EP0382790A4 - Compositions and methods for alleviating stress, anxiety and seizure activity - Google Patents
Compositions and methods for alleviating stress, anxiety and seizure activityInfo
- Publication number
- EP0382790A4 EP0382790A4 EP19890900688 EP89900688A EP0382790A4 EP 0382790 A4 EP0382790 A4 EP 0382790A4 EP 19890900688 EP19890900688 EP 19890900688 EP 89900688 A EP89900688 A EP 89900688A EP 0382790 A4 EP0382790 A4 EP 0382790A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- anxiety
- compositions
- methods
- seizure activity
- alleviating stress
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8936287A | 1987-08-25 | 1987-08-25 | |
US89362 | 1993-07-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0382790A1 EP0382790A1 (en) | 1990-08-22 |
EP0382790A4 true EP0382790A4 (en) | 1991-03-27 |
Family
ID=22217242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19890900688 Withdrawn EP0382790A4 (en) | 1987-08-25 | 1988-08-24 | Compositions and methods for alleviating stress, anxiety and seizure activity |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0382790A4 (en) |
JP (1) | JPH03500049A (en) |
AU (1) | AU609927B2 (en) |
DK (1) | DK48790A (en) |
WO (1) | WO1989002272A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5120723A (en) * | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
US5232917A (en) | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
US5212167A (en) * | 1991-09-12 | 1993-05-18 | Trustees Of Boston University | Modulation of receptor-mediated ion transport |
US5795870A (en) * | 1991-12-13 | 1998-08-18 | Trustees Of Princeton University | Compositions and methods for cell transformation |
US5693769A (en) * | 1991-12-13 | 1997-12-02 | Transcell Technologies, Inc. | Glycosylated steroid derivatives for transport across biological membranes and process for making and using same |
US5206415A (en) * | 1991-12-20 | 1993-04-27 | Washington University | Tricyclic steroid analogs |
DE69435286D1 (en) * | 1993-05-24 | 2010-05-20 | Purdue Pharma Ltd | METHOD AND COMPOSITIONS FOR EFFECTING SLEEP |
DE602006020353D1 (en) | 2005-03-24 | 2011-04-07 | Univ Emory | Progesterone dosage instructions in the treatment of traumatic brain injury |
US7473687B2 (en) | 2005-03-24 | 2009-01-06 | Emory University | Methods for the treatment of a traumatic central nervous system injury |
EP2766380B1 (en) * | 2011-10-14 | 2019-04-24 | Sage Therapeutics, Inc. | 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof |
JP7438956B2 (en) * | 2018-02-11 | 2024-02-27 | 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 | Steroid derivative modulator, its production method and application |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB804522A (en) * | 1954-10-21 | 1958-11-19 | Pfizer & Co C | Steroids and the preparation thereof |
FR1549153A (en) * | 1962-06-15 | 1968-12-13 | ||
US3558673A (en) * | 1966-10-29 | 1971-01-26 | Ormonoterapia Richter Spa | 10beta-amino-19-nor-pregnanes and method for the preparation thereof |
FR2281123A1 (en) * | 1974-08-05 | 1976-03-05 | Schering Ag | OXO-20 PREGNANES AND MEDICINAL PRODUCTS CONTAINING IT |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2414514A1 (en) * | 1978-01-11 | 1979-08-10 | Roussel Uclaf | NEW 17AARYL OR AHETEROARYLE STEROID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS A MEDICINAL PRODUCT |
US4273763A (en) * | 1978-01-23 | 1981-06-16 | Efamol Limited | Pharmaceutical and dietary compositions |
US4605649A (en) * | 1983-02-22 | 1986-08-12 | Liehr Joachim G | Method of treatment of estrogen deficiency disease |
FI83087C (en) * | 1984-05-16 | 1991-05-27 | Schering Ag | Process for the preparation of therapeutically useful estriol-3,17-d esters |
-
1988
