CU20170102A7 - Nueva triterpenona c-3 con derivados de amida reversa c-17 como inhibidores de vih - Google Patents

Nueva triterpenona c-3 con derivados de amida reversa c-17 como inhibidores de vih

Info

Publication number
CU20170102A7
CU20170102A7 CUP2017000102A CU20170102A CU20170102A7 CU 20170102 A7 CU20170102 A7 CU 20170102A7 CU P2017000102 A CUP2017000102 A CU P2017000102A CU 20170102 A CU20170102 A CU 20170102A CU 20170102 A7 CU20170102 A7 CU 20170102A7
Authority
CU
Cuba
Prior art keywords
triterpenone
new
reversa
hiv inhibitors
derivatives
Prior art date
Application number
CUP2017000102A
Other languages
English (en)
Other versions
CU24476B1 (es
Inventor
Reddy Kasireddy Bhaskar
Krupadanam Gazula Levi David
Reddy Adulla Panduranga
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Subrahmanyam Lanka Vl
Original Assignee
Hetero Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57153504&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20170102(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hetero Labs Ltd filed Critical Hetero Labs Ltd
Publication of CU20170102A7 publication Critical patent/CU20170102A7/es
Publication of CU24476B1 publication Critical patent/CU24476B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<p>La invención de refiere a una nueva triterpenona C-3 con derivados amida inversa C-17, compuestos relacionados y composiciones farmacéuticas útiles para el tratamiento terapéutico de enfermedades virales y particularmente enfermedades mediadas por VIH. </p>
CU2017000102A 2015-02-09 2016-02-09 Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih CU24476B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN623CH2015 2015-02-09
PCT/IB2016/000811 WO2016178092A2 (en) 2015-02-09 2016-02-09 C-3 novel triterpenone with c-28 reverse amide derivatives as hiv inhibitors

Publications (2)

Publication Number Publication Date
CU20170102A7 true CU20170102A7 (es) 2018-01-10
CU24476B1 CU24476B1 (es) 2020-03-04

Family

ID=57153504

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2017000102A CU24476B1 (es) 2015-02-09 2016-02-09 Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih

Country Status (22)

Country Link
US (3) US10533035B2 (es)
EP (1) EP3256483B1 (es)
JP (1) JP2018505216A (es)
KR (1) KR20170110143A (es)
CN (1) CN107428797A (es)
AU (1) AU2016258274B2 (es)
BR (1) BR112017017109A2 (es)
CA (1) CA2975359A1 (es)
CL (1) CL2017002034A1 (es)
CO (1) CO2017008765A2 (es)
CU (1) CU24476B1 (es)
DK (1) DK3256483T3 (es)
EA (1) EA033264B1 (es)
ES (1) ES2780649T3 (es)
IL (1) IL253844A0 (es)
MA (1) MA40886B1 (es)
MX (1) MX2017010297A (es)
PE (1) PE20171433A1 (es)
PH (1) PH12017550077A1 (es)
SG (1) SG11201706189PA (es)
WO (1) WO2016178092A2 (es)
ZA (1) ZA201705253B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018029604A1 (en) * 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2019150300A1 (en) 2018-02-02 2019-08-08 Glaxosmithkline Intellectual Property (No.2) Limited Crystalline forms of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid
GEP20237476B (en) 2018-09-21 2023-03-27 Pfizer N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
WO2020165742A1 (en) * 2019-02-11 2020-08-20 Hetero Labs Limited Novel triterpenone derivatives as hiv inhibitors

