AR071203A1 - Compuesto de trifluorometil-indol-carboxamida, su uso para la fabricacion de un medicamento util para el tratamiento de un trastorno psicotico o deterioro cognitivo y composicion farmaceutica que lo comprende - Google Patents
Compuesto de trifluorometil-indol-carboxamida, su uso para la fabricacion de un medicamento util para el tratamiento de un trastorno psicotico o deterioro cognitivo y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR071203A1 AR071203A1 ARP090101342A ARP090101342A AR071203A1 AR 071203 A1 AR071203 A1 AR 071203A1 AR P090101342 A ARP090101342 A AR P090101342A AR P090101342 A ARP090101342 A AR P090101342A AR 071203 A1 AR071203 A1 AR 071203A1
- Authority
- AR
- Argentina
- Prior art keywords
- carboxamide
- manufacture
- treatment
- pharmaceutical composition
- psychotic disorder
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuesto de trifluorometil-indol-carboxamida, de formula (1) o una sal del mismo, en la que R1 es hidrogeno o alquilo C1-3; R2 es hidrogeno, halo o ciano; y R3 es el grupo de formula (2) donde Ra es halo, alquilo C1-6, alcoxi C1-6, haloalquilo C1-6, haloalcoxi C1-6 o ciano. Actua como medicamento en la modulacion del receptor nicotinico de acetilcolina (nAChR)alfa7. Uso de dicho compuesto para la fabricacion de un medicamento util para el tratamiento de un trastorno psicotico como ser esquizofrenia o deterioro cognitivo. Composicion farmacéutica que lo comprende.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0807050A GB0807050D0 (en) | 2008-04-17 | 2008-04-17 | Novel compounds |
GB0810229A GB0810229D0 (en) | 2008-06-04 | 2008-06-04 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071203A1 true AR071203A1 (es) | 2010-06-02 |
Family
ID=40791353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101342A AR071203A1 (es) | 2008-04-17 | 2009-04-16 | Compuesto de trifluorometil-indol-carboxamida, su uso para la fabricacion de un medicamento util para el tratamiento de un trastorno psicotico o deterioro cognitivo y composicion farmaceutica que lo comprende |
Country Status (19)
Country | Link |
---|---|
US (2) | US8377941B2 (es) |
EP (2) | EP2279184B1 (es) |
JP (2) | JP2011516598A (es) |
KR (2) | KR20100133016A (es) |
CN (2) | CN102066357B (es) |
AR (1) | AR071203A1 (es) |
AU (2) | AU2009237649B2 (es) |
BR (2) | BRPI0911682A2 (es) |
CA (2) | CA2725441C (es) |
CL (1) | CL2009000916A1 (es) |
EA (2) | EA018113B1 (es) |
ES (2) | ES2392795T3 (es) |
IL (2) | IL208574A (es) |
MX (2) | MX2010011358A (es) |
PE (1) | PE20091724A1 (es) |
TW (1) | TW201004939A (es) |
UY (1) | UY31769A1 (es) |
WO (2) | WO2009127679A1 (es) |
ZA (2) | ZA201006855B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
CA2697974C (en) | 2007-10-18 | 2015-06-30 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
EP2752406A1 (en) | 2008-01-30 | 2014-07-09 | Cephalon, Inc. | Substituted pyridazine derivatives which have histamine H3 antagonist activity |
KR101564303B1 (ko) | 2008-03-19 | 2015-11-06 | 얀센 파마슈티카 엔.브이. | 니코틴성 아세틸콜린 수용체 조절제로서의 삼치환된 1,2,4-트리아졸 |
WO2009135944A1 (en) | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
BRPI1014471A2 (pt) | 2009-04-16 | 2016-04-05 | Proximagen Ltd | moduladores derivados de indol do receptor nicotínico alfa 7 de acetilcolina |
TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α7活化劑之用途 |
GB201012686D0 (en) * | 2010-07-28 | 2010-09-15 | Glaxo Group Ltd | Novel compounds |
JO3078B1 (ar) * | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
CN103443092B (zh) | 2011-02-03 | 2015-11-25 | 鲁平有限公司 | 用作α7胆碱受体调节剂的吡咯衍生物 |
CU24177B1 (es) | 2011-02-23 | 2016-04-25 | Lupin Ltd | Derivados de heteroarilo como moduladores de nachr alfa 7 |
BR112013023813A2 (pt) * | 2011-03-18 | 2016-12-13 | Novartis Ag | combinações de ativadores do receptor acetilcolina nicotínico alfa 7 e antagonistas de mglur5 para uso em dopamina induzida por discinesia na doença de parkinson |