- 1988-08-24 WO PCT/US1988/002827 patent/WO1989002272A1/en not_active Application Discontinuation
- 1988-08-24 JP JP50067189A patent/JPH03500049A/en active Pending
- 1988-08-24 EP EP19890900688 patent/EP0382790A4/en not_active Withdrawn
- 1988-08-24 AU AU28283/89A patent/AU609927B2/en not_active Ceased
-
1990
- 1990-02-23 DK DK048790A patent/DK48790A/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB804522A (en) * | 1954-10-21 | 1958-11-19 | Pfizer & Co C | Steroids and the preparation thereof |
FR1549153A (en) * | 1962-06-15 | 1968-12-13 | ||
US3558673A (en) * | 1966-10-29 | 1971-01-26 | Ormonoterapia Richter Spa | 10beta-amino-19-nor-pregnanes and method for the preparation thereof |
FR2281123A1 (en) * | 1974-08-05 | 1976-03-05 | Schering Ag | OXO-20 PREGNANES AND MEDICINAL PRODUCTS CONTAINING IT |
Non-Patent Citations (1)
Title |
---|
See also references of WO8902272A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2828389A (en) | 1989-04-17 |
DK48790D0 (en) | 1990-02-23 |
EP0382790A1 (en) | 1990-08-22 |
WO1989002272A1 (en) | 1989-03-23 |
DK48790A (en) | 1990-04-25 |
JPH03500049A (en) | 1991-01-10 |
AU609927B2 (en) | 1991-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0311983A3 (en) | Method for the preparation of titanium-silicalites | |
GB8610297D0 (en) | Turbomachinery | |
GB8712844D0 (en) | Adjustable-width seating | |
BG60030B2 (en) | Method for the preparation of /d/-ethyl-2-oxo-1-pirrolidineacetamide | |
DE3561864D1 (en) | Solid silicone defoaming agent and method for its production | |
EP0234223A3 (en) | Method for the preparation of aromatic block copolyethers | |
EP0382790A4 (en) | Compositions and methods for alleviating stress, anxiety and seizure activity | |
GR871701B (en) | Method for preparing 5,6 - dihydrixyindol, and its 3 - alkylated derivative and intermediates | |
EP0183436A3 (en) | Methods, compositions and uses thereof for reduction of stress | |
AU8170091A (en) | Compositions and methods for alleviating stress, anxiety and seizure activity | |
ZA887372B (en) | Method for the preparation of anilinofumarate | |
IL76243A0 (en) | Process and intermediates for the preparation of aromatic-1,4-oxazepinones and-thiones | |
EP0297447A3 (en) | Method for the preparation of 2-cyclopentenones | |
ZA862695B (en) | Composition,method for preparing and use thereof | |
EP0161548A3 (en) | Process for the preparation of riboflavin, and intermediates for this process | |
EP0307001A3 (en) | Method for the preparation of polycyclic 1,3-thiazolidines | |
BG43438A1 (en) | 2- phenyl- 1h- indene- 1, 3 (2h)- dions and method for their preparation | |
CS967687A1 (en) | Method of 2,6-dialkyl-n-/1 -methoxy-2-propylidene/aniline preparation | |
BG42754A1 (en) | Thiphosphatic derivative of ethylaminopropionamid, method for preparation and its use | |
BG47569A1 (en) | 1- thiocarbamoylmethylpyrolidene- 2- tion and method for its preparation | |
BG48273A1 (en) | Polymerisationable oligoimide and method for its preparation | |
BG40061A1 (en) | (+)- 4- phenyl- 2- methyl- 8- amino- 1, 2, 3, 4- tetrahydroisoquinoline and method for its preparation | |
IL73371A0 (en) | Compositions and method for the modification of insulin activity | |
RO101419B1 (en) | Diphenylmethane methyl - substitute preparation method | |
CS967587A1 (en) | Method of 2,6-dialkyl-n-/l-methoxy-2-propyl-aniline preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19900223 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): BE CH DE FR GB IT LI SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19910205 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): BE CH DE FR GB IT LI SE |
|
17Q | First examination report despatched |
Effective date: 19921022 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19941116 |