JP2011132222A5 - - Google Patents
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- Publication number
- JP2011132222A5 JP2011132222A5 JP2010262058A JP2010262058A JP2011132222A5 JP 2011132222 A5 JP2011132222 A5 JP 2011132222A5 JP 2010262058 A JP2010262058 A JP 2010262058A JP 2010262058 A JP2010262058 A JP 2010262058A JP 2011132222 A5 JP2011132222 A5 JP 2011132222A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- alkoxy
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 34
- 125000001424 substituent group Chemical group 0.000 claims 31
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 30
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 26
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 19
- 241000124008 Mammalia Species 0.000 claims 10
- 125000004043 oxo group Chemical group O=* 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 230000000069 prophylactic effect Effects 0.000 claims 7
- 230000001225 therapeutic effect Effects 0.000 claims 7
- 208000023275 Autoimmune disease Diseases 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- 208000027866 inflammatory disease Diseases 0.000 claims 6
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 5
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- -1 di-substituted amino group Chemical group 0.000 claims 4
- 208000026935 allergic disease Diseases 0.000 claims 3
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 238000002054 transplantation Methods 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- RRHONYZEMUNMJX-UHFFFAOYSA-N N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3-methylbutan-2-ylamino)methyl]benzamide Chemical compound C1=C(C(=O)N2CCN(CC2)C(C)=O)C(OC)=CC(C)=C1SC(S1)=CN=C1NC(=O)C1=CC=C(CNC(C)C(C)C)C=C1 RRHONYZEMUNMJX-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- DNFSJPQKIIZICR-UHFFFAOYSA-N CC(C(N(C)c1cc([nH]c(-c2n[nH]c3c2CCC(C)(C)C3)c2)c2cc1)=O)N1CC(O)OCC1 Chemical compound CC(C(N(C)c1cc([nH]c(-c2n[nH]c3c2CCC(C)(C)C3)c2)c2cc1)=O)N1CC(O)OCC1 DNFSJPQKIIZICR-UHFFFAOYSA-N 0.000 description 1
- UDYOEVNNUSZBQF-UHFFFAOYSA-N CC(C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N(C(C)COC1)C1=O Chemical compound CC(C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N(C(C)COC1)C1=O UDYOEVNNUSZBQF-UHFFFAOYSA-N 0.000 description 1
- SUUWVRLGBXRDPY-UHFFFAOYSA-N CC(C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N(CCOC1)C1=O Chemical compound CC(C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N(CCOC1)C1=O SUUWVRLGBXRDPY-UHFFFAOYSA-N 0.000 description 1
- ICECFMIVUFSVFJ-UHFFFAOYSA-N CC(C)C(C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N1CCOCC1 Chemical compound CC(C)C(C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N1CCOCC1 ICECFMIVUFSVFJ-UHFFFAOYSA-N 0.000 description 1
- 0 CC1(*)C=Cc([n]c(-c2n[n]c3c2C*(*)CC(*)(*)C3)c2)c2C=C1 Chemical compound CC1(*)C=Cc([n]c(-c2n[n]c3c2C*(*)CC(*)(*)C3)c2)c2C=C1 0.000 description 1
- MSMFCGKDZPDAMO-UHFFFAOYSA-N CCN(C(C(C)C1CCOCC1)=O)c1ccc(cc(C(C(CCC(C)(C)C2)=C2N)=N)[nH]2)c2c1 Chemical compound CCN(C(C(C)C1CCOCC1)=O)c1ccc(cc(C(C(CCC(C)(C)C2)=C2N)=N)[nH]2)c2c1 MSMFCGKDZPDAMO-UHFFFAOYSA-N 0.000 description 1
- PVISOYBMIRDZIW-QHCPKHFHSA-N CC[C@@H](C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N1CCOCC1 Chemical compound CC[C@@H](C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N1CCOCC1 PVISOYBMIRDZIW-QHCPKHFHSA-N 0.000 description 1
- PVISOYBMIRDZIW-HSZRJFAPSA-N CC[C@H](C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N1CCOCC1 Chemical compound CC[C@H](C(N(C)c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N1CCOCC1 PVISOYBMIRDZIW-HSZRJFAPSA-N 0.000 description 1