JP2014509641A (ja) | 2011-03-31 | 2014-04-21 | ルピン・リミテッド | アルツハイマー病やパーキンソン病などの神経変性疾患の治療に用いられるニコチン性アセチルコリン受容体モジュレータとしてのピロール誘導体 |
TW201245185A (en) | 2011-04-01 | 2012-11-16 | Lundbeck & Co As H | New positive allosteric modulators of nicotinic acetylcholine receptor |
WO2013005153A1 (en) | 2011-07-05 | 2013-01-10 | Lupin Limited | Biaryl derivatives as nachr modulators |
EP2822946A1 (en) | 2012-03-06 | 2015-01-14 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
US20150099758A1 (en) * | 2012-05-08 | 2015-04-09 | Anvyl Llc | Alpha 7 Nicotinic Acetylcholine Receptor Allosteric Modulators, Their Derivatives and Uses Thereof |
MX2015004285A (es) * | 2012-10-02 | 2015-08-06 | Sumitomo Dainippon Pharma Co Ltd | Derivado de imidazol. |
EP2945936A1 (en) | 2012-11-12 | 2015-11-25 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
CN103006642B (zh) * | 2013-01-04 | 2014-10-22 | 中国药科大学 | 一类炔亚甲基吲哚-2-酮类衍生物的用途 |
WO2014111839A1 (en) | 2013-01-16 | 2014-07-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
US10058310B2 (en) | 2013-03-13 | 2018-08-28 | Ethicon Llc | Electrosurgical device with drum-driven articulation |
CA2892682A1 (en) | 2013-03-13 | 2014-09-18 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
AU2014282886A1 (en) | 2013-06-17 | 2015-12-17 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
US20170182058A1 (en) * | 2014-03-25 | 2017-06-29 | Emicipi Llc | Treatment of rett syndrome |
JP6870304B2 (ja) * | 2016-12-05 | 2021-05-12 | 住友電気工業株式会社 | 半導体装置の製造方法 |
US11046683B2 (en) | 2016-12-15 | 2021-06-29 | Ono Pharmaceutical Co., Ltd. | Activator of TREK (TWIK RElated K+ channels) channels |
HU231414B1 (hu) | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
HU231478B1 (hu) | 2018-07-13 | 2024-02-28 | Richter Gedeon Nyrt. | Szubsztituált (aza)indol származékok |
HU231333B1 (hu) * | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
CA3162166A1 (en) * | 2019-12-02 | 2021-06-10 | Storm Therapeutics Limited | Polyheterocyclic compounds as mettl3 inhibitors |
CN111285792B (zh) * | 2020-03-23 | 2023-05-02 | 三峡大学 | 2-取代吲哚化合物及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9903997D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
GB0403155D0 (en) * | 2004-02-12 | 2004-03-17 | Vernalis Res Ltd | Chemical compounds |
CA2713519A1 (en) * | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
-
2009
- 2009-04-16 ES ES09732038T patent/ES2392795T3/es active Active
- 2009-04-16 EP EP09733402A patent/EP2279184B1/en active Active
- 2009-04-16 CA CA2725441A patent/CA2725441C/en not_active Expired - Fee Related
- 2009-04-16 UY UY031769A patent/UY31769A1/es not_active Application Discontinuation
- 2009-04-16 CA CA2721630A patent/CA2721630A1/en not_active Abandoned
- 2009-04-16 EA EA201071201A patent/EA018113B1/ru not_active IP Right Cessation
- 2009-04-16 EP EP09732038A patent/EP2279183B1/en active Active
- 2009-04-16 AU AU2009237649A patent/AU2009237649B2/en not_active Ceased
- 2009-04-16 WO PCT/EP2009/054495 patent/WO2009127679A1/en active Application Filing
- 2009-04-16 CL CL2009000916A patent/CL2009000916A1/es unknown
- 2009-04-16 JP JP2011504457A patent/JP2011516598A/ja not_active Ceased
- 2009-04-16 AR ARP090101342A patent/AR071203A1/es not_active Application Discontinuation
- 2009-04-16 JP JP2011504458A patent/JP2011516599A/ja not_active Ceased
- 2009-04-16 CN CN200980123031.3A patent/CN102066357B/zh not_active Expired - Fee Related
- 2009-04-16 WO PCT/EP2009/054493 patent/WO2009127678A1/en active Application Filing
- 2009-04-16 US US12/936,431 patent/US8377941B2/en not_active Expired - Fee Related
- 2009-04-16 KR KR1020107025697A patent/KR20100133016A/ko not_active Application Discontinuation
- 2009-04-16 US US12/936,408 patent/US8283365B2/en not_active Expired - Fee Related
- 2009-04-16 MX MX2010011358A patent/MX2010011358A/es active IP Right Grant
- 2009-04-16 CN CN200980123025.8A patent/CN102066356B/zh not_active Expired - Fee Related
- 2009-04-16 EA EA201071202A patent/EA017726B1/ru not_active IP Right Cessation