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152815A (ja) 1982-03-05 1983-09-10 Tamio Nishimura 医療用抗ウイルス剤
CA2165188A1 (en) 1993-07-09 1995-01-19 Neal A. Deluca Selection and use of antiviral peptides
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
WO1998046238A1 (en) 1997-04-15 1998-10-22 Medichem Research, Inc. Biflavinoids and derivatives thereof as antiviral agents, alone or in combination with at least one known antiviral agent
HUP9701080A3 (en) 1997-06-23 1999-05-28 Gene Res Lab Inc New York N Pharmaceutical composition containing a compound of antiviral activity and a hydroximic acid ester derivative
US6670345B1 (en) 1997-09-30 2003-12-30 Dabur Research Foundation Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
US6427248B1 (en) 1997-10-09 2002-08-06 David M. Albert Grip-enhancing glove
EP1131337B1 (en) 1998-11-18 2009-01-14 Dabur Pharma Ltd. Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors
AU7268000A (en) 1999-07-21 2001-02-13 Martin Heinkelein Method for quantization of the antiviral effect of antiviral active principles
KR100618100B1 (ko) 1999-09-09 2006-08-29 다브르 리서치 파운데이션 항맥관형성 활성을 가지는 새로운 베툴린산 유도체,이러한 유도체의 제조 방법 및 종양 관련 맥관형성증의치료를 위한 이들의 용도
WO2002091858A1 (en) 2001-05-11 2002-11-21 University Of Ottawa Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
WO2003037908A1 (en) 2001-10-31 2003-05-08 Ribapharm Inc. Antiviral combination therapy and compositions
WO2004072092A1 (de) 2003-02-11 2004-08-26 Novelix Pharmaceuticals, Inc. Medikament zur wachstumsinhibierung von tumoren
US7026305B2 (en) 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
MXPA06010592A (es) 2004-03-17 2007-06-12 Panacos Pharmaceuticals Inc Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico.
KR101021828B1 (ko) 2004-10-27 2011-03-17 다이이찌 산쿄 가부시키가이샤 2 이상의 치환기를 갖는 벤젠 화합물
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
WO2006105356A2 (en) 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
US20090149429A1 (en) 2005-06-22 2009-06-11 Myriad Genetics, Incorporated Antiviral compounds
CN101287744A (zh) 2005-06-22 2008-10-15 美瑞德生物工程公司 抗病毒化合物
CN100475835C (zh) 2006-05-12 2009-04-08 中国药科大学 23-羟基白桦酸类衍生物、其制备方法、制剂及用途
FI20065389A7 (fi) 2006-06-07 2007-12-31 Valtion Teknillinen Tutkimuskeskus Betuliiniperäiset yhdisteet kasvien tuholaisten syönnin estäjinä
FI121468B (fi) 2006-06-07 2010-11-30 Valtion Teknillinen Betuliiniperäiset yhdisteet antimikrobisina aineina
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
US20110144069A1 (en) 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
AR063546A1 (es) * 2006-11-03 2009-01-28 Panacos Pharmaceuticals Inc DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH.
US20110152229A1 (en) 2006-11-22 2011-06-23 Duke University Betulinic acid derivatives as anti-hiv agents
WO2008091532A1 (en) 2007-01-19 2008-07-31 Panacos Pharmaceuticals, Inc. Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof
WO2009082819A1 (en) * 2008-01-03 2009-07-09 Virochem Pharma Inc. Novel lupane derivatives
US8269026B2 (en) 2008-01-03 2012-09-18 Vertex Pharmaceuticals Incorporated Lupane derivatives useful for treating HIV
CN101977924A (zh) 2008-01-03 2011-02-16 Viro化学制药公司 新的c-21-酮基羽扇烷衍生物、其制备方法和应用
EP2257567A1 (en) 2008-02-14 2010-12-08 Virochem Pharma Inc. Novel 17 beta lupane derivatives
US20120101098A1 (en) 2009-05-15 2012-04-26 Kuo-Hsiung Lee 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
EA201290632A1 (ru) 2010-02-11 2013-03-29 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Производные бетулина
MX2012013628A (es) 2010-06-04 2012-12-17 Bristol Myers Squibb Co Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih).
CN103038245B (zh) 2010-06-04 2015-03-25 百时美施贵宝公司 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
WO2012095705A1 (en) 2011-01-10 2012-07-19 Hetero Research Foundation Pharmaceutically acceptable salts of novel betulinic acid derivatives
WO2013001144A1 (en) 2011-06-30 2013-01-03 Nokia Corporation Method and apparatus for face tracking utilizing integral gradient projections
WO2013020245A1 (en) 2011-08-08 2013-02-14 Glaxosmithkline Llc Carbonyl derivatives of betulin
WO2013091144A1 (en) 2011-12-21 2013-06-27 Glaxosmithkline Llc Propenoate derivatives of betulin
ES2584684T3 (es) 2011-12-14 2016-09-28 Glaxosmithkline Llc Derivados de propenoato de betulina
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
CN103242413B (zh) * 2012-02-08 2015-08-26 江西青峰药业有限公司 Lupane三萜系衍生物及其药学用途
US20150119373A1 (en) 2012-04-24 2015-04-30 Hetero Research Foundation Novel betulinic acid derivatives as hiv inhibitors
MA38182A1 (fr) 2012-12-14 2018-04-30 Glaxosmithkline Llc Compositions pharmaceutiques a action prolongée pur une utilisation dans le traitement ou la prévention d'infections par le virus de l’immunodéficience humaine (vih)
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
WO2017017630A1 (en) 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
WO2017021922A1 (en) 2015-08-05 2017-02-09 Hetero Research Foundation Novel substituted amides of triterpene derivatives as hiv inhibitors
US10669305B2 (en) 2015-10-13 2020-06-02 Hetero Labs Limited C-3 novel triterpenone with C-28 urea derivatives as HIV inhibitors
WO2017115329A1 (en) 2015-12-30 2017-07-06 Hetero Research Foundation C-3 novel triterpenone derivatives as hiv inhibitors
WO2017149518A1 (en) 2016-03-04 2017-09-08 Hetero Labs Limited C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors
WO2018025247A1 (en) 2016-08-05 2018-02-08 Hetero Labs Limited C-3 novel triterpenone with c-28 diamide derivatives as hiv inhibitors
WO2018029604A1 (en) 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2018029602A1 (en) 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-28 heterocycle derivatives as hiv inhibitors
WO2018029610A1 (en) 2016-08-09 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 n-amide derivatives as hiv inhibitors
US20180097839A1 (en) 2016-10-01 2018-04-05 Neeraj S. Upasani Systems, apparatuses, and methods for platform security
WO2018069857A1 (en) 2016-10-12 2018-04-19 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide heterocycle derivatives as hiv inhibitors