- YGVCLWHEKVYJCQ-KRWDZBQOSA-N C[C@@H](C(N(CC=[IH])c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N1CCOCC1 Chemical compound C[C@@H](C(N(CC=[IH])c1ccc(cc(-c2n[nH]c3c2CCC(C)(C)C3)[nH]2)c2c1)=O)N1CCOCC1 YGVCLWHEKVYJCQ-KRWDZBQOSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010262058A JP5734628B2 (ja) | 2009-11-25 | 2010-11-25 | インドール化合物及びその医薬用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009268040 | 2009-11-25 | ||
| JP2009268040 | 2009-11-25 | ||
| JP2010262058A JP5734628B2 (ja) | 2009-11-25 | 2010-11-25 | インドール化合物及びその医薬用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015083457A Division JP2015172051A (ja) | 2009-11-25 | 2015-04-15 | インドール化合物の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011132222A JP2011132222A (ja) | 2011-07-07 |
| JP2011132222A5 true JP2011132222A5 (enExample) | 2014-01-16 |
| JP5734628B2 JP5734628B2 (ja) | 2015-06-17 |
Family
ID=44066507
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010262058A Active JP5734628B2 (ja) | 2009-11-25 | 2010-11-25 | インドール化合物及びその医薬用途 |
| JP2015083457A Ceased JP2015172051A (ja) | 2009-11-25 | 2015-04-15 | インドール化合物の製造方法 |
| JP2016205949A Ceased JP2017039761A (ja) | 2009-11-25 | 2016-10-20 | インドール化合物の製造方法 |
| JP2018112445A Pending JP2018158935A (ja) | 2009-11-25 | 2018-06-13 | インドール化合物の製造方法 |
| JP2020017065A Ceased JP2020079276A (ja) | 2009-11-25 | 2020-02-04 | インドール化合物及びその医薬用途 |
| JP2021033138A Pending JP2021091718A (ja) | 2009-11-25 | 2021-03-03 | インドール化合物及びその医薬用途 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015083457A Ceased JP2015172051A (ja) | 2009-11-25 | 2015-04-15 | インドール化合物の製造方法 |
| JP2016205949A Ceased JP2017039761A (ja) | 2009-11-25 | 2016-10-20 | インドール化合物の製造方法 |
| JP2018112445A Pending JP2018158935A (ja) | 2009-11-25 | 2018-06-13 | インドール化合物の製造方法 |
| JP2020017065A Ceased JP2020079276A (ja) | 2009-11-25 | 2020-02-04 | インドール化合物及びその医薬用途 |
| JP2021033138A Pending JP2021091718A (ja) | 2009-11-25 | 2021-03-03 | インドール化合物及びその医薬用途 |
Country Status (31)
| Country | Link |
|---|---|
| US (6) | US8299070B2 (enExample) |
| EP (3) | EP3059234A1 (enExample) |
| JP (6) | JP5734628B2 (enExample) |
| KR (1) | KR101766502B1 (enExample) |
| CN (1) | CN102712624B (enExample) |
| AR (1) | AR079164A1 (enExample) |
| AU (1) | AU2010323579C1 (enExample) |
| BR (1) | BR112012012529B1 (enExample) |
| CA (1) | CA2781660C (enExample) |
| CL (1) | CL2012001328A1 (enExample) |
| CO (1) | CO6541645A2 (enExample) |
| CY (1) | CY1117559T1 (enExample) |
| DK (1) | DK2505586T3 (enExample) |
| ES (1) | ES2572935T3 (enExample) |
| HR (1) | HRP20160579T1 (enExample) |
| HU (1) | HUE028016T2 (enExample) |
| IL (1) | IL220009A (enExample) |
| ME (1) | ME02447B (enExample) |
| MX (1) | MX2012006017A (enExample) |
| MY (1) | MY161095A (enExample) |
| NZ (1) | NZ600840A (enExample) |
| PE (1) | PE20121358A1 (enExample) |
| PH (1) | PH12012501021A1 (enExample) |
| PL (1) | PL2505586T3 (enExample) |
| PT (1) | PT2505586E (enExample) |
| RS (1) | RS54910B1 (enExample) |
| RU (1) | RU2556216C2 (enExample) |
| SI (1) | SI2505586T1 (enExample) |
| SM (1) | SMT201600258B (enExample) |
| TW (1) | TWI491591B (enExample) |
| WO (1) | WO2011065402A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
| NZ736048A (en) | 2010-06-03 | 2019-09-27 | Pharmacyclics Llc | The use of inhibitors of bruton’s tyrosine kinase (btk) |
| KR20180088926A (ko) | 2012-07-24 | 2018-08-07 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이 |
| KR20150080592A (ko) | 2012-11-02 | 2015-07-09 | 파마시클릭스, 인코포레이티드 | Tec 패밀리 키나제 억제제 애쥬번트 요법 |
| CN103804364A (zh) * | 2012-11-06 | 2014-05-21 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
| CN103804361A (zh) * | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
| CN103800337A (zh) * | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
| CN103804291A (zh) * | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
