JP2014511374A5 - - Google Patents
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- Publication number
- JP2014511374A5 JP2014511374A5 JP2013552693A JP2013552693A JP2014511374A5 JP 2014511374 A5 JP2014511374 A5 JP 2014511374A5 JP 2013552693 A JP2013552693 A JP 2013552693A JP 2013552693 A JP2013552693 A JP 2013552693A JP 2014511374 A5 JP2014511374 A5 JP 2014511374A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- brain injury
- traumatic brain
- disulfonyl
- induced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 47
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 13
- 230000009529 traumatic brain injury Effects 0.000 claims 13
- JYIYPKOJFKMEKS-UHFFFAOYSA-N n-(2,2-dimethyl-1-phenylpropylidene)hydroxylamine Chemical compound CC(C)(C)C(=NO)C1=CC=CC=C1 JYIYPKOJFKMEKS-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- WZXBYDBYBIGAQN-UWVGGRQHSA-N (2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-3-(diethylcarbamoylsulfanyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CCN(CC)C(=O)SC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O WZXBYDBYBIGAQN-UWVGGRQHSA-N 0.000 claims 6
- JKRODHBGNBKZLE-YUMQZZPRSA-N (2s)-2-amino-5-[[(2r)-1-[(2-ethoxy-2-oxoethyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O JKRODHBGNBKZLE-YUMQZZPRSA-N 0.000 claims 6
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 claims 6
- 229930182818 D-methionine Natural products 0.000 claims 6
- DYEFUKCXAQOFHX-UHFFFAOYSA-N Ebselen Chemical compound [se]1C2=CC=CC=C2C(=O)N1C1=CC=CC=C1 DYEFUKCXAQOFHX-UHFFFAOYSA-N 0.000 claims 6
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 6
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims 6
- 108700024319 S-ethyl glutathione Proteins 0.000 claims 6
- 208000009205 Tinnitus Diseases 0.000 claims 6
- 229960004308 acetylcysteine Drugs 0.000 claims 6
- 108700006011 carbamathione Proteins 0.000 claims 6
- 229950010033 ebselen Drugs 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 231100000886 tinnitus Toxicity 0.000 claims 6
- 206010063602 Exposure to noise Diseases 0.000 claims 4
- 208000029028 brain injury Diseases 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161439671P | 2011-02-04 | 2011-02-04 | |
| US61/439,671 | 2011-02-04 | ||
| PCT/US2012/023855 WO2012106654A1 (en) | 2011-02-04 | 2012-02-03 | Methods for treating brain injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017029662A Division JP6286589B2 (ja) | 2011-02-04 | 2017-02-21 | 外傷性脳損傷を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511374A JP2014511374A (ja) | 2014-05-15 |
| JP2014511374A5 true JP2014511374A5 (enExample) | 2015-03-26 |
| JP6099574B2 JP6099574B2 (ja) | 2017-03-22 |
Family
ID=46603106
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552693A Active JP6099574B2 (ja) | 2011-02-04 | 2012-02-03 | 外傷性脳損傷を処置する方法 |
| JP2017029662A Active JP6286589B2 (ja) | 2011-02-04 | 2017-02-21 | 外傷性脳損傷を処置する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017029662A Active JP6286589B2 (ja) | 2011-02-04 | 2017-02-21 | 外傷性脳損傷を処置する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US9289404B2 (enExample) |
| EP (1) | EP2670403B1 (enExample) |
| JP (2) | JP6099574B2 (enExample) |
| AU (1) | AU2012211989B2 (enExample) |
| CA (1) | CA2826602C (enExample) |
| ES (1) | ES2893825T3 (enExample) |
| IL (2) | IL227768A (enExample) |
| WO (1) | WO2012106654A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9050305B2 (en) | 2012-03-29 | 2015-06-09 | Chs Pharma, Inc. | Treatment for ischemic stroke |
| US20160074401A1 (en) * | 2013-04-18 | 2016-03-17 | Wayne State University | Compositions and methods utilizing phosphodiesterase inhibitors to treat blast-induced tinnitus and/or hearing loss |
| US20180256756A1 (en) * | 2015-09-18 | 2018-09-13 | Oklahoma Medical Research Foundation | Method of transporting an agent across blood-brain, blood-cochlear or blood-cerebrospinal fluid barrier |
