EA201071201A1 - ИНДОЛЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ НИКОТИНОВОГО РЕЦЕПТОРА АЦЕТИЛХОЛИНА ПОДТИПА α-71 - Google Patents

ИНДОЛЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ НИКОТИНОВОГО РЕЦЕПТОРА АЦЕТИЛХОЛИНА ПОДТИПА α-71

Info

Publication number
EA201071201A1
EA201071201A1 EA201071201A EA201071201A EA201071201A1 EA 201071201 A1 EA201071201 A1 EA 201071201A1 EA 201071201 A EA201071201 A EA 201071201A EA 201071201 A EA201071201 A EA 201071201A EA 201071201 A1 EA201071201 A1 EA 201071201A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indoles
modulators
nicotinic receptor
acetylcholine subtype
receptor acetylcholine
Prior art date
Application number
EA201071201A
Other languages
English (en)
Other versions
EA018113B1 (ru
Inventor
Кевин Диннелл
Эндрю П. Лайтфут
Говард Роберт Маршалл
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0807050A external-priority patent/GB0807050D0/en
Priority claimed from GB0810229A external-priority patent/GB0810229D0/en
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of EA201071201A1 publication Critical patent/EA201071201A1/ru
Publication of EA018113B1 publication Critical patent/EA018113B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение относится к модуляции никотинового рецептора α7 ацетилхолина (nAChR) соединением формулы (I) или его солью.
EA201071201A 2008-04-17 2009-04-16 Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-71 EA018113B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0807050A GB0807050D0 (en) 2008-04-17 2008-04-17 Novel compounds
GB0810229A GB0810229D0 (en) 2008-06-04 2008-06-04 Novel compounds
PCT/EP2009/054493 WO2009127678A1 (en) 2008-04-17 2009-04-16 Indoles as modulators of nicotinic acetylcholin receptor subtype alpha-71

Publications (2)

Publication Number Publication Date
EA201071201A1 true EA201071201A1 (ru) 2011-04-29
EA018113B1 EA018113B1 (ru) 2013-05-30

Family

ID=40791353

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201071201A EA018113B1 (ru) 2008-04-17 2009-04-16 Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-71
EA201071202A EA017726B1 (ru) 2008-04-17 2009-04-16 Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-7

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201071202A EA017726B1 (ru) 2008-04-17 2009-04-16 Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-7

Country Status (19)

Country Link
US (2) US8377941B2 (ru)
EP (2) EP2279184B1 (ru)
JP (2) JP2011516599A (ru)
KR (2) KR20100135911A (ru)
CN (2) CN102066356B (ru)
AR (1) AR071203A1 (ru)
AU (2) AU2009237650B2 (ru)
BR (2) BRPI0910585A2 (ru)
CA (2) CA2725441C (ru)
CL (1) CL2009000916A1 (ru)
EA (2) EA018113B1 (ru)
ES (2) ES2392795T3 (ru)
IL (2) IL208574A (ru)
MX (2) MX2010011359A (ru)
PE (1) PE20091724A1 (ru)
TW (1) TW201004939A (ru)
UY (1) UY31769A1 (ru)
WO (2) WO2009127679A1 (ru)
ZA (2) ZA201006856B (ru)

