JP2014518882A5 - - Google Patents
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- Publication number
- JP2014518882A5 JP2014518882A5 JP2014512183A JP2014512183A JP2014518882A5 JP 2014518882 A5 JP2014518882 A5 JP 2014518882A5 JP 2014512183 A JP2014512183 A JP 2014512183A JP 2014512183 A JP2014512183 A JP 2014512183A JP 2014518882 A5 JP2014518882 A5 JP 2014518882A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently selected
- compound
- alkoxy
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- -1 C 1 -C 4 alkenyl ester Chemical class 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000004438 haloalkoxy group Chemical group 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 235000013877 carbamide Nutrition 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- 239000005977 Ethylene Chemical group 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 239000004202 carbamide Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490881P | 2011-05-27 | 2011-05-27 | |
| US61/490,881 | 2011-05-27 | ||
| US201161504905P | 2011-07-06 | 2011-07-06 | |
| US61/504,905 | 2011-07-06 | ||
| US201161567216P | 2011-12-06 | 2011-12-06 | |
| US61/567,216 | 2011-12-06 | ||
| PCT/US2012/039835 WO2012166716A2 (en) | 2011-05-27 | 2012-05-29 | Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating hcv infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044853A Division JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518882A JP2014518882A (ja) | 2014-08-07 |
| JP2014518882A5 true JP2014518882A5 (enExample) | 2015-07-09 |
| JP6198721B2 JP6198721B2 (ja) | 2017-09-20 |
Family
ID=47219638
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512183A Expired - Fee Related JP6198721B2 (ja) | 2011-05-27 | 2012-05-29 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
| JP2017044853A Pending JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044853A Pending JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US8809313B2 (enExample) |
| EP (2) | EP3059241B1 (enExample) |
| JP (2) | JP6198721B2 (enExample) |
| KR (1) | KR101931311B1 (enExample) |
| CN (2) | CN103561739B (enExample) |
| AP (1) | AP2013007263A0 (enExample) |
| AU (2) | AU2012262338B2 (enExample) |
| BR (1) | BR112013030045A2 (enExample) |
| CA (1) | CA2837481A1 (enExample) |
| CY (1) | CY1118111T1 (enExample) |
| EA (2) | EA201791776A1 (enExample) |
| ES (1) | ES2584418T3 (enExample) |
| HR (1) | HRP20160863T1 (enExample) |
| HU (1) | HUE029326T2 (enExample) |
| IL (3) | IL229165A (enExample) |
| LT (1) | LT2714036T (enExample) |
| MX (2) | MX349079B (enExample) |
| PH (1) | PH12013502455A1 (enExample) |
| PL (1) | PL2714036T3 (enExample) |
| PT (1) | PT2714036T (enExample) |
| RS (1) | RS55123B1 (enExample) |
| SG (1) | SG194681A1 (enExample) |
| SI (1) | SI2714036T1 (enExample) |
| SM (1) | SMT201600325B (enExample) |
| WO (1) | WO2012166716A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2454254A2 (en) | 2009-07-16 | 2012-05-23 | Vertex Pharmaceuticals Incorporated | Benzimidazole analogues for the treatment or prevention of flavivirus infections |
| MX2012010918A (es) | 2010-03-24 | 2013-01-18 | Vertex Pharma | Analogos para el tratamiento o prevencion de infecciones por flavivirus. |
| EP2616461A4 (en) | 2010-08-26 | 2014-03-26 | Rfs Pharma Llc | POTENTIVE AND SELECTIVE INHIBITORS OF HEPATITIS C VIRUS |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| KR101931311B1 (ko) | 2011-05-27 | 2018-12-20 | 아칠리온 파르마세우티칼스 인코포레이티드 | Ｈｃｖ 감염 치료에 유용한 치환된 앨리팬, 시클로팬, 헤테라팬, 헤테로팬, 헤테로-헤테라팬 및 메탈로센 |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| BR112015025766A2 (pt) | 2013-04-12 | 2017-10-17 | Achillion Pharmaceuticals Inc | derivado de nucleosídeo altamente ativo para o tratamento de hcv |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| WO2015005901A1 (en) * | 2013-07-09 | 2015-01-15 | Bristol-Myers Squibb Company | Combinations of hepatitis c virus inhibitors |
| JP2016525114A (ja) * | 2013-07-17 | 2016-08-22 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃ型肝炎ウイルスの治療に使用するためのトリシクロヘキサデカヘキサエン誘導体を含む組み合わせ |