| CN103800328A (zh) * | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
| CN103800340A (zh) * | 2012-11-09 | 2014-05-21 | 韩冰 | 一类治疗青光眼的化合物及其用途 |
| CN103804351A (zh) * | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
| CN103804363A (zh) * | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
| CN103804272A (zh) * | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
| CN103804302A (zh) * | 2012-11-14 | 2014-05-21 | 杨育新 | 一类治疗创伤性脑损伤疾病的化合物及其用途 |
| CN104628657A (zh) * | 2013-11-06 | 2015-05-20 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
| WO2015143400A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| AR099936A1 (es) | 2014-04-04 | 2016-08-31 | Sanofi Sa | Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados |
| WO2016002918A1 (ja) * | 2014-07-04 | 2016-01-07 | 日本たばこ産業株式会社 | インドール化合物の製造方法 |
| WO2016010108A1 (ja) * | 2014-07-18 | 2016-01-21 | 塩野義製薬株式会社 | 含窒素複素環誘導体およびそれらを含有する医薬組成物 |
| CN104356086A (zh) * | 2014-11-28 | 2015-02-18 | 湖南科技大学 | 一种适于工业生产3-吗啉酮的制备方法 |
| EP3804727B1 (en) * | 2018-05-25 | 2023-10-11 | Japan Tobacco Inc. | Indol-containing compound for use in the treatment of the nephrotic syndrome |
| WO2019225740A1 (ja) | 2018-05-25 | 2019-11-28 | 日本たばこ産業株式会社 | インドール化合物を含む多発性硬化症の治療又は予防剤 |
| ES2983998T3 (es) * | 2018-05-25 | 2024-10-28 | Japan Tobacco Inc | Compuesto de indol para tratar la cistitis intersticial |
| AU2020405536B2 (en) | 2019-12-20 | 2023-09-07 | Pfizer Inc. | Benzimidazole derivatives |
| KR102270026B1 (ko) * | 2020-01-31 | 2021-06-28 | 현대약품 주식회사 | (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법 |
| CA3205020A1 (en) * | 2020-12-15 | 2022-06-23 | Pfizer Inc. | Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease |
| EP4263538A1 (en) * | 2020-12-15 | 2023-10-25 | Pfizer Inc. | Pyrido[2,3-d]imidazole derivatives and their use as inhibitors of itk for the teatment of skin disease |
| WO2022235698A1 (en) * | 2021-05-03 | 2022-11-10 | Nurix Therapeutics, Inc. | Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use |
| JP2024517831A (ja) * | 2021-05-03 | 2024-04-23 | ニューリックス セラピューティクス，インコーポレイテッド | Ｉｔｋを阻害又は分解するための化合物、それを含む組成物、それらの作製方法及びそれらの使用方法 |
| TW202315618A (zh) * | 2021-06-11 | 2023-04-16 | 美商愛德亞生物科學公司 | 作為DNA聚合酶θ抑制劑之O-聯結噻二唑基化合物 |
| US20250002489A1 (en) * | 2021-10-19 | 2025-01-02 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading itk via ubiquitin proteosome pathway |
| WO2024213082A1 (en) * | 2023-04-13 | 2024-10-17 | Danatlas Pharmaceuticals Co., Ltd. | Thiadiazolone derivatives, compositions and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US953411A (en) * | 1908-09-02 | 1910-03-29 | Erastus De Moulin | Trick weight-lifting machine. |
| EP1441725A1 (en) * | 2001-10-26 | 2004-08-04 | Aventis Pharmaceuticals Inc. | Benzimidazoles and analogues and their use as protein kinases inhibitors |
| WO2003057696A1 (en) * | 2002-01-07 | 2003-07-17 | Eisai Co. Ltd. | Deazapurines and uses thereof |
| JP2003231687A (ja) | 2002-02-04 | 2003-08-19 | Japan Tobacco Inc | ピラゾリル縮合環化合物及びその医薬用途 |
| FR2854159B1 (fr) * | 2003-04-25 | 2008-01-11 | Aventis Pharma Sa | Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr |
| US20050032869A1 (en) * | 2003-07-08 | 2005-02-10 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| KR20060069490A (ko) * | 2003-09-08 | 2006-06-21 | 아벤티스 파마슈티칼스 인크. | 티에노피라졸 |
| WO2006112479A1 (ja) * | 2005-04-19 | 2006-10-26 | Kyowa Hakko Kogyo Co., Ltd. | 含窒素複素環化合物 |
| WO2007076228A2 (en) | 2005-12-20 | 2007-07-05 | Boehringer Ingelheim International Gmbh | 2-(ih-thieno [3,2-c] pyrazol-3yl)-ih-indole derivatives and related compounds as tec kinase inhibitors for the treatment of inflammations and immunological disorders |
| GB0602178D0 (en) * | 2006-02-03 | 2006-03-15 | Merck Sharp & Dohme | Therapeutic treatment |
