JP2015536307A5 - - Google Patents
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- JP2015536307A5 JP2015536307A5 JP2015536972A JP2015536972A JP2015536307A5 JP 2015536307 A5 JP2015536307 A5 JP 2015536307A5 JP 2015536972 A JP2015536972 A JP 2015536972A JP 2015536972 A JP2015536972 A JP 2015536972A JP 2015536307 A5 JP2015536307 A5 JP 2015536307A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- acceptable salt
- salt
- gsk3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261713314P | 2012-10-12 | 2012-10-12 | |
| US61/713,314 | 2012-10-12 | ||
| US201361779394P | 2013-03-13 | 2013-03-13 | |
| US61/779,394 | 2013-03-13 | ||
| PCT/US2013/064716 WO2014059383A1 (en) | 2012-10-12 | 2013-10-11 | Gsk3 inhibitors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018072831A Division JP6606691B2 (ja) | 2012-10-12 | 2018-04-05 | Ｇｓｋ３阻害剤およびその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536307A JP2015536307A (ja) | 2015-12-21 |
| JP2015536307A5 true JP2015536307A5 (enExample) | 2016-12-22 |
| JP6321662B2 JP6321662B2 (ja) | 2018-05-09 |
Family
ID=49474737
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536972A Active JP6321662B2 (ja) | 2012-10-12 | 2013-10-11 | Ｇｓｋ３阻害剤およびその使用の方法 |
| JP2018072831A Active JP6606691B2 (ja) | 2012-10-12 | 2018-04-05 | Ｇｓｋ３阻害剤およびその使用の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018072831A Active JP6606691B2 (ja) | 2012-10-12 | 2018-04-05 | Ｇｓｋ３阻害剤およびその使用の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9096594B2 (enExample) |
| EP (1) | EP2909204B1 (enExample) |
| JP (2) | JP6321662B2 (enExample) |
| CA (1) | CA2887701C (enExample) |
| CY (1) | CY1122601T1 (enExample) |
| DK (1) | DK2909204T3 (enExample) |
| ES (1) | ES2719776T3 (enExample) |
| HR (1) | HRP20190406T1 (enExample) |
| HU (1) | HUE043853T2 (enExample) |
| LT (1) | LT2909204T (enExample) |
| PL (1) | PL2909204T3 (enExample) |
| PT (1) | PT2909204T (enExample) |
| RS (1) | RS58700B1 (enExample) |
| SI (1) | SI2909204T1 (enExample) |
| SM (1) | SMT201900136T1 (enExample) |
| WO (1) | WO2014059383A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2909204T (pt) | 2012-10-12 | 2019-03-21 | Dana Farber Cancer Inst Inc | Inibidores de gsk3 e métodos de utilização dos mesmos |
| WO2014159356A1 (en) | 2013-03-14 | 2014-10-02 | The Brigham And Women's Hospital, Inc. | Compositions and methods for epithelial stem cell expansion and culture |
| US10004751B2 (en) | 2014-07-10 | 2018-06-26 | The J. David Gladstone Institutes | Compositions and methods for treating Dengue virus infection |
| IL299964A (en) | 2014-09-03 | 2023-03-01 | Massachusetts Inst Technology | Preparations, systems and methods for producing hair cells in the inner ear to treat hearing loss |
| WO2016061344A1 (en) * | 2014-10-15 | 2016-04-21 | Mirx Pharmaceuticals Llc | Gsk3 inhibitors and their uses |
| JP2019506153A (ja) | 2016-01-08 | 2019-03-07 | マサチューセッツ インスティテュート オブ テクノロジー | 分化した腸内分泌細胞およびインスリン産生細胞の作製 |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| CN110392686A (zh) | 2016-12-30 | 2019-10-29 | 频率治疗公司 | 1h-吡咯-2,5-二酮化合物以及使用它们来诱导干/祖支持细胞自我更新的方法 |
| WO2018187630A1 (en) * | 2017-04-05 | 2018-10-11 | The Broad Institute, Inc. | Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof |
| WO2018217766A1 (en) | 2017-05-22 | 2018-11-29 | Whitehead Institute For Biomedical Research | Kcc2 expression enhancing compounds and uses thereof |
| CN110407769B (zh) * | 2018-04-27 | 2022-11-08 | 复旦大学 | 3,4-二氢-苯并[f][1,4]硫氮杂䓬-5(2H)-酮类化合物及其药物用途 |
| AU2019280693B2 (en) | 2018-06-05 | 2024-10-10 | Actuate Therapeutics Inc. | Methods of treating malignant lymphoproliferative disorders |
| US20210299233A1 (en) * | 2018-07-12 | 2021-09-30 | The Children's Medical Center Corporation | Method for treating cancer |
| CA3109647A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating jag-1 |
| WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
| US20220133740A1 (en) | 2019-02-08 | 2022-05-05 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
| WO2021102305A1 (en) * | 2019-11-20 | 2021-05-27 | Washington University | Methods and compositions for generating functionally mature beta cells and uses thereof |