| CN105530933B (zh) | 2013-07-17 | 2018-12-11 | 百时美施贵宝公司 | 用于治疗hcv的包含联苯衍生物的组合产品 |
| CR20170076A (es) | 2014-08-04 | 2017-06-26 | Nuevolution As | Derivados de pirimidima sustituidos con heterociclilo opcionalmente condensados útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias |
| WO2016054240A1 (en) | 2014-09-30 | 2016-04-07 | Sean Dalziel | Fixed dose combinations for the treatment of viral diseases |
| WO2017023631A1 (en) | 2015-08-06 | 2017-02-09 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
| EP3340983B1 (en) | 2015-08-26 | 2023-10-04 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| WO2017035405A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) * | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| CN108349907B (zh) * | 2015-11-06 | 2021-08-31 | 江苏豪森药业集团有限公司 | 1,4(1,4)-二苯杂环六蕃-12,43-二基衍生物及其制备方法与应用 |
| WO2017076194A1 (zh) * | 2015-11-06 | 2017-05-11 | 江苏豪森药业集团有限公司 | 具有抑制hcv活性的化合物及其制备方法和应用 |
| CN106083829B (zh) * | 2016-01-12 | 2019-01-22 | 深圳市塔吉瑞生物医药有限公司 | 一种丙型肝炎病毒抑制剂、药物组合物及其应用 |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| EP4483875A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| WO2018064585A1 (en) * | 2016-09-29 | 2018-04-05 | Janssen Pharmaceuticals, Inc. | Odalasvir polymorphs and methods of manufacture thereof |
| KR102632860B1 (ko) | 2017-03-01 | 2024-02-02 | 아칠리온 파르마세우티칼스 인코포레이티드 | 의학적 장애의 치료를 위한 아릴, 헤테로아릴, 및 헤테로사이클릭 약학적 화합물 |
| WO2018160892A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for treatment of medical disorders |
| WO2018160891A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceutical, Inc. | Pharmaceutical compounds for treatment of medical disorders |
| EP3641762B1 (en) | 2017-06-20 | 2026-02-18 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| EP3661493A4 (en) | 2017-08-02 | 2021-04-14 | Achillion Pharmaceuticals, Inc. | THERAPY PLANS FOR TREATMENT OF PAROXYSMALER NIGHTLY HEMOGLOBINURIA |
| US11814363B2 (en) | 2018-09-06 | 2023-11-14 | Achillion Pharmaceuticals, Inc. | Morphic forms of danicopan |
| EP3846803A4 (en) | 2018-09-06 | 2022-08-10 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| EP3856164B1 (en) | 2018-09-25 | 2024-08-07 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor d inhibitors |
| BR112021011727A2 (pt) | 2018-12-17 | 2021-08-31 | Achillion Pharmaceuticals, Inc | Dosagem direcionada para o tratamento de distúrbios mediados do complemento |
| WO2020198062A1 (en) | 2019-03-22 | 2020-10-01 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
| WO2020219808A1 (en) * | 2019-04-25 | 2020-10-29 | Beta Pharma, Inc. | Dicarbamate inhibitors of ns5a for treatment of hepatitis c virus infections and related diseases |
| AU2020408107B2 (en) | 2019-12-20 | 2026-04-23 | Nuevolution A/S | Compounds active towards nuclear receptors |
| AU2020405446A1 (en) | 2019-12-20 | 2022-05-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
| US11613532B2 (en) | 2020-03-31 | 2023-03-28 | Nuevolution A/S | Compounds active towards nuclear receptors |
| EP4126874A1 (en) | 2020-03-31 | 2023-02-08 | Nuevolution A/S | Compounds active towards nuclear receptors |
| CN115181117B (zh) * | 2022-08-08 | 2024-05-17 | 中国医学科学院医学生物学研究所 | 一种s构型手性分子化合物及其制备方法和作为疫苗佐剂的应用 |
| WO2025175249A1 (en) | 2024-02-14 | 2025-08-21 | Olema Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
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| US6448392B1 (en) | 1985-03-06 | 2002-09-10 | Chimerix, Inc. | Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use |
| US6599887B2 (en) | 1988-07-07 | 2003-07-29 | Chimerix, Inc. | Methods of treating viral infections using antiviral liponucleotides |
| DE4010531A1 (de) * | 1990-04-02 | 1991-10-10 | Thomae Gmbh Dr K | Cyclophane, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| CA2429359A1 (en) * | 2000-11-20 | 2002-08-08 | Bristol-Myers Squibb Company | Hepatitis c tripeptide inhibitors |
| MY140680A (en) * | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| SG159561A1 (en) | 2005-05-09 | 2010-03-30 | Achillion Pharmaceuticals Inc | Thiazole compounds and methods of use |
