CU20170102A7 - Nueva triterpenona c-3 con derivados de amida reversa c-17 como inhibidores de vih - Google Patents

Nueva triterpenona c-3 con derivados de amida reversa c-17 como inhibidores de vih

Info

Publication number
CU20170102A7
CU20170102A7 CUP2017000102A CU20170102A CU20170102A7 CU 20170102 A7 CU20170102 A7 CU 20170102A7 CU P2017000102 A CUP2017000102 A CU P2017000102A CU 20170102 A CU20170102 A CU 20170102A CU 20170102 A7 CU20170102 A7 CU 20170102A7
Authority
CU
Cuba
Prior art keywords
triterpenone
new
reversa
hiv inhibitors
derivatives
Prior art date
Application number
CUP2017000102A
Other languages
English (en)
Other versions
CU24476B1 (es
Inventor
Reddy Kasireddy Bhaskar
Krupadanam Gazula Levi David
Reddy Adulla Panduranga
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Subrahmanyam Lanka Vl
Original Assignee
Hetero Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57153504&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20170102(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hetero Labs Ltd filed Critical Hetero Labs Ltd
Publication of CU20170102A7 publication Critical patent/CU20170102A7/es
Publication of CU24476B1 publication Critical patent/CU24476B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<p>La invención de refiere a una nueva triterpenona C-3 con derivados amida inversa C-17, compuestos relacionados y composiciones farmacéuticas útiles para el tratamiento terapéutico de enfermedades virales y particularmente enfermedades mediadas por VIH. </p>
CU2017000102A 2015-02-09 2016-02-09 Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih CU24476B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN623CH2015 2015-02-09
PCT/IB2016/000811 WO2016178092A2 (en) 2015-02-09 2016-02-09 C-3 novel triterpenone with c-28 reverse amide derivatives as hiv inhibitors

Publications (2)

Publication Number Publication Date
CU20170102A7 true CU20170102A7 (es) 2018-01-10
CU24476B1 CU24476B1 (es) 2020-03-04

Family

ID=57153504

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2017000102A CU24476B1 (es) 2015-02-09 2016-02-09 Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih

Country Status (22)

Country Link
US (3) US20170008921A1 (es)
EP (1) EP3256483B1 (es)
JP (1) JP2018505216A (es)
KR (1) KR20170110143A (es)
CN (1) CN107428797A (es)
AU (1) AU2016258274B2 (es)
BR (1) BR112017017109A2 (es)
CA (1) CA2975359A1 (es)
CL (1) CL2017002034A1 (es)
CO (1) CO2017008765A2 (es)
CU (1) CU24476B1 (es)
DK (1) DK3256483T3 (es)
EA (1) EA033264B1 (es)
ES (1) ES2780649T3 (es)
IL (1) IL253844A0 (es)
MA (1) MA40886B1 (es)
MX (1) MX2017010297A (es)
PE (1) PE20171433A1 (es)
PH (1) PH12017550077A1 (es)
SG (1) SG11201706189PA (es)
WO (1) WO2016178092A2 (es)
ZA (1) ZA201705253B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018029604A1 (en) * 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2019150300A1 (en) 2018-02-02 2019-08-08 Glaxosmithkline Intellectual Property (No.2) Limited Crystalline forms of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid
EP3852879A1 (en) 2018-09-21 2021-07-28 Pfizer Inc. N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
US12378281B2 (en) 2019-02-11 2025-08-05 Hetero Labs Limited Triterpenone derivatives as HIV inhibitors

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152815A (ja) 1982-03-05 1983-09-10 Tamio Nishimura 医療用抗ウイルス剤
EP0724650A4 (en) 1993-07-09 1998-12-02 Univ Pittsburgh Selection and use of antiviral peptides
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
AU7124398A (en) 1997-04-15 1998-11-11 Medichem Research, Inc. Biflavinoids and derivatives thereof as antiviral agents, alone or in combination with at least one known antiviral agent
HUP9701080A3 (en) 1997-06-23 1999-05-28 Gene Res Lab Inc New York N Pharmaceutical composition containing a compound of antiviral activity and a hydroximic acid ester derivative
US6670345B1 (en) 1997-09-30 2003-12-30 Dabur Research Foundation Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
US6427248B1 (en) 1997-10-09 2002-08-06 David M. Albert Grip-enhancing glove
WO2000046235A1 (en) 1998-11-18 2000-08-10 Dabur Research Foundation Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors
WO2001007646A2 (de) 1999-07-21 2001-02-01 Martin Heinkelein Verfahren zur quantifizierung der antiviralen wirkung antiviraler wirkstoffe
DE69917684T2 (de) 1999-09-09 2005-07-21 Dabur Research Foundation, Sahibabad Betulinsäure-derivate mit antiangiogener wirkung, verfahren zur herstellung solcher derivate und deren verwendung für die behandlung tumorassoziierter angiogenese
US7488722B2 (en) 2001-05-11 2009-02-10 University Of Ottawa Anxiolytic Marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
WO2003037908A1 (en) 2001-10-31 2003-05-08 Ribapharm Inc. Antiviral combination therapy and compositions
US7312205B2 (en) 2003-02-11 2007-12-25 Novelix Pharmaceuticals, Inc. Methods and compositions for inhibiting tumor growth
US7026305B2 (en) 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
CA2560266A1 (en) 2004-03-17 2005-09-29 Panacos Pharmaceuticals, Inc. Pharmaceutical salts of 3-o-(3',3'-dimethylsuccinyl) betulinic acid
AU2005297984B2 (en) 2004-10-27 2009-11-12 Daiichi Sankyo Company, Limited Benzene compound having 2 or more substituents
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
US20090023698A1 (en) 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
CN101287744A (zh) 2005-06-22 2008-10-15 美瑞德生物工程公司 抗病毒化合物
JP2008543945A (ja) 2005-06-22 2008-12-04 ミリアド ジェネティクス， インコーポレイテッド 抗ウイルス化合物
CN100475835C (zh) 2006-05-12 2009-04-08 中国药科大学 23-羟基白桦酸类衍生物、其制备方法、制剂及用途
FI20065389A7 (fi) 2006-06-07 2007-12-31 Valtion Teknillinen Tutkimuskeskus Betuliiniperäiset yhdisteet kasvien tuholaisten syönnin estäjinä
FI121468B (fi) 2006-06-07 2010-11-30 Valtion Teknillinen Betuliiniperäiset yhdisteet antimikrobisina aineina
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
WO2008115281A2 (en) 2006-10-16 2008-09-25 Myriad Genetics, Inc. Compounds for treating viral infections
US9505800B2 (en) * 2006-11-03 2016-11-29 Myrexis, Inc. Extended triterpene derivatives
US20110152229A1 (en) 2006-11-22 2011-06-23 Duke University Betulinic acid derivatives as anti-hiv agents
WO2008091532A1 (en) 2007-01-19 2008-07-31 Panacos Pharmaceuticals, Inc. Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof
JP2011508747A (ja) 2008-01-03 2011-03-17 バイロケム ファーマ インコーポレイテッド 新規のｃ−２１ケトルパン誘導体、それらの調製および使用
MX2010007375A (es) * 2008-01-03 2010-09-30 Virochem Pharma Inc Nuevos derivados de lupano.
CA2714049A1 (en) 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17.beta. lupane derivatives
US8431556B2 (en) 2008-03-26 2013-04-30 Vertex Pharmaceuticals Incorporated C-21-keto lupane derivatives preparation and use thereof
US20120101098A1 (en) 2009-05-15 2012-04-26 Kuo-Hsiung Lee 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
WO2011100308A1 (en) 2010-02-11 2011-08-18 Glaxosmithkline Llc Derivatives of betulin
ES2548905T3 (es) 2010-06-04 2015-10-21 Bristol-Myers Squibb Company Amidas C-28 de derivados del ácido betulínico C-3 modificados como inhibidores de la maduración del VIH
EA022393B1 (ru) 2010-06-04 2015-12-30 Бристол-Майерс Сквибб Компани С-3 модифицированные производные бетулиновой кислоты в качестве ингибиторов созревания вич
WO2012095705A1 (en) 2011-01-10 2012-07-19 Hetero Research Foundation Pharmaceutically acceptable salts of novel betulinic acid derivatives
EP2727047A4 (en) 2011-06-30 2015-04-22 Nokia Corp METHOD AND DEVICE FOR FACE TRACKING WITH INTEGRATED GRADIENT PROJECTIONS
WO2013020245A1 (en) 2011-08-08 2013-02-14 Glaxosmithkline Llc Carbonyl derivatives of betulin
WO2013091144A1 (en) 2011-12-21 2013-06-27 Glaxosmithkline Llc Propenoate derivatives of betulin
ES2584684T3 (es) 2011-12-14 2016-09-28 Glaxosmithkline Llc Derivados de propenoato de betulina
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
CN103242413B (zh) * 2012-02-08 2015-08-26 江西青峰药业有限公司 Lupane三萜系衍生物及其药学用途
US20150119373A1 (en) 2012-04-24 2015-04-30 Hetero Research Foundation Novel betulinic acid derivatives as hiv inhibitors
KR20150093819A (ko) 2012-12-14 2015-08-18 글락소스미스클라인 엘엘씨 약제 조성물
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
WO2017017630A1 (en) 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
WO2017021922A1 (en) 2015-08-05 2017-02-09 Hetero Research Foundation Novel substituted amides of triterpene derivatives as hiv inhibitors
US10669305B2 (en) 2015-10-13 2020-06-02 Hetero Labs Limited C-3 novel triterpenone with C-28 urea derivatives as HIV inhibitors
WO2017115329A1 (en) 2015-12-30 2017-07-06 Hetero Research Foundation C-3 novel triterpenone derivatives as hiv inhibitors
WO2017149518A1 (en) 2016-03-04 2017-09-08 Hetero Labs Limited C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors
WO2018025247A1 (en) 2016-08-05 2018-02-08 Hetero Labs Limited C-3 novel triterpenone with c-28 diamide derivatives as hiv inhibitors
WO2018029604A1 (en) 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2018029602A1 (en) 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-28 heterocycle derivatives as hiv inhibitors
WO2018029610A1 (en) 2016-08-09 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 n-amide derivatives as hiv inhibitors
US20180097839A1 (en) 2016-10-01 2018-04-05 Neeraj S. Upasani Systems, apparatuses, and methods for platform security
WO2018069857A1 (en) 2016-10-12 2018-04-19 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide heterocycle derivatives as hiv inhibitors

