DK3256483T3 - Hidtil ukendt c-3-triterpenon med omvendte c-17-amidderivater som hiv-hæmmere patentkrav - Google Patents

Hidtil ukendt c-3-triterpenon med omvendte c-17-amidderivater som hiv-hæmmere patentkrav Download PDF

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Publication number
DK3256483T3
DK3256483T3 DK16784277.2T DK16784277T DK3256483T3 DK 3256483 T3 DK3256483 T3 DK 3256483T3 DK 16784277 T DK16784277 T DK 16784277T DK 3256483 T3 DK3256483 T3 DK 3256483T3
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DK
Denmark
Prior art keywords
triterpenon
unknown
reverse
amide derivatives
hiv inhibitors
Prior art date
Application number
DK16784277.2T
Other languages
English (en)
Inventor
Reddy Bandi Parthasaradhi
Krupadanam Gazula Levi David
Reddy Adulla Panduranga
Reddy Kasireddy Bhaskar
Subrahmanyam Lanka Vl
Reddy Kura Rathnakar
Original Assignee
Hetero Labs Ltd
Dfh Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57153504&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3256483(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hetero Labs Ltd, Dfh Therapeutics Inc filed Critical Hetero Labs Ltd
Application granted granted Critical
Publication of DK3256483T3 publication Critical patent/DK3256483T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK16784277.2T 2015-02-09 2016-02-09 Hidtil ukendt c-3-triterpenon med omvendte c-17-amidderivater som hiv-hæmmere patentkrav DK3256483T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN623CH2015 2015-02-09
PCT/IB2016/000811 WO2016178092A2 (en) 2015-02-09 2016-02-09 C-3 novel triterpenone with c-28 reverse amide derivatives as hiv inhibitors

Publications (1)

Publication Number Publication Date
DK3256483T3 true DK3256483T3 (da) 2020-03-23

Family

ID=57153504

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16784277.2T DK3256483T3 (da) 2015-02-09 2016-02-09 Hidtil ukendt c-3-triterpenon med omvendte c-17-amidderivater som hiv-hæmmere patentkrav

Country Status (22)

Country Link
US (3) US10533035B2 (da)
EP (1) EP3256483B1 (da)
JP (1) JP2018505216A (da)
KR (1) KR20170110143A (da)
CN (1) CN107428797A (da)
AU (1) AU2016258274B2 (da)
BR (1) BR112017017109A2 (da)
CA (1) CA2975359A1 (da)
CL (1) CL2017002034A1 (da)
CO (1) CO2017008765A2 (da)
CU (1) CU24476B1 (da)
DK (1) DK3256483T3 (da)
EA (1) EA033264B1 (da)
ES (1) ES2780649T3 (da)
IL (1) IL253844A0 (da)
MA (1) MA40886B1 (da)
MX (1) MX2017010297A (da)
PE (1) PE20171433A1 (da)
PH (1) PH12017550077A1 (da)
SG (1) SG11201706189PA (da)
WO (1) WO2016178092A2 (da)
ZA (1) ZA201705253B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018029604A1 (en) * 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2019150300A1 (en) 2018-02-02 2019-08-08 Glaxosmithkline Intellectual Property (No.2) Limited Crystalline forms of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
EP3924362A4 (en) * 2019-02-11 2022-10-26 Hetero Labs Limited NEW TRITERPENONE DERIVATIVES AS HIV Inhibitors

