JP2014518882A5 - - Google Patents
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- Publication number
- JP2014518882A5 JP2014518882A5 JP2014512183A JP2014512183A JP2014518882A5 JP 2014518882 A5 JP2014518882 A5 JP 2014518882A5 JP 2014512183 A JP2014512183 A JP 2014512183A JP 2014512183 A JP2014512183 A JP 2014512183A JP 2014518882 A5 JP2014518882 A5 JP 2014518882A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently selected
- compound
- alkoxy
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- -1 C 1 -C 4 alkenyl ester Chemical class 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000004438 haloalkoxy group Chemical group 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 235000013877 carbamide Nutrition 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- 239000005977 Ethylene Chemical group 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 239000004202 carbamide Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490881P | 2011-05-27 | 2011-05-27 | |
| US61/490,881 | 2011-05-27 | ||
| US201161504905P | 2011-07-06 | 2011-07-06 | |
| US61/504,905 | 2011-07-06 | ||
| US201161567216P | 2011-12-06 | 2011-12-06 | |
| US61/567,216 | 2011-12-06 | ||
| PCT/US2012/039835 WO2012166716A2 (en) | 2011-05-27 | 2012-05-29 | Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating hcv infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044853A Division JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518882A JP2014518882A (ja) | 2014-08-07 |
| JP2014518882A5 true JP2014518882A5 (enExample) | 2015-07-09 |
| JP6198721B2 JP6198721B2 (ja) | 2017-09-20 |
Family
ID=47219638
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512183A Expired - Fee Related JP6198721B2 (ja) | 2011-05-27 | 2012-05-29 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
| JP2017044853A Pending JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044853A Pending JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US8809313B2 (enExample) |
| EP (2) | EP3059241B1 (enExample) |
| JP (2) | JP6198721B2 (enExample) |
| KR (1) | KR101931311B1 (enExample) |
| CN (2) | CN103561739B (enExample) |
| AP (1) | AP2013007263A0 (enExample) |
| AU (2) | AU2012262338B2 (enExample) |
| BR (1) | BR112013030045A2 (enExample) |
| CA (1) | CA2837481A1 (enExample) |
| CY (1) | CY1118111T1 (enExample) |
| EA (2) | EA029099B1 (enExample) |
| ES (1) | ES2584418T3 (enExample) |
| HR (1) | HRP20160863T1 (enExample) |
| HU (1) | HUE029326T2 (enExample) |
| IL (3) | IL229165A (enExample) |
| LT (1) | LT2714036T (enExample) |
| MX (2) | MX357867B (enExample) |
| PH (1) | PH12013502455A1 (enExample) |
| PL (1) | PL2714036T3 (enExample) |
| PT (1) | PT2714036T (enExample) |
| RS (1) | RS55123B1 (enExample) |
| SG (1) | SG194681A1 (enExample) |
| SI (1) | SI2714036T1 (enExample) |
| SM (1) | SMT201600325B (enExample) |
| WO (1) | WO2012166716A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012533569A (ja) | 2009-07-16 | 2012-12-27 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体 |
| JP2013522375A (ja) | 2010-03-24 | 2013-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染を処置または予防するためのアナログ |
| CA2809261A1 (en) | 2010-08-26 | 2012-03-01 | Rfs Pharma, Llc | Potent and selective inhibitors of hepatitis c virus |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| PH12013502455A1 (en) * | 2011-05-27 | 2014-01-20 | Achillion Pharmaceuticals Inc | Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating hcv infections |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2909270A1 (en) | 2013-04-12 | 2014-10-16 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of hcv |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| JP6333372B2 (ja) * | 2013-07-09 | 2018-05-30 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃ型肝炎ウイルス阻害剤の組み合わせ |
| US9775831B2 (en) | 2013-07-17 | 2017-10-03 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of HCV |
| CN105555266B (zh) * | 2013-07-17 | 2018-11-30 | 百时美施贵宝公司 | 用于治疗丙型肝炎病毒的包含三环十六碳六烯衍生物的组合产品 |
| SG11201700777VA (en) | 2014-08-04 | 2017-02-27 | Nuevolution As | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| WO2016054240A1 (en) | 2014-09-30 | 2016-04-07 | Sean Dalziel | Fixed dose combinations for the treatment of viral diseases |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
