喃-7-基)-N-甲基甲胺用于治疗神经和精神方面的病症 |
| EP4214212A1 (en) | 2020-09-16 | 2023-07-26 | Teva Pharmaceuticals International GmbH | Solid state forms of sep-363856 and process for preparation thereof |
| IL305489A (en) * | 2021-03-29 | 2023-10-01 | Shujing Biopharma Co Ltd | Spiro-containing derivative, and preparation method therefor and use thereof |
| AU2022254568A1 (en) * | 2021-04-10 | 2023-11-16 | Sumitomo Pharma Co., Ltd. | Bicyclic pyridine derivative |
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