CN104193761B - 多环化合物及其使用方法 - Google Patents
多环化合物及其使用方法 Download PDFInfo
- Publication number
- CN104193761B CN104193761B CN201410333332.1A CN201410333332A CN104193761B CN 104193761 B CN104193761 B CN 104193761B CN 201410333332 A CN201410333332 A CN 201410333332A CN 104193761 B CN104193761 B CN 104193761B
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- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- alkyl
- optionally substituted
- Prior art date
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Classifications
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
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Abstract
Description
化合物/剂量 | 作用 |
化合物5 | |
10mg/kg | - |
30mg/kg | +++ |
100mg/kg | +++ |
化合物58 | |
10mg/kg | +++ |
30mg/kg | + |
100mg/kg | +++ |
化合物57 | |
10mg/kg | - |
30mg/kg | - |
100mg/kg | ++ |
化合物4 | |
10mg/kg | +++ |
30mg/kg | - |
100mg/kg | +++ |
化合物27 | |
10mg/kg | - |
30mg/kg | - |
100mg/kg | - |
化合物28 | |
10mg/kg | - |
30mg/kg | +++ |
100mg/kg | +++ |
化合物1 | |
10mg/kg | - |
30mg/kg | +++ |
100mg/kg | +++ |
化合物/剂量 | 作用 |
化合物2 | |
10mg/kg | - |
30mg/kg | - |
100mg/kg | +++ |
化合物3 | |
10mg/kg | +++ |
30mg/kg | +++ |
100mg/kg | - |
化合物10 | |
10mg/kg | +++ |
30mg/kg | +++ |
100mg/kg | +++ |
化合物75 | |
10mg/kg | - |
30mg/kg | - |
100mg/kg | - |
化合物76 | |
10mg/kg | - |
30mg/kg | - |
100mg/kg | - |
化合物13 | |
10mg/kg | - |
30mg/kg | - |
100mg/kg | +++ |
化合物140 | |
10mg/kg | - |
30mg/kg | - |
100mg/kg | - |
化合物78 | |
10mg/kg | - |
30mg/kg | - |
100mg/kg | - |
化合物/剂量 | 作用 |
化合物158 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | - |
100mg/kg | +++ |
化合物130 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | - |
化合物131 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | - |
化合物171 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | - |
100mg/kg | +++ |
化合物172 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | - |
100mg/kg | - |
化合物129 | |
3mg/kg | +++ |
10mg/kg | +++ |
30mg/kg | +++ |
化合物310 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | +++ |
化合物/剂量 | 作用 |
化合物205 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | +++ |
化合物311 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | +++ |
化合物213 | |
3mg/kg | - |
10mg/kg | +++ |
30mg/kg | +++ |
化合物170 | |
3mg/kg | - |
10mg/kg | +++ |
30mg/kg | +++ |
化合物242 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | - |
化合物127 | |
3mg/kg | +++ |
10mg/kg | - |
30mg/kg | +++ |
化合物102 | |
3mg/kg | - |
10mg/kg | - |
30mg/kg | - |
化合物/剂量 | 总移动距离(cm) |
化合物4 | |
0.3mg/kg化合物+PCP | + |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物27 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | - |
3mg/kg化合物+PCP | - |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物28 | |
0.3mg/kg化合物+PCP | + |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物2 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | - |
化合物3 | |
10mg/kg化合物+PCP | - |
30mg/kg化合物+PCP | - |
100mg/kg化合物+PCP | - |
化合物/剂量 | 总移动距离(cm) |
化合物1 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | - |
化合物5 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物57 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物58 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物10 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物75 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | - |
100mg/kg化合物+PCP | + |
化合物76 | |
10mg/kg化合物+PCP | - |
30mg/kg化合物+PCP | - |
100mg/kg化合物+PCP | + |
化合物140 | |
10mg/kg化合物+PCP | - |
30mg/kg化合物+PCP | - |
100mg/kg化合物+PCP | + |
化合物/剂量 | 总移动距离(cm) |
化合物78 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物129 | |
0.3mg/kg化合物+PCP | + |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物130 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | - |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物119 | |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物158 | |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
100mg/kg化合物+PCP | + |
化合物131 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
化合物/剂量 | 总移动距离(cm) |
化合物171 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | - |
3mg/kg化合物+PCP | - |
10mg/kg化合物+PCP | - |
30mg/kg化合物+PCP | + |
化合物172 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | - |
30mg/kg化合物+PCP | - |
化合物127 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | - |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | - |
化合物310 | |
0.3mg/kg化合物+PCP | + |
1mg/kg化合物+PCP | - |
3mg/kg化合物+PCP | - |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
化合物311 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
化合物/剂量 | 总移动距离(cm) |
化合物205 | |
0.3mg/kg化合物+PCP | + |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
化合物213 | |
0.3mg/kg化合物+PCP | + |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
化合物170 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | - |
3mg/kg化合物+PCP | - |
10mg/kg化合物+PCP | - |
30mg/kg化合物+PCP | - |
化合物242 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
化合物102 | |
0.3mg/kg化合物+PCP | - |
1mg/kg化合物+PCP | + |
3mg/kg化合物+PCP | + |
10mg/kg化合物+PCP | + |
30mg/kg化合物+PCP | + |
Claims (36)
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