- 2009-04-16 TW TW098112580A patent/TW201004939A/zh unknown
- 2009-04-16 BR BRPI0911682A patent/BRPI0911682A2/pt not_active IP Right Cessation
- 2009-04-16 PE PE2009000537A patent/PE20091724A1/es not_active Application Discontinuation
- 2009-04-16 ES ES09733402T patent/ES2392796T3/es active Active
- 2009-04-16 BR BRPI0910585A patent/BRPI0910585A2/pt not_active IP Right Cessation
- 2009-04-16 AU AU2009237650A patent/AU2009237650B2/en not_active Ceased
- 2009-04-16 MX MX2010011359A patent/MX2010011359A/es active IP Right Grant
- 2009-04-16 KR KR1020107025698A patent/KR20100135911A/ko not_active Application Discontinuation
-
2010
- 2010-09-27 ZA ZA2010/06855A patent/ZA201006855B/en unknown
- 2010-09-27 ZA ZA2010/06856A patent/ZA201006856B/en unknown
- 2010-10-07 IL IL208574A patent/IL208574A/en not_active IP Right Cessation
- 2010-10-07 IL IL208575A patent/IL208575A/en not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR071203A1 (es) | Compuesto de trifluorometil-indol-carboxamida, su uso para la fabricacion de un medicamento util para el tratamiento de un trastorno psicotico o deterioro cognitivo y composicion farmaceutica que lo comprende | |
AR074238A1 (es) | Compuesto de n-{[(1r,4s,6r)-3-(2-piridinilcarbonil)-3-azabiciclo[4,1.0]hept-4-il]metil}-2-heteroarilamina, su uso para la preparacion de un medicamento util para el tratamiento de una enfermedad que requiere un antagonista del receptor de orexina humano y composicion farmaceutica que lo comprende | |
AR068369A1 (es) | Sal de xinafoato de n4-[(2,2-difluor-4h-benzo[1,4]oxazin-3-on)-6-il]-5-fluor-n2-[3-(metilaminocarbonilmetilenoxi)-fenil]2,4-pirimidindiamina" | |
MX2010012298A (es) | Activadores de glucocinasa. | |
EA201170772A1 (ru) | Органические соединения | |
AR110128A2 (es) | Compuesto del grupo de las 3-(imidazoil)-pirazolo[3,4-b]piridinas, composición farmacéutica que lo comprende y método para preparar el mismo | |
UY30659A1 (es) | Grupo de compuestos de benzoilamino heterociclico, composiciones farmacéuticas, porcesos para su preparacion y aplicaciones. | |
AR059977A1 (es) | Compuesto de ciclohexil piperidinil dihidrobenzimidazol composicion farmaceutica que lo comprende su uso para la preparacion de un medicamento proceso para preparalo y compuesto intermediario para la sintesis del mismo | |
BRPI0911208A2 (pt) | moduladores inflamatórios antioxidantes: ácido oleanólico derivados com saturação no c-anel. | |
GT200900194A (es) | Derivados de espirocromanona sustituida como inhibidores de acc. | |
CO6630189A2 (es) | Compuestos heterocíclicos de nitrógeno útiles como inhibidores de pde10 | |
UY32098A (es) | Heteroarilos sustituidos | |
AR064736A1 (es) | Agonistas de gpcr | |
EA200971143A1 (ru) | Бензамидные mglur5 позитивные аллостерические модуляторы и способы их получения и применения | |
CR10992A (es) | Preparacion solida que comprende alogliptina y pioglitazona | |
UY30966A1 (es) | Nuevos compuestos de adenina, sales farmaccuticamente aceptables, composiciones contenicndolos y aplicaciones | |
CL2008002162A1 (es) | Compuestos derivados de 3-benzoisoxazol-piperidin; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento y/o prevencion de trastornos cognitivos, adiccion a drogas, depresion, ansiedad, entre otras. | |
BRPI0410238A (pt) | compostos orgánicos | |
AR064127A1 (es) | Compuesto de tiazolopiridinona, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento | |
BR112015004698A2 (pt) | combinações parasiticidas de isoxazolina espirocíclica | |
ATE525350T1 (de) | Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung | |
UA109290C2 (uk) | Спільні кристали і солі інгібіторів ccr3 | |
CO6390058A2 (es) | Piperidina espiro pirrolidinona y piperidinona sustituidas usadas como moduladores de h3 | |
BRPI0615614A2 (pt) | compostos orgánicos | |
EA201001855A1 (ru) | Соединения, содержащие циклобутоксигруппу |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |