EA200802427A1 - Новые соединения 1н-индол-1-ил-мочевины, способ их получения и фармацевтические композиции, содержащие их - Google Patents

Новые соединения 1н-индол-1-ил-мочевины, способ их получения и фармацевтические композиции, содержащие их

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Publication number
EA200802427A1
EA200802427A1 EA200802427A EA200802427A EA200802427A1 EA 200802427 A1 EA200802427 A1 EA 200802427A1 EA 200802427 A EA200802427 A EA 200802427A EA 200802427 A EA200802427 A EA 200802427A EA 200802427 A1 EA200802427 A1 EA 200802427A1
Authority
EA
Eurasian Patent Office
Prior art keywords
branched
linear
indol
urea
reception
Prior art date
Application number
EA200802427A
Other languages
English (en)
Inventor
Жан-Даньель Брион
Абдаллах Дейин
Ален Ле-Ридан
Катрин Арпей
Original Assignee
Ле Лаборатуар Сервье
Сентр Насьональ Де-Ля Решерш Сайнтифик
Юниверсите Пари Сюд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье, Сентр Насьональ Де-Ля Решерш Сайнтифик, Юниверсите Пари Сюд filed Critical Ле Лаборатуар Сервье
Publication of EA200802427A1 publication Critical patent/EA200802427A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Соединения формулы (I)где Rи R, которые могут быть одинаковыми или разными, представляют собой атом водорода или линейную или разветвленную (С-С)алкильную группу, Rозначает атом водорода или галогена, линейную или разветвленную (C-С)алкильную группу или линейную или разветвленную (C-С)алкоксигруппу, Het означает пиридильную, пиримидинильную или пиперидильную группу, которая необязательно замещена одной или несколькими группами, выбранными из галогена, линейной или разветвленной (С-С)алкильной группы и линейной или разветвленной (С-С)алкоксигруппы, означает одинарную связь или двойную связь, их энантиомеры и диастереомеры, а также их соли присоединения с фармацевтически приемлемой кислотой или основанием. Лекарственные средства.
EA200802427A 2008-01-04 2008-12-29 Новые соединения 1н-индол-1-ил-мочевины, способ их получения и фармацевтические композиции, содержащие их EA200802427A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0800043A FR2926077A1 (fr) 2008-01-04 2008-01-04 Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
EA200802427A1 true EA200802427A1 (ru) 2009-06-30

Family

ID=39427563

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802427A EA200802427A1 (ru) 2008-01-04 2008-12-29 Новые соединения 1н-индол-1-ил-мочевины, способ их получения и фармацевтические композиции, содержащие их

Country Status (17)

Country Link
US (1) US20090176794A1 (ru)
EP (1) EP2078716A1 (ru)
JP (1) JP2009196976A (ru)
KR (1) KR20090075632A (ru)
CN (1) CN101475560A (ru)
AR (1) AR070070A1 (ru)
AU (1) AU2009200010A1 (ru)
BR (1) BRPI0900030A2 (ru)
CA (1) CA2648836A1 (ru)
EA (1) EA200802427A1 (ru)
FR (1) FR2926077A1 (ru)
MA (1) MA30619B1 (ru)
MX (1) MX2009000254A (ru)
NZ (1) NZ573976A (ru)
SG (1) SG153774A1 (ru)
WO (1) WO2009106753A1 (ru)
ZA (1) ZA200810841B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113710319B (zh) * 2019-02-01 2024-10-11 霍夫曼技术有限责任公司 用于治疗焦虑相关病症的组合物和方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3454583A (en) 1965-07-19 1969-07-08 Us Health Education & Welfare Synthesis of vincamine
FR2381048A1 (fr) 1977-02-22 1978-09-15 Roussel Uclaf Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments
FR2433528A2 (fr) 1978-08-16 1980-03-14 Roussel Uclaf Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments
FR2614022B1 (fr) 1987-04-15 1989-12-01 Roussel Uclaf Nouveaux derives 17-aza de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et ces compositions les renfermant
WO1993018026A1 (en) * 1992-03-04 1993-09-16 Beecham Group Plc Indole ureas as 5-ht1c receptor antogonists
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
FR2713644B1 (fr) 1993-12-14 1996-02-09 Adir Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
AUPO390996A0 (en) * 1996-11-29 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. Urea derivatives
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR2911143A1 (fr) * 2007-01-05 2008-07-11 Servier Lab Utilisation de composes neuroprotecteurs pour l'obtention de medicaments destines au traitement de maladies neurodegeneratives.

Also Published As

Publication number Publication date
EP2078716A1 (fr) 2009-07-15
FR2926077A1 (fr) 2009-07-10
SG153774A1 (en) 2009-07-29
ZA200810841B (en) 2009-12-30
NZ573976A (en) 2010-05-28
WO2009106753A1 (fr) 2009-09-03
BRPI0900030A2 (pt) 2009-09-15
MA30619B1 (fr) 2009-08-03
US20090176794A1 (en) 2009-07-09
AU2009200010A1 (en) 2009-07-23
MX2009000254A (es) 2009-08-12
AR070070A1 (es) 2010-03-10
KR20090075632A (ko) 2009-07-08
JP2009196976A (ja) 2009-09-03
CA2648836A1 (fr) 2009-07-04
CN101475560A (zh) 2009-07-08

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