IT201600132360A1 - Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t - Google Patents

Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t

Info

Publication number
IT201600132360A1
IT201600132360A1 IT102016000132360A IT201600132360A IT201600132360A1 IT 201600132360 A1 IT201600132360 A1 IT 201600132360A1 IT 102016000132360 A IT102016000132360 A IT 102016000132360A IT 201600132360 A IT201600132360 A IT 201600132360A IT 201600132360 A1 IT201600132360 A1 IT 201600132360A1
Authority
IT
Italy
Prior art keywords
teller
acute
treatment
notch inhibitors
lymphoblastic cells
Prior art date
Application number
IT102016000132360A
Other languages
English (en)
Inventor
Bruno Botta
Isabella Screpanti
Luca Tottone
Nadezda Zhdanoskaya
Cinzia Ingallina
Francesca Giulimondi
Deborah Quaglio
Rocco Palermo
Mattia Mori
Francesca Ghirga
Original Assignee
Univ Degli Studi Roma La Sapienza
Fondazione St Italiano Tecnologia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Roma La Sapienza, Fondazione St Italiano Tecnologia filed Critical Univ Degli Studi Roma La Sapienza
Priority to IT102016000132360A priority Critical patent/IT201600132360A1/it
Priority to EP17829316.3A priority patent/EP3562803A1/en
Priority to US16/473,986 priority patent/US11104657B2/en
Priority to PCT/IB2017/058204 priority patent/WO2018122689A1/en
Publication of IT201600132360A1 publication Critical patent/IT201600132360A1/it
Priority to US17/397,509 priority patent/US20210363121A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT102016000132360A 2016-12-29 2016-12-29 Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t IT201600132360A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT102016000132360A IT201600132360A1 (it) 2016-12-29 2016-12-29 Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t
EP17829316.3A EP3562803A1 (en) 2016-12-29 2017-12-20 Notch inhibitors for use in the treatment of t-cell acute lymphoblastic leukemia
US16/473,986 US11104657B2 (en) 2016-12-29 2017-12-20 Notch inhibitors for use in the treatment of t-cell acute lymphoblastic leukemia
PCT/IB2017/058204 WO2018122689A1 (en) 2016-12-29 2017-12-20 Notch inhibitors for use in the treatment of t-cell acute lymphoblastic leukemia
US17/397,509 US20210363121A1 (en) 2016-12-29 2021-08-09 Notch inhibitors for use in the treatment of t-cell acute lymphoblastic leukemia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102016000132360A IT201600132360A1 (it) 2016-12-29 2016-12-29 Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t

Publications (1)

Publication Number Publication Date
IT201600132360A1 true IT201600132360A1 (it) 2018-06-29

Family

ID=58671766

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102016000132360A IT201600132360A1 (it) 2016-12-29 2016-12-29 Inibitori di notch per uso nel trattamento della leucemia linfoblastica acuta a cellule t

Country Status (4)

Country Link
US (2) US11104657B2 (it)
EP (1) EP3562803A1 (it)
IT (1) IT201600132360A1 (it)
WO (1) WO2018122689A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109293492A (zh) * 2018-09-25 2019-02-01 内蒙古医科大学 一种查尔酮类似物的阴离子识别剂及其阴离子检测的方法
CN114409522B (zh) * 2022-03-01 2023-08-15 贵州省天然产物研究中心 一种查尔酮衍生物及其制备方法与用途
CN115433073B (zh) * 2022-08-15 2024-04-19 兰州大学 一种卡瓦胡椒素b类似物的制备方法及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020040029A1 (en) * 1999-12-23 2002-04-04 Bowen J. Phillip Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1990446A (zh) * 2005-12-28 2007-07-04 中国科学院上海药物研究所 查尔酮类化合物、其制备方法、包括该化合物的组合物及其应用
EP2606884A1 (en) 2011-12-21 2013-06-26 Ecole Polytechnique Fédérale de Lausanne (EPFL) Inhibitors of notch signaling pathway and use thereof in treatment of cancers
JP6138928B2 (ja) 2012-06-01 2017-05-31 ライプニッツ−インスティテュート フュア アルテルスフォルシュング−フリッツ−リップマン−インスティテュート エー．ファウ．（エフエルイー） 医薬に使用されるｎｏｔｃｈシグナル伝達経路及び分泌の阻害物質

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020040029A1 (en) * 1999-12-23 2002-04-04 Bowen J. Phillip Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AHCÈNE BOUMENDJEL ET AL: "Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure-Activity Relationship", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 7, 1 April 2008 (2008-04-01), pages 2307 - 2310, XP055109501, ISSN: 0022-2623, DOI: 10.1021/jm0708331 *
BOGUMI?A KUPCEWICZ ET AL: "Cytotoxic activity of substituted chalcones in terms of molecular electronic properties", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, no. 17, 1 September 2014 (2014-09-01), AMSTERDAM, NL, pages 4260 - 4265, XP055384806, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2014.07.027 *
CHUN WAI MAI ET AL: "Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 77, 1 April 2014 (2014-04-01), FR, pages 378 - 387, XP055224582, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.03.002 *
DUCKI S ET AL: "Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: Synthesis and biological evaluation of antivascular activity", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 17, no. 22, 15 November 2009 (2009-11-15), pages 7698 - 7710, XP026721454, ISSN: 0968-0896, [retrieved on 20090925], DOI: 10.1016/J.BMC.2009.09.039 *
GIOVANNI ROTI ET AL: "Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer", CANCER CELL, vol. 23, no. 3, 1 March 2013 (2013-03-01), US, pages 390 - 405, XP055384751, ISSN: 1535-6108, DOI: 10.1016/j.ccr.2013.01.015 *
MAHMOUD YOUNS ET AL: "Sensitivity and resistance towards isoliquiritigenin, doxorubicin and methotrexate in T cell acute lymphoblastic leukaemia cell lines by pharmacogenomics", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 382, no. 3, 29 July 2010 (2010-07-29), pages 221 - 234, XP019838868, ISSN: 1432-1912 *
MATTIA MORI ET AL: "Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia", SCIENTIFIC REPORTS, vol. 7, no. 1, 19 May 2017 (2017-05-19), XP055384745, DOI: 10.1038/s41598-017-02316-9 *
PARDEDE ANTONI ET AL: "Flavonoid profile and antileukemic activity ofCoreopsis lanceolataflowers", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 26, no. 12, 23 April 2016 (2016-04-23), pages 2784 - 2787, XP029557121, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2016.04.069 *
TANAKA S ET AL: "INFLUENCE OF NATURAL AND SYNTHETIC COMPOUNDS ON CELL SURFACE EXPRESSION OF CELL ADHESION MOLECULES, ICAM-1 AND VCAM-1", PLANTA ME, THIEME VERLAG, DE, vol. 67, no. 2, 1 January 2001 (2001-01-01), pages 108 - 113, XP009003131, ISSN: 0032-0943, DOI: 10.1055/S-2001-11514 *

Also Published As

Publication number Publication date
EP3562803A1 (en) 2019-11-06
WO2018122689A1 (en) 2018-07-05
US20190337916A1 (en) 2019-11-07
US11104657B2 (en) 2021-08-31
US20210363121A1 (en) 2021-11-25

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