| WO2017035405A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017035409A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| CN108348504B (zh) * | 2015-11-06 | 2021-06-29 | 江苏豪森药业集团有限公司 | 具有抑制hcv活性的化合物及其制备方法和应用 |
| CN108349907B (zh) * | 2015-11-06 | 2021-08-31 | 江苏豪森药业集团有限公司 | 1,4(1,4)-二苯杂环六蕃-12,43-二基衍生物及其制备方法与应用 |
| CN106083829B (zh) * | 2016-01-12 | 2019-01-22 | 深圳市塔吉瑞生物医药有限公司 | 一种丙型肝炎病毒抑制剂、药物组合物及其应用 |
| EP4483875A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| WO2018064585A1 (en) * | 2016-09-29 | 2018-04-05 | Janssen Pharmaceuticals, Inc. | Odalasvir polymorphs and methods of manufacture thereof |
| CN110603252A (zh) | 2017-03-01 | 2019-12-20 | 艾其林医药公司 | 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物 |
| EP3589287B1 (en) | 2017-03-01 | 2022-09-14 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for treatment of medical disorders |
| WO2018160891A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceutical, Inc. | Pharmaceutical compounds for treatment of medical disorders |
| WO2018237026A1 (en) | 2017-06-20 | 2018-12-27 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| EP3661493A4 (en) | 2017-08-02 | 2021-04-14 | Achillion Pharmaceuticals, Inc. | TREATMENT DIET FOR THE TREATMENT OF PAROXYSTIC NOCTURAL HEMOGLOBINURIA |
| EP3847174A4 (en) | 2018-09-06 | 2022-06-15 | Achillion Pharmaceuticals, Inc. | MORPHIC FORMS OF COMPLEMENT D FACTOR INHIBITORS |
| EP3846803A4 (en) | 2018-09-06 | 2022-08-10 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| CA3114039A1 (en) | 2018-09-25 | 2020-04-02 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor d inhibitors |
| KR20210104071A (ko) | 2018-12-17 | 2021-08-24 | 아칠리온 파르마세우티칼스 인코포레이티드 | 보체 매개 장애의 치료를 위한 표적 투약 |
| MX2021011507A (es) | 2019-03-22 | 2021-12-15 | Achillion Pharmaceuticals Inc | Compuestos farmaceuticos para el tratamiento de trastornos mediados por complemento. |
| TW202106677A (zh) * | 2019-04-25 | 2021-02-16 | 美商貝達醫藥公司 | 用於治療c型肝炎病毒感染之ns5a的二胺甲酸酯抑制劑 |
| TWI872177B (zh) | 2019-12-20 | 2025-02-11 | 丹麥商紐韋盧森公司 | 對核受體具有活性之化合物 |
| US11447479B2 (en) | 2019-12-20 | 2022-09-20 | Nuevolution A/S | Compounds active towards nuclear receptors |
| JP7713953B2 (ja) | 2020-03-31 | 2025-07-28 | ヌエヴォリューション・アクティーゼルスカブ | 核内受容体に対して活性な化合物 |
| CA3174176A1 (en) | 2020-03-31 | 2021-10-07 | Sanne Schroder Glad | Compounds active towards nuclear receptors |
| CN115181117B (zh) * | 2022-08-08 | 2024-05-17 | 中国医学科学院医学生物学研究所 | 一种s构型手性分子化合物及其制备方法和作为疫苗佐剂的应用 |
| WO2025175249A1 (en) | 2024-02-14 | 2025-08-21 | Olema Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
Family Cites Families (24)
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| US6448392B1 (en) | 1985-03-06 | 2002-09-10 | Chimerix, Inc. | Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use |
| US6599887B2 (en) | 1988-07-07 | 2003-07-29 | Chimerix, Inc. | Methods of treating viral infections using antiviral liponucleotides |
| DE4010531A1 (de) * | 1990-04-02 | 1991-10-10 | Thomae Gmbh Dr K | Cyclophane, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| CN100391967C (zh) * | 2000-11-20 | 2008-06-04 | 布里斯托尔-迈尔斯斯奎布公司 | 丙型肝炎三肽抑制剂 |
| MY140680A (en) * | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| BRPI0608910A2 (pt) | 2005-05-09 | 2010-02-17 | Achillion Pharmaceuticals Inc | uso de um composto da fórmula ou um sal ou hidrato farmaceuticamente aceitável desse, composto ou sal ou hidrato do mesmo, composição farmacêutica e composição farmacêutica embalada |
| EP2012799B1 (en) | 2006-05-03 | 2016-08-24 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
| EP2041156B1 (en) | 2006-07-13 | 2013-11-20 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
| UA101468C2 (ru) * | 2006-07-13 | 2013-04-10 | Ачілліон Фармасьютікалз, Інк. | 4-амино-4-оксобутаноиловые пептиды как ингибиторы вирусной репликации |
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| BRPI0811939A2 (pt) | 2007-05-22 | 2014-11-25 | Achillion Pharmaceuticals Inc | Tiazóis substituídos por heteroarila |
| EP2190858A4 (en) * | 2007-09-24 | 2013-02-13 | Achillion Pharmaceuticals Inc | PEPTIDES CONTAINING UREA AS INHIBITORS OF VIRAL REPLICATION |