Also Published As

Publication number Publication date
CU24476B1 (es) 2020-03-04
JP2018505216A (ja) 2018-02-22
PH12017550077A1 (en) 2018-02-12
IL253844A0 (en) 2017-09-28
US20200087342A1 (en) 2020-03-19
MX2017010297A (es) 2018-11-12
EP3256483A2 (en) 2017-12-20
EP3256483B1 (en) 2019-12-11
WO2016178092A3 (en) 2017-01-05
AU2016258274B2 (en) 2019-12-05
CO2017008765A2 (es) 2017-11-10
CL2017002034A1 (es) 2018-04-27
KR20170110143A (ko) 2017-10-10
PE20171433A1 (es) 2017-09-26
ES2780649T3 (es) 2020-08-26
BR112017017109A2 (pt) 2018-04-03
US20170008921A1 (en) 2017-01-12
WO2016178092A2 (en) 2016-11-10
US20180215780A1 (en) 2018-08-02
CN107428797A (zh) 2017-12-01
WO2016178092A8 (en) 2017-09-21
SG11201706189PA (en) 2017-08-30
CA2975359A1 (en) 2016-11-10
EA201791807A1 (ru) 2018-01-31
AU2016258274A1 (en) 2017-09-07
US11034718B2 (en) 2021-06-15
US10533035B2 (en) 2020-01-14
DK3256483T3 (da) 2020-03-23
MA40886B1 (fr) 2020-03-31
ZA201705253B (en) 2020-01-29
EA033264B1 (ru) 2019-09-30

Similar Documents

Publication Publication Date Title
CU20170102A7 (es) Nueva triterpenona c-3 con derivados de amida reversa c-17 como inhibidores de vih
MX2020010737A (es) Derivados de sulfamoilarilamida ciclados y su uso como medicamentos para el tratamiento de la hepatitis b.
CL2016000698A1 (es) Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del vih
CL2018000684A1 (es) Moduladores de la proteína de núcleo de la hepatitis b.
CU24397B1 (es) Derivados de piperidinil-indol como inhibidores del factor de complemento b
CO2017003279A2 (es) Compuestos y composiciones farmacéuticamente aceptables de los mismos, eficaces como inhibidores de mk2
CL2016001973A1 (es) Derivados de nucleosido sustituidos con 4&#39; -difluorometilo como inhibidores de la replicación de arn de la influenza.
MX371050B (es) Compuestos para tratar atrofia muscular espinal.
NI201600018A (es) Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
MX2017002028A (es) Compuestos de pirrolopirimidina usados como agonista del receptor de tipo toll 7 (tlr7).
BR112017012377A2 (pt) conjugados anticorpo-fármaco com inibidores de bcl-xl permeáveis à célula
CL2015002698A1 (es) Nuevos compuestos y composiciones para la inhibicion de fasn
EA201692437A1 (ru) Комбинация
MX2021005052A (es) Oxiesteroles y métodos de uso de los mismos.
CR20120008A (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
CR20170005A (es) Derivados de insoindolina
MX376122B (es) Composiciones de plinabulina.
EA201591406A1 (ru) C-19 модифицированные тритерпеноиды с ингибиторной активностью созревания вич
MX2017011655A (es) Compuestos de aza-piridona y usos de estos.
CL2017000152A1 (es) Derivados de isoindolinona
UY36263A (es) Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y métodos de uso
MX374383B (es) Derivados de carboxamida como inhibidores de smurf-1
MX384392B (es) Moduladores heterocíclicos de la síntesis de lípidos para su uso contra el cáncer e infecciones virales.
CL2018002084A1 (es) Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1.
CL2016002879A1 (es) Composiciones farmacéuticas para tratar enfermedades infecciosas