Also Published As

Publication number Publication date
US20170008921A1 (en) 2017-01-12
MA40886B1 (fr) 2020-03-31
ZA201705253B (en) 2020-01-29
CU24476B1 (es) 2020-03-04
SG11201706189PA (en) 2017-08-30
DK3256483T3 (da) 2020-03-23
CL2017002034A1 (es) 2018-04-27
US20200087342A1 (en) 2020-03-19
PE20171433A1 (es) 2017-09-26
ES2780649T3 (es) 2020-08-26
EA201791807A1 (ru) 2018-01-31
US20180215780A1 (en) 2018-08-02
PH12017550077A1 (en) 2018-02-12
CO2017008765A2 (es) 2017-11-10
EP3256483A2 (en) 2017-12-20
WO2016178092A2 (en) 2016-11-10
EP3256483B1 (en) 2019-12-11
CA2975359A1 (en) 2016-11-10
IL253844A0 (en) 2017-09-28
AU2016258274B2 (en) 2019-12-05
KR20170110143A (ko) 2017-10-10
MX2017010297A (es) 2018-11-12
US10533035B2 (en) 2020-01-14
WO2016178092A3 (en) 2017-01-05
EA033264B1 (ru) 2019-09-30
WO2016178092A8 (en) 2017-09-21
AU2016258274A1 (en) 2017-09-07
CN107428797A (zh) 2017-12-01
US11034718B2 (en) 2021-06-15
JP2018505216A (ja) 2018-02-22
BR112017017109A2 (pt) 2018-04-03

Similar Documents

Publication Publication Date Title
CU20170102A7 (es) Nueva triterpenona c-3 con derivados de amida reversa c-17 como inhibidores de vih
MX2020010737A (es) Derivados de sulfamoilarilamida ciclados y su uso como medicamentos para el tratamiento de la hepatitis b.
CL2016000698A1 (es) Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del vih
CL2018000684A1 (es) Moduladores de la proteína de núcleo de la hepatitis b.
CU24397B1 (es) Derivados de piperidinil-indol como inhibidores del factor de complemento b
CO2017003279A2 (es) Compuestos y composiciones farmacéuticamente aceptables de los mismos, eficaces como inhibidores de mk2
CL2016001973A1 (es) Derivados de nucleosido sustituidos con 4&#39; -difluorometilo como inhibidores de la replicación de arn de la influenza.
MX371050B (es) Compuestos para tratar atrofia muscular espinal.
NI201600018A (es) Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
MX2017002028A (es) Compuestos de pirrolopirimidina usados como agonista del receptor de tipo toll 7 (tlr7).
BR112017012377A2 (pt) conjugados anticorpo-fármaco com inibidores de bcl-xl permeáveis à célula
CL2015002698A1 (es) Nuevos compuestos y composiciones para la inhibicion de fasn
EA201692437A1 (ru) Комбинация
MX2021005052A (es) Oxiesteroles y métodos de uso de los mismos.
CR20120008A (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
CR20170005A (es) Derivados de insoindolina
MX376122B (es) Composiciones de plinabulina.
EA201591406A1 (ru) C-19 модифицированные тритерпеноиды с ингибиторной активностью созревания вич
MX2017011655A (es) Compuestos de aza-piridona y usos de estos.
CL2017000152A1 (es) Derivados de isoindolinona
UY36263A (es) Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y métodos de uso
MX374383B (es) Derivados de carboxamida como inhibidores de smurf-1
MX384392B (es) Moduladores heterocíclicos de la síntesis de lípidos para su uso contra el cáncer e infecciones virales.
CL2018002084A1 (es) Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1.
CL2016002879A1 (es) Composiciones farmacéuticas para tratar enfermedades infecciosas