| WO2023056463A1 (en) * | 2021-09-30 | 2023-04-06 | Trustees Of Tufts College | Glycogen synthase kinase 3 (gsk3) inhibitors for treating ctnnb1 syndrome |
| WO2024081939A2 (en) * | 2022-10-13 | 2024-04-18 | The Broad Institute, Inc. | Glycogen synthase kinase 3 inhibitors and uses thereof |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2024259178A1 (en) | 2023-06-14 | 2024-12-19 | The Broad Institute, Inc. | Glycogen synthase kinase 3 inhibitors and uses thereof |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
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| DE2722416A1 (de) | 1977-05-18 | 1978-11-30 | Thomae Gmbh Dr K | Neue thiazolo-pyridine |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
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| CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
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| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
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| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
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| US8778986B1 (en) | 2007-01-25 | 2014-07-15 | University Of South Florida | Treatment of glycogen synthase kinase-based disease |
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| US9265764B2 (en) | 2009-02-27 | 2016-02-23 | Massachusetts Institute Of Technology | Uses of chemicals to modulate GSK-3 signaling for treatment of bipolar disorder and other brain disorders |
| FR2945535B1 (fr) | 2009-05-18 | 2011-06-10 | Sanofi Aventis | Compose anticancereux et composition pharmaceutique le contenant |
| DE102011106990B3 (de) | 2011-07-08 | 2013-01-03 | Technische Universität Darmstadt | Verbindungen als Glykogen Synthase Kinase 3 (GSK-3) Inhibitoren für die Behandlung von GSK-3-vermittelten Erkrankungen |
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| PT2909204T (pt) | 2012-10-12 | 2019-03-21 | Dana Farber Cancer Inst Inc | Inibidores de gsk3 e métodos de utilização dos mesmos |
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| JP2014139870A (ja) * | 2013-01-21 | 2014-07-31 | Hitachi Consumer Electronics Co Ltd | 照明装置およびこれを用いた映像表示装置 |
| WO2015087996A1 (ja) | 2013-12-13 | 2015-06-18 | 第一三共株式会社 | イミダゾピリジン誘導体 |
| KR101602559B1 (ko) | 2014-04-29 | 2016-03-10 | 경북대학교 산학협력단 | 2,5,6,7-사중치환 티아졸로[4,5-b]피리딘 유도체 및 이의 용도 |
| US10437707B2 (en) * | 2015-03-19 | 2019-10-08 | Teachers Insurance And Annuity Association Of America | Evaluating and presenting software testing project status indicators |
| WO2018187630A1 (en) | 2017-04-05 | 2018-10-11 | The Broad Institute, Inc. | Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof |
-
2013
- 2013-10-11 PT PT13780300T patent/PT2909204T/pt unknown
- 2013-10-11 HR HRP20190406TT patent/HRP20190406T1/hr unknown
- 2013-10-11 EP EP13780300.3A patent/EP2909204B1/en active Active
- 2013-10-11 US US14/052,661 patent/US9096594B2/en active Active
- 2013-10-11 JP JP2015536972A patent/JP6321662B2/ja active Active
- 2013-10-11 CA CA2887701A patent/CA2887701C/en active Active
- 2013-10-11 ES ES13780300T patent/ES2719776T3/es active Active
- 2013-10-11 HU HUE13780300A patent/HUE043853T2/hu unknown
- 2013-10-11 SI SI201331368T patent/SI2909204T1/sl unknown
- 2013-10-11 RS RS20190292A patent/RS58700B1/sr unknown
- 2013-10-11 DK DK13780300.3T patent/DK2909204T3/en active
- 2013-10-11 WO PCT/US2013/064716 patent/WO2014059383A1/en not_active Ceased
- 2013-10-11 LT LTEP13780300.3T patent/LT2909204T/lt unknown
- 2013-10-11 SM SM20190136T patent/SMT201900136T1/it unknown
- 2013-10-11 PL PL13780300T patent/PL2909204T3/pl unknown
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2015
- 2015-07-14 US US14/799,281 patent/US10137122B2/en active Active
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2018
- 2018-04-05 JP JP2018072831A patent/JP6606691B2/ja active Active
- 2018-11-21 US US16/198,589 patent/US11052080B2/en active Active
-
2019
- 2019-03-05 CY CY20191100268T patent/CY1122601T1/el unknown
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2021
- 2021-06-10 US US17/344,830 patent/US12419885B2/en active Active