RS54910B1 - Jedinjenje indola i njegova upotreba u farmaciji - Google Patents
Jedinjenje indola i njegova upotreba u farmacijiInfo
- Publication number
- RS54910B1 RS54910B1 RS20160385A RSP20160385A RS54910B1 RS 54910 B1 RS54910 B1 RS 54910B1 RS 20160385 A RS20160385 A RS 20160385A RS P20160385 A RSP20160385 A RS P20160385A RS 54910 B1 RS54910 B1 RS 54910B1
- Authority
- RS
- Serbia
- Prior art keywords
- group
- groups
- optionally substituted
- alkoxy
- substituted
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Jedinjenje predstavljeno sledećom formulom [I], ili neka njegova farmaceutski prihvatljiva so:naznačeno time, što suR1 je(1) atom vodonika,(2) hidroksilna grupa, ili(3) C1-6 alkoksi grupa, supstituisana sa C6-10 aril grupom (grupama);R2 i R3 su iste ili različite grupe, a svaka je(1) atom vodonika, ili(2) neka C1-6 alkil grupa, opciono supstituisana sa 1 do 3 supstituenta koji se biraju između(a) hidroksilne grupe, i(b) neke C1-6 alkoksi grupe; aR4 je neka grupa predstavljena sakoja je vezana u položaju 5 ili položaju 6 prstena indola,pri čemuR5 predstavlja(1) atom vodonika, ili(2) neka C1-6 alkil grupa, a R6 predstavlja(1) atom vodonika,(2) neka C1-6 alkil grupa, opciono supstituisana sa 1 do 3 supstituenta koji se biraju između(a) hidroksi grupe,(b) neke C1-6 alkoksi grupe,(c) neke karboksi grupe,(d) neke C1-6 alkoksi-karbonil grupe,(e) neke C6-10 aril grupe,(f) neke C6-10 ariloksi grupe,(g) neke amino grupe, opciono mono- ili di-supstituisane sa C1-6 alkil grupom (grupama,(h) neke 5- ili 6-člane nezasićene heterociklične grupe, opciono supstituisane sa C1-6 alkil grupom (grupama), i(i) neke 5- ili 6-člane zasićene heterociklične grupe,(3) neka C1-6 alkoksi grupa,(4) neka C6-10 aril grupa, ili(5) neka 5- ili 6-člana nezasićena heterociklična grupa, opciono supstituisana sa 1 do 3 supstituenta koji se biraju između(a) hidroksilne grupe, i(b) neke C1-6 alkoksi grupe,iliR5 i R6 formiraju, zajedno sa atomom azota za koji su vezane, neki 5- do 6-člani ciklični amin (pomenuti ciklični amin je opciono kondenzovan sa 5- ili 6-članim nezasićenim heterociklom), opciono supstituisan sa 1 do 3 supstituenta, koji se biraju između(a) hidroksi grupe,(b) neke C1-6 alkil grupe,(c) neke C1-6 alkoksi grupe, i(d) neke C1-6 alkoksi-karbonil grupe;R7 predstavlja(1) atom vodonika, ili(2)neka C1-6 alkil grupa, opciono supstituisana sa 1 do 3 supstituenta koji se biraju između(a) hidroksi grupe,(b) neke C1-6 alkoksi grupe, i(c) neke amino grupe, opciono mono- ili di-supstituisane sa C1-6 alkil grupom (grupama, iR8 predstavlja(1) neka C1-6 alkil grupa, opciono supstituisana sa 1 do 3 supstituenta koji se biraju između(a) hidroksi grupe,(b) C1-6 alkoksi grupe, supstituisane sa C6-10 aril grupom (grupama),(c) neke C3-6 cikloalkil grupe, opciono supstituisane sa C1-6 alkoksi grupom (grupama),(d) neke C6-10 aril grupe,(e) neke 5- ili 6-člane nezasićene heterociklične grupe, opciono supstituisane sa okso grupom (grupama),(f) neke 5- do 8-člane zasićene heterociklične grupe, opciono supstituisane sa 1 do 3 supstituenta, koji se biraju između(i) hidroksi grupe,(ii) neke C1-6 alkil grupe, opciono supstituisane sa 1 do 3 supstituenta koji se biraju između hidroksi grupe i neke C1-6 alkoksi grupe,(iii) neke C1-6 alkoksi grupe, i(iv) neke okso grupe,(g) neke C3-6 cikloalkiloksi grupe,(h) neke C6-10 ariloksi grupe,(i) neke 5- ili 6-člane nezasićene heterocikliloksi grupe,(j) neke 5- ili 6-člane zasićene heterocikliloksi grupe, i(k) neke amino grupe, opciono mono- ili di-supstituisane sa supstituentima koji se biraju između(i) neke C1-6 alkil grupe, opciono supstituisane sa 1 do 3 supstituenta koji se biraju između hidroksilne grupe, neke karboksi grupe i neke karboksi C1-6 alkoksi grupe,(ii) neke C1-6 alkil-karbonil grupe, opciono supstituisane sa 1 do 3 supstituenta, koji se biraju između hidroksi grupe i neke C1-6 alkoksi grupe,(iii) neke C1-6 alkoksi-karbonil