| EP2001480A4 (en) * | 2006-03-31 | 2011-06-15 | Abbott Lab | Indazole CONNECTIONS |
| US8604031B2 (en) * | 2006-05-18 | 2013-12-10 | Mannkind Corporation | Intracellular kinase inhibitors |
| EP2108642A1 (en) * | 2006-10-17 | 2009-10-14 | Kyowa Hakko Kirin Co., Ltd. | Jak inhibitor |
| US8362066B2 (en) | 2006-11-17 | 2013-01-29 | Treventis Corporation | Compounds and methods for treating protein folding disorders |
| UA99459C2 (en) | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
| JP2009268040A (ja) | 2008-04-23 | 2009-11-12 | Teruhiko Daiho | ループアンテナ装置 |
| US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
-
2010
- 2010-11-24 US US12/954,438 patent/US8299070B2/en active Active
- 2010-11-25 ES ES10833248.7T patent/ES2572935T3/es active Active
- 2010-11-25 EP EP16158053.5A patent/EP3059234A1/en not_active Withdrawn
- 2010-11-25 PT PT108332487T patent/PT2505586E/pt unknown
- 2010-11-25 DK DK10833248.7T patent/DK2505586T3/en active
- 2010-11-25 AU AU2010323579A patent/AU2010323579C1/en active Active
- 2010-11-25 BR BR112012012529-0A patent/BR112012012529B1/pt active IP Right Grant
- 2010-11-25 SI SI201031188A patent/SI2505586T1/sl unknown
- 2010-11-25 KR KR1020127016311A patent/KR101766502B1/ko active Active
- 2010-11-25 MY MYPI2012002292A patent/MY161095A/en unknown
- 2010-11-25 CA CA2781660A patent/CA2781660C/en active Active
- 2010-11-25 PE PE2012000713A patent/PE20121358A1/es active IP Right Grant
- 2010-11-25 PH PH1/2012/501021A patent/PH12012501021A1/en unknown
- 2010-11-25 CN CN201080062299.3A patent/CN102712624B/zh active Active
- 2010-11-25 EP EP20189306.2A patent/EP3766877A1/en not_active Withdrawn
- 2010-11-25 TW TW099140715A patent/TWI491591B/zh active
- 2010-11-25 HR HRP20160579TT patent/HRP20160579T1/hr unknown
- 2010-11-25 MX MX2012006017A patent/MX2012006017A/es active IP Right Grant
- 2010-11-25 ME MEP-2016-107A patent/ME02447B/me unknown
- 2010-11-25 RU RU2012126129/04A patent/RU2556216C2/ru active
- 2010-11-25 JP JP2010262058A patent/JP5734628B2/ja active Active
- 2010-11-25 AR ARP100104362A patent/AR079164A1/es active IP Right Grant
- 2010-11-25 NZ NZ600840A patent/NZ600840A/en unknown
- 2010-11-25 PL PL10833248.7T patent/PL2505586T3/pl unknown
- 2010-11-25 WO PCT/JP2010/070988 patent/WO2011065402A1/ja not_active Ceased
- 2010-11-25 HU HUE10833248A patent/HUE028016T2/en unknown
- 2010-11-25 EP EP10833248.7A patent/EP2505586B1/en active Active
- 2010-11-25 RS RS20160385A patent/RS54910B1/sr unknown
-
2012
- 2012-05-23 CL CL2012001328A patent/CL2012001328A1/es unknown
- 2012-05-24 IL IL220009A patent/IL220009A/en active IP Right Grant
- 2012-06-22 CO CO12105036A patent/CO6541645A2/es active IP Right Grant
- 2012-09-26 US US13/627,047 patent/US20130116240A1/en not_active Abandoned
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2015
- 2015-04-15 JP JP2015083457A patent/JP2015172051A/ja not_active Ceased
-
2016
- 2016-05-26 CY CY20161100462T patent/CY1117559T1/el unknown
- 2016-08-03 SM SM201600258T patent/SMT201600258B/it unknown
- 2016-10-20 JP JP2016205949A patent/JP2017039761A/ja not_active Ceased
- 2016-10-28 US US15/337,583 patent/US20170267662A1/en not_active Abandoned
-
2018
- 2018-01-12 US US15/869,250 patent/US20180362506A1/en not_active Abandoned
- 2018-06-13 JP JP2018112445A patent/JP2018158935A/ja active Pending
-
2019
- 2019-09-19 US US16/575,724 patent/US20200255408A1/en not_active Abandoned
-
2020
- 2020-02-04 JP JP2020017065A patent/JP2020079276A/ja not_active Ceased
- 2020-09-23 US US17/029,642 patent/US20210284627A1/en not_active Abandoned
-
2021
- 2021-03-03 JP JP2021033138A patent/JP2021091718A/ja active Pending
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