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152815A (ja) 1982-03-05 1983-09-10 Tamio Nishimura 医療用抗ウイルス剤
WO1995002071A1 (en) 1993-07-09 1995-01-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Selection and use of antiviral peptides
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
WO1998046238A1 (en) 1997-04-15 1998-10-22 Medichem Research, Inc. Biflavinoids and derivatives thereof as antiviral agents, alone or in combination with at least one known antiviral agent
HUP9701080A3 (en) 1997-06-23 1999-05-28 Gene Res Lab Inc New York N Pharmaceutical composition containing a compound of antiviral activity and a hydroximic acid ester derivative
US6670345B1 (en) 1997-09-30 2003-12-30 Dabur Research Foundation Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
US6427248B1 (en) 1997-10-09 2002-08-06 David M. Albert Grip-enhancing glove
KR20010080507A (ko) 1998-11-18 2001-08-22 추후보정 신규한 베툴린산 유도체, 그의 제조 방법 및 암 성장억제제로서의 그의 용도
WO2001007646A2 (de) 1999-07-21 2001-02-01 Martin Heinkelein Verfahren zur quantifizierung der antiviralen wirkung antiviraler wirkstoffe
CA2384433C (en) 1999-09-09 2007-10-23 Dabur Research Foundation Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis
EP2567625A1 (en) 2001-05-11 2013-03-13 University Of Ottawa Preparation containing betulinic acid, obtained from a plant of the family Marcgraviaceae
WO2003037908A1 (en) 2001-10-31 2003-05-08 Ribapharm Inc. Antiviral combination therapy and compositions
ES2319653T3 (es) 2003-02-11 2009-05-11 Novelix Pharmaceuticals, Inc. Medicamento para la inhibicion del crecimiento de tumores.
US7026305B2 (en) 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
JP2007529544A (ja) 2004-03-17 2007-10-25 パナコス ファーマシューティカルズ， インコーポレイテッド ３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸の製薬的な塩
CA2585623C (en) 2004-10-27 2012-06-05 Daiichi Sankyo Company Limited Ortho-substituted benzene derivatives
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
US20090023698A1 (en) 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
WO2007002411A1 (en) 2005-06-22 2007-01-04 Myriad Genetics, Inc. Antiviral compounds
CN101287744A (zh) 2005-06-22 2008-10-15 美瑞德生物工程公司 抗病毒化合物
CN100475835C (zh) 2006-05-12 2009-04-08 中国药科大学 23-羟基白桦酸类衍生物、其制备方法、制剂及用途
FI20065389A (fi) 2006-06-07 2007-12-31 Valtion Teknillinen Betuliiniperäiset yhdisteet kasvien tuholaisten syönnin estäjinä
FI121468B (fi) 2006-06-07 2010-11-30 Valtion Teknillinen Betuliiniperäiset yhdisteet antimikrobisina aineina
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
US20110144069A1 (en) 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
WO2008057420A2 (en) 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
US20110152229A1 (en) 2006-11-22 2011-06-23 Duke University Betulinic acid derivatives as anti-hiv agents
WO2008091532A1 (en) 2007-01-19 2008-07-31 Panacos Pharmaceuticals, Inc. Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof
US8269026B2 (en) 2008-01-03 2012-09-18 Vertex Pharmaceuticals Incorporated Lupane derivatives useful for treating HIV
EP2240504A1 (en) 2008-01-03 2010-10-20 Virochem Pharma Inc. Novel c-21-keto lupane derivatives preparation and use thereof
CN101981047A (zh) * 2008-01-03 2011-02-23 Viro化学制药公司 新的羽扇烷衍生物
JP2011511812A (ja) 2008-02-14 2011-04-14 バイロケム ファーマ インコーポレイテッド 新規１７βルパン誘導体
US20120101098A1 (en) 2009-05-15 2012-04-26 Kuo-Hsiung Lee 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
MX2012009319A (es) 2010-02-11 2012-09-12 Glaxosmithkline Llc Derivados de betulina.
CN103038245B (zh) 2010-06-04 2015-03-25 百时美施贵宝公司 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
US8802661B2 (en) 2010-06-04 2014-08-12 Bristol-Myers Squibb Company C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors
US20140221328A1 (en) 2011-01-10 2014-08-07 Bandi Parthasaradhi Reddy Pharmaceutically acceptable salts of novel betulinic acid derivatives
WO2013001144A1 (en) 2011-06-30 2013-01-03 Nokia Corporation Method and apparatus for face tracking utilizing integral gradient projections
WO2013020245A1 (en) 2011-08-08 2013-02-14 Glaxosmithkline Llc Carbonyl derivatives of betulin
WO2013091144A1 (en) 2011-12-21 2013-06-27 Glaxosmithkline Llc Propenoate derivatives of betulin
KR20140101869A (ko) 2011-12-14 2014-08-20 글락소스미스클라인 엘엘씨 베툴린의 프로페노에이트 유도체
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
CN103242413B (zh) * 2012-02-08 2015-08-26 江西青峰药业有限公司 Lupane三萜系衍生物及其药学用途
US20150119373A1 (en) 2012-04-24 2015-04-30 Hetero Research Foundation Novel betulinic acid derivatives as hiv inhibitors
CA2893959A1 (en) 2012-12-14 2014-06-19 Shenshen Cai Pharmaceutical compositions
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
WO2015198263A2 (en) 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
WO2017017630A1 (en) 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
WO2017021922A1 (en) 2015-08-05 2017-02-09 Hetero Research Foundation Novel substituted amides of triterpene derivatives as hiv inhibitors
US10669305B2 (en) 2015-10-13 2020-06-02 Hetero Labs Limited C-3 novel triterpenone with C-28 urea derivatives as HIV inhibitors
WO2017115329A1 (en) 2015-12-30 2017-07-06 Hetero Research Foundation C-3 novel triterpenone derivatives as hiv inhibitors
WO2017149518A1 (en) 2016-03-04 2017-09-08 Hetero Labs Limited C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors
WO2018025247A1 (en) 2016-08-05 2018-02-08 Hetero Labs Limited C-3 novel triterpenone with c-28 diamide derivatives as hiv inhibitors
WO2018029604A1 (en) 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2018029602A1 (en) 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-28 heterocycle derivatives as hiv inhibitors
WO2018029610A1 (en) 2016-08-09 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 n-amide derivatives as hiv inhibitors
US20180097839A1 (en) 2016-10-01 2018-04-05 Neeraj S. Upasani Systems, apparatuses, and methods for platform security
WO2018069857A1 (en) 2016-10-12 2018-04-19 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide heterocycle derivatives as hiv inhibitors

Also Published As

Publication number Publication date
PH12017550077A1 (en) 2018-02-12
US11034718B2 (en) 2021-06-15
US20180215780A1 (en) 2018-08-02
EP3256483B1 (en) 2019-12-11
AU2016258274A1 (en) 2017-09-07
CU24476B1 (es) 2020-03-04
BR112017017109A2 (pt) 2018-04-03
US10533035B2 (en) 2020-01-14
WO2016178092A2 (en) 2016-11-10
MA40886B1 (fr) 2020-03-31
ZA201705253B (en) 2020-01-29
WO2016178092A3 (en) 2017-01-05
PE20171433A1 (es) 2017-09-26
KR20170110143A (ko) 2017-10-10
CL2017002034A1 (es) 2018-04-27
SG11201706189PA (en) 2017-08-30
US20200087342A1 (en) 2020-03-19
CA2975359A1 (en) 2016-11-10
AU2016258274B2 (en) 2019-12-05
MX2017010297A (es) 2018-11-12
EP3256483A2 (en) 2017-12-20
CN107428797A (zh) 2017-12-01
CO2017008765A2 (es) 2017-11-10
ES2780649T3 (es) 2020-08-26
US20170008921A1 (en) 2017-01-12
CU20170102A7 (es) 2018-01-10
EA201791807A1 (ru) 2018-01-31
WO2016178092A8 (en) 2017-09-21
JP2018505216A (ja) 2018-02-22
IL253844A0 (en) 2017-09-28
EA033264B1 (ru) 2019-09-30

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