grupe, opciono supstituisane sa C6-10 aril grupom (grupama), i(iv) neke C3-6 cikloalkil-karbonil grupe, opciono supstituisane sa C1-6 alkoksi grupom (grupama),(2) C1-6 alkoksi grupa, supstituisana sa Ce-io aril grupom (grupama),(3) neka C3-6 cikloalkil grupa, opciono supstituisana sa 1 do 3 supstituenta, koji se biraju između(a) hidroksilne grupe, i(b) neke C1-6 alkoksi grupe,(4) neka C6-10 aril grupa, opciono supstituisana sa C1-6 alkil grupom (grupama), opciono supstituisanom sa 1 do 3 atoma halogena,(5) neka amino grupa, opciono mono- ili di-supstituisana sa nekom C1-6 alkil grupom (grupama), opciono supstituisanom sa C6-10 aril grupom (grupama),(6) neka 5- ili 6-člana nezasićena heterociklična grupa, opciono supstituisana sa C1-6 alkil grupom (grupama),(7) neka 5- ili 6-člana zasićena heterociklična grupa, opciono supstituisana sa 1 do 3 supstituenta, koji se biraju između(a) neke C1-6 alkil grupe,(b) neke C1-6 alkil-karbonil grupe, i(c) neke okso grupe,(8) neka C3-6 cikloalkiloksi grupa, ili(9) neka C6-10 aril-karbonil grupa,iliR7 i R8 formiraju, zajedno sa atomom ugljenika za koji su vezane, neki 5- do 6-člani ciklični amin, supstituisan sa nekom okso grupom i opciono još supstituisan sa 1 do 3 supstituenta koji se biraju između(a) hidroksi grupe,(b) neke C1-6 alkil grupe, opciono supstituisane sa hidroksi grupom (grupama),(c) neke C1-6 alkoksi grupe, i(d) neke C3-6 cikloalkil grupe.Prijava sadrži još 31 patentni zahtev.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009268040 | 2009-11-25 | ||
PCT/JP2010/070988 WO2011065402A1 (ja) | 2009-11-25 | 2010-11-25 | インドール化合物及びその医薬用途 |
EP10833248.7A EP2505586B1 (en) | 2009-11-25 | 2010-11-25 | Indole compound and pharmaceutical use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
RS54910B1 true RS54910B1 (sr) | 2016-10-31 |
Family
ID=44066507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20160385A RS54910B1 (sr) | 2009-11-25 | 2010-11-25 | Jedinjenje indola i njegova upotreba u farmaciji |
Country Status (31)
Country | Link |
---|---|
US (6) | US8299070B2 (sr) |
EP (3) | EP3766877A1 (sr) |
JP (6) | JP5734628B2 (sr) |
KR (1) | KR101766502B1 (sr) |
CN (1) | CN102712624B (sr) |
AR (1) | AR079164A1 (sr) |
AU (1) | AU2010323579C1 (sr) |
BR (1) | BR112012012529B1 (sr) |
CA (1) | CA2781660C (sr) |
CL (1) | CL2012001328A1 (sr) |
CO (1) | CO6541645A2 (sr) |
CY (1) | CY1117559T1 (sr) |
DK (1) | DK2505586T3 (sr) |
ES (1) | ES2572935T3 (sr) |
HK (1) | HK1174025A1 (sr) |
HR (1) | HRP20160579T1 (sr) |
HU (1) | HUE028016T2 (sr) |
IL (1) | IL220009A (sr) |
ME (1) | ME02447B (sr) |
MX (1) | MX2012006017A (sr) |
MY (1) | MY161095A (sr) |
NZ (1) | NZ600840A (sr) |
PE (1) | PE20121358A1 (sr) |
PL (1) | PL2505586T3 (sr) |
PT (1) | PT2505586E (sr) |
RS (1) | RS54910B1 (sr) |
RU (1) | RU2556216C2 (sr) |
SI (1) | SI2505586T1 (sr) |
SM (1) | SMT201600258B (sr) |
TW (1) | TWI491591B (sr) |
WO (1) | WO2011065402A1 (sr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
EA031737B1 (ru) | 2010-06-03 | 2019-02-28 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) для лечения лейкоза и лимфомы |
WO2014018567A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
CA2890111A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
CN103804364A (zh) * | 2012-11-06 | 2014-05-21 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
CN103800337A (zh) * | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103804291A (zh) * | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103800328A (zh) * | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103804361A (zh) * | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103800340A (zh) * | 2012-11-09 | 2014-05-21 | 韩冰 | 一类治疗青光眼的化合物及其用途 |
CN103804302A (zh) * | 2012-11-14 | 2014-05-21 | 杨育新 | 一类治疗创伤性脑损伤疾病的化合物及其用途 |
CN103804351A (zh) * | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
CN103804272A (zh) * | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
