JP2013533879A5 - - Google Patents
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- JP2013533879A5 JP2013533879A5 JP2013518581A JP2013518581A JP2013533879A5 JP 2013533879 A5 JP2013533879 A5 JP 2013533879A5 JP 2013518581 A JP2013518581 A JP 2013518581A JP 2013518581 A JP2013518581 A JP 2013518581A JP 2013533879 A5 JP2013533879 A5 JP 2013533879A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- substituted
- unsubstituted
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35956910P | 2010-06-29 | 2010-06-29 | |
| US61/359,569 | 2010-06-29 | ||
| PCT/US2011/042215 WO2012003189A1 (en) | 2010-06-29 | 2011-06-28 | Compositions and methods for modulating the wnt signaling pathway |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533879A JP2013533879A (ja) | 2013-08-29 |
| JP2013533879A5 true JP2013533879A5 (enExample) | 2014-07-03 |
| JP5778270B2 JP5778270B2 (ja) | 2015-09-16 |
Family
ID=44514972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518581A Expired - Fee Related JP5778270B2 (ja) | 2010-06-29 | 2011-06-28 | Wntシグナル伝達経路調節のための組成物および方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9181235B2 (enExample) |
| EP (1) | EP2588453B1 (enExample) |
| JP (1) | JP5778270B2 (enExample) |
| KR (1) | KR20130131290A (enExample) |
| CN (1) | CN102958917B (enExample) |
| AR (1) | AR082029A1 (enExample) |
| AU (1) | AU2011271479B2 (enExample) |
| BR (1) | BR112012033350A2 (enExample) |
| CA (1) | CA2803879A1 (enExample) |
| CL (1) | CL2012003604A1 (enExample) |
| CO (1) | CO6650353A2 (enExample) |
| CU (1) | CU20120174A7 (enExample) |
| DO (1) | DOP2012000329A (enExample) |
| EA (1) | EA201390032A1 (enExample) |
| EC (1) | ECSP13012410A (enExample) |
| ES (1) | ES2536216T3 (enExample) |
| MA (1) | MA34388B1 (enExample) |
| MX (1) | MX2012015092A (enExample) |
| NI (1) | NI201200190A (enExample) |
| PE (1) | PE20130311A1 (enExample) |
| PH (1) | PH12012502571A1 (enExample) |
| SG (1) | SG186473A1 (enExample) |
| TN (1) | TN2012000575A1 (enExample) |
| TW (1) | TW201206921A (enExample) |
| UY (1) | UY33469A (enExample) |
| WO (1) | WO2012003189A1 (enExample) |
| ZA (1) | ZA201300319B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| EP2331136B1 (en) | 2008-09-26 | 2018-01-10 | OncoMed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
| CN102971337B (zh) | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
| UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
| TWI567061B (zh) | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
| RU2486859C1 (ru) * | 2012-02-02 | 2013-07-10 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский институт глазных болезней имени Гельмгольца" Министерства здравоохранения и социального развития Российской Федерации | Способ оценки эффективности комбинированного органосохраняющего лечения первичной начальной ретинобластомы у детей |
| RU2627712C2 (ru) | 2012-06-15 | 2017-08-10 | Кьюрдженикс Инк. | Соединение как ингибитор передачи сигналов wnt, его композиции и применение |
| JP2015536933A (ja) * | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路結合剤を用いて神経内分泌腫瘍を処置する方法 |
| CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| GB201309333D0 (en) * | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
| DK3063143T3 (en) * | 2013-11-01 | 2018-08-20 | Novartis Ag | Amino heteroaryl benzamides as kinase inhibitors |
| BR112017007218B1 (pt) * | 2014-10-08 | 2023-10-10 | Redx Pharma Plc | Derivados de n-piridil acetamida como inibidores da via de sinalização de wnt, formulações farmacêuticas compreendendo os mesmos e seus usos |
| SMT201900615T1 (it) | 2014-10-08 | 2020-01-14 | Redx Pharma Plc | Derivati di acetammide n-piridinile come inibitori del percorso di segnalazione wnt |
| CN104557862B (zh) * | 2014-12-15 | 2017-05-17 | 苏州云轩医药科技有限公司 | 具有Wnt信号通路抑制活性的杂环化合物 |
| CA3011685C (en) | 2015-02-03 | 2021-07-20 | Kadmon Pharmaceuticals, Llc | Stable trientine formulations |
| US20180092866A1 (en) * | 2015-04-15 | 2018-04-05 | University Of Utah Research Foundation | Substituted n-([1,1'-biphenyl]-3-yl)-[1,1'-biphenyl]-3-carboxamide analogs as inhibitors for beta-catenin/b-cell lymphoma 9 interactions |
| WO2016191525A1 (en) * | 2015-05-26 | 2016-12-01 | Curegenix Corporation | Tumor biomarkers and use thereof |
| CN107759584B (zh) * | 2016-08-16 | 2021-06-01 | 苏州云轩医药科技有限公司 | 一种具有Wnt信号通路抑制活性的氨基五元杂环化合物及其应用 |
| CN107056754B (zh) * | 2015-12-07 | 2020-12-04 | 苏州信诺维医药科技有限公司 | 内嵌脲类结构的wnt通路抑制剂 |
| CN107056755B (zh) * | 2015-12-07 | 2019-02-22 | 苏州信诺维医药科技有限公司 | 五元杂环酰胺类wnt通路抑制剂 |
| WO2017165839A1 (en) | 2016-03-25 | 2017-09-28 | University Of Utah Research Foundation | Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/b-cell lymphoma 9 inhibitors |