| CA2743912A1 (en) * | 2008-11-20 | 2010-05-27 | Achillion Pharmaceuticals, Inc. | Cyclic carboxamide compounds and analogues thereof as of hepatitis c virus |
| US20100152103A1 (en) | 2008-12-10 | 2010-06-17 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication |
| WO2010068760A2 (en) * | 2008-12-10 | 2010-06-17 | Achillion Pharmaceuticals, Inc. | New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
| EP2393359A4 (en) * | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| SG10201402969QA (en) | 2009-03-27 | 2014-09-26 | Merck Sharp & Dohme | Inhibitors of hepatitis c virus replication |
| TWI476190B (zh) * | 2009-03-30 | 2015-03-11 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| NZ619205A (en) | 2009-05-13 | 2015-04-24 | Gilead Pharmasset Llc | Antiviral compounds |
| WO2011031904A1 (en) | 2009-09-11 | 2011-03-17 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
| WO2011050146A1 (en) * | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Chemical compounds |
| WO2011091532A1 (en) | 2010-01-28 | 2011-08-04 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
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-
2012
- 2012-05-29 PH PH1/2013/502455A patent/PH12013502455A1/en unknown
- 2012-05-29 AU AU2012262338A patent/AU2012262338B2/en not_active Ceased
- 2012-05-29 EP EP16157270.6A patent/EP3059241B1/en not_active Not-in-force
- 2012-05-29 EP EP12793566.6A patent/EP2714036B1/en active Active
- 2012-05-29 EA EA201301335A patent/EA029099B1/ru not_active IP Right Cessation
- 2012-05-29 BR BR112013030045A patent/BR112013030045A2/pt not_active Application Discontinuation
- 2012-05-29 LT LTEP12793566.6T patent/LT2714036T/lt unknown
- 2012-05-29 AP AP2013007263A patent/AP2013007263A0/xx unknown
- 2012-05-29 SI SI201230643A patent/SI2714036T1/sl unknown
- 2012-05-29 CA CA2837481A patent/CA2837481A1/en not_active Abandoned
- 2012-05-29 WO PCT/US2012/039835 patent/WO2012166716A2/en not_active Ceased
- 2012-05-29 CN CN201280025427.6A patent/CN103561739B/zh not_active Expired - Fee Related
- 2012-05-29 HU HUE12793566A patent/HUE029326T2/hu unknown
- 2012-05-29 JP JP2014512183A patent/JP6198721B2/ja not_active Expired - Fee Related
- 2012-05-29 HR HRP20160863TT patent/HRP20160863T1/hr unknown
- 2012-05-29 PT PT127935666T patent/PT2714036T/pt unknown
- 2012-05-29 CN CN201610206020.3A patent/CN105801467A/zh active Pending
- 2012-05-29 MX MX2017001464A patent/MX357867B/es unknown
- 2012-05-29 SG SG2013080155A patent/SG194681A1/en unknown
- 2012-05-29 EA EA201791776A patent/EA201791776A1/ru unknown
- 2012-05-29 RS RS20160570A patent/RS55123B1/sr unknown
- 2012-05-29 PL PL12793566T patent/PL2714036T3/pl unknown
- 2012-05-29 MX MX2013013670A patent/MX349079B/es active IP Right Grant
- 2012-05-29 US US13/482,558 patent/US8809313B2/en active Active
- 2012-05-29 KR KR1020137031871A patent/KR101931311B1/ko not_active Expired - Fee Related
- 2012-05-29 ES ES12793566.6T patent/ES2584418T3/es active Active
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2013
- 2013-10-31 IL IL229165A patent/IL229165A/en active IP Right Grant
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2014
- 2014-07-10 US US14/328,312 patent/US9273082B2/en not_active Expired - Fee Related
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2015
- 2015-12-17 US US14/972,913 patent/US9474742B2/en not_active Expired - Fee Related
- 2015-12-17 US US14/972,827 patent/US9468629B2/en not_active Expired - Fee Related
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2016
- 2016-08-22 CY CY20161100824T patent/CY1118111T1/el unknown
- 2016-09-19 SM SM201600325T patent/SMT201600325B/it unknown
- 2016-09-20 US US15/271,066 patent/US9592222B2/en not_active Expired - Fee Related
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2017
- 2017-02-01 IL IL250389A patent/IL250389A/en not_active IP Right Cessation
- 2017-02-20 US US15/437,117 patent/US9833440B2/en active Active
- 2017-03-07 AU AU2017201535A patent/AU2017201535B2/en not_active Ceased
- 2017-03-09 JP JP2017044853A patent/JP2017101086A/ja active Pending
- 2017-09-11 IL IL254422A patent/IL254422A0/en unknown
- 2017-11-06 US US15/804,842 patent/US10092547B2/en active Active
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2018
- 2018-06-29 US US16/024,021 patent/US20180303800A1/en not_active Abandoned