CN103804363A (zh) * | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
CN104628657A (zh) * | 2013-11-06 | 2015-05-20 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
EP3119910A4 (en) | 2014-03-20 | 2018-02-21 | Pharmacyclics LLC | Phospholipase c gamma 2 and resistance associated mutations |
TW201625605A (zh) * | 2014-04-04 | 2016-07-16 | 賽諾菲公司 | 用於治療糖尿病、肥胖、血脂異常及相關病症之作為gpr119調節劑的經取代之稠合雜環類 |
WO2016002918A1 (ja) * | 2014-07-04 | 2016-01-07 | 日本たばこ産業株式会社 | インドール化合物の製造方法 |
WO2016010108A1 (ja) * | 2014-07-18 | 2016-01-21 | 塩野義製薬株式会社 | 含窒素複素環誘導体およびそれらを含有する医薬組成物 |
CN104356086A (zh) * | 2014-11-28 | 2015-02-18 | 湖南科技大学 | 一种适于工业生产3-吗啉酮的制备方法 |
WO2019225768A1 (en) * | 2018-05-25 | 2019-11-28 | Japan Tobacco Inc. | Method of treating pain or interstitial cystitis using indole compound |
WO2019225741A1 (ja) | 2018-05-25 | 2019-11-28 | 日本たばこ産業株式会社 | インドール化合物を含むネフローゼ症候群の治療又は予防剤 |
EP3804726A4 (en) * | 2018-05-25 | 2022-03-16 | Japan Tobacco Inc. | THERAPEUTIC OR PROPHYLACTIC AGENT FOR MULTIPLE SCLEROSIS CONTAINING AN INDOLE COMPOUND |
CR20220299A (es) | 2019-12-20 | 2022-08-05 | Pfizer | Derivados de becimidazol |
KR102270026B1 (ko) * | 2020-01-31 | 2021-06-28 | 현대약품 주식회사 | (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법 |
JP2023552863A (ja) * | 2020-12-15 | 2023-12-19 | ファイザー・インク | ベンゾイミダゾール誘導体および皮膚疾患の処置のためのitkの阻害剤としてのそれらの使用 |
US20240124439A1 (en) * | 2020-12-15 | 2024-04-18 | Pfizer Inc. | Pyrido[2,3-D]Imidazole Derivatives and Their Use As Inhibitors of ITK for the Treatment of Skin Disease |
CA3217892A1 (en) * | 2021-05-03 | 2022-11-10 | Joel Mcintosh | Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use |
CN117693502A (zh) * | 2021-05-03 | 2024-03-12 | 纽力克斯治疗公司 | 用于抑制或降解itk的化合物、包含其的组合物、其制备方法及其使用方法 |
TW202315618A (zh) * | 2021-06-11 | 2023-04-16 | 美商愛德亞生物科學公司 | 作為DNA聚合酶θ抑制劑之O-聯結噻二唑基化合物 |
WO2023069514A2 (en) * | 2021-10-19 | 2023-04-27 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading itk via ubiquitin proteosome pathway |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US953411A (en) * | 1908-09-02 | 1910-03-29 | Erastus De Moulin | Trick weight-lifting machine. |
IL161576A0 (en) * | 2001-10-26 | 2004-09-27 | Aventis Pharma Inc | Benzimidazoles and analogues and their use as protein kinases inhibitors |
CN100503608C (zh) * | 2002-01-07 | 2009-06-24 | 卫材R&D管理株式会社 | 脱氮嘌呤及其用途 |
JP2003231687A (ja) | 2002-02-04 | 2003-08-19 | Japan Tobacco Inc | ピラゾリル縮合環化合物及びその医薬用途 |
FR2854159B1 (fr) * | 2003-04-25 | 2008-01-11 | Aventis Pharma Sa | Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr |
US20050032869A1 (en) * | 2003-07-08 | 2005-02-10 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
DK1682553T3 (da) * | 2003-09-08 | 2010-08-23 | Aventis Pharma Inc | Thienopyrazoler |
CN101163675A (zh) * | 2005-04-19 | 2008-04-16 | 协和发酵工业株式会社 | 含氮杂环化合物 |
WO2007076228A2 (en) | 2005-12-20 | 2007-07-05 | Boehringer Ingelheim International Gmbh | 2-(ih-thieno [3,2-c] pyrazol-3yl)-ih-indole derivatives and related compounds as tec kinase inhibitors for the treatment of inflammations and immunological disorders |
GB0602178D0 (en) * | 2006-02-03 | 2006-03-15 | Merck Sharp & Dohme | Therapeutic treatment |
EP2001480A4 (en) * | 2006-03-31 | 2011-06-15 | Abbott Lab | Indazole CONNECTIONS |
CA2858520A1 (en) * | 2006-05-18 | 2007-11-29 | Pharmacyclics Inc. | Intracellular kinase inhibitors |
WO2008047831A1 (fr) * | 2006-10-17 | 2008-04-24 | Kyowa Hakko Kirin Co., Ltd. | Inhibiteurs de JAK |
WO2008058402A1 (en) | 2006-11-17 | 2008-05-22 | Queen's University At Kingston | Compounds and methods for treating protein folding disorders |
UA99459C2 (en) | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
JP2009268040A (ja) | 2008-04-23 | 2009-11-12 | Teruhiko Daiho | ループアンテナ装置 |
US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
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2010
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