AR072803A1 - Tetrahidrocinolinas como inhibidores de la 11- beta -hsd1 para la diabetes - Google Patents

Tetrahidrocinolinas como inhibidores de la 11- beta -hsd1 para la diabetes

Info

Publication number
AR072803A1
AR072803A1 ARP090102663A ARP090102663A AR072803A1 AR 072803 A1 AR072803 A1 AR 072803A1 AR P090102663 A ARP090102663 A AR P090102663A AR P090102663 A ARP090102663 A AR P090102663A AR 072803 A1 AR072803 A1 AR 072803A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
methyl
hydrogen
pyrazolyl
Prior art date
Application number
ARP090102663A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41050326&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR072803(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR072803A1 publication Critical patent/AR072803A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

También reivindica proceso y composiciones farmacéuticas y uso para preparar medicamentos. Reivindicacion 1: Compuestos de la formula (1) en la que A es CRaRb o -CH2-CH2-; R1 es hidrogeno o alquilo; R2 es hidrogeno o alquilo; R3 es alquilo, cicloalquilo, cicloalquil-alquilo, arilo, arilo sustituido, 1H-pirazolilo o 1H-pirazolilo sustituido, dicho arilo sustituido es arilo sustituido de una a tres veces por sustituyentes elegidos con independencia entre alquilo, halogeno y haloalquilo, y dicho 1H-pirazolilo sustituido es 1H-pirazolilo sustituido de una a tres veces por sustituyentes elegidos con independencia entre alquilo y arilo; Ra es hidrogeno o metilo; Rb es hidrogeno o metilo; o Ra y Rb junto con el átomo de carbono al que están unidos forman un ciclopropilo, ciclobutilo o ciclopentilo; con la condicion de que si Ra y Rb son ambos hidrogeno o ambos metilo al mismo tiempo, entonces R3 sea (1-metil-ciclopropil) metilo; y las sales y ésteres farmacéuticamente aceptables de los mismos.
ARP090102663A 2008-07-15 2009-07-14 Tetrahidrocinolinas como inhibidores de la 11- beta -hsd1 para la diabetes AR072803A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08160446 2008-07-15

Publications (1)

Publication Number Publication Date
AR072803A1 true AR072803A1 (es) 2010-09-22

Family

ID=41050326

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102663A AR072803A1 (es) 2008-07-15 2009-07-14 Tetrahidrocinolinas como inhibidores de la 11- beta -hsd1 para la diabetes

Country Status (17)

Country Link
US (1) US8501940B2 (es)
EP (1) EP2313375A1 (es)
JP (1) JP5575762B2 (es)
KR (1) KR20110036579A (es)
CN (1) CN102089287B (es)
AR (1) AR072803A1 (es)
AU (1) AU2009272895A1 (es)
BR (1) BRPI0915862A2 (es)
CA (1) CA2730059A1 (es)
CL (1) CL2011000061A1 (es)
IL (1) IL209723A0 (es)
MX (1) MX2011000226A (es)
PE (1) PE20110207A1 (es)
RU (1) RU2541533C2 (es)
TW (1) TW201006802A (es)
WO (1) WO2010006940A1 (es)
ZA (1) ZA201009182B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
KR20150072412A (ko) * 2012-10-05 2015-06-29 리겔 파마슈티칼스, 인크. Gdf-8 억제제
CA2929194A1 (en) * 2013-11-05 2015-05-14 F. Hoffmann-La Roche Ag 5,6,7,8-tetrahydro-5,8-methanocinnoline derivatives as rorc modulators for the treatment of autoimmune diseases
WO2016177686A1 (en) * 2015-05-04 2016-11-10 F. Hoffmann-La Roche Ag PYRIDAZINE DERIVATIVES AS RORc MODULATORS
CN107635971A (zh) * 2015-05-04 2018-01-26 豪夫迈·罗氏有限公司 作为RORc调节剂的哒嗪衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1423381E (pt) * 2001-09-06 2007-04-30 Schering Corp Inibidores de 17-b-hidroxiesteróide-desidrogenase do tipo 3 para o tratamento de doenças dependentes de androgénio
CA2474168A1 (en) * 2002-02-01 2003-08-14 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
RU2292337C2 (ru) * 2002-02-19 2007-01-27 Оно Фармасьютикал Ко., Лтд. Конденсированные производные пиридазина и лекарственные препараты, содержащие данные соединения в качестве активного ингредиента
DE60332862D1 (de) * 2002-11-18 2010-07-15 Schering Corp 17beta-hydroxysteroid dehydrogenase typ-3 hemmer zur behandlung von androgen abhängigen erkrankungen
EP1904455B1 (en) 2005-07-05 2011-08-17 F. Hoffmann-La Roche AG Pyridazine derivatives
KR101089012B1 (ko) * 2006-07-05 2011-12-01 에프. 호프만-라 로슈 아게 11베타 하이드록시스테로이드 탈수소효소 유형 1(11β-ＨＳＤ1)의 저해제로서의 알킬-피리다진 유도체

Also Published As

Publication number Publication date
PE20110207A1 (es) 2011-03-31
AU2009272895A1 (en) 2010-01-21
BRPI0915862A2 (pt) 2015-11-03
EP2313375A1 (en) 2011-04-27
US20100016325A1 (en) 2010-01-21
MX2011000226A (es) 2011-02-24
CN102089287B (zh) 2013-10-23
CL2011000061A1 (es) 2011-07-01
IL209723A0 (en) 2011-02-28
CA2730059A1 (en) 2010-01-21
CN102089287A (zh) 2011-06-08
ZA201009182B (en) 2011-10-26
JP5575762B2 (ja) 2014-08-20
RU2541533C2 (ru) 2015-02-20
JP2011528003A (ja) 2011-11-10
WO2010006940A1 (en) 2010-01-21
US8501940B2 (en) 2013-08-06
TW201006802A (en) 2010-02-16
KR20110036579A (ko) 2011-04-07
RU2011105058A (ru) 2012-08-20

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