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RU2474579C2 (ru) 2007-10-18 2013-02-10 Янссен Фармацевтика Нв Тризамещенные 1,2,4-триазолы
MX2010008384A (es) 2008-01-30 2010-11-30 Cephalon Inc Derivados de piridazina substituida, con actividad antagonista de h3 de histamina.
AU2009226988B2 (en) 2008-03-19 2013-05-23 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
BRPI1014471A2 (pt) * 2009-04-16 2016-04-05 Proximagen Ltd moduladores derivados de indol do receptor nicotínico alfa 7 de acetilcolina
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
GB201012686D0 (en) * 2010-07-28 2010-09-15 Glaxo Group Ltd Novel compounds
JO3078B1 (ar) 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
AU2012213086B2 (en) 2011-02-03 2016-05-05 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nAChR
RS55433B1 (sr) 2011-02-23 2017-04-28 Lupin Ltd Derivati heteroarila kao modulatori nachr alfa7
KR20140018286A (ko) * 2011-03-18 2014-02-12 노파르티스 아게 파킨슨병에서의 도파민 유발 이상운동증에서 사용하기 위한 알파 7 니코틴성 아세틸콜린 수용체 활성화제 및 mGluR5 길항제의 조합물
EP2691368A1 (en) 2011-03-31 2014-02-05 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
WO2013005153A1 (en) 2011-07-05 2013-01-10 Lupin Limited Biaryl derivatives as nachr modulators
CA2866015A1 (en) 2012-03-06 2013-09-12 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
EP2846803B1 (en) * 2012-05-08 2017-06-21 Alpharmagen, LLC Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
WO2014054635A1 (ja) * 2012-10-02 2014-04-10 大日本住友製薬株式会社 イミダゾール誘導体
EP2945936A1 (en) 2012-11-12 2015-11-25 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
CN103006642B (zh) * 2013-01-04 2014-10-22 中国药科大学 一类炔亚甲基吲哚-2-酮类衍生物的用途
EP2945941B1 (en) 2013-01-16 2016-12-07 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
US9617210B2 (en) 2013-03-13 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 NACHR modulators
US10058310B2 (en) 2013-03-13 2018-08-28 Ethicon Llc Electrosurgical device with drum-driven articulation
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
CA2913987A1 (en) 2013-06-17 2014-12-24 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
JP6738797B2 (ja) * 2014-03-25 2020-08-12 イーエムアイシーアイピーアイ・エルエルシーＥｍｉｃｉｐｉ Ｌｌｃ レット症候群治療薬
JP6870304B2 (ja) * 2016-12-05 2021-05-12 住友電気工業株式会社 半導体装置の製造方法
JP7120549B2 (ja) * 2016-12-15 2022-08-17 小野薬品工業株式会社 Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ
HU231333B1 (hu) 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
US20230116403A1 (en) * 2019-12-02 2023-04-13 Storm Therapeutics Limited Polyheterocyclic compounds as mettl3 inhibitors
CN111285792B (zh) * 2020-03-23 2023-05-02 三峡大学 2-取代吲哚化合物及其制备方法

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Also Published As

Publication number Publication date
EA018113B1 (ru) 2013-05-30
EP2279184A1 (en) 2011-02-02
AU2009237649B2 (en) 2012-07-26
UY31769A1 (es) 2009-09-30
KR20100135911A (ko) 2010-12-27
EA201071202A1 (ru) 2011-06-30
TW201004939A (en) 2010-02-01
ES2392795T3 (es) 2012-12-13
EA017726B1 (ru) 2013-02-28
CN102066357A (zh) 2011-05-18
EP2279183A1 (en) 2011-02-02
US20110034515A1 (en) 2011-02-10
WO2009127678A1 (en) 2009-10-22
AU2009237650A1 (en) 2009-10-22
CN102066357B (zh) 2014-04-09
BRPI0910585A2 (pt) 2015-09-22
US8377941B2 (en) 2013-02-19
CN102066356B (zh) 2014-06-11
IL208574A0 (en) 2010-12-30
MX2010011358A (es) 2010-11-10
ZA201006856B (en) 2011-06-29
JP2011516598A (ja) 2011-05-26
CL2009000916A1 (es) 2010-12-31
MX2010011359A (es) 2010-11-12
IL208575A (en) 2014-04-30
JP2011516599A (ja) 2011-05-26
WO2009127679A1 (en) 2009-10-22
KR20100133016A (ko) 2010-12-20
PE20091724A1 (es) 2009-12-06
IL208575A0 (en) 2010-12-30
AU2009237650B2 (en) 2012-05-31
US20110028486A1 (en) 2011-02-03
ES2392796T3 (es) 2012-12-13
US8283365B2 (en) 2012-10-09
CA2725441C (en) 2014-05-27
AR071203A1 (es) 2010-06-02
EP2279183B1 (en) 2012-08-08
CN102066356A (zh) 2011-05-18
CA2721630A1 (en) 2009-10-22
IL208574A (en) 2014-04-30
AU2009237649A1 (en) 2009-10-22
ZA201006855B (en) 2011-06-29
CA2725441A1 (en) 2009-10-22
EP2279184B1 (en) 2012-08-08
BRPI0911682A2 (pt) 2015-10-13

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU