AR077084A1 - Esteres derivados de azetidinas, su preparacion y su aplicacion en terapeutica - Google Patents

Esteres derivados de azetidinas, su preparacion y su aplicacion en terapeutica

Info

Publication number
AR077084A1
AR077084A1 ARP100102090A ARP100102090A AR077084A1 AR 077084 A1 AR077084 A1 AR 077084A1 AR P100102090 A ARP100102090 A AR P100102090A AR P100102090 A ARP100102090 A AR P100102090A AR 077084 A1 AR077084 A1 AR 077084A1
Authority
AR
Argentina
Prior art keywords
alkyl group
hydrogen atom
group
alkyl
alkoxy
Prior art date
Application number
ARP100102090A
Other languages
English (en)
Inventor
Pascal George
Jean-Francois Sabuco
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR077084A1 publication Critical patent/AR077084A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos que responden a la formula (1) en la que R representa un grupo alquilo C1-6, haloalquilo C1-6; A representa un átomo de carbono opcionalmente sustituido con uno o varios átomos de hidrogeno o grupos alquilo C1-6; R5 representa uno o dos átomos de carbono sustituido con uno o varios grupos elegidos entre los grupos hidroxi, alcoxi C1-6, OCOR2, OCOOR6, NRaRb o un grupo heterocíclico opcionalmente sustituido con un átomo de halogeno, un grupo alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, oxo; R1 representa un átomo de hidrogeno o un grupo alquilo C1-6; R2 representa un átomo de hidrogeno, un grupo alquilo C1-6, R3 y R4 representan cada uno un grupo fenilo, opcionalmente sustituido con uno o varios átomos o grupos elegidos entre un átomo de hidrogeno, un halogeno, un grupo alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6 o ciano; R6 representa un grupo alquilo C1-6; Ra, Rb representan independientemente uno del otros un átomo de hidrogeno o un grupo alquilo C1-6; Y representa un átomo de hidrogeno, un halogeno, un grupo alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquilo C1-6-S(O)p o ciano; p está comprendido entre 0 y 2; en forma de base o de sal de adicion de un ácido. Procedimiento de preparacion y aplicacion en terapéutica, en el tratamiento de enfermedades que implican receptores cannabinoides CB1.
ARP100102090A 2009-06-16 2010-06-14 Esteres derivados de azetidinas, su preparacion y su aplicacion en terapeutica AR077084A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0954039A FR2946650B1 (fr) 2009-06-16 2009-06-16 Esters derives d'azetidines, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
AR077084A1 true AR077084A1 (es) 2011-08-03

Family

ID=41382313

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102090A AR077084A1 (es) 2009-06-16 2010-06-14 Esteres derivados de azetidinas, su preparacion y su aplicacion en terapeutica

Country Status (3)

Country Link
AR (1) AR077084A1 (es)
FR (1) FR2946650B1 (es)
WO (1) WO2010146299A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2805817B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation
ES2369256T3 (es) 2000-06-26 2011-11-28 Helen Of Troy Limited Sistema de lámpara recargable.
FR2833842B1 (fr) * 2001-12-21 2004-02-13 Aventis Pharma Sa Compositions pharmaceutiques a base de derives d'azetidine
RU2006133258A (ru) * 2004-02-17 2008-04-10 Лабораториос Дель Др. Эстеве С.А. (Es) Замещенные азетидиновые производные, их получение и применение в качестве лекарственных средств
CA2709863A1 (fr) * 2007-12-18 2009-09-03 Sanofi-Aventis Derives d'azetidines, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
WO2010146299A1 (fr) 2010-12-23
FR2946650B1 (fr) 2011-08-19
FR2946650A1 (fr) 2010-12-17

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