AR077084A1 - ESTERES DERIVED FROM AZETIDINES, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents

ESTERES DERIVED FROM AZETIDINES, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Info

Publication number
AR077084A1
AR077084A1 ARP100102090A ARP100102090A AR077084A1 AR 077084 A1 AR077084 A1 AR 077084A1 AR P100102090 A ARP100102090 A AR P100102090A AR P100102090 A ARP100102090 A AR P100102090A AR 077084 A1 AR077084 A1 AR 077084A1
Authority
AR
Argentina
Prior art keywords
alkyl group
hydrogen atom
group
alkyl
alkoxy
Prior art date
Application number
ARP100102090A
Other languages
Spanish (es)
Inventor
Pascal George
Jean-Francois Sabuco
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR077084A1 publication Critical patent/AR077084A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos que responden a la formula (1) en la que R representa un grupo alquilo C1-6, haloalquilo C1-6; A representa un átomo de carbono opcionalmente sustituido con uno o varios átomos de hidrogeno o grupos alquilo C1-6; R5 representa uno o dos átomos de carbono sustituido con uno o varios grupos elegidos entre los grupos hidroxi, alcoxi C1-6, OCOR2, OCOOR6, NRaRb o un grupo heterocíclico opcionalmente sustituido con un átomo de halogeno, un grupo alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, oxo; R1 representa un átomo de hidrogeno o un grupo alquilo C1-6; R2 representa un átomo de hidrogeno, un grupo alquilo C1-6, R3 y R4 representan cada uno un grupo fenilo, opcionalmente sustituido con uno o varios átomos o grupos elegidos entre un átomo de hidrogeno, un halogeno, un grupo alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6 o ciano; R6 representa un grupo alquilo C1-6; Ra, Rb representan independientemente uno del otros un átomo de hidrogeno o un grupo alquilo C1-6; Y representa un átomo de hidrogeno, un halogeno, un grupo alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquilo C1-6-S(O)p o ciano; p está comprendido entre 0 y 2; en forma de base o de sal de adicion de un ácido. Procedimiento de preparacion y aplicacion en terapéutica, en el tratamiento de enfermedades que implican receptores cannabinoides CB1.Compounds that respond to formula (1) in which R represents a C1-6 alkyl, C1-6 haloalkyl group; A represents a carbon atom optionally substituted with one or more hydrogen atoms or C1-6 alkyl groups; R5 represents one or two carbon atoms substituted with one or more groups selected from the hydroxy, C1-6 alkoxy, OCOR2, OCOOR6, NRaRb or a heterocyclic group optionally substituted with a halogen atom, a C1-6 alkyl group, haloalkyl group C1-6, C1-6 alkoxy, oxo; R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, R3 and R4 each represent a phenyl group, optionally substituted with one or more atoms or groups chosen from a hydrogen atom, a halogen, a C1-6 alkyl group, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy or cyano; R6 represents a C1-6 alkyl group; Ra, Rb independently represent one another a hydrogen atom or a C1-6 alkyl group; Y represents a hydrogen atom, a halogen, a C1-6 alkyl group, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6-S (O) alkyl p or cyano; p is between 0 and 2; in the form of base or salt of addition of an acid. Procedure for preparation and application in therapeutics, in the treatment of diseases involving CB1 cannabinoid receptors.

ARP100102090A 2009-06-16 2010-06-14 ESTERES DERIVED FROM AZETIDINES, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AR077084A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0954039A FR2946650B1 (en) 2009-06-16 2009-06-16 ESTERS DERIVED FROM AZETIDINES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS.

Publications (1)

Publication Number Publication Date
AR077084A1 true AR077084A1 (en) 2011-08-03

Family

ID=41382313

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102090A AR077084A1 (en) 2009-06-16 2010-06-14 ESTERES DERIVED FROM AZETIDINES, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Country Status (3)

Country Link
AR (1) AR077084A1 (en)
FR (1) FR2946650B1 (en)
WO (1) WO2010146299A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2805817B1 (en) * 2000-03-03 2002-04-26 Aventis Pharma Sa PHARMACEUTICAL COMPOSITIONS CONTAINING AZETIDINE DERIVATIVES, NOVEL AZETIDINE DERIVATIVES AND THEIR PREPARATION
ES2369256T3 (en) 2000-06-26 2011-11-28 Helen Of Troy Limited RECHARGEABLE LAMP SYSTEM.
FR2833842B1 (en) * 2001-12-21 2004-02-13 Aventis Pharma Sa PHARMACEUTICAL COMPOSITIONS BASED ON AZETIDINE DERIVATIVES
KR20060124756A (en) * 2004-02-17 2006-12-05 라보라토리오스 델 드라. 에스테브.에스.에이. Substituted azetidine compounds, their preparation and use as medicaments
KR20100098563A (en) * 2007-12-18 2010-09-07 사노피-아벤티스 Azetidine derivatives, their preparation and their application in therapy

Also Published As

Publication number Publication date
FR2946650B1 (en) 2011-08-19
WO2010146299A1 (en) 2010-12-23
FR2946650A1 (en) 2010-12-17

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