JP6099574B2 - 外傷性脳損傷を処置する方法 - Google Patents

外傷性脳損傷を処置する方法 Download PDF

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JP6099574B2
JP6099574B2 JP2013552693A JP2013552693A JP6099574B2 JP 6099574 B2 JP6099574 B2 JP 6099574B2 JP 2013552693 A JP2013552693 A JP 2013552693A JP 2013552693 A JP2013552693 A JP 2013552693A JP 6099574 B2 JP6099574 B2 JP 6099574B2
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composition
noise
exposure
brain injury
traumatic brain
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JP2014511374A (ja
JP2014511374A5 (enExample
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リチャード ディ. コプケ、
リチャード ディ. コプケ、
ロバート エイ. フロイド、
ロバート エイ. フロイド、
レアール タウナー、
レアール タウナー、
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Oklahoma Medical Research Foundation
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • A61K38/063Glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2013552693A 2011-02-04 2012-02-03 外傷性脳損傷を処置する方法 Active JP6099574B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161439671P 2011-02-04 2011-02-04
US61/439,671 2011-02-04
PCT/US2012/023855 WO2012106654A1 (en) 2011-02-04 2012-02-03 Methods for treating brain injury

Related Child Applications (1)

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JP2017029662A Division JP6286589B2 (ja) 2011-02-04 2017-02-21 外傷性脳損傷を処置する方法

Publications (3)

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JP2014511374A JP2014511374A (ja) 2014-05-15
JP2014511374A5 JP2014511374A5 (enExample) 2015-03-26
JP6099574B2 true JP6099574B2 (ja) 2017-03-22

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JP2013552693A Active JP6099574B2 (ja) 2011-02-04 2012-02-03 外傷性脳損傷を処置する方法
JP2017029662A Active JP6286589B2 (ja) 2011-02-04 2017-02-21 外傷性脳損傷を処置する方法

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US (4) US9289404B2 (enExample)
EP (1) EP2670403B1 (enExample)
JP (2) JP6099574B2 (enExample)
AU (1) AU2012211989B2 (enExample)
CA (1) CA2826602C (enExample)
ES (1) ES2893825T3 (enExample)
IL (2) IL227768A (enExample)
WO (1) WO2012106654A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9050305B2 (en) 2012-03-29 2015-06-09 Chs Pharma, Inc. Treatment for ischemic stroke
WO2014172583A2 (en) * 2013-04-18 2014-10-23 Jinsheng Zhang Compositions and methods utilizing phosphodiesterase inhibitors to treat blast-induced tinnitus and/or hearing loss
EP3340972A4 (en) * 2015-09-18 2019-05-01 Oklahoma Medical Research Foundation METHOD FOR TRANSPORTING AN ACTIVE AGENT THROUGH THE BLOOD BRAIN, BLOOD COCHLEA OR BLOOD LIQUOR BARRIER
HUE069280T2 (hu) * 2016-05-18 2025-02-28 Sound Pharmaceuticals Incorporated Ebselen a Meniere-kór kezelésére történõ felhasználásra
JP2019537582A (ja) * 2016-10-31 2019-12-26 ハフ イアー インスティテュート シナプス形成および神経突起形成を増強するための方法
EP3570826A4 (en) * 2017-01-19 2020-09-23 Otologic Pharmaceutics, Inc. N-ACETYLCYSTEIN FORMULATIONS AND THEIR USES
US11617731B2 (en) 2017-04-28 2023-04-04 Axcella Health, Inc. Amino acid compositions and their use for the treatment of traumatic brain injury
JP7370960B2 (ja) * 2017-08-14 2023-10-30 アクセラ・ヘルス・インコーポレイテッド 神経細胞損傷の治療のためのアミノ酸組成物
US11660280B2 (en) 2017-09-20 2023-05-30 Oklahoma Medical Research Foundation Treatment of drug resistant gliomas
EP3700525A4 (en) 2017-10-27 2021-08-25 Beyond Barriers Therapeutics, Inc. IMPROVED PROVISION OF ANTIOXIDANTS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES WITH OXIDATIVE STRESS
WO2019213245A1 (en) * 2018-05-03 2019-11-07 Hough Ear Institute Methods for reducing accumulated pathologic tau protein
US20210369147A1 (en) * 2018-07-18 2021-12-02 The Regents Of The University Of California Multimodal Neuroimaging-Based Diagnostic Systems and Methods for Detecting Tinnitus
WO2020023755A1 (en) 2018-07-26 2020-01-30 CHS Pharma Inc. Treatment for ischemic stroke
KR102899320B1 (ko) * 2018-09-12 2025-12-12 호 이어 인스티튜트 인공 와우 수술에 따른 난청의 치료 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488145A (en) 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
WO2000027376A2 (de) 1998-10-26 2000-05-18 Michael Schedler Verwendung von thiolverbindungen, oxidoreduktasen und/oder hydrolasen zur behandlung des tinnitus, insbesondere des chronischen tinnitus
AU1574701A (en) 1999-10-22 2001-04-30 Wrair Walter Reed Army Institute Of Research A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
SE0001916D0 (sv) 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
US6428474B1 (en) 2000-05-24 2002-08-06 Sol Weiss Surgical instrument
US7115666B2 (en) 2002-10-15 2006-10-03 Renovis, Inc. Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain
RU2376028C2 (ru) 2004-01-23 2009-12-20 Корнелл Рисеч Фаундейшн, Инк. Способ уменьшения окислительного повреждения (варианты)
EP1877044A4 (en) 2005-04-21 2009-09-02 Glenn A Goldstein AMIDE N-ACETYLCYSTEINE (AMIDE NAC) FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH OXIDATIVE STRESS
US8231629B2 (en) 2006-06-29 2012-07-31 L.R.S. Ortho Ltd. System and method for locating of distal holes of an intramedullary nail
WO2008013866A2 (en) * 2006-07-25 2008-01-31 Hough Ear Institute Methods for treating acute acoustic trauma
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US9289462B2 (en) * 2008-09-17 2016-03-22 Terry Gage Method for medical treatment utilizing glutathione

Also Published As

Publication number Publication date
EP2670403A1 (en) 2013-12-11
AU2012211989B2 (en) 2017-03-02
CA2826602C (en) 2019-06-11
JP2017137321A (ja) 2017-08-10
IL247911A0 (en) 2016-11-30
US9642823B2 (en) 2017-05-09
IL227768A0 (en) 2013-09-30
JP2014511374A (ja) 2014-05-15
US9289404B2 (en) 2016-03-22
US20170281583A1 (en) 2017-10-05
US20160158173A1 (en) 2016-06-09
JP6286589B2 (ja) 2018-02-28
CA2826602A1 (en) 2012-08-09
EP2670403A4 (en) 2014-07-09
IL227768A (en) 2016-10-31
IL247911B (en) 2021-05-31
US20170202797A1 (en) 2017-07-20
US20140187631A1 (en) 2014-07-03
WO2012106654A1 (en) 2012-08-09
ES2893825T3 (es) 2022-02-10
US10022346B2 (en) 2018-07-17
EP2670403B1 (en) 2021-08-18
AU2012211989A1 (en) 2013-08-22
US10111843B2 (en) 2018-10-30

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