| US10793544B2 (en) * | 2016-09-01 | 2020-10-06 | The Board Of Regents Of The University Of Texas System | Disubstituted and trisubstituted 1,2,3-triazoles as Wnt inhibitors |
| WO2019106146A1 (en) * | 2017-11-30 | 2019-06-06 | Step Pharma S.A.S. | Compounds |
| EP3717459B1 (en) | 2017-11-30 | 2026-01-21 | Step Pharma S.A.S. | Compounds |
| WO2019124603A1 (ko) * | 2017-12-22 | 2019-06-27 | 경상대학교병원 | Iwr-1을 유효성분으로 함유하는 켈로이드 예방 또는 치료용 조성물 |
| CR20200464A (es) | 2018-03-08 | 2021-04-14 | Incyte Corp | Compuestos diólicos de aminopirazina como inhibidores de pi3k-y |
| EP3787612A4 (en) * | 2018-05-04 | 2021-11-17 | Remedy Plan, Inc. | CANCER TREATMENTS AGAINST CANCER STEM CELLS |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| CN111662228B (zh) * | 2019-03-07 | 2023-07-28 | 中国医学科学院药物研究所 | 吡啶酮酰联芳基胺类化合物及其用途 |
| IL288508B2 (en) | 2019-06-04 | 2026-02-01 | Step Pharma S A S | History of n-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl)tetrahydro-h2-pyran-4-carboxamide and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases |
| WO2023093845A1 (zh) | 2021-11-25 | 2023-06-01 | 江苏恒瑞医药股份有限公司 | 一种用于雄激素受体蛋白靶向降解的嵌合体化合物、其制备方法及其在医药上的应用 |
| EP4540228A1 (en) * | 2022-06-14 | 2025-04-23 | Amygdala Neurosciences, Inc. | Aldh-2 inhibitor compounds and methods of use |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| AU2003234464B2 (en) * | 2002-05-03 | 2009-06-04 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| FR2847253B1 (fr) | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
| DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP2007519754A (ja) * | 2004-01-30 | 2007-07-19 | スミスクライン ビーチャム コーポレーション | 化合物 |
| WO2007098352A2 (en) * | 2006-02-16 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
| AR062709A1 (es) * | 2006-09-08 | 2008-11-26 | Genentech Inc | Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt |
| WO2009058298A1 (en) | 2007-10-31 | 2009-05-07 | Merck & Co., Inc. | P2x3, receptor antagonists for treatment of pain |
| JP2011506445A (ja) | 2007-12-13 | 2011-03-03 | アムジエン・インコーポレーテツド | γ−セクレターゼ調節剤 |
| AU2009225869B2 (en) * | 2008-03-18 | 2014-01-23 | Merck Sharp & Dohme Llc | Substituted 4-hydroxypyrimidine-5-carboxamides |
| CN102105464A (zh) * | 2008-05-27 | 2011-06-22 | 德克萨斯大学系统董事会 | Wnt蛋白信号转导抑制剂 |
| US8384140B2 (en) | 2008-07-29 | 2013-02-26 | International Business Machines Corporation | Structure for dual contact trench capacitor and structure thereof |
| UA103918C2 (en) * | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
-
2011
- 2011-06-27 UY UY0001033469A patent/UY33469A/es not_active Application Discontinuation
- 2011-06-28 KR KR1020137002280A patent/KR20130131290A/ko not_active Withdrawn
- 2011-06-28 CA CA2803879A patent/CA2803879A1/en not_active Abandoned
- 2011-06-28 PH PH1/2012/502571A patent/PH12012502571A1/en unknown
- 2011-06-28 JP JP2013518581A patent/JP5778270B2/ja not_active Expired - Fee Related
- 2011-06-28 EP EP11733945.7A patent/EP2588453B1/en active Active
- 2011-06-28 AU AU2011271479A patent/AU2011271479B2/en not_active Expired - Fee Related
- 2011-06-28 PE PE2012002648A patent/PE20130311A1/es not_active Application Discontinuation
- 2011-06-28 ES ES11733945.7T patent/ES2536216T3/es active Active
- 2011-06-28 BR BR112012033350A patent/BR112012033350A2/pt not_active IP Right Cessation
- 2011-06-28 SG SG2012095980A patent/SG186473A1/en unknown
- 2011-06-28 CN CN201180032354.9A patent/CN102958917B/zh not_active Expired - Fee Related
- 2011-06-28 WO PCT/US2011/042215 patent/WO2012003189A1/en not_active Ceased
- 2011-06-28 MX MX2012015092A patent/MX2012015092A/es not_active Application Discontinuation
- 2011-06-28 EA EA201390032A patent/EA201390032A1/ru unknown
- 2011-06-28 MA MA35576A patent/MA34388B1/fr unknown
- 2011-06-28 US US13/701,982 patent/US9181235B2/en active Active
- 2011-06-29 TW TW100122939A patent/TW201206921A/zh unknown
- 2011-06-29 AR ARP110102283A patent/AR082029A1/es not_active Application Discontinuation
-
2012
- 2012-12-05 TN TNP2012000575A patent/TN2012000575A1/en unknown
- 2012-12-20 CL CL2012003604A patent/CL2012003604A1/es unknown
- 2012-12-20 NI NI201200190A patent/NI201200190A/es unknown
- 2012-12-20 CU CU2012000174A patent/CU20120174A7/es unknown
- 2012-12-27 DO DO2012000329A patent/DOP2012000329A/es unknown
- 2012-12-27 CO CO12234891A patent/CO6650353A2/es unknown
-
2013
- 2013-01-14 ZA ZA2013/00319A patent/ZA201300319B/en unknown
- 2013-01-29 EC ECSP13012410 patent/ECSP13012410A/es unknown
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