EA201101325A1 - ПРОИЗВОДНЫЕ ИНДОЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРА α7 nAChR - Google Patents

ПРОИЗВОДНЫЕ ИНДОЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРА α7 nAChR

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Publication number
EA201101325A1
EA201101325A1 EA201101325A EA201101325A EA201101325A1 EA 201101325 A1 EA201101325 A1 EA 201101325A1 EA 201101325 A EA201101325 A EA 201101325A EA 201101325 A EA201101325 A EA 201101325A EA 201101325 A1 EA201101325 A1 EA 201101325A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptor modulators
nachr receptor
indol derivatives
nachr
indol
Prior art date
Application number
EA201101325A
Other languages
English (en)
Other versions
EA019518B1 (ru
Inventor
Кевин Диннелл
Original Assignee
Проксимаген Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Проксимаген Лимитед filed Critical Проксимаген Лимитед
Publication of EA201101325A1 publication Critical patent/EA201101325A1/ru
Publication of EA019518B1 publication Critical patent/EA019518B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к модуляции никотиновых ацетилхолиновых α7-рецепторов (nAChR) соединением формулы (I) или его сольюгде Rпредставляет собой имидазолил, пиридинил или пиримидинил, каждый из которых необязательно замещен одной группой, которую независимо выбирают из Cалкила и Cалкокси.
EA201101325A 2009-04-16 2010-04-14 ПРОИЗВОДНЫЕ ИНДОЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРА α7 nAChR EA019518B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16974209P 2009-04-16 2009-04-16
PCT/EP2010/054910 WO2010119078A1 (en) 2009-04-16 2010-04-14 Indole derivative modulators of the alpha 7 nachr

Publications (2)

Publication Number Publication Date
EA201101325A1 true EA201101325A1 (ru) 2012-05-30
EA019518B1 EA019518B1 (ru) 2014-04-30

Family

ID=42235211

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201101325A EA019518B1 (ru) 2009-04-16 2010-04-14 ПРОИЗВОДНЫЕ ИНДОЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРА α7 nAChR

Country Status (15)

Country Link
US (2) US8829031B2 (ru)
EP (1) EP2419420B1 (ru)
JP (1) JP5642154B2 (ru)
KR (1) KR20120089190A (ru)
CN (1) CN102712622B (ru)
AU (1) AU2010238518A1 (ru)
BR (1) BRPI1014471A2 (ru)
CA (1) CA2758772A1 (ru)
EA (1) EA019518B1 (ru)
IL (1) IL215551A (ru)
MX (1) MX2011010734A (ru)
NZ (1) NZ596390A (ru)
SG (1) SG175084A1 (ru)
WO (1) WO2010119078A1 (ru)
ZA (1) ZA201107988B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2419420B1 (en) * 2009-04-16 2013-03-13 Proximagen Limited Indole derivative modulators of the alpha 7 nachr
GB201012686D0 (en) * 2010-07-28 2010-09-15 Glaxo Group Ltd Novel compounds
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903997D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New compounds
US20040242559A1 (en) * 2003-04-25 2004-12-02 Aventis Pharma S.A. Novel indole derivatives, preparation thereof as medicinal products and pharmaceutical compositions, and especially as KDR inhibitors
GB0403155D0 (en) * 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
CA2679817A1 (en) * 2007-03-02 2008-09-12 Merck & Co., Inc. Bipyridine carboxamide orexin receptor antagonists
CA2713519A1 (en) * 2008-02-07 2009-08-13 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
CN102066357B (zh) * 2008-04-17 2014-04-09 葛兰素集团有限公司 作为烟碱型乙酰胆碱受体亚型α71的调节剂的吲哚衍生物
EP2419420B1 (en) * 2009-04-16 2013-03-13 Proximagen Limited Indole derivative modulators of the alpha 7 nachr

Also Published As

Publication number Publication date
WO2010119078A9 (en) 2011-02-03
US20120136009A1 (en) 2012-05-31
CN102712622B (zh) 2014-05-07
BRPI1014471A2 (pt) 2016-04-05
AU2010238518A1 (en) 2011-12-01
EP2419420B1 (en) 2013-03-13
ZA201107988B (en) 2012-07-25
EA019518B1 (ru) 2014-04-30
MX2011010734A (es) 2011-12-06
IL215551A (en) 2014-07-31
JP5642154B2 (ja) 2014-12-17
CN102712622A (zh) 2012-10-03
CA2758772A1 (en) 2010-10-21
IL215551A0 (en) 2011-12-29
NZ596390A (en) 2013-08-30
WO2010119078A1 (en) 2010-10-21
JP2012524043A (ja) 2012-10-11
US20150038517A1 (en) 2015-02-05
EP2419420A1 (en) 2012-02-22
US8829031B2 (en) 2014-09-09
SG175084A1 (en) 2011-11-28
KR20120089190A (ko) 2012-08-09

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU