ATE510829T1 - Neue verbindungen als adenosin-a1-rezeptor- antagonisten - Google Patents
Neue verbindungen als adenosin-a1-rezeptor- antagonistenInfo
- Publication number
- ATE510829T1 ATE510829T1 AT08835072T AT08835072T ATE510829T1 AT E510829 T1 ATE510829 T1 AT E510829T1 AT 08835072 T AT08835072 T AT 08835072T AT 08835072 T AT08835072 T AT 08835072T AT E510829 T1 ATE510829 T1 AT E510829T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- straight
- branched
- group
- halogen atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200702643A ES2331220B1 (es) | 2007-10-02 | 2007-10-02 | Nuevos compuestos como antagonistas de los receptores a1 de adenosina. |
| PCT/IB2008/002556 WO2009044250A1 (en) | 2007-10-02 | 2008-09-30 | New compounds as adenosine a1 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE510829T1 true ATE510829T1 (de) | 2011-06-15 |
Family
ID=40303525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08835072T ATE510829T1 (de) | 2007-10-02 | 2008-09-30 | Neue verbindungen als adenosin-a1-rezeptor- antagonisten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8410282B2 (de) |
| EP (1) | EP2197860B1 (de) |
| JP (1) | JP5463592B2 (de) |
| KR (1) | KR101312198B1 (de) |
| CN (1) | CN101835766B (de) |
| AT (1) | ATE510829T1 (de) |
| AU (1) | AU2008306553B2 (de) |
| BR (1) | BRPI0816554B8 (de) |
| CA (1) | CA2700526C (de) |
| CY (1) | CY1112079T1 (de) |
| DK (1) | DK2197860T3 (de) |
| EA (1) | EA022473B1 (de) |
| ES (2) | ES2331220B1 (de) |
| HR (1) | HRP20110557T1 (de) |
| MX (1) | MX2010003576A (de) |
| PL (1) | PL2197860T3 (de) |
| PT (1) | PT2197860E (de) |
| SI (1) | SI2197860T1 (de) |
| WO (1) | WO2009044250A1 (de) |
| ZA (1) | ZA201002139B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011076734A1 (en) * | 2009-12-21 | 2011-06-30 | Euroscreen S.A. | Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases |
| EP2941420B1 (de) * | 2013-01-03 | 2018-09-05 | Council of Scientific & Industrial Research | (4e)-4-(4-substituierte benzylidenamino)-2,3-dihydro-3-substituierte-2-thioxothiazol-5-carbonitrile als a2ar-antagonisten und verfahren zu deren herstellng |
| US9663529B2 (en) | 2013-07-02 | 2017-05-30 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
| JP6434968B2 (ja) | 2013-07-02 | 2018-12-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｒｏｃｋ阻害剤としての三環式ピリド−カルボキサミド誘導体 |
| ES2578363B1 (es) * | 2015-01-22 | 2017-01-31 | Palobiofarma, S.L. | Moduladores de los receptores A3 de adenosina |
| ES2676535B1 (es) * | 2017-01-20 | 2019-04-29 | Palobiofarma Sl | Moduladores de los receptores a3 de adenosina |
| WO2018162505A1 (en) | 2017-03-06 | 2018-09-13 | Palobiofarma, S.L. | Amine salt of (1r,3s)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcarbamoyl)cyclopentane carboxylic acid |
| CN107739350B (zh) * | 2017-09-26 | 2020-12-22 | 天津大学 | 一种合成2-氨基噻唑衍生物的方法 |
| EP3882240A1 (de) | 2020-03-16 | 2021-09-22 | Palobiofarma, S.L. | Cokristalle von (1r,3s)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcabamoyl)cyclopentancarbonsäure |
| EP3957308A1 (de) | 2020-08-21 | 2022-02-23 | Palobiofarma, S.L. | (1r,3s)-3-((5-cyano-4-phenylthiazol-2-yl)carbamoyl)cyclopentan-1-carbonsäure und deren derivate zur verwendung bei der behandlung von atemwegserkrankungen |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1441732A2 (de) * | 2001-11-08 | 2004-08-04 | Fujisawa Pharmaceutical Co., Ltd. | Thiazolderivat und seine pharmazeutische anwendung |
| CA2472711C (en) * | 2002-01-18 | 2012-03-20 | Yamanouchi Pharmaceutical Co., Ltd. | 2-acylaminothiazole derivative or salt thereof |
| JP2009529059A (ja) * | 2006-03-08 | 2009-08-13 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 抗ｃ型肝炎ウイルス活性を有する置換アミノチアゾール誘導体 |
| WO2007116106A1 (es) * | 2006-04-12 | 2007-10-18 | Palobiofarma, S.L. | Nuevos compuestos como antagonistas de los receptores a1 de adenosina |
-
2007
- 2007-10-02 ES ES200702643A patent/ES2331220B1/es not_active Expired - Fee Related
-
2008
- 2008-09-30 EP EP08835072A patent/EP2197860B1/de active Active
- 2008-09-30 JP JP2010527561A patent/JP5463592B2/ja active Active
- 2008-09-30 AU AU2008306553A patent/AU2008306553B2/en not_active Ceased
- 2008-09-30 US US12/679,941 patent/US8410282B2/en active Active
- 2008-09-30 ES ES08835072T patent/ES2366075T3/es active Active
- 2008-09-30 AT AT08835072T patent/ATE510829T1/de active
- 2008-09-30 CA CA2700526A patent/CA2700526C/en active Active
- 2008-09-30 PL PL08835072T patent/PL2197860T3/pl unknown
- 2008-09-30 PT PT08835072T patent/PT2197860E/pt unknown
- 2008-09-30 EA EA201000393A patent/EA022473B1/ru not_active IP Right Cessation
- 2008-09-30 WO PCT/IB2008/002556 patent/WO2009044250A1/en active Application Filing
- 2008-09-30 BR BRPI0816554A patent/BRPI0816554B8/pt active IP Right Grant
- 2008-09-30 DK DK08835072.3T patent/DK2197860T3/da active
- 2008-09-30 CN CN2008801126777A patent/CN101835766B/zh active Active
- 2008-09-30 KR KR1020107008768A patent/KR101312198B1/ko active IP Right Grant
- 2008-09-30 MX MX2010003576A patent/MX2010003576A/es active IP Right Grant
- 2008-09-30 SI SI200830350T patent/SI2197860T1/sl unknown
-
2010
- 2010-03-25 ZA ZA2010/02139A patent/ZA201002139B/en unknown
-
2011
- 2011-07-26 HR HR20110557T patent/HRP20110557T1/hr unknown
- 2011-08-22 CY CY20111100805T patent/CY1112079T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101835766B (zh) | 2013-09-25 |
| PL2197860T3 (pl) | 2011-09-30 |
| SI2197860T1 (sl) | 2011-09-30 |
| DK2197860T3 (da) | 2011-08-15 |
| CA2700526C (en) | 2014-03-18 |
| CN101835766A (zh) | 2010-09-15 |
| ES2366075T3 (es) | 2011-10-17 |
| BRPI0816554B1 (pt) | 2019-04-09 |
| BRPI0816554B8 (pt) | 2022-08-30 |
| EP2197860B1 (de) | 2011-05-25 |
| HRP20110557T1 (hr) | 2011-09-30 |
| PT2197860E (pt) | 2011-08-26 |
| MX2010003576A (es) | 2010-04-22 |
| AU2008306553A1 (en) | 2009-04-09 |
| EA022473B1 (ru) | 2016-01-29 |
| JP5463592B2 (ja) | 2014-04-09 |
| AU2008306553B2 (en) | 2011-06-09 |
| EP2197860A1 (de) | 2010-06-23 |
| EA201000393A1 (ru) | 2010-08-30 |
| ZA201002139B (en) | 2011-06-29 |
| KR101312198B1 (ko) | 2013-09-27 |
| ES2331220A1 (es) | 2009-12-23 |
| US20100311703A1 (en) | 2010-12-09 |
| WO2009044250A1 (en) | 2009-04-09 |
| JP2010540615A (ja) | 2010-12-24 |
| ES2331220B1 (es) | 2010-09-23 |
| BRPI0816554A2 (pt) | 2015-11-24 |
| CY1112079T1 (el) | 2015-11-04 |
| KR20100058653A (ko) | 2010-06-03 |
| CA2700526A1 (en) | 2009-04-09 |
| US8410282B2 (en) | 2013-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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