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| SI2041156T1 (sl) * | 2006-07-13 | 2014-04-30 | Achillion Pharmacetuticals, Inc. | Peptidi 4-amino-4-oksobutanoila kot inhibitorji virusne replikacije |
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| CN102427729B (zh) | 2009-03-27 | 2014-09-03 | 默沙东公司 | 丙型肝炎病毒复制的抑制剂 |
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| RS56654B8 (sr) | 2009-05-13 | 2021-06-30 | Gilead Pharmasset Llc | Antiviralna jedinjenja |
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| WO2011050146A1 (en) * | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Chemical compounds |
| JP2013518062A (ja) | 2010-01-28 | 2013-05-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃ型肝炎阻害化合物 |
| KR101931311B1 (ko) | 2011-05-27 | 2018-12-20 | 아칠리온 파르마세우티칼스 인코포레이티드 | Ｈｃｖ 감염 치료에 유용한 치환된 앨리팬, 시클로팬, 헤테라팬, 헤테로팬, 헤테로-헤테라팬 및 메탈로센 |
| US10509949B1 (en) | 2019-01-24 | 2019-12-17 | Capital One Services, Llc | Method and system for customizing user experience |
-
2012
- 2012-05-29 KR KR1020137031871A patent/KR101931311B1/ko not_active Expired - Fee Related
- 2012-05-29 CN CN201280025427.6A patent/CN103561739B/zh not_active Expired - Fee Related
- 2012-05-29 MX MX2013013670A patent/MX349079B/es active IP Right Grant
- 2012-05-29 PT PT127935666T patent/PT2714036T/pt unknown
- 2012-05-29 AP AP2013007263A patent/AP2013007263A0/xx unknown
- 2012-05-29 EP EP16157270.6A patent/EP3059241B1/en not_active Not-in-force
- 2012-05-29 SG SG2013080155A patent/SG194681A1/en unknown
- 2012-05-29 CA CA2837481A patent/CA2837481A1/en not_active Abandoned
- 2012-05-29 SI SI201230643A patent/SI2714036T1/sl unknown
- 2012-05-29 HR HRP20160863TT patent/HRP20160863T1/hr unknown
- 2012-05-29 EP EP12793566.6A patent/EP2714036B1/en active Active
- 2012-05-29 EA EA201791776A patent/EA201791776A1/ru unknown
- 2012-05-29 PH PH1/2013/502455A patent/PH12013502455A1/en unknown
- 2012-05-29 LT LTEP12793566.6T patent/LT2714036T/lt unknown
- 2012-05-29 CN CN201610206020.3A patent/CN105801467A/zh active Pending
- 2012-05-29 JP JP2014512183A patent/JP6198721B2/ja not_active Expired - Fee Related
- 2012-05-29 EA EA201301335A patent/EA029099B1/ru not_active IP Right Cessation
- 2012-05-29 AU AU2012262338A patent/AU2012262338B2/en not_active Ceased
- 2012-05-29 WO PCT/US2012/039835 patent/WO2012166716A2/en not_active Ceased
- 2012-05-29 BR BR112013030045A patent/BR112013030045A2/pt not_active Application Discontinuation
- 2012-05-29 US US13/482,558 patent/US8809313B2/en active Active
- 2012-05-29 PL PL12793566T patent/PL2714036T3/pl unknown
- 2012-05-29 MX MX2017001464A patent/MX357867B/es unknown
- 2012-05-29 RS RS20160570A patent/RS55123B1/sr unknown
- 2012-05-29 ES ES12793566.6T patent/ES2584418T3/es active Active
- 2012-05-29 HU HUE12793566A patent/HUE029326T2/hu unknown
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2013
- 2013-10-31 IL IL229165A patent/IL229165A/en active IP Right Grant
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2014
- 2014-07-10 US US14/328,312 patent/US9273082B2/en not_active Expired - Fee Related
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2015
- 2015-12-17 US US14/972,913 patent/US9474742B2/en not_active Expired - Fee Related
- 2015-12-17 US US14/972,827 patent/US9468629B2/en not_active Expired - Fee Related
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2016
- 2016-08-22 CY CY20161100824T patent/CY1118111T1/el unknown
- 2016-09-19 SM SM201600325T patent/SMT201600325B/it unknown
- 2016-09-20 US US15/271,066 patent/US9592222B2/en not_active Expired - Fee Related
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2017
- 2017-02-01 IL IL250389A patent/IL250389A/en not_active IP Right Cessation
- 2017-02-20 US US15/437,117 patent/US9833440B2/en not_active Expired - Fee Related
- 2017-03-07 AU AU2017201535A patent/AU2017201535B2/en not_active Ceased
- 2017-03-09 JP JP2017044853A patent/JP2017101086A/ja active Pending
- 2017-09-11 IL IL254422A patent/IL254422A0/en unknown
- 2017-11-06 US US15/804,842 patent/US10092547B2/en active Active
-
2018
- 2018-06-29 US US16/024,021 patent/US20180303800A1/en not_active Abandoned