| HUE069280T2 (hu) | 2016-05-18 | 2025-02-28 | Sound Pharmaceuticals Incorporated | Ebselen a Meniere-kór kezelésére történõ felhasználásra |
| WO2018081614A1 (en) * | 2016-10-31 | 2018-05-03 | Hough Ear Institute | Methods for enhancing synaptogenesis and neuritogenesis |
| EP3570826A4 (en) * | 2017-01-19 | 2020-09-23 | Otologic Pharmaceutics, Inc. | N-ACETYLCYSTEIN FORMULATIONS AND THEIR USES |
| EP3615018A1 (en) | 2017-04-28 | 2020-03-04 | Axcella Health Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| AU2018318091A1 (en) * | 2017-08-14 | 2020-02-13 | Axcella Health Inc. | Amino acid compositions for the treatment of neuronal injury |
| EP3684345B1 (en) | 2017-09-20 | 2025-12-17 | Oklahoma Medical Research Foundation | Treatment of drug resistant gliomas |
| EP3700525A4 (en) * | 2017-10-27 | 2021-08-25 | Beyond Barriers Therapeutics, Inc. | IMPROVED PROVISION OF ANTIOXIDANTS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES WITH OXIDATIVE STRESS |
| US20210137861A1 (en) * | 2018-05-03 | 2021-05-13 | Hough Ear Institute | Methods for reducing accumulated pathologic tau protein |
| US20210369147A1 (en) * | 2018-07-18 | 2021-12-02 | The Regents Of The University Of California | Multimodal Neuroimaging-Based Diagnostic Systems and Methods for Detecting Tinnitus |
| WO2020023755A1 (en) | 2018-07-26 | 2020-01-30 | CHS Pharma Inc. | Treatment for ischemic stroke |
| WO2020056056A1 (en) * | 2018-09-12 | 2020-03-19 | Hough Ear Institute | Methods for treating hearing loss incident to cochlear implant surgery |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5488145A (en) | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
| WO2000027376A2 (de) | 1998-10-26 | 2000-05-18 | Michael Schedler | Verwendung von thiolverbindungen, oxidoreduktasen und/oder hydrolasen zur behandlung des tinnitus, insbesondere des chronischen tinnitus |
| WO2001028578A2 (en) | 1999-10-22 | 2001-04-26 | Wrair | A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME |
| SE0001916D0 (sv) * | 2000-05-23 | 2000-05-23 | Astrazeneca Ab | Novel formulation |
| US6428474B1 (en) | 2000-05-24 | 2002-08-06 | Sol Weiss | Surgical instrument |
| US7115666B2 (en) | 2002-10-15 | 2006-10-03 | Renovis, Inc. | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain |
| CA2851972C (en) | 2004-01-23 | 2015-06-23 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| JP2008538586A (ja) * | 2005-04-21 | 2008-10-30 | グレン エー． ゴールドスタイン， | 酸化ストレスに関連する疾患および病気の処置のためのｎ−アセチルシステインアミド（ｎａｃアミド） |
| ES2352303T3 (es) | 2006-06-29 | 2011-02-17 | L.R.S. Ortho Ltd. | Sistema para ubicar agujeros distales de un clavo intramedular. |
| ES2529050T3 (es) * | 2006-07-25 | 2015-02-16 | Hough Ear Institute | Métodos para el tratamiento del trauma acústico agudo |
| US8784870B2 (en) * | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| US9289462B2 (en) * | 2008-09-17 | 2016-03-22 | Terry Gage | Method for medical treatment utilizing glutathione |
-
2012
- 2012-02-03 ES ES12742491T patent/ES2893825T3/es active Active
- 2012-02-03 JP JP2013552693A patent/JP6099574B2/ja active Active
- 2012-02-03 AU AU2012211989A patent/AU2012211989B2/en active Active
- 2012-02-03 EP EP12742491.9A patent/EP2670403B1/en active Active
- 2012-02-03 WO PCT/US2012/023855 patent/WO2012106654A1/en not_active Ceased
- 2012-02-03 US US13/983,515 patent/US9289404B2/en active Active
- 2012-02-03 CA CA2826602A patent/CA2826602C/en active Active
-
2013
- 2013-08-01 IL IL227768A patent/IL227768A/en active IP Right Grant
-
2016
- 2016-02-18 US US15/046,676 patent/US9642823B2/en active Active
- 2016-09-19 IL IL247911A patent/IL247911B/en active IP Right Grant
-
2017
- 2017-01-27 US US15/418,406 patent/US10022346B2/en active Active
- 2017-02-21 JP JP2017029662A patent/JP6286589B2/ja active Active
- 2017-06-23 US US15/632,230 patent/US